IJMS, Vol. 20, Pages 5271: Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20215271 Authors: Matthew T. Lewis Jonathan D. Kasper Jason N. Bazil Jefferson C. Frisbee Robert W. Wiseman Type 2 diabetes (T2D) is a growing health concern with nearly 400 million affected worldwide as of 2014. T2D presents with hyperglycemia and insulin resistance resulting...
Thu Oct 24, 2019 03:00
IJMS, Vol. 20, Pages 5270: The Hedgehog Signaling Pathway in Ischemic Tissues International Journal of Molecular Sciences doi: 10.3390/ijms20215270 Authors: Igor Giarretta Eleonora Gaetani Margherita Bigossi Paolo Tondi Takayuki Asahara Roberto Pola Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1778: Serum Level and Activity of Butylcholinesterase: A Biomarker for Post-Stroke Dementia Journal of Clinical Medicine doi: 10.3390/jcm8111778 Authors: Chen Chou Fang Liu Tsou Wang Liu Cholinergic neurotransmission regulates the immune response and inhibits cytokine release after stroke. The changes in the level/activity of blood cholinesterase (ChE) in patients with post-stroke dementia (PSD) are less known. This study aimed to examine post-stroke...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1779: Development of a Minimum Data Set Registry for Chronic Venous Insufficiency of the Lower Limbs Journal of Clinical Medicine doi: 10.3390/jcm8111779 Authors: Homs-Romero Romero-Collado The purpose of this study was to develop a minimum data set (MDS) registry for the prevention, diagnosis and treatment of chronic venous insufficiency (CVI) of the lower limbs. We designed the instrument in two phases, comprising a literature review and an e-Delphi study to...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1776: Decontamination of Intravaginal Probes Infected by Human Papillomavirus (HPV) Using UV-C Decontamination System Journal of Clinical Medicine doi: 10.3390/jcm8111776 Authors: Pichon Lebail-Carval Billaud Lina Gaucherand Mekki Background: This three-step study evaluated ultraviolet-C (UV-C) efficacy against human papillomavirus (HPV) found on vaginal ultrasound probes. Methods: The first two steps evaluated UV-C disinfection of vaginal ultrasound...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1777: Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy—Review of the Literature and Future Outlook Journal of Clinical Medicine doi: 10.3390/jcm8111777 Authors: Möhn Beutel Gutzmer Ivanyi Satzger Immune checkpoint inhibitor (ICI) therapy has revolutionized the management of various cancers with previously poor prognosis. Despite its great efficacy, the therapy is associated with a wide spectrum...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1775: Noninvasive and Convenient Screening of Metabolic Syndrome Using the Controlled Attenuation Parameter Technology: An Evaluation Based on Self-Paid Health Examination Participants Journal of Clinical Medicine doi: 10.3390/jcm8111775 Authors: Yu-Jiun Lin Chang-Hsien Lin Sen-Te Wang Shiyng-Yu Lin Shy-Shin Chang Background: There is a medical need for an easy, fast, and non-invasive method for metabolic syndrome (MetS) screening. This study aimed to assess...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1773: Analysis of Pulse Arrival Time as an Indicator of Blood Pressure in a Large Surgical Biosignal Database: Recommendations for Developing Ubiquitous Blood Pressure Monitoring Methods Journal of Clinical Medicine doi: 10.3390/jcm8111773 Authors: Joonnyong Lee Seungman Yang Saram Lee Hee Chan Kim As non-invasive continuous blood pressure monitoring (NCBPM) has gained wide attraction in the recent decades, many pulse arrival time (PAT) or pulse transit time...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1774: Recovery from Anesthesia after Robotic-Assisted Radical Cystectomy: Two Different Reversals of Neuromuscular Blockade Journal of Clinical Medicine doi: 10.3390/jcm8111774 Authors: Claudia Claroni Marco Covotta Giulia Torregiani Maria Elena Marcelli Gabriele Tuderti Giuseppe Simone Alessandra Scotto di Uccio Antonio Zinilli Ester Forastiere During robot-assisted radical cystectomy (RARC), specific surgical conditions (a steep Trendelenburg...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1771: Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields Journal of Clinical Medicine doi: 10.3390/jcm8111771 Authors: Simone Krueger Sophie Achilles Julius Zimmermann Thomas Tischer Rainer Bader Anika Jonitz-Heincke Treatment of cartilage lesions remains a clinical challenge. Therefore, biophysical stimuli like electric fields seem to be a promising tool for chondrocytic differentiation...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1770: An Association of Gut Microbiota with Different Phenotypes in Chinese Patients with Rheumatoid Arthritis Journal of Clinical Medicine doi: 10.3390/jcm8111770 Authors: Hsin-I Chiang Jian-Rong Li Chun-Chi Liu Po-Yu Liu Hsin-Hua Chen Yi-Ming Chen Joung-Liang Lan Der-Yuan Chen We aimed to investigate the association of gut microbiota with disease activity, inflammatory parameters, and auto-antibodies profile in rheumatoid arthritis (RA). A total...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1772: A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer Journal of Clinical Medicine doi: 10.3390/jcm8111772 Authors: Hariprasad Thangavel Carmine De Angelis Suhas Vasaikar Raksha Bhat Mohit Kumar Jolly Chandandeep Nagi Chad J. Creighton Fengju Chen Lacey E. Dobrolecki Jason T. George Tanya Kumar Noor Mazin Abdulkareem Sufeng Mao Agostina Nardone...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1768: Opioid-Related Diagnoses and Concurrent Claims for HIV, HBV, or HCV among Medicare Beneficiaries, United States, 2015 Journal of Clinical Medicine doi: 10.3390/jcm8111768 Authors: Man-Huei Chang Ramal Moonesinghe Lyna Z. Schieber Benedict I. Truman Unsterile opioid injection increases risk for infection transmission, including HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV). We assess prevalence of and risk factors associated with opioid overdose...
