IJERPH, Vol. 16, Pages 4086: Characteristics of Traditional Chinese Medicine Use for Carpal Tunnel Syndrome International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214086 Authors: Meng-Chuan Tsai Yu-Hsien Kuo Chih-Hsin Muo Li-Wei Chou Chung-Yen Lu Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder and an occupational disease caused by repeated exercise or overuse of the hand. We investigated the characteristics of traditional...
Thu Oct 24, 2019 03:00
IJERPH, Vol. 16, Pages 4085: Effectiveness of Cardiac Rehabilitation in Exercise Capacity Increase in Patients with ST-Segment Elevation Myocardial Infarction International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214085 Authors: Anna Kasperowicz Maciej Cymerys Tomasz Kasperowicz Background: The efficacy of interventions in ST-segment elevation myocardial infarction (STEMI) assessed by a decrease in inpatient mortality in Poland is very high. However,...
Thu Oct 24, 2019 03:00
IJERPH, Vol. 16, Pages 4088: A Novel Preference Elicitation Technique Based on a Graph Model and Its Application to a Brownfield Redevelopment Conflict in China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214088 Authors: Shinan Zhao Haiyan Xu Disputes are very common and pervasive in brownfield redevelopment projects, in which multiple stakeholders or decision-makers (DMs) strategically interact with each other with a conflict of interest....
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5307: Detection and Quantification of eDNA-Associated Bacterial Membrane Vesicles by Flow Cytometry International Journal of Molecular Sciences doi: 10.3390/ijms20215307 Authors: Valentina Puca Eva Ercolino Christian Celia Giuseppina Bologna Luisa Di Marzio Gabriella Mincione Marco Marchisio Sebastiano Miscia Raffaella Muraro Paola Lanuti Rossella Grande Bacteria generate membrane vesicles, which are structures known as extracellular...
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IJMS, Vol. 20, Pages 5306: The Significance of the Intrinsically Disordered Regions for the Functions of the bHLH Transcription Factors International Journal of Molecular Sciences doi: 10.3390/ijms20215306 Authors: Aneta Tarczewska Beata Greb-Markiewicz The bHLH proteins are a family of eukaryotic transcription factors regulating expression of a wide range of genes involved in cell differentiation and development. They contain the Helix-Loop-Helix (HLH) domain, preceded by a stretch...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5304: Pathophysiology of Calcium Mediated Ventricular Arrhythmias and Novel Therapeutic Options with Focus on Gene Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20215304 Authors: Paar Jirak Larbig Zagidullin Brandt Lichtenauer Hoppe Motloch Cardiac arrhythmias constitute a major health problem with a huge impact on mortality rates and health care costs. Despite ongoing research efforts, the understanding of the...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5302: The Positive Effects of Grifola frondosa Heteropolysaccharide on NAFLD and Regulation of the Gut Microbiota International Journal of Molecular Sciences doi: 10.3390/ijms20215302 Authors: Li Zeng Huang Liu : Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. In this study, the ability of Grifola frondosa heteropolysaccharide (GFP) to ameliorate NAFLD was investigated in rats fed a high-fat diet (HFD). The...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5301: The Association between Nitric Oxide Pathway, Blood Pressure Abnormalities, and Cardiovascular Risk Profile in Pediatric Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms20215301 Authors: Hsu Lu Lo Lin Tain Cardiovascular disease (CVD) is common in chronic kidney disease (CKD), while major CV events are rare in young CKD patients. In addition to nitric oxide (NO)-related biomarkers, several surrogate markers...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5303: Protein Abundance of Clinically Relevant Drug Transporters in The Human Kidneys International Journal of Molecular Sciences doi: 10.3390/ijms20215303 Authors: Stefan Oswald Janett Müller Ute Neugebauer Rita Schröter Edwin Herrmann Hermann Pavenstädt Giuliano Ciarimboli Renal drug transporters such as the organic cation transporters (OCTs), organic anion transporters (OATs) and multidrug resistance proteins (MRPs) play an important role in...