Publication date: Available online 24 October 2019Source: Behavioural Brain ResearchAuthor(s): Chao Shang, Ying Guo, Jun-Qi Yao, Xin-Xin Fang, Li-Jun Sun, Xiang-Yun Jiang, Zhen-Chun Ding, Yu-Hua Ran, Heng-lin Wang, Li-Ming Zhang, Yun-Feng LiABSTRACTThere is a serious need for fast-acting drugs to treat post-traumatic stress disorder (PTSD). Our previous studies revealed that YL-IPA08, a novel small-molecule TSPO agonist, exerted significant anti-PTSD effects in various animal models. However, the...
Thu Oct 24, 2019 14:35
Publication date: Available online 23 October 2019Source: Behavioural Brain ResearchAuthor(s): Sanders A. McDougall, Jasmine W. Rios, Matthew G. Apodaca, Ginny I. Park, Nazaret R. Montejano, Jordan A. Taylor, Andrea E. Moran, Jasmine A.M. Robinson, Timothy J. Baum, Angie Teran, Cynthia A. CrawfordABSTRACTThe pattern of ketamine-induced locomotor activity varies substantially across ontogeny and according to sex. Although ketamine is classified as an NMDA channel blocker, it appears to stimulate the...
Thu Oct 24, 2019 14:35
Publication date: Available online 23 October 2019Source: Behavioural Brain ResearchAuthor(s): Kelsey Panfil, Carrie Bailey, Ian Davis, Anne Mains, Kimberly KirkpatrickAbstractTime-based interventions have emerged as promising treatments for disorders associated with impulsivity. These interventions can be implemented to test their efficacy in preventing or treating impulsive choice in animal models of diseases related to impulsivity such as drug abuse. Impulsive choice is typically defined as choosing...
Thu Oct 24, 2019 14:35
124 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/10/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Oct 24, 2019 14:32
Related ArticlesFood Insecurity among College Students in the United States: A Scoping Review. Adv Nutr. 2019 Oct 23;: Authors: Nikolaus CJ, An R, Ellison B, Nickols-Richardson SM Abstract Reports of college students experiencing food insecurity (FI), defined as inadequate access, availability, adequacy, and stability of food, have sparked national calls for alleviation and prevention policies. However, there are a wide variety of FI rates reported across...
Thu Oct 24, 2019 14:29
Related ArticlesArrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome. J Mol Cell Cardiol. 2018 10;123:13-25 Authors: Montnach J, Chizelle FF, Belbachir N, Castro C, Li L, Loussouarn G, Toumaniantz G, Carcouët A, Meinzinger AJ, Shmerling D, Benitah JP, Gómez AM, Charpentier F, Baró I Abstract AIM: Deletion of QKP1507-1509 amino-acids in SCN5A gene product, the voltage-gated Na+ channel Nav1.5,...
Thu Oct 24, 2019 14:23
Abstract Objective This study investigated the effects of abutment screw withdrawal after conical abutment settlement on the stability of the implant–abutment connection. Material and methods Twenty implants of a conical connection system were used. Two two‐piece abutment designs were used: cone only (n = 10; NI) and cone plus octagonal index design (n = 10; I); for each design, five samples were used with (S) and without (NS) abutment screw withdrawal before a cyclic test. Finally, four...
Thu Oct 24, 2019 13:18
Spontaneous rupture of the spleen in malarial infection or malarial splenic rupture (MSR) is a rare but life-threatening condition complicating severe malarial infection in tropics and subtropics, and hence it deserves special attention. A high index of clinical suspicion is warranted for the early diagnosis as delayed or missed diagnosis can be potentially fatal. We report on a 32-year-old male who was diagnosed with severe Plasmodium falciparum infection and presented with an acute abdomen due...
Thu Oct 24, 2019 13:05
Abstract Aims/hypothesis Ovarian cancer (OC) is a malignant tumor with a poor prognosis. Emerging evidence has shown that long non‐coding RNAs (lncRNAs) are new regulators for prognosis, diagnosis and targeted therapy of cancers. Therefore, our purpose is to investigate the possible regulatory role of EPB41L4A‐AS2 in the progression of OC. Methods Initially, EPB41L4A‐AS2 expression in OC tissues and matched paracancerous tissues was determined. Then the RNA crosstalk among EPB41L4A‐AS2,...
