Nature Communications - current - nature.com science feeds
- Multi-strategic RNA-seq analysis reveals a high-resolution transcriptional landscape in cottonNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12575-xIn-depth functional characterization of genomes relies on comprehensive transcriptome data. Here, the authors employ four complementary RNA sequencing technologies to explore the transcription landscape across 16 tissues or different organ types in diploid A genome cotton using a newly developed computational pipeline.
- Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylationNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12551-5Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H3K14 promotes acetylation of H3K23 by this complex to activate
- Mice with hyper-long telomeres show less metabolic aging and longer lifespansNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12664-xTelomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of cancer.
- Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in waterNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12586-8Reversibility of peptide hydrogen bonded supramolecular assemblies makes them tunable but highly dynamic and prone to disassembly at the low concentration. Here the authors show a secondary hydrophobic interaction, near the peptide core that stabilises the peptide bonds, without losing the solubility of the systems in aqueous conditions.
- Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and diseaseNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12464-3Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states in disease.
- The evolution of parental care diversity in amphibiansNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12608-5Parental care can take many forms but how this diversity arises is not well understood. Here, the authors compile data for over 1300 amphibian species and show that different forms of care evolve at different rates, prolonged care can be easily reduced, and biparental care is evolutionarily unstable.
- Transforming protein-polymer conjugate purification by tuning protein solubilityNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12612-9Therapeutic proteins are often conjugated with polymers, but separating the conjugate from unconjugated protein and free polymer is a major challenge. Here, the authors discover that proteins conjugated to charged or zwitterionic polymers maintain solubility in 100% ammonium sulfate, greatly simplifying purification.
- UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cellsNature Communications, Published online: 17 October 2019; doi:10.1038/s41467-019-12455-4Retrotransposons are silenced by an epigenetic mechanism and piRNA pathway in the mammalian germline. Here, the authors report that UHRF1 suppresses retrotransposons by interacting with PRMT5 and PIWI proteins during spermatogenesis.
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