Related ArticlesImpact of lumbar interbody fusion surgery on postoperative outcomes in patients with recurrent lumbar disc herniation: Analysis of the US national inpatient sample. J Clin Neurosci. 2019 Oct 17;: Authors: Ye YP, Hu JW, Zhang YG, Xu H Abstract Little information is available on associations between different lumbar interbody fusion (LIF) surgeries and postoperative outcomes. The present study aims to comprehensively investigate whether...
Tue Oct 22, 2019 13:08
Related ArticlesObesity Is Not Associated With Postoperative Complications After Vestibular Schwannoma Surgery in a Large Single Institution Series. Otol Neurotol. 2019 Oct 18;: Authors: Lipschitz N, Kohlberg GD, Walters ZA, Tawfik KO, Samy RN, Pensak ML, Zuccarello M, Andaluz N, Dinapoli VA, Breen JT Abstract OBJECTIVE: Determine whether elevated body mass index (BMI) is associated with postoperative complications after vestibular schwannoma (VS) surgery....
Tue Oct 22, 2019 14:59
Related ArticlesFailure Pressures of Dural Repairs in a Porcine Ex Vivo Model: Novel Use of Titanium Clips Versus Tissue Glue. Allergy Rhinol (Providence). 2019 Jan-Dec;10:2152656719879677 Authors: Chorath K, Krysinski M, Bunegin L, Majors J, Weitzel EK, McMains KC, Chen PG Abstract Objective: Endoscopic skull base surgery is advancing, and it is important to have reliable methods to repair the resulting defect. The objective of this study was to determine...
Tue Oct 22, 2019 14:59
Related ArticlesNivolumab plus ipilimumab versus sunitinib in previously untreated advanced renal-cell carcinoma: analysis of Japanese patients in CheckMate 214 with extended follow-up. Jpn J Clin Oncol. 2019 Oct 21;: Authors: Tomita Y, Kondo T, Kimura G, Inoue T, Wakumoto Y, Yao M, Sugiyama T, Oya M, Fujii Y, Obara W, Motzer RJ, Uemura H Abstract BACKGROUND: Nivolumab plus ipilimumab (NIVO+IPI) demonstrated superior efficacy over sunitinib (SUN) for...
Tue Oct 22, 2019 15:04
Related ArticlesCervical Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis. Front Neurol. 2019;10:1043 Authors: Chen G, Yu G, Li Y, Zhao X, Dai X, Wang G Abstract Objective: The objective of our study was to investigate the potential association between the occurrence of benign paroxysmal positional vertigo (BPPV) and saccular dysfunction using cervical vestibular evoked myogenic potentials...
Tue Oct 22, 2019 15:03
Related ArticlesComparison of ocular vestibular myogenic response by acoustic stimulation at 500 and 1000 Hz in healthy subjects. Cir Cir. 2019;87(6):640-644 Authors: Segura-Hernández M, Ramos-Maldonado D, Luna-Reyes FA, Lino-González AL, Arch-Tirado E Abstract Objective: To compare the amplitude of potentials by acoustic stimulation at 500 Hz versus 1000 Hz in healthy subjects. Methods: 25 subjects; potentials were performed with acoustic stimuli...
Tue Oct 22, 2019 13:01
Tue Oct 22, 2019 11:59
Publication date: Available online 21 October 2019Source: Journal of VoiceAuthor(s): Janaina Regina Bosso, Regina Helena Garcia Martins, Adriana Bueno Benito Pessin, Elaine Lara Mendes Tavares, Celso Vieira Leite, Luiz Eduardo NaresseSummaryIntroductionObesity modifies vocal characteristics, causing abnormal fat deposition in the abdominal region and upper airways. For some authors the voice of the obese is not different from nonobese and the vocal symptoms are scarce; for others dysphonia in obese...
Tue Oct 22, 2019 12:48
Publication date: Available online 21 October 2019Source: Journal of VoiceAuthor(s): David E. Rosow, Jennylee Diaz, Debbie R. Pan, Adam T. LloydSummaryBackgroundVoice therapy is a well-studied, evidence-based treatment in the management of voice disorders, yet it is known that adherence rates are generally decreased due to a variety of identified factors. In light of this fact, a high rate of nonadherence to voice therapy has been anecdotally observed in the Hispanic community comprising a sizable...
Tue Oct 22, 2019 12:48
Abstract Objectives There is a long history of studies into cystic lesions of the jaws. However, there is little data on postoperative bone regeneration. The aim of the study was to calculate the size of the residual bone lesions after cystostomies and cystectomies to predict the postoperative bone healing. Material and methods This retrospective...
Tue Oct 22, 2019 12:39
Background: Cochlear implantation is an important method of hearing rehabilitation. Earlier studies have shown the influence of implantation on the vestibular system. However, until now, the effect of hearing rehabilitation with cochlear implants (CI) on postural control and body stability has not been sufficiently studied. Objective: To analyse the effect of hearing rehabilitation with activated CI and different sound inputs (music, speech text, and white noise) on postural control and risk of falls...
