European Journal of Cancer
- Cetuximab, fluorouracil and cisplatin with or without docetaxel for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CeFCiD): an open-label phase II randomised trial (AIO/IAG-KHT trial 1108)Publication date: November 2019Source: European Journal of Cancer, Volume 122Author(s): K. Klinghammer, T. Gauler, A. Dietz, V. Grünwald, J. Stöhlmacher, S. Knipping, M. Schroeder, O. Guntinas-Lichius, N. Frickhofen, H.-W. Lindeman, R. Fietkau, B. Haxel, C. Große-Thie, G. Maschmeyer, M. Zipfel, P. Martus, M. Knoedler, U. KeilholzAbstractBackgroundThe combination of cisplatin, 5-fluorouracil (5-FU) and cetuximab (PFC) is the reference first-line t
- Breast conserving therapy is associated with improved overall survival compared to mastectomy in early-stage, lymph node-negative breast cancerPublication date: Available online 12 October 2019Source: Radiotherapy and OncologyAuthor(s): Muayad F. Almahariq, Thomas J. Quinn, Zaid Siddiqui, Maha S. Jawad, Peter Y. Chen, Gregory S. Gustafson, Joshua T. DilworthAbstractBackground and purposeRecent retrospective studies suggest improved overall survival (OS) with breast conserving therapy (BCT), including breast conserving surgery and adjuvant whole breast radiotherapy, compared to mastectom
- Prediction of Late Enophthalmos using Quantitative Measures in Isolated Medial Orbital Wall Fracture: Multiple Regression AnalysisPublication date: Available online 12 October 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Young Woong Mo, Sung Woo Kim, Hea Kyeong ShinSummaryBackgroundEnophthalmos is one of the most distressing complications of orbital fracture and when faced with a blow-out fracture, plastic surgeons often find it difficult to determine the need for surgical correction. Although a number of studies have been conducted on this t
European Journal of Neuroscience
- Update on temporal lobe‐dependent information processing, in health and diseaseAbstract The past decade has been characterized by a lot of remodeling in the field of learning and memory. Both of them, often associated with neuronal oscillations, an emergent property of brain networks, are governed by temporal lobe (TL) functional connectivity. An impairment of oscillatory mechanisms indeed often leads to TL‐dependent cognitive deficits. While the classical view assigned the TL a major role in spatial information processing
- Mechanisms of NMDA receptor inhibition by diarylamidine compoundsAbstract Pentamidine, diminazene and 4′,6‐diamidino‐2‐phenylindole (DAPI) are anti‐protozoal diarylamidine compounds. In the present work we have studied their action on native N‐methyl‐D‐aspartate (NMDA) receptors in rat hippocampal pyramidal neurons. All three compounds inhibited NMDA receptors at ‐80 mV holding voltage with IC50 of 0.41 ± 0.08, 13 ± 3 and 3.1 ± 0.6 μM, respectively. The inhibition by pentamidine was strongly voltage‐dependent
- Light Aerobic Exercise Modulates Executive Function and Cortical ExcitabilityAbstract Single bouts of aerobic exercise can modulate cortical excitability and executive cognitive function, but less is known about the effect of light intensity exercise, an intensity of exercise more achievable for certain clinical populations. Fourteen healthy adults (aged 22 to 30) completed the following study procedures twice (≥7 days apart) before and after 30‐minutes of either light aerobic exercise (cycling) or seated rest: neurocogn
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
- Improving single-cell transcriptome sequencing efficiency with a microfluidic phase-switch deviceAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00823C, PaperBaoyue Zhang, Hong Xu, Yuqing Huang, Weiliang Shu, Hongtao Feng, Jin Cai, Jiang F. Zhong, Yan ChenIn this paper, we present a novel method to improve the efficiency of single-cell transcriptome sequencing for analyzing valuable cell samples. The microfluidic device we designed integrates multiple single-cell isolation...The content of this RSS Feed (c) The Royal Society of Chemistry
Cancer
- In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cellsBritish Journal of Cancer, Published online: 14 October 2019; doi:10.1038/s41416-019-0600-9In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells
- Association between the exposure to anti-angiogenic agents and tumour immune microenvironment in advanced gastrointestinal stromal tumoursBritish Journal of Cancer, Published online: 14 October 2019; doi:10.1038/s41416-019-0596-1Association between the exposure to anti-angiogenic agents and tumour immune microenvironment in advanced gastrointestinal stromal tumours
- Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanismsBritish Journal of Cancer, Published online: 14 October 2019; doi:10.1038/s41416-019-0599-yImmune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms
Chemical Senses
- Multisensory interactions underlying flavor consumption in rats: The role of experience and unisensory component likingAbstractThe mechanisms by which taste and odor are combined in determining food choice behavior are poorly understood. Previous work in human subjects has yielded mixed results, potentially due to differences in task context across studies, and a lack of control over flavor experience. Here, we used rats as a model system to systematically investigate the role of experience and unisensory component liking in the multisensory interactions underlyi
- ’Squeeze & Excite’ Guided Few-Shot Segmentation of Volumetric ImagesPublication date: Available online 13 October 2019Source: Medical Image AnalysisAuthor(s): Abhijit Guha Roy, Shayan Siddiqui, Sebastian Pölsterl, Nassir Navab, Christian WachingerAbstractDeep neural networks enable highly accurate image segmentation, but require large amounts of manually annotated data for supervised training. Few-shot learning aims to address this shortcoming by learning a new class from a few annotated support examples. We intr
- Hypoxia and lncRNAs in gastrointestinal cancersPublication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Lining Huang, Weina Wang, Zengtao Hu, Canghai Guan, Wenzhi Li, Xingming JiangAbstractObjectivesHypoxia is a hallmark of the tumor microenvironment, and hypoxia regions are frequently found in gastrointestinal cancers, which are associated with worse patients⿿ survival and therapy resistance. However, the potential mechanisms of hypoxic tumor micr
- Downregulation of oncogenic gene TGFβR2 by miRNA-107 suppresses non-small cell lung cancerPublication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Zong Wu, Qian Yuan, Chenghao Yang, Xinju Zhang, Pengfei Qi, Hai Huang, Zhongliang MaAbstractNon-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases with a low 5-year survival rate. MicroRNAs may be targeted in the clinical treatment of the disease. In this study, miR-107 showed low expression in NSCLC serum samples, and
- Prognostic and clinicopathological significance of CapG in various cancers: evidence from a meta-analysisPublication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Zhiquan Lang, Yuting Chen, Hanyan Zhu, Yuting Sun, Hao Zhang, Junfu Huang, Zhenhong ZouAbstractBackgroundThe gelsolin-like actin-capping protein (CapG) is an actin-binding protein in the gelsolin superfamily. Increasing evidence indicates that CapG is highly expressed in various types of cancer. However, the role of CapG in malignant tumors is st
- Dysregulation of microRNA-106a-5p-RUNX1 axis associates with clinical progression and prognosis of osteosarcoma patientsPublication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Kun Chen, Guobiao PanAbstractMicroRNA-106a-5p (miR-106a-5p) functions as a tumor suppressor in osteosarcoma cells. Here, we aimed to identify novel target genes of miR-106a-5p in osteosarcoma, as well as to investigate their prognostic value and the biological functions. At first, the mammalian runt-related factor 1 (RUNX1) was identified as one
- Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcomaPublication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Yan Jin, Lisen Li, Tongtong Zhu, Guangyao LiuAbstractOsteosarcoma (OS) is known as a tumor that derives from skeletal system with increasing incidence worldwide. This study aimed to explore the effect of a circular RNA (circRNA), circ_0102049, on OS and reveal its potential molecular mechanism. In this work, the expression of circ_0102049 was det