Thu Oct 24, 2019 03:00
JCM, Vol. 8, Pages 1769: Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis Journal of Clinical Medicine doi: 10.3390/jcm8111769 Authors: David Rice Peter McNair Eva Huysmans Janelle Letzen Patrick Finan Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which most commonly affects the joints of the knee, hip, and hand. To date, there are no established disease modifying interventions that can halt or reverse OA progression....
Thu Oct 24, 2019 03:00
J. Imaging, Vol. 5, Pages 83: Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging Journal of Imaging doi: 10.3390/jimaging5110083 Authors: Qimei Zhang Anna M. Grabowska Philip A. Clarke Stephen P. Morgan The spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations...
Thu Oct 24, 2019 03:00
Medicina, Vol. 55, Pages 713: Technical Factors Affecting Ultrasound Breast Tumor Size as Correlated with Pathological Type Medicina doi: 10.3390/medicina55110713 Authors: Eman Ahmed Shawky Sabek Hala Taha Salem Background and Objective: Accurate breast tumor sizing is very important in treatment planning; as a result, ultrasound (US) plays an important role in diagnosing breast masses, due to its non-magnified image and its availability. The continuous change in the disease pathogenesis...
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Medicina, Vol. 55, Pages 712: Characterization of Patients with Allergic Rhinitis to Ragweed Pollen in Two Distinct Regions of Romania Medicina doi: 10.3390/medicina55110712 Authors: Ioana Corina Bocsan Ioana Adriana Muntean Corina Ureche Raluca Maria Pop Maria Adriana Neag Octavia Sabin Diana Deleanu Anca Dana Buzoianu Background and objectives: Ragweed pollen is a major source of allergen, which has rarely been observed in Romania until now. In this study, we evaluated...
Thu Oct 24, 2019 03:00
Membranes, Vol. 9, Pages 137: Electrowinning of Iron from Spent Leaching Solutions Using Novel Anion Exchange Membranes Membranes doi: 10.3390/membranes9110137 Authors: Wouter Dirk Badenhorst Cloete Rossouw Hyeongrae Cho Jochen Kerres Dolf Bruinsma Henning Krieg In the Pyror process, electrowinning (EW) is used to recover acid and iron from spent leaching solutions (SLS), where a porous Terylene membrane acts as a separator between the cathode and anode. In this study,...
Thu Oct 24, 2019 03:00
Metabolites, Vol. 9, Pages 250: Analytic Correlation Filtration: A New Tool to Reduce Analytical Complexity of Metabolomic Datasets Metabolites doi: 10.3390/metabo9110250 Authors: Monnerie Petera Lyan Gaudreau Comte Pujos-Guillot Metabolomics generates massive and complex data. Redundant different analytical species and the high degree of correlation in datasets is a constraint for the use of data mining/statistical methods and interpretation. In this context, we...
Thu Oct 24, 2019 03:00
Metabolites, Vol. 9, Pages 248: Quantitative 1H NMR Metabolomics Reveal Distinct Metabolic Adaptations in Human Macrophages Following Differential Activation Metabolites doi: 10.3390/metabo9110248 Authors: Amanda L. Fuchs Sage M. Schiller Wyatt J. Keegan Mary Cloud B. Ammons Brian Eilers Brian Tripet Valérie Copié Macrophages (MΦs) are phagocytic immune cells that are found in nearly all human tissues, where they modulate innate and adaptive immune responses,...