Tue Oct 22, 2019 11:26
Background: This work aimed to explore the predictors of lymph node metastasis (LNM) and analyze the prognosis of patients with clinically node-negative (cN0) T1–T2 supraglottic laryngeal carcinoma (SGLC). Methods: Data for 130 patients with cN0 T1–T2 SGLC who initially underwent surgery were retrospectively reviewed. Occult LNM incidence, relevant factors, and prognosis were analyzed. Results: Of the 130 patients with cN0 T1–T2 SGLC, 21 (16.2%) had occult LNM. Based on univariate and multivariable...
Tue Oct 22, 2019 11:27
New England Journal of Medicine, Ahead of Print.
Mon Oct 21, 2019 14:02
New England Journal of Medicine, Ahead of Print.
Mon Oct 21, 2019 14:00
New England Journal of Medicine, Ahead of Print.
Mon Oct 21, 2019 04:01
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition characterized by widespread inflammation due to massive immune activation and cytokine release. It is of 2 types, primary or familial and secondary or acquired. Diagnosis is made by fulfilling 5 of 8 criteria as determined by the Histiocyte Society. Treatment includes etoposide, dexamethasone, with or without intrathecal...
Tue Oct 22, 2019 09:34
Abstract Objectives Riparian or gallery forests are critical habitats for numerous plants and animals today. Paleoanthropologically, reliance on such habitats informs behavioral and ecological reconstructions; for example, gallery forest habitats likely played a critical role in the transition from ape to hominin in the early Pliocene and may represent a preferred habitat for the last common ancestor of chimpanzees and humans. Direct indicators for gallery forest habitats preference are lacking....
Mon Oct 21, 2019 22:00
Abstract Objectives Accessory digits have evolved independently within several mammalian lineages. Most notable among these is the pseudothumb of the giant panda, which has long been considered one of the most extraordinary examples of contingent evolution. To date, no primate has been documented to possess such an adaptation. Here, we investigate the presence of this structure within the aye‐aye (Daubentonia madagascariensis), a species renowned for several other specialized morphological adaptations...
Mon Oct 21, 2019 22:00
Abstract Objective This study aims to develop a comparative basis for assessing the developmental stage of KNM‐ER 42700 based on the ontogenetic pattern of the ectocranial surface of the basicranium in modern humans and chimpanzees. Materials and methods A total of 33 landmarks were collected from an ontogenetic sample of modern humans (80), chimpanzees (51), and 12 individuals classified as Homo erectus s.l. Ontogenetic trajectories were analyzed, and common aspects were extracted for...
Mon Oct 21, 2019 12:39
Abstract Objectives We are testing competing scenarios regarding the population history of the ancient Greek colonization of southern Italy using dental phenotypic evidence. Materials and Methods We collected dental metric and nonmetric trait data for 481 human skeletons from six archaeological sites along the Gulf of Taranto, dating to pre‐colonial (900–700 BC) and post‐colonial periods (700–200 BC). We are evaluating scenarios through an individual‐level biodistance analysis using a three‐pronged...
Mon Oct 21, 2019 12:36
The Asian clam, Corbicula fluminea, is a commonly consumed small freshwater bivalve in East Asia. However, available genetic information of this clam is still limited. In this study, the transcriptome of female C. fluminea was sequenced using the Illumina HiSeq 2500 platform. A total of 89,563 unigenes were assembled with an average length of 859 bp, and 36.7% of them were successfully annotated. Six members of Sox gene family namely SoxB1, SoxB2, SoxC, SoxD, SoxE and SoxF were identified. Based...
Tue Oct 22, 2019 03:00
Background Key natural enemy-pest interactions can be mapped in agricultural food webs by analysing predator gut content for the presence of a focal pest species. For this, PCR-based approaches are the most widely used methods providing the incidence of consumption of a focal pest in field sampled predators. To interpret such data the rate of prey DNA decay in the predators’ gut, described by DNA detectability half-life (t1/2), is needed. DNA decay may depend on the presence of alternative...
Tue Oct 22, 2019 03:00
This study develops a modelling framework by utilizing multi-sensor imagery for classifying different forest and land use types in the Phnom Kulen National Park (PKNP) in Cambodia. Three remote sensing datasets (Landsat optical data, ALOS L-band data and LiDAR derived Canopy Height Model (CHM)) were used in conjunction with three different machine learning (ML) regression techniques (Support Vector Machines (SVM), Random Forests (RF) and Artificial Neural Networks (ANN)). These ML methods were implemented...
Tue Oct 22, 2019 03:00
Background The kinase of Aurora A has been regarded as a promising therapeutic target due to its altered expression in various human cancers. However, given the high similarity of the active binding site of Aurora A to other kinases, designing highly selective inhibitors towards Aurora A remains a challenge. Recently, two potential small-molecule inhibitors named AT9283 and Danusertib were reported to exhibit significant selectivity to Aurora A, but not to Gleevec. It was argued...