Wed Oct 23, 2019 14:10
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12886-zMonitoring catalyst structural changes under working conditions is crucial for understanding how catalysts operate. Here, authors examine single-atom Ru electrocatalyst by operando synchrotron spectroscopies to identify the catalytic mechanism during the acidic oxygen evolution reaction.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12879-yEngineering Taxol pathway in microbes needs to overcome the difficulty of expressing plant P450 enzymes. Here, the authors use a compartmentalized metabolic engineering strategy to construct the taxanes production pathway in chloroplasts of Nicotiana benthamiana and realize the production of taxadience-5α-ol.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12829-8DNA repair by microhomology-mediated end joining creates precise deletions based on flanking microhomologies. Here the authors use CRISPR-Cas9 to recreate pathogenic deletion mutations using existing microhomologies in the human genome identified by their program MHcut.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12800-7The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12848-5The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within cancer cells.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12754-wSoft porous crystals hold big promise as functional nanoporous materials due to their stimuli responsive flexibility. Here, molecular dynamics simulations reveal a new type of spatial disorder in mesoscale crystals that helps to understand the size-dependency of their phase transition behavior.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12412-1Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have an ROS-resistant phenotype enabling metastasis in vivo.
Thu Oct 24, 2019 03:00
Nature Communications, Published online: 24 October 2019; doi:10.1038/s41467-019-12813-2Three-dimensional invisibility cloaks are either limited in bandwidth or disregard the phase of the impinging wave or work only in specific directions. Here, the authors report that these restrictions can be lifted by using cloaks made of fast-light media where the wave group velocity is larger than the speed of light in vacuum.
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Related ArticlesThe Focal Adhesion Scaffold Protein Hic-5 Regulates Vimentin Organization in Fibroblasts. Mol Biol Cell. 2019 Oct 23;:mbcE19080442 Authors: Vohnoutka RB, Gulvady AC, Goreczny G, Alpha K, Handelman SK, Sexton JZ, Turner CE Abstract Focal adhesion (FA)-stimulated reorganization of the F-actin cytoskeleton regulates cellular size, shape, and mechanical properties. However, FA crosstalk with the intermediate filament cytoskeleton is poorly...
Thu Oct 24, 2019 15:52
Related ArticlesHAX1 impact on collective cell migration, cell adhesion and cell shape is linked to the regulation of actomyosin contractility. Mol Biol Cell. 2019 Oct 23;:mbcE19050304 Authors: Balcerak A, Trebinska-Stryjewska A, Wakula M, Chmielarczyk M, Smietanka U, Rubel T, Konopinski R, Macech-Klicka E, Zub R, Grzybowska EA Abstract HAX1 protein is involved in the regulation of apoptosis, cell motility and calcium homeostasis. Its overexpression...
Thu Oct 24, 2019 15:52
Related ArticlesA mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1. Mol Biol Cell. 2019 Oct 23;:mbcE19080430 Authors: Opalko HE, Nasa I, Kettenbach AN, Moseley JB Abstract To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1. SAD family protein kinases regulate Wee1 signaling in yeast and humans. In S. pombe, two SAD kinases (Cdr1/Nim1 and Cdr2) act as upstream inhibitors of Wee1. Previous studies found...
Thu Oct 24, 2019 15:52
Related ArticlesRNA 3D structure prediction guided by independent folding of homologous sequences. BMC Bioinformatics. 2019 Oct 22;20(1):512 Authors: Magnus M, Kappel K, Das R, Bujnicki JM Abstract BACKGROUND: The understanding of the importance of RNA has dramatically changed over recent years. As in the case of proteins, the function of an RNA molecule is encoded in its tertiary structure, which in turn is determined by the molecule's sequence. The...