Thu Oct 24, 2019 03:00
Metabolites, Vol. 9, Pages 249: Abscisic Acid Receptors Modulate Metabolite Levels and Phenotype in Arabidopsis Under Normal Growing Conditions Metabolites doi: 10.3390/metabo9110249 Authors: Xiaoyi Li Lintao Wu Yao Qiu Tao Wang Qin Zhou Qian Zhang Wei Zhang Zhibin Liu Abscisic acid (ABA) is a vital phytohormone that accumulates in response to various biotic and abiotic stresses, as well as plant growth. In Arabidopsis thaliana, there are 14 members of the ABA receptor...
Thu Oct 24, 2019 03:00
Metabolites, Vol. 9, Pages 247: Troubleshooting in Large-Scale LC-ToF-MS Metabolomics Analysis: Solving Complex Issues in Big Cohorts Metabolites doi: 10.3390/metabo9110247 Authors: Juan Rodríguez-Coira María Delgado-Dolset David Obeso Mariana Dolores-Hernández Guillermo Quintás Santiago Angulo Domingo Barber Teresa Carrillo María Escribese Alma Villaseñor Metabolomics, understood as the science that manages the study of compounds from the metabolism, is an...
Thu Oct 24, 2019 03:00
Metabolites, Vol. 9, Pages 246: Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion Metabolites doi: 10.3390/metabo9110246 Authors: Negin Karimian Siavash Raigani Viola Huang Sonal Nagpal Ehab O. A. Hafiz Irene Beijert Paria Mahboub Robert J. Porte Korkut Uygun Martin Yarmush Heidi Yeh There continues to be significant debate regarding the most effective...
Thu Oct 24, 2019 03:00
Microorganisms, Vol. 7, Pages 486: Microbial Community Structure and Methane Cycling Potential along a Thermokarst Pond-Peatland Continuum Microorganisms doi: 10.3390/microorganisms7110486 Authors: Adrien Vigneron Perrine Cruaud Najat Bhiry Connie Lovejoy Warwick F. Vincent The thawing of ice-rich permafrost soils in northern peatlands leads to the formation of thermokarst ponds, surrounded by organic-rich soils. These aquatic ecosystems are sites of intense microbial activity,...
Thu Oct 24, 2019 03:00
Microorganisms, Vol. 7, Pages 485: Elucidation of the Initial Growth Process and the Infection Mechanism of Penicillium digitatum on Postharvest Citrus (Citrus reticulata Blanco) Microorganisms doi: 10.3390/microorganisms7110485 Authors: Xin Qian Qiya Yang Qidi Zhang Mandour H. Abdelhai Solairaj Dhanasekaran Boateng Nana Adwoa Serwah Ning Gu Hongyin Zhang Green mold disease, a common citrus post-harvest disease caused by Penicillium digitatum, has an unresolved initial...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3839: Heterocycles in Medicinal Chemistry Molecules doi: 10.3390/molecules24213839 Authors: Josef Jampilek Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon substructures in aliphatic structures or real heterocycles [...]
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Molecules, Vol. 24, Pages 3840: Natural Occurrence, Bioactivity and Biosynthesis of Elaiophylin Analogues Molecules doi: 10.3390/molecules24213840 Authors: Min Gui Meng-xue Zhang Wen-hui Wu Peng Sun Elaiophylins belong to a special family of 16-membered macrodiolides with C2-symmetry. They have exhibited remarkable biological activities, such as antimicrobial, anthelmintic, anticancer, immunosuppressive, anti-inflammatory, antiviral, and α-glucosidase inhibitory activities....
