Publication date: Available online 23 October 2019Source: American Journal of OtolaryngologyAuthor(s): Gino Marioni, Giancarlo Ottaviano, Andrea Lovato, Leonardo Franz, Luigia Bandolin, Giacomo Contro, Luciano Giacomelli, Lara Alessandrini, Roberto Stramare, Cosimo de Filippis, Stella BlandamuraAbstractPurposeThe main aim of this study was to conduct a preliminary investigation into the possible relationship between mTOR and the nuclear tumor suppressor maspin in laryngeal carcinoma (LSCC).Materials...
Thu Oct 24, 2019 17:51
Abstract Objective To investigate the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMP) in the development of cervical metastases in papillary thyroid cancer Our hypothesis is that level of expression of MMPs and TIMPs is associated with the development of cervical metastases and the pattern of metastatic process in papillary thyroid cancer. Design This research retrospectively investigates the expression of MMP‐1, ‐2 and ‐9 as well as TIMP‐1 and ‐2 in papillary thyroid...
Wed Oct 23, 2019 20:49
Condition: Airway Complication of AnesthesiaIntervention: Device: UltrasoundSponsor: Samuel Lunenfeld Research Institute, Mount Sinai HospitalNot yet recruiting
Thu Oct 24, 2019 17:16
Condition: Esophageal Squamous Cell CarcinomaInterventions: Drug: Paclitaxel, Cisplatin; Radiation: neoadjuvant chemoradiation therapySponsor: Henan Cancer HospitalRecruiting
Thu Oct 24, 2019 17:16
Condition: Unresectable Esophageal CancerInterventions: Radiation: Definitive Radiochemotherapy; Procedure: Neoadjuvant RadiochemotherapySponsor: Tianjin Medical University Cancer Institute and HospitalRecruiting
Thu Oct 24, 2019 17:16
Abstract Background This study evaluated the combination of tumor budding and depth (BD model) and worst pattern of invasion (WPOI) as histopathological prognostic factors in clinical N0 early oral tongue carcinoma. Methods Data from 62 patients were retrospectively analyzed. Associations between histopathological factors (differentiation, stage, lymphatic invasion, blood vessel invasion, WPOI, and BD model) and regional control (RC) or disease‐free survival (DFS) were evaluated. Results...
Thu Oct 24, 2019 13:03
Abstract Background Eicosapentaenoic acid (EPA) containing nutritional supplement can reverse weight loss and increase lean body mass in a perioperative period of patients with head and neck cancer. To study effects of an EPA‐enriched supplement compared with a conventional supplement in malnourished patients with head and neck cancer following surgery is primary objective. Methods The patients were randomized into EPA‐enriched and standard formula group. The supplements were prescribed...
Thu Oct 24, 2019 12:54
Related ArticlesPredictors of changes in quality of life in head and neck cancer patients: a prospective study over a 6-month period. Eur Arch Otorhinolaryngol. 2019 Oct 23;: Authors: Roick J, Danker H, Dietz A, Papsdorf K, Singer S Abstract PURPOSE: Patients with head and neck cancer experience multiple complaints during treatment which also affect quality of life. The present study assessed predictors of temporal changes in quality of life over a 6-month...
Thu Oct 24, 2019 14:39
This cross-sectional study examines the association between site-neutral payment reform and otolaryngologists practicing within the Hospital Outpatient Prospective Payment System.
Thu Oct 24, 2019 03:00
This case report describes a patient who presented with intractable cough after bilateral tympanostomy tube placement, which resolved after tube removal.
Thu Oct 24, 2019 03:00
A woman in her 30s with a medical history of epilepsy and alcohol use disorder who was taking lamotrigine presented with severe head trauma. What is your diagnosis?
Thu Oct 24, 2019 03:00
This diagnostic study describes an automated machine learning model that uses ultrasonographic images of thyroid lesions to identify and estimate genetic risk or status.
Thu Oct 24, 2019 03:00
Considerable evidence now indicates that individuals living in underprivileged neighbourhoods have higher rates of mortality and morbidity independent of individual-level characteristics. This study explored t...
Thu Oct 24, 2019 03:00
Now effective adjuvant therapy has arrived in melanoma, accurate staging and patient selection to optimize its risk/benefit ratio is crucial. The American Joint Committee on Cancer staging system is the most widely used and validated melanoma staging system, which recently released its 8th edition. We aimed to externally validate the prognostic and discriminatory ability for survival of the 8th edition compared to the 7th edition and evaluate prognostic factors. Prospective database of stage III...
