Zusammenfassung Bei dem als „IgG4-assoziierte Erkrankung“ bezeichneten Krankheitsbild handelt es sich um einen potenziell systemischen, chronisch entzündlichen und fibrosierenden Prozess. Unabhängig von der Organmanifestation sind die histologischen Hauptmerkmale ein lymphoplasmazelluläres Infiltrat, eine storiforme Fibrose und eine obliterative Phlebitis. Diese Hauptmerkmale werden jedoch in bestimmten Organen unterschiedlich gewichtet. Wenn mehrere dieser Merkmale vorliegen bei...
Tue Oct 22, 2019 03:00
Publication date: Available online 22 October 2019Source: Autoimmunity ReviewsAuthor(s): Daniel Blockmans, Raashid Luqmani, Lucia Spaggiari, Carlo SalvaraniAbstractWith advances in our understanding of the pathogenesis of large vessel vasculitides, we recognise the persistence of inflammation in large vessels, sometimes despite therapy to control clinical symptoms. Achieving an early diagnosis and establishing the extent of disease are important steps in improving our management of these diseases....
Tue Oct 22, 2019 13:28
Publication date: Available online 21 October 2019Source: Autoimmunity ReviewsAuthor(s): Hagit Peleg, Yaakov Naparstek, Francesca Regola, Angela Tincani, Vittorio Pengo, Gentian DenasAbstractSecondary thromboprophylaxis with low molecular heparin or vitamin K antagonists (VKAs) is recommended in patients with definite antiphospholipid syndrome (APS). Direct oral anticoagulant (DOACs) have been approved in different prothrombotic conditions and have numerous advantages compared to VKAs. Whether DOACs...
Tue Oct 22, 2019 13:28
Publication date: Available online 21 October 2019Source: Autoimmunity ReviewsAuthor(s): Piercarlo Sarzi-Puttini, Jacob Ablin, Adva Trabelsi, Mary-Ann Fitzcharles, Daniela Marotto, Winfried HäuserAbstractMedical cannabis is being increasingly used in the treatment of rheumatic diseases because, despite the paucity of evidence regarding its safety and efficacy, a growing number of countries are legalising its use for medical purposes in response to social pressure. Cannabinoids may be useful in the...
Tue Oct 22, 2019 13:28
Related Articles3D printed myringotomy and tube simulation as an introduction to otolaryngology for medical students. Int J Pediatr Otorhinolaryngol. 2019 Oct 15;128:109730 Authors: Sparks D, Kavanagh KR, Vargas JA, Valdez TA Abstract OBJECTIVES: Surgical simulation models have been shown to improve surgical skill and confidence for surgical residents before real life procedures. Surgical simulators can be similarly applied in undergraduate medical education...
Tue Oct 22, 2019 15:33
Related ArticlesParents' views about factors facilitating their involvement in the oral early intervention services provided for their children with hearing loss in Kuwait. Int J Pediatr Otorhinolaryngol. 2019 Oct 11;128:109717 Authors: Alduhaim A, Purcell A, Cumming S, Doble M Abstract OBJECTIVES: Developed countries (such as the Unites States of America, the United Kingdom, and Australia) provide high-quality services to children with hearing loss...
Tue Oct 22, 2019 15:33
Related ArticlesUCBG 2-04: Long-term results of the PACS 04 trial evaluating adjuvant epirubicin plus docetaxel in node-positive breast cancer and trastuzumab in the human epidermal growth factor receptor 2-positive subgroup. Eur J Cancer. 2019 Oct 18;122:91-100 Authors: D'Hondt V, Canon JL, Roca L, Levy C, Pierga JY, Le Du F, Campone M, Desmoulins I, Goncalves A, Debled M, Rios M, Ferrero JM, Serin D, Hardy-Bessard AC, Piot G, Brain E, Dohollou N, Orfeuvre H, Lemonnier...
Tue Oct 22, 2019 15:30
Related ArticlesAcute Cardiotoxicity With Concurrent Trastuzumab and Hypofractionated Radiation Therapy in Breast Cancer Patients. Front Oncol. 2019;9:970 Authors: Sayan M, Abou Yehia Z, Gupta A, Toppmeyer D, Ohri N, Haffty BG Abstract Purpose: Radiotherapy for patients with non-metastatic human epidermal growth factor receptor 2 (HER2) positive breast cancer is commonly administered concurrently with adjuvant trastuzumab. However, there is limited data...