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Molecules, Vol. 24, Pages 3838: Trash to Treasure: Eco-Friendly and Practical Synthesis of Amides by Nitriles Hydrolysis in WEPPA Molecules doi: 10.3390/molecules24213838 Authors: Yajun Sun Weiwei Jin Chenjiang Liu The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3836: Analysis of Nitraria Tangutourum Bobr-Derived Fatty Acids with HPLC-FLD-Coupled Online Mass Spectrometry Molecules doi: 10.3390/molecules24213836 Authors: Na Hu Jian Ouyang Qi Dong Honglun Wang Fatty acids (FAs) are basic components in plants. The pharmacological significance of FAs has attracted attentions of nutritionists and pharmaceutists. Sensitive and accurate detection of FAs is of great importance. In the present study, a pre-column derivatization...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3837: Metabolomic Approach for Discrimination of Cultivation Age and Ripening Stage in Ginseng Berry Using Gas Chromatography-Mass Spectrometry Molecules doi: 10.3390/molecules24213837 Authors: Seong-Eun Park Seung-Ho Seo Eun-Ju Kim Dae-Hun Park Kyung-Mok Park Seung-Sik Cho Hong-Seok Son The purpose of this study was to analyze metabolic differences of ginseng berries according to cultivation age and ripening stage using gas chromatography-mass...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3834: Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts Molecules doi: 10.3390/molecules24213834 Authors: Sora Huh Seulki Lee Su Jin Choi Zhexue Wu Jae-Han Cho Lina Kim Yu Su Shin Byung Woog Kang Jong Gwang Kim Kwanghyeon Liu Hyosun Cho Hyojeung Kang Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3835: Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies Molecules doi: 10.3390/molecules24213835 Authors: Irina V. Kholodenko Daniel V. Kalinovsky Elena V. Svirshchevskaya Igor I. Doronin Maria V. Konovalova Alexey V. Kibardin Tatyana V. Shamanskaya Sergey S. Larin Sergey M. Deyev Roman V. Kholodenko Antigen-binding fragments of antibodies specific to the tumor-associated...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3833: An Amphiphilic Pyridinoyl-hydrazone Probe for Colorimetric and Fluorescence pH Sensing Molecules doi: 10.3390/molecules24213833 Authors: Rosita Diana Barbara Panunzi Angela Tuzi Stefano Piotto Simona Concilio Ugo Caruso A new pH sensor based on a substituted aroylhydrazide with a flexible side chain and a terminal trimethyl ammonium group (PHA+) was designed and synthesized. The terminal quaternary ammonium guarantees excellent solubility...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3832: Synthesis of the C3 and C1 Constitutional Isomers of Trifluorosubphthalocyanine and Their Fluorescence within MDA-MB-231 Breast Tumor Cells Molecules doi: 10.3390/molecules24213832 Authors: Rosemarie L. Calandrino Katherine J. McAuliffe Lauren E. Dolmage Evan R. Trivedi Metal tetrapyrrole macrocycles such as porphyrins and chlorins are ubiquitous in nature. Synthetic analogs, including phthalocyanines, have found applications in medicine, particularly...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3831: Molecular Structures and Spectral Properties of Natural Indigo and Indirubin: Experimental and DFT Studies Molecules doi: 10.3390/molecules24213831 Authors: Zixin Ju Jie Sun Yanping Liu This paper presents a comparative study on natural indigo and indirubin in terms of molecular structures and spectral properties by using both computational and experimental methods. The spectral properties were analyzed with Fourier transform infrared (FTIR), Raman,...
Thu Oct 24, 2019 03:00
Molecules, Vol. 24, Pages 3830: Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam Molecules doi: 10.3390/molecules24213830 Authors: Hong Le Quynh Do Mai Doan Quyen Vu Mai Nguyen Thu Vu Hai Nguyen Nguyen Duong Manh Tran Van Chau Van Pham Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities....
Thu Oct 24, 2019 03:00
Nanomaterials, Vol. 9, Pages 1514: Tuning the Properties of Nanogel Surfaces by Grafting Charged Alkylamine Brushes Nanomaterials doi: 10.3390/nano9111514 Authors: Zbyšek Posel Paola Posocco Nanogels are chemically crosslinked polymeric nanoparticles endowed with high encapsulation ability, tunable size, ease of preparation, and responsiveness to external stimuli. The presence of specific functional groups on their surfaces provides an opportunity to tune their surface properties...
Thu Oct 24, 2019 03:00
Nanomaterials, Vol. 9, Pages 1515: A Strategy toward Realizing Ultrashort Channels and Microstructures Array by Piezoelectric Inkjet Printing Nanomaterials doi: 10.3390/nano9111515 Authors: Jianqiu Chen Liao Gan Zhipeng Pan Honglong Ning Zhiqiang Fang Hongfu Liang Ruiqiang Tao Wei Cai Rihui Yao Junbiao Peng Inkjet printing has been proved to be a powerful tool in the cost-effective ambient deposition of functional materials for the fabrication of electronic...
Thu Oct 24, 2019 03:00
Nanomaterials, Vol. 9, Pages 1513: SmS/EuS/SmS Tri-Layer Thin Films: The Role of Diffusion in the Pressure Triggered Semiconductor-Metal Transition Nanomaterials doi: 10.3390/nano9111513 Authors: Andreas Sousanis Dirk Poelman Philippe F. Smet While SmS thin films show an irreversible semiconductor-metal transition upon application of pressure, the switching characteristics can be modified by alloying with other elements, such as europium. This manuscript reports on the resistance...
Thu Oct 24, 2019 03:00
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