Tue Oct 22, 2019 03:00
Advanced metastatic melanoma, one of the most aggressive skin malignancies, is currently without reliable therapy. The process of angiogenesis is crucial for progression and metastasis of the majority of solid tumors including melanomas. Therefore, new therapies are urgently needed. Mangiferin is a naturally occurring glucosylxanthone which exerts many pharmacological activities against cancer-inflammation. However, the effect of mangiferin on metastasis and tumor growth of metastatic melanoma remains...
Tue Oct 22, 2019 03:00
Purpose of review The current review provides an update of literature published in the past 2 years related to treatment of voice-gender incongruence in the gender expansive population, commonly referred to as transgender voice modification. Recent findings Four main themes have emerged in research during the review period. These include comparison of surgical and behavioral techniques for raising pitch, with consistent findings of a greater increase in fundamental frequency (F0) following...
Wed Oct 23, 2019 03:00
Purpose of review Laryngeal amyloidosis is a rare hematological disorder of plasma cells. The cause is still considered idiopathic. The otolaryngology literature predominantly comprises case reports and short series. The present review summarizes the amyloid literature more generally in order to assist the otolaryngologist managing this disorder. Recent findings Distinguishing localized amyloidosis from systemic disease continues to be challenging. Both radiological and hematological investigations...
Wed Oct 23, 2019 03:00
Purpose of review The current article reviews recent literature examining occupational voice use and occupational voice disorders (January 2018–July 2019). Recent findings Our understanding of the prevalence of voice disorders and work-related vocal use, vocal load and vocal ergonomics (environmental and person influences) across different occupations is continuing to build. There is encouraging evidence for the value of intervention programs for occupational voice users, particularly of...
Wed Oct 23, 2019 03:00
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Guy SlonimskySaccular disorders extending beyond the thyrohyoid membrane are classified as external, or combined, based on to their extension beyond the thyrohyoid membrane and the proportion of the external to the internal component. The workup is the same as for internal saccular disorders and airway safety is of utmost importance. The open/transcervical approach is currently...
Thu Oct 24, 2019 14:48
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Stefan Mattheis, Timon Hussain, Benedikt Höing, Pia Haßkamp, Laura Holtmann, Stephan LangWhile transoral laser microsurgery has been the gold standard for laryngeal surgery for many years, recently transoral robotic surgery (TORS) has become a new treatment option not being restricted to a straight line of view which can be an obstacle during resection. In combination with...
Thu Oct 24, 2019 14:48
Purpose of review The current article reviews recent literature examining occupational voice use and occupational voice disorders (January 2018–July 2019). Recent findings Our understanding of the prevalence of voice disorders and work-related vocal use, vocal load and vocal ergonomics (environmental and person influences) across different occupations is continuing to build. There is encouraging evidence for the value of intervention programs for occupational voice users, particularly of...
Wed Oct 23, 2019 03:00
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Guy SlonimskySaccular disorders extending beyond the thyrohyoid membrane are classified as external, or combined, based on to their extension beyond the thyrohyoid membrane and the proportion of the external to the internal component. The workup is the same as for internal saccular disorders and airway safety is of utmost importance. The open/transcervical approach is currently...
Thu Oct 24, 2019 14:48
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Stefan Mattheis, Timon Hussain, Benedikt Höing, Pia Haßkamp, Laura Holtmann, Stephan LangWhile transoral laser microsurgery has been the gold standard for laryngeal surgery for many years, recently transoral robotic surgery (TORS) has become a new treatment option not being restricted to a straight line of view which can be an obstacle during resection. In combination with...
Thu Oct 24, 2019 14:48
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Guy SlonimskyLaryngeal saccular disorders are rare lesions presenting as abnormal saccular dilation, either mainly filled with air (laryngoceles) or fluid (saccular cysts). These are further categorized as internal when confined in the endolarynx, external, or combined. In adults, saccular disorders are mostly idiopathic with various reported proportion associated with...
Thu Oct 24, 2019 14:48
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Oksana Jackson, Nicholas Wingate, Alfred Lee, Alison E. KayeAbstractObjectivesThe bilateral cleft nasal deformity is characterized by a short columella and a broad, flattened nasal tip. Secondary correction is challenging and often complicated by skin envelope scarring and hypoplastic alar cartilages. Adequate and durable tip projection requires a procedure that adequately augments...