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5305: Which Low-Abundance Proteins are Present in the Human Milieu of Gamete/Embryo Maternal Interaction? International Journal of Molecular Sciences doi: 10.3390/ijms20215305 Authors: Canha-Gouveia Paradela Ramos-Fernández Prieto-Sánchez Sánchez-Ferrer Corrales Coy The improvement of the embryo culture media is of high relevance due to its influence on successful implantation rates, pregnancy, neonatal outcomes, and potential effects in...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5300: USP14 Inhibition Regulates Tumorigenesis by Inducing Autophagy in Lung Cancer In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms20215300 Authors: Kyung Ho Han Minseok Kwak Tae Hyeong Lee Min-soo Park In-ho Jeong Min Ji Kim Jun-O Jin Peter Chang-Whan Lee The ubiquitin–proteasome system is an essential regulator of several cellular pathways involving oncogenes. Deubiquitination negatively regulates target proteins...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5295: The Role of the Gut Microbiota in Colorectal Cancer Causation International Journal of Molecular Sciences doi: 10.3390/ijms20215295 Authors: Alhinai Walton Commane Here, we reviewed emerging evidence on the role of the microbial community in colorectal carcinogenesis. A healthy gut microbiota promotes intestinal homeostasis and can exert anti-cancer effects; however, this microbiota also produces a variety of metabolites that are genotoxic and which...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5299: Dynamic Regulation of miRNA Expression by Functionally Enhanced Placental Mesenchymal Stem Cells PromotesHepatic Regeneration in a Rat Model with Bile Duct Ligation International Journal of Molecular Sciences doi: 10.3390/ijms20215299 Authors: Jae Yeon Kim Ji Hye Jun Soo Young Park Seong Wook Yang Si Hyun Bae Gi Jin Kim Placenta-derived mesenchymal stem cells (PD-MSCs) were highlighted as therapeutic sources in several degenerative diseases....
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5298: Insights on Calcium-Dependent Protein Kinases (CPKs) Signaling for Abiotic Stress Tolerance in Plants International Journal of Molecular Sciences doi: 10.3390/ijms20215298 Authors: Atif Shahid Waqas Ali Rashid Azeem Nawaz Wani Chung Abiotic stresses are the major limiting factors influencing the growth and productivity of plants species. To combat these stresses, plants can modify numerous physiological, biochemical, and molecular...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5294: Inducible Slc7a7 Knockout Mouse Model Recapitulates Lysinuric Protein Intolerance Disease International Journal of Molecular Sciences doi: 10.3390/ijms20215294 Authors: Bodoy Sotillo Espino-Guarch Sperandeo Ormazabal Zorzano Sebastio Artuch Palacín Lysinuric protein intolerance (LPI) is a rare autosomal disease caused by defective cationic amino acid (CAA) transport due to mutations in SLC7A7, which encodes for the y+LAT1 transporter....
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5297: Prolactin-Releasing Peptide: Physiological and Pharmacological Properties
IJMS, Vol. 20, Pages 5297: Prolactin-Releasing Peptide: Physiological and Pharmacological Properties International Journal of Molecular Sciences doi: 10.3390/ijms20215297 Authors: Pražienková Popelová Kuneš Maletínská Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation of food intake and energy expenditure. This review focuses not only on the...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5293: Immunobiology of Atherosclerosis: A Complex Net of Interactions International Journal of Molecular Sciences doi: 10.3390/ijms20215293 Authors: Herrero-Fernandez Gomez-Bris Somovilla-Crespo Gonzalez-Granado Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction, intimal...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5292: SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20215292 Authors: Claudio A. Valenzuela Ricardo Quintanilla Alexandra Olate-Briones Whitney Venturini Daniel Mancilla Angel Cayo Rodrigo Moore-Carrasco Nelson E. Brown Alterations in platelet aggregation are common in aging individuals and in the context of age-related...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5290: Understanding G Protein Selectivity of Muscarinic Acetylcholine Receptors Using Computational Methods International Journal of Molecular Sciences doi: 10.3390/ijms20215290 Authors: Luis Santiago Ravinder Abrol The neurotransmitter molecule acetylcholine is capable of activating five muscarinic acetylcholine receptors, M1 through M5, which belong to the superfamily of G-protein-coupled receptors (GPCRs). These five receptors share high sequence and structure...