NEJM : Research
- Randomized Trial of Medical versus Surgical Treatment for Refractory HeartburnIn the United States, approximately 20% of adults regularly have symptoms of gastroesophageal reflux disease (GERD), and annual costs for managing GERD exceed $12 billion. Patients with heartburn, the cardinal symptom of GERD, report reduced work productivity and significant impairments in…
- 20-Year Follow-up of Statins in Children with Familial HypercholesterolemiaFamilial hypercholesterolemia is a common autosomal dominant disorder of lipoprotein metabolism. It is caused by mutations in genes encoding key proteins involved in the low-density lipoprotein (LDL) receptor endocytic and recycling pathways that lead to decreased cellular uptake of LDL…
- Case 32-2019: A 70-Year-Old Woman with Rapidly Progressive AtaxiaPresentation of Case. Dr. Kun-Wei Song (Neurology): A 70-year-old woman was admitted to this hospital because of rapidly progressive ataxia. The patient had been in her usual state of good health until 3 months before this admission, when fatigue and general unsteadiness developed. Two months…
- Democratizing Evidence Production — A 51-Year-Old Man with Sudden Onset of Dense HemiparesisIn 2015, a 51-year-old farmer, Mr. K. arrived at the Jan Swasthya Sahyog hospital — an approximately 100-bed hospital in an underserved part of rural central India that provides care to a population of 1.5 million, mostly from poor, marginalized indigenous communities. Mr. K. presented with a…
- Preexisting ConditionsDoc gets these calls more often now, cries for help from family and friends. They call him, he says, because he’s the one doctor they know who answers the phone himself (he’s retired) — none of that "please listen carefully, our menu has changed." Often the calls come from a distance, like when his…
- Calcinosis in Juvenile DermatomyositisA 4-year-old girl with juvenile dermatomyositis was brought to the rheumatology clinic with a rash and limb weakness. She had had continuous disease activity without remission despite receiving treatment with multiple medications, including glucocorticoids, intravenous immune globulin,…
Πέμπτη 17 Οκτωβρίου 2019
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