Tue Oct 22, 2019 15:30
Related ArticlesPREVENTIVE ROLE OF VITAMIN D SUPPLEMENTATION FOR ACUTE PHASE REACTION AFTER BISPHOSPHONATE INFUSION IN PAGET'S DISEASE. J Clin Endocrinol Metab. 2019 Oct 22;: Authors: Merlotti D, Rendina D, Muscariello R, Picchioni T, Alessandri M, De Filippo G, Materozzi M, Bianciardi S, Franci MB, Lucani B, Cenci S, Strazzullo P, Nuti R, Gennari L Abstract CONTEXT: Intravenous amino-bisphosphonates (N-BPs) can induce an acute phase reaction (APR) in...
Tue Oct 22, 2019 15:21
Related ArticlesResponse to Letter to the Editor: Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation. J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Lin YF, Peng KY, Chang CH, Hu YH, Wu VC, Chueh JS PMID: 31634403 [PubMed - as supplied by publisher]
Tue Oct 22, 2019 15:21
Related ArticlesLetter to the Editor: "Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation". J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Almeida MQ PMID: 31633788 [PubMed - as supplied by publisher]
Tue Oct 22, 2019 15:21
Related ArticlesCirculating IGF-I independently predicts blood pressure in children with higher calcium-phosphorus product levels. J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Xargay-Torrent S, Dorado-Ceballos E, Benavides-Boixader A, Lizárraga-Mollinedo E, Mas-Parés B, Montesinos-Costa M, De Zegher F, Ibáñez L, Bassols J, López-Bermejo A Abstract OBJECTIVE: To study the association between IGF-I and blood pressure in children, in particular, the...
Tue Oct 22, 2019 15:21
Related ArticlesTreatment with 90Y/177Lu DOTATOC in patients with metastatic adrenocortical carcinoma expressing somatostatin receptors. J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Grisanti S, Filice A, Basile V, Cosentini D, Rapa I, Albano D, Morandi A, Laganà M, Dalla Volta A, Bertagna F, Tiberio GMA, Volante M, Terzolo M, Versari A, Berruti A Abstract CONTEXT: We investigated the role of 68Ga-DOTATOC PET/CT in detecting somatostatin receptors...
Tue Oct 22, 2019 15:21
Related ArticlesLetter to the Editor: Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study. J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Lee YM, Lee DH PMID: 31633183 [PubMed - as supplied by publisher]
Tue Oct 22, 2019 15:21
Related ArticlesResponse to letter to the Editor: "Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study". J Clin Endocrinol Metab. 2019 Oct 21;: Authors: Lee JY, Lee YH PMID: 31633182 [PubMed - as supplied by publisher]
Tue Oct 22, 2019 15:21
Publication date: Available online 21 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Karl Kuusik, Teele Kepler, Mihkel Zilmer, Jaan Eha, Mare Vähi, Jaak KalsObjectivesRemote ischaemic preconditioning (RIPC) is a phenomenon that promotes protection of tissues and organs against ischaemia reperfusion injury. RIPC has been shown to reduce myocardial and renal injury but its effect on arterial stiffness in patients undergoing lower limb digital subtraction angiography...
Tue Oct 22, 2019 13:21
Abstract Despite the recent improvements, pulmonary embolism (PE) is a major cause of cardiovascular morbidity and mortality.1‐3 Therefore, timely and accurate risk stratification is critical, both for communicating the risk with patients and families, and to implement therapies that may help improve patient outcomes. Over the past several years, a host of risk stratification tools have been developed and some have been incorporated into guideline recommendations and clinical practice.4 However,...
Mon Oct 21, 2019 19:09
Related ArticlesImplication of the SH3TC2 gene in Charcot-Marie-Tooth disease associated with deafness and/or scoliosis: Illustration with four new pathogenic variants. J Neurol Sci. 2019 Jun 26;406:116376 Authors: Lerat J, Magdelaine C, Lunati A, Dzugan H, Dejoie C, Rego M, Beze Beyrie P, Bieth E, Calvas P, Cintas P, Delaubrier A, Demurger F, Gilbert-Dussardier B, Goizet C, Journel H, Laffargue F, Magy L, Taithe F, Toutain A, Urtizberea JA, Sturtz F, Lia AS ...
Tue Oct 22, 2019 16:16
Related ArticlesDiffuse histology-proven mucinous cystic neoplasm of the pancreas: A case report and review of literature. Int J Surg Case Rep. 2019 Oct 15;64:123-127 Authors: Nicolas CT, Al Diffalha S, Reddy S Abstract INTRODUCTION: Mucinous cystic neoplasms (MCN) are rare premalignant neoplasms of the pancreas that are typically found as single lesions in the pancreatic body and tail of women in the fifth and sixth decade of life, do not communicate...