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5296: Microbial Metabolites Determine Host Health and the Status of Some Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20215296 Authors: Panida Sittipo Jae-won Shim Yun Kyung Lee The gastrointestinal (GI) tract is a highly complex organ composed of the intestinal epithelium layer, intestinal microbiota, and local immune system. Intestinal microbiota residing in the GI tract engages in a mutualistic relationship with the host. Different...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5291: In Vitro and In Vivo Evaluations of Mesoporous Iron Particles for Iron Bioavailability International Journal of Molecular Sciences doi: 10.3390/ijms20215291 Authors: Lin Wu Liao Jakfar Tang Chen Lin Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5286: The Modulating Effect of p-Coumaric Acid on The Surface Charge Density of Human Glioblastoma Cell Membranes International Journal of Molecular Sciences doi: 10.3390/ijms20215286 Authors: Marcin Andrzej Kruszewski Joanna Kotyńska Magdalena Kusaczuk Miroslav Gál Monika Naumowicz p-Coumaric acid (p-CoA), a phenolic acid belonging to the hydroxycinnamic acids family, is a compound with tentative anticancer potential. Microelectrophoretic mobility measurements...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5288: Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches International Journal of Molecular Sciences doi: 10.3390/ijms20215288 Authors: Krzesimir Ciura Joanna Fedorowicz Filip Andrić Katarzyna Ewa Greber Alina Gurgielewicz Wiesław Sawicki Jarosław Sączewski Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5287: The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) International Journal of Molecular Sciences doi: 10.3390/ijms20215287 Authors: Francesca Caccuri Antonella Bugatti Silvia Corbellini Sara Roversi Alberto Zani Pietro Mazzuca Stefania Marsico Arnaldo Caruso Cinzia Giagulli In recent years immunomodulators have gained a strong interest and represent nowadays an active expanding area...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5289: How Oxygen Availability Affects the Antimicrobial Efficacy of Host Defense Peptides: Lessons Learned from Studying the Copper-Binding Peptides Piscidins 1 and 3 International Journal of Molecular Sciences doi: 10.3390/ijms20215289 Authors: Adenrele Oludiran David S. Courson Malia D. Stuart Anwar R. Radwan John C. Poutsma Myriam L. Cotten Erin B. Purcell The development of new therapeutic options against Clostridioides difficile (C. difficile)...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5284: Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20215284 Authors: Maxim Shevtsov Gabriele Multhoff Elena Mikhaylova Atsushi Shibata Irina Guzhova Boris Margulis Most molecular chaperones belonging to heat shock protein (HSP) families are known to protect cancer cells from pathologic, environmental and pharmacological stress factors and thereby can hamper anti-cancer...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5285: Host Genotype and Precipitation Influence of Fungal Endophyte Symbiosis and Mycotoxin Abundance in a Locoweed International Journal of Molecular Sciences doi: 10.3390/ijms20215285 Authors: Wei He Linwei Guo Lei Wang Qianqian Zhao Lizhu Guo Wei Cao Luis A. J. Mur Yahui Wei Many plant endophytes produce mycotoxins, but how host genetic variation influences endophyte colonization and mycotoxin production under natural conditions is poorly...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5282: Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations International Journal of Molecular Sciences doi: 10.3390/ijms20215282 Authors: Asia Parveen Sher Alam Khan Muhammad Usman Mirza Hina Bashir Fatima Arshad Maria Iqbal Waseem Ahmad Ahsan Wahab Amal Fiaz Sidra Naz Fareeha Ashraf Tayyaba Mobeen Salman Aziz Syed Shoaib Ahmed Noor...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5281: Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis International Journal of Molecular Sciences doi: 10.3390/ijms20215281 Authors: Linlin Wang Helen Ka Wai Law Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5280: Long Non-Coding RNA GAS5 and Intestinal MMP2 and MMP9 Expression: A Translational Study in Pediatric Patients with IBD International Journal of Molecular Sciences doi: 10.3390/ijms20215280 Authors: Marianna Lucafò Letizia Pugnetti Matteo Bramuzzo Debora Curci Alessia Di Silvestre Annalisa Marcuzzi Alberta Bergamo Stefano Martelossi Vincenzo Villanacci Anna Bozzola Moris Cadei Sara De Iudicibus Giuliana Decorti Gabriele Stocco...