• The Journal of Physiology ,
• Synaptic cleft microenvironment influences potassium permeation and synaptic transmission in hair cells surrounded by calyx afferents in the turtle

  Key points In central regions of vestibular semicircular canal epithelia, the [K+] c in the synaptic cleft contributes to setting the hair cell and afferent membrane potentials. The potassium efflux from type I hair cells results from the interdependent gating of three conductances. Elevation of [K+] c occurs through a calcium‐activated potassium conductance, GBK, and a low‐voltage‐activating delayed rectifier, GK(LV), that activates

  The Journal of Physiology

  Thu Oct 17, 2019 03:43
• TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels

  Key points Eact is a putative pharmacological activator of TMEM16A Eact is strongly effective in recombinant FRT cells but not in airway epithelial cells with endogenous TMEM16A expression Transcriptomic analysis, gene silencing, and functional studies in FRT cells reveal that Eact is actually an activator of the Ca2+‐permeable TRPV4 channel In airway epithelial cells TRPV4 and TMEM16A are expressed in separate cell types Intracellular Ca2

  The Journal of Physiology

  Thu Oct 17, 2019 01:54
• Exercise training: Thinking ahead to counteract systemic manifestations of spinal muscular atrophy

  The Journal of Physiology

  Thu Oct 17, 2019 07:37