Tue Oct 22, 2019 14:26
Related ArticlesClinicopathologic Assessment of Monoclonal Immunoglobulin-Associated Renal Disease in the Kidney Allograft. A Retrospective Study and Review of the Literature. Transplantation. 2019 Oct 17;: Authors: Kamal J, Khairallah P, Crew RJ, Ye X, Swanson SJ, Kudose S, Park DC, Appel GB, Markowitz GS, D'Agati VD, Batal I Abstract BACKGROUND: Monoclonal immunoglobulin (MIg) associated renal disease (MIgARD) comprises a group of disorders caused...
Tue Oct 22, 2019 14:26
Related ArticlesAppendiceal neuroendrocrine neoplasms: incidentaloma or something we should worry about? Curr Opin Gastroenterol. 2019 Oct 16;: Authors: Lousberg L, Collignon J, Detry O Abstract PURPOSE OF REVIEW: To synthesize the current knowledge and guidelines on the management of appendiceal neuroendocrine neoplasms (ANENs). RECENT FINDINGS: Most recent guidelines are essentially based on heterogeneous retrospective series. With the advent...
Tue Oct 22, 2019 14:26
Related ArticlesGenomic profiles and current therapeutic agents in neuroendocrine neoplasms. Curr Drug Targets. 2019 Oct 13;: Authors: Ohmoto A, Morizane C Abstract Neuroendocrine neoplasms (NENs) are rare tumors that mainly occur in the gastroenteropancreatic (GEP) tract and lungs. According to the current World Health Organization classification for GEP-NENs and lung NENs, treatment strategies differ for well-differentiated and poorly differentiated...
Tue Oct 22, 2019 14:26
Related ArticlesDuodenal Adenocarcinoma at the Ligament of Treitz: Management and Outcome. Hawaii J Health Soc Welf. 2019 Oct;78(10):316-319 Authors: Biello AR, Lin-Hurtubise KM, Condon FJ, Allen EJ Abstract Primary small bowel neoplasms at the ligament of Treitz are extremely rare and require advanced surgical technique for extirpation. The insidious onset of disease allows for a delayed presentation, often accompanied by moderate-size growth of the...
Tue Oct 22, 2019 14:26
Related ArticlesImaging in pregnancy-associated breast cancer: a case report. Acta Med Litu. 2019;26(2):134-139 Authors: Untanas A, Grigaitė I, Briedienė R Abstract Background: PABC (pregnancy-associated breast cancer) is a rare condition that appears as a malignancy in 1 per 3000 pregnant women and is one of the most common cancers diagnosed during pregnancy or the postpartum period. If a woman who is pregnant or within a year after delivery has complaints...
Tue Oct 22, 2019 14:26
Related ArticlesBenign non-carcinoid neoplasms of the cecal appendix: presentation of 36 cases during the last 17 years in a third level hospital. Cir Cir. 2019;87(6):630-635 Authors: Trujillo-Díaz JJ, Ruiz-Soriano M, de Solórzano-Aurusa JO, De Andrés-Asenjo B, Corrales-Cruz D, Rentería JPBH Abstract Background: The tumors of the cecal appendix are a rare and heterogeneous group of neoplasms with variable prognosis and evolution, its incidence is very...
Tue Oct 22, 2019 13:15
Related ArticlesNucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate. Biochim Biophys Acta Mol Cell Res. 2019 Oct 18;:118560 Authors: Tanaka T, Hozumi Y, Martelli AM, Iino M, Goto K Abstract The p53 tumor suppressor regulates expression of genes involved in various stress responses. Upon genotoxic stress, p53 induces target genes regulating cell cycle arrest for survival or apoptosis. Nevertheless, detailed mechanisms...
Tue Oct 22, 2019 15:16
Related ArticlesFisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells. Biofactors. 2019 Oct 21;: Authors: Sundarraj K, Raghunath A, Panneerselvam L, Perumal E Abstract Fisetin (3,7,3',4'-tetrahydroxyflavone), a bioactive dietary flavonoid, intrigued scientists for its anticancer potential against various cancer types. We investigated the fisetin-induced inhibition of growth and survival of human hepatocellular carcinoma....