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5283: Endophytic Bacteria Potentially Promote Plant Growth by Synthesizing Different Metabolites and their Phenotypic/Physiological Profiles in the Biolog GEN III MicroPlateTM Test International Journal of Molecular Sciences doi: 10.3390/ijms20215283 Authors: Małgorzata Woźniak Anna Gałązka Renata Tyśkiewicz Jolanta Jaroszuk-Ściseł Endophytic bacteria, as the most promising components of effective, biofertilizers biostimulating and biocontrol preparations,...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5278: Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior? International Journal of Molecular Sciences doi: 10.3390/ijms20215278 Authors: Liza Weinstein-Fudim Zivanit Ergaz Gadi Turgeman Joseph Yanai Moshe Szyf Asher Ornoy In previous studies we produced autism like behavioral changes in mice by Valproic...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5277: The Pivotal Role of TRP Channels in Homeostasis and Diseases throughout the Gastrointestinal Tract International Journal of Molecular Sciences doi: 10.3390/ijms20215277 Authors: Alessandro Alaimo Josep Rubert The transient receptor potential (TRP) channels superfamily are a large group of proteins that play crucial roles in cellular processes. For example, these cation channels act as sensors in the detection and transduction of stimuli of temperature, small...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5279: Molecular Cloning and Exploration of the Biochemical and Functional Analysis of Recombinant Glucose-6-Phosphate Dehydrogenase from Gluconoacetobacter diazotrophicus PAL5 International Journal of Molecular Sciences doi: 10.3390/ijms20215279 Authors: Edson Jiovany Ramírez-Nava Daniel Ortega-Cuellar Abigail González-Valdez Rosa Angélica Castillo-Rodríguez Gabriel Yaxal Ponce-Soto Beatriz Hernández-Ochoa Noemí Cárdenas-Rodríguez Víctor Martínez-Rosas...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5275: Anticoagulants and Osteoporosis International Journal of Molecular Sciences doi: 10.3390/ijms20215275 Authors: Salvatore Santo Signorelli Salvatore Scuto Elisa Marino Michele Giusti Anastasia Xourafa Agostino Gaudio Anticoagulant agents are widely used in the treatment of thromboembolic events and in stroke prevention. Data about their effects on bone tissue are in some cases limited or inconsistent (oral anti-vitamin K agents), and in others...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5276: Role of Matrix Metalloproteinases 7 in the Pathogenesis of Laryngopharyngeal Reflux: Decreased E-cadherin in Acid exposed Primary Human Pharyngeal Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20215276 Authors: Nu-Ri Im Doh Young Lee Byoungjae Kim Jian Kim Kwang-Yoon Jung Tae Hoon Kim Seung-Kuk Baek Cleavage of E-cadherin and the resultant weakness in the cell-cell links in the laryngeal epithelium lining is...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5272: Vitamin D Receptor Gene Expression in Adipose Tissue of Obese Individuals is Regulated by miRNA and Correlates with the Pro-Inflammatory Cytokine Level International Journal of Molecular Sciences doi: 10.3390/ijms20215272 Authors: Marta Izabela Jonas Alina Kuryłowicz Zbigniew Bartoszewicz Wojciech Lisik Maurycy Jonas Krzysztof Kozniewski Monika Puzianowska-Kuznicka Background: Given the role that vitamin D (VD) plays in the regulation of the...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5273: Interleukin-6 Induces Myogenic Differentiation via JAK2-STAT3 Signaling in Mouse C2C12 Myoblast Cell Line and Primary Human Myoblasts International Journal of Molecular Sciences doi: 10.3390/ijms20215273 Authors: Paul J. Steyn Kevin Dzobo Robert I. Smith Kathryn H. Myburgh Postnatal muscle growth and exercise- or injury-induced regeneration are facilitated by myoblasts. Myoblasts respond to a variety of proteins such as cytokines that activate various...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5274: The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity International Journal of Molecular Sciences doi: 10.3390/ijms20215274 Authors: Akinori Takahashi Shohei Takaoka Shungo Kobori Tomokazu Yamaguchi Sara Ferwati Keiji Kuba Tadashi Yamamoto Toru Suzuki Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which...
Thu Oct 24, 2019 03:00
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