Thu Oct 24, 2019 13:50
Related ArticlesCorrection to: Towards pixel-to-pixel deep nucleus detection in microscopy images. BMC Bioinformatics. 2019 Oct 22;20(1):509 Authors: Xing F, Xie Y, Shi X, Chen P, Zhang Z, Yang L Abstract Following publication of the original article [1], we have been notified of a few errors in the html version.PMID: 31640559 [PubMed - in process]
Thu Oct 24, 2019 13:50
Related ArticlesPredicting rice blast disease: machine learning versus process-based models. BMC Bioinformatics. 2019 Oct 22;20(1):514 Authors: Nettleton DF, Katsantonis D, Kalaitzidis A, Sarafijanovic-Djukic N, Puigdollers P, Confalonieri R Abstract BACKGROUND: In this study, we compared four models for predicting rice blast disease, two operational process-based models (Yoshino and Water Accounting Rice Model (WARM)) and two approaches based on machine...
Thu Oct 24, 2019 13:50
Related ArticlesGlycosylator: a Python framework for the rapid modeling of glycans. BMC Bioinformatics. 2019 Oct 22;20(1):513 Authors: Lemmin T, Soto C Abstract BACKGROUND: Carbohydrates are a class of large and diverse biomolecules, ranging from a simple monosaccharide to large multi-branching glycan structures. The covalent linkage of a carbohydrate to the nitrogen atom of an asparagine, a process referred to as N-linked glycosylation, plays an important...
Thu Oct 24, 2019 13:50
Related ArticlesA question-entailment approach to question answering. BMC Bioinformatics. 2019 Oct 22;20(1):511 Authors: Ben Abacha A, Demner-Fushman D Abstract BACKGROUND: One of the challenges in large-scale information retrieval (IR) is developing fine-grained and domain-specific methods to answer natural language questions. Despite the availability of numerous sources and datasets for answer retrieval, Question Answering (QA) remains a challenging...
Thu Oct 24, 2019 13:50
Related ArticlesIncorporating genetic networks into case-control association studies with high-dimensional DNA methylation data. BMC Bioinformatics. 2019 Oct 22;20(1):510 Authors: Kim K, Sun H Abstract BACKGROUND: In human genetic association studies with high-dimensional gene expression data, it has been well known that statistical selection methods utilizing prior biological network knowledge such as genetic pathways and signaling pathways can outperform...
Thu Oct 24, 2019 13:50
Abstract Predation is a ubiquitous and strong selective pressure on living organisms. Transparency is a predation defence widespread in water but rare on land. Some Lepidoptera display transparent patches combined with already cryptic opaque patches. A recent study showed that transparency reduced detectability of aposematic prey with conspicuous patches. However, whether transparency has any effect at reducing detectability of already cryptic prey is still unknown. We conducted field predation...
Wed Oct 23, 2019 15:45
Related ArticlesIL-17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes. J Cell Physiol. 2019 Oct 23;: Authors: Liao C, Zhang C, Jin L, Yang Y Abstract Bone remodeling is a strictly regulated dynamic process that cycles between bone formation and resorption, and interleukin-17 (IL-17) critically orchestrates the activation and differentiation of both osteoblasts and osteoclasts. Mesenchymal stem cells (MSCs) within...
Thu Oct 24, 2019 15:45
Related ArticlesCircular RNA circC3P1 restrains kidney cancer cell activity by regulating miR-21/PTEN axis and inactivating PI3K/AKT and NF- kB pathways. J Cell Physiol. 2019 Oct 23;: Authors: Chen T, Yu Q, Xin L, Guo L Abstract Kidney cancer (KC) seriously impacts public health. We detected the function and mechanism of circular RNA C3P1 (circC3P1) in KC cells. CCK-8, flow cytometry, migration, and invasion assay were respectively used to investigate...
Thu Oct 24, 2019 15:45
Related ArticlesBZW2 promotes the malignant progression of colorectal cancer via activating the ERK/MAPK pathway. J Cell Physiol. 2019 Oct 23;: Authors: Huang L, Chen S, Fan H, Ai F, Sheng W Abstract Colorectal cancer (CRC) is one of the most prevalent malignant solid cancers worldwide involving the dysregulation of multiple signaling molecules. However, the role and corresponding mechanism of basic leucine zipper and W2 domains 2 (BZW2) in CRC development,...
Thu Oct 24, 2019 15:45
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