Tue Oct 22, 2019 03:00
Background European mouflon (Ovis orientalis musimon) has been reintroduced in mainland Europe since the 18th-century sourcing from the Sardinian and Corsican autochthonous mouflon populations. The European mouflon is currently considered the feral descendent of the Asian mouflon (O. orientalis), and the result of first wave of sheep domestication occurred 11,000 years ago in the Fertile Crescent, and brought to Corsica and Sardinia ca. 6,000 years ago, where they still live as autochthonous...
Tue Oct 22, 2019 03:00
Background Bladder cancer is one of the most common cancers, and its histopathological type is mainly bladder urothelial carcinoma, accounting for about 90%. The prognostic biomarkers of bladder cancer are classified into clinical features biomarkers and molecular biomarkers. Nevertheless, due to the existence of individual specificity, patients with similar pathological characteristics still have great differences in the risk of disease recurrence. Therefore, it is often inaccurate to predict...
Tue Oct 22, 2019 03:00
Background Cutaneous melanoma (CM) is the deadliest form of skin cancer. Numerous studies have revealed that microRNAs (miRNAs) are expressed abnormally in melanoma tissues. Our work aimed to assess multiple miRNAs using bioinformatic analysis in order to predict the prognoses of cutaneous melanoma patients. Methods The microarray dataset GSE35579 was downloaded from the Gene Expression Omnibus (GEO) database to detect...
Tue Oct 22, 2019 03:00
Temperature and water availability are two of the most important variables affecting all aspects of an anuran’s key physiological processes such as body temperature (Tb), evaporative water loss (EWL) and standard metabolic rate (SMR). Since anurans display pronounced sexual dimorphism, evidence suggests that these processes are further influenced by other factors such as vapour pressure deficit (VPD), sex and body mass (Mb). However, a limited number of studies have tested the generality of these...
Tue Oct 22, 2019 03:00
Abstract Radiation therapy is one of the cornerstones in the treatment of head and neck squamous cell carcinomas (HNSCC), alone or in combination with chemotherapy or surgery. Technological advances which occurred over the last few decades have increased the efficacy of radiotherapy (RT), particularly, intensity‐modulated RT (IMRT). IMRT can deliver treatments on complex tumoral targets with dose escalation while sparing organs at risk; anyway IMRT deposits dose in unpredictable patterns outside...
Mon Oct 21, 2019 14:19
Abstract The laser has become an integral part of modern medicine, procedures based on this technique have found their way into a multitude of medical disciplines. There is, however, no data available on the detailed quantitative development of laser use in the medical sector. This fact gave rise to the idea of the present study, which analysed the raw data of the quality report of German hospitals with respect to this subject. Over the nine years of report, a steady increase in the cumulative number...
Mon Oct 21, 2019 21:13
We estimated mortality figures for 2019 in seven Latin American countries, with focus on breast cancer. We retrieved cancer death certification and population data from the WHO and PAHO databases. We obtained mortality statistics for Argentina, Brazil, Chile, Colombia, Cuba, Mexico and Venezuela for 1970‐2015. We predicted current death numbers and age‐standardized (world population) mortality rates using joinpoint regression models. Total cancer mortality is predicted to decline in all countries...
Mon Oct 21, 2019 21:05
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. This study aimed to discover blood‐based markers for the early detection of CRC and to ascertain their efficiency in discriminating healthy controls, patients with polyps and adenomas...
Mon Oct 21, 2019 18:45
To achieve higher coverage and effectiveness in limited resource settings, World Health Organization (WHO) guidelines for cervical cancer prevention recommend a screen‐and‐treat strategy with high‐risk human papillomavirus (HPV) testing. We piloted a real‐word project to examine the feasibility of this approach in rural Cameroon. Nurses from the Women's Health Program (WHP) of the Cameroon Baptist Convention Health Services (CBCHS) educated women in remote villages on cervical cancer prevention....
Mon Oct 21, 2019 18:38
Whether PD‐L1‐positive patients derive more overall survival benefit from PD‐1/PD‐L1 inhibitors in the treatment of advanced solid tumours is unclear. We systematically searched the PubMed, Cochrane library, and EMBASE databases from January 1, 1966 to March 1, 2019 to identify randomized controlled trials of PD‐1/PD‐L1 inhibitors (nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab) that had available hazard ratios (HRs) for death according to PD‐L1 status. A random‐effects model was used...
Mon Oct 21, 2019 18:34
Mon Oct 21, 2019 18:34
In the general population, moderate exercise, physical activity, and participation in sports have important health benefits, including slowing cognitive decline and preventing dementia. Participation in elite-level sports, not surprisingly, is also associated with reductions in all-cause mortality…
Mon Oct 21, 2019 03:00
Concerns have been raised about the risk of several neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and chronic traumatic encephalopathy (CTE), associated with participation in contact sports. Recognition of the pathologic changes of CTE in former players who…
Mon Oct 21, 2019 03:00
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