Thu Oct 24, 2019 14:03
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): F. Jahshan, O. Ertracht, N. Eisenbach, A. Daoud, E. Sela, A. Abu Ammar, M. GruberAbstractObjectiveTracheal mucosal damage is a well-known complication of endo-tracheal intubation and animal models are essential for studying the underlying cellular injury cascade. The novel rat model described here is based on retrograde intubation via tracheotomy and suture fixation of the tube....
Thu Oct 24, 2019 14:03
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Christen L. Caloway, Sarah Bouhabel, Christopher J. HartnickAbstractWhile Ansa to recurrent laryngeal nerve reinnervation is gaining popularity in the treatment of unilateral vocal fold immobility, little has been reported on commonly encountered surgical challenges with this procedure. Here, we present a cohort of 21 pediatric patients who underwent this procedure with a full...
Thu Oct 24, 2019 14:03
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Kiri Mealings, Samantha Harkus, Jennifer Hwang, Jacinto Fragoso, King Chung, Harvey DillonAbstractObjectiveOtitis media resulting in conductive hearing loss is a major health issue for Aboriginal and Torres Strait Islander children, which can also lead to the child developing spatial processing disorder (SPD). This study examined the prevalence of hearing loss and deficits in...
Thu Oct 24, 2019 14:03
Objectives/Hypothesis The purpose of the study was to compare the prevalence of vocal fold pathologies among first‐year singing students from the classical, musical theatre, and contemporary commercial music (CCM) genres. Study Design Prospective cohort study. Methods Videostroboscopic examinations were rated by blinded expert raters. Vocal pathology was defined as a vocal fold abnormality on the membranous or cartilaginous portions of the vocal folds or hypomobility. Consensus among...
Thu Oct 24, 2019 14:13
Objective Most type 1 thyroplasty implants and some common injectable materials are mechanically stiff. Placing them close to the supple vocal fold mucosa can potentially dampen vibration and adversely impact phonation, yet this effect has not been systematically investigated. This study aims to examine the effect of implant depth on vocal fold vibration and vocal output. Study Design Computational simulation. Methods Voice production was simulated with a fiber‐gel finite element computational...
Wed Oct 23, 2019 18:38
Objectives Determine rates and reasons for unplanned revisits after ambulatory otologic surgery. Methods Cross‐sectional analysis of State Ambulatory Surgery Databases of California, Florida, Iowa, and New York was performed for years 2010 and 2011. Ambulatory adult otology surgical procedures were linked to ambulatory, emergency, and inpatient databases for revisit encounters occurring within 30 days. The numbers of revisits and associated diagnoses were analyzed. Results A total of...
Wed Oct 23, 2019 18:37
Background/Objectives Idiopathic progressive subglottic stenosis (IPSS) predominantly affects females in perimenopause. It has, therefore, been hypothesized that estrogen is involved in its pathogenesis. There are two main types of estrogen receptors: ER‐α and ER‐β. Abnormal variants of ER‐β have previously been shown to be associated with poor wound healing. Estrogen receptors have recently been identified in subglottic tissue samples, with elevated levels of ER‐α and progesterone receptors, and...
Wed Oct 23, 2019 18:36
Objectives Globus pharyngeus (GP) is described as the subjective sensation of having a “lump” in the throat in the absence of correlating physical findings or dysphagia. Historically, despite the frequency of patient complaints, GP has been difficult to quantify with current outcome measures. This is in large part due to lack of a user‐friendly, modernized, objective patient‐reported outcome measure (PROM) of symptom severity. The aim of this study is to develop a modernized, practical, validated...
Wed Oct 23, 2019 18:35
Objectives/Hypothesis To outline a possible decision‐making process for sporadic vestibular schwannoma (VS) with contralateral nonserviceable hearing at diagnosis. Study Design Retrospective case series. Methods Diagnosed VS was studied in a tertiary referral center from 1995 to 2013. Results Twenty‐eight patients were included, with a mean follow‐up of 6.9 years (range = 0.5–20 years). Ten were stage 1, 10 were stage 2, five were stage 3, and three were stage 4. Ipsilateral hearing...
Wed Oct 23, 2019 18:34
Objective To investigate the relations of monoallelic (M1), biallelic (M2), or the absence of mutations (M0) in SLC26A4 to inner ear morphology and hearing levels in individuals with Pendred syndrome (PS) or nonsyndromic enlarged vestibular aqueduct (NSEVA) associated with hearing loss. Methods In a cohort of 139 PS/NSEVA individuals, 115 persons from 95 unrelated families had full genetic sequencing of SLC26A4, and 113 had retrievable images for re‐assessment of inner ear morphology. The...
Mon Oct 21, 2019 18:34
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