Tue Oct 22, 2019 15:16
Related ArticlesTBC1D20 deficiency induces Sertoli cell apoptosis by triggering irreversible endoplasmic reticulum stress in mice. Mol Hum Reprod. 2019 Oct 21;: Authors: Chang WL, Cui L, Gu Y, Li M, Ma Q, Zhang Z, Ye J, Zhang F, Yu J, Gui Y Abstract Male 'blind sterile' mice with the causative TBC1 domain family member 20 (TBC1D20) deficiency are infertile with excessive germ cell apoptosis and spermatogenesis arrest at the spermatid stage. Sertoli cells...
Tue Oct 22, 2019 15:16
Related ArticlesGrowth inhibitory efficacy and anti-aromatase activity of Tabebuia avellanedae in a model for post-menopausal Luminal A breast cancer. Biomed Rep. 2019 Nov;11(5):222-229 Authors: Telang N, Nair HB, Wong GYC Abstract Aromatase inhibitors (AIs) represent a treatment option for post-menopausal estrogen receptor-positive (ER+) breast cancer as monotherapy, or in combination with cyclin-dependent kinase 4/6 or mTOR inhibitors. Long-term treatment...
Tue Oct 22, 2019 15:16
Related ArticlesMechanism of GPER promoting proliferation, migration and invasion of triple-negative breast cancer cells through CAF. Am J Transl Res. 2019;11(9):5858-5868 Authors: Yang K, Yao Y Abstract Triple-negative breast cancer (TNBC) is an important histological subtype of breast cancer. Abnormal GPER expression has been reported in human breast cancer. However, the functional mechanism of GPER through carcinoma-associated fibroblast (CAF) in...
Tue Oct 22, 2019 15:16
Related ArticlesBZD9L1 sirtuin inhibitor as a potential adjuvant for sensitization of colorectal cancer cells to 5-fluorouracil. Ther Adv Med Oncol. 2019;11:1758835919878977 Authors: Tan YJ, Lee YT, Petersen SH, Kaur G, Kono K, Tan SC, Majid AMSA, Oon CE Abstract Background: This study aims to investigate the combination effect of a novel sirtuin inhibitor (BZD9L1) with 5-fluorouracil (5-FU) and to determine its molecular mechanism of action in colorectal...
Tue Oct 22, 2019 15:16
Related ArticlesHypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression. Onco Targets Ther. 2019;12:8105-8115 Authors: Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Studies have demonstrated that epigenetic modifications play essential roles in the development of CRC. ADHFE1...
Tue Oct 22, 2019 15:16
Related ArticlesIndole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway. Drug Des Devel Ther. 2019;13:3539-3550 Authors: Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer which is associated with poor patient outcome and lack of targeted therapy. Our...
Tue Oct 22, 2019 15:16
Related Articles[Effects of Histone Methyltransferase Inhibitors on the Survival, Apoptosis and Cell Cycle of Raji Cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 May;50(3):305-310 Authors: Xiao LR, Hou C, Zheng SJ, Guo B, Chen DN, Yan NH Abstract Objective: To determine the effects of three histone methylase inhibitors UNC1999, DZNep and GSK343 on the survival, apoptosis and cell cycle of non-hodgkin's lymphoma Raji cells. Methods: PCR amplified...
Tue Oct 22, 2019 13:14
Related ArticlesBruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway. Cancer Med. 2019 Oct 21;: Authors: Wang S, Hu H, Zhong B, Shi D, Qing X, Cheng C, Deng X, Zhang Z, Shao Z Abstract Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting with metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are a potential cause of tumor metastasis, relapse,...
Tue Oct 22, 2019 13:14
Related ArticlesSilencing of Synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration. Histol Histopathol. 2019 Oct 21;:18174 Authors: Wu Z, Sun Z, Huang R, Zang D, Wang C, Yan X, Yan W Abstract BACKGROUND: Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:...
Tue Oct 22, 2019 13:14
Related ArticlesRe-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 Oct 16;: Authors: Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y Abstract H3K27M mutations resulting in epigenetic dysfunction are frequently observed in...
Tue Oct 22, 2019 13:14
Related ArticlesChemomodulatory effects of Alysicarpus vaginalis extract via mitochondria-dependent apoptosis and necroptosis in breast cancer. Nutr Cancer. 2019 Oct 21;:1-11 Authors: Sakle NS, More SA, Mokale SN Abstract The present study intended to assess the anticancer potential of Alysicarpus vaginalis ethyl acetate fraction (AVEAF) in breast cancer cell lines (MCF-7 and MDA-MB-453) and against N-methyl-N-nitrosourea (MNU) induced mammary carcinoma...
Tue Oct 22, 2019 13:14
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