- Design and development of a robotic predator as a stimulus in conditioned place aversion for the study of the effect of ethanol and citalopram in zebrafishPublication date: Available online 12 October 2019Source: Behavioural Brain ResearchAuthor(s): Romain J.G. Clément, Simone Macrì, Maurizio PorfiriAbstractZebrafish are becoming a species of choice in psychopharmacology, laying a promising path to refined pharmacological manipulations and high-throughput behavioral phenotyping. The field of robotics has the potential to accelerate progress along this path, by offering unprecedented means for the d
- Within-animal comparisons of novelty and cocaine neuronal ensemble overlap in the nucleus accumbens and prefrontal cortexPublication date: Available online 12 October 2019Source: Behavioural Brain ResearchAuthor(s): Natalie N. Nawarawong, Christopher M. OlsenAbstractNovelty seeking is a personality trait associated with an increased vulnerability for substance abuse. In rodents, elevated novelty seeking has been shown to be a predictor for elevated drug self-administration and compulsive use. While previous studies have shown that both novelty and drugs of abuse ha
- The Effects of Visual Distractors on Cognitive Load in a Motor Imagery Brain-Computer InterfacePublication date: Available online 12 October 2019Source: Behavioural Brain ResearchAuthor(s): Zahra Emami, Tom ChauAbstractA brain-computer interface (BCI) is a system that translates neural activity into a practical output. Its functionality, therefore, depends not only on the computer itself, but also on the cognitive system of the user. Distractors have the potential to capture attention, increase cognitive load, and may therefore impact BCI
- Deep brain stimulation of the thalamic centromedian-parafascicular nucleus improves behavioural and neuronal traits in a rat model of TourettePublication date: Available online 12 October 2019Source: Behavioural Brain ResearchAuthor(s): Thomas Elle, Mesbah Alam, Charlene Voigt, Joachim K. Krauss, Nadine John, Kerstin SchwabeAbstractDeficient prepulse inhibition (PPI) of the acoustic startle reaction after injection of the dopamine receptor agonist apomorphine has been experimentally used to model certain aspects of Tourette syndrome (TS) in rats. Deep brain stimulation (DBS) of the cen
- Role of sensorimotor areas in early detection of motor errors: an EEG and TMS studyPublication date: Available online 12 October 2019Source: Behavioural Brain ResearchAuthor(s): Laura Maffongelli, Elisabetta Ferrari, Eleonora Bartoli, Claudio Campus, Etienne Olivier, Luciano Fadiga, Alessandro D’AusilioAbstractAction execution is prone to errors and, while engaged in interaction, our brain is tuned to detect deviations from what one expects from other’s action. Prior research has shown that Event-Related-Potentials (ERPs) are s
- Proteomic analysis of thioproline misincorporation in <em>Escherichia coli</em>Publication date: Available online 13 October 2019Source: Journal of ProteomicsAuthor(s): Jingjing Liu, Chunlin Hao, Long Wu, Wan Chan, Henry LamAbstractRecently it was discovered that thioproline, an unnatural analog of proline, can arise in vivo from the reaction of cysteine and formaldehyde in cells under oxidative stress. Sequence-specific bioincorporation of thioproline into proteins was studied via shotgun proteomics of Escherichia coli (E.
- Randomized trial of a resilience intervention on resilience, behavioral strengths and difficulties of mainstreamed adolescent students with hearing lossPublication date: Available online 12 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nikta Hatamizadeh, Narges Adibsereshki, Anoshirvan Kazemnejad, Firoozeh SajediAbstractObjectivesAdolescents with hearing loss have shown emotional and behavioral difficulties. This study evaluated the effectiveness of a resilience-focused intervention on resilience, behavioral strengths, and difficulties of mainstreamed adole
- The Impact of Persistent Pediatric Obstructive Sleep Apnea on the Quality of Life of Patients’ FamiliesPublication date: Available online 12 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mathieu Bergeron, Angela L. Duggins, Aliza P. Cohen, Brittany A. Leader, Stacey L. IshmanAbstractObjectivesTo (1) quantify the quality of life (QOL) for families of children affected by persistent obstructive sleep apnea (OSA), and (2) assess factors contributing to the negative impact of OSA on families.MethodsProspective ca
Κυριακή 13 Οκτωβρίου 2019
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