Πέμπτη 24 Οκτωβρίου 2019


 , Posterior-Wall Myocardial Infarction
Figure 1.
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Thu Oct 24, 2019 03:00
Calcinosis in Systemic Sclerosis
Figure 1.
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Thu Oct 24, 2019 03:00
Case 33-2019: A 35-Year-Old Woman with Cardiopulmonary Arrest during Cesarean Section
Presentation of Case. Dr. Rachel Wood (Obstetrics and Gynecology): A 35-year-old pregnant woman was admitted to the labor and delivery unit of this hospital at 36 weeks 4 days of gestation for a planned repeat cesarean section because of placenta previa. At 6 weeks 4 days of gestation, the patient…
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Thu Oct 24, 2019 03:00
Structural basis for the docking of mTORC1 on the lysosomal surface
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)–Ragulator complex. Nutrients switch the heterodimeric Rag GTPases among four different nucleotide-binding states, only one of which (RagA/B•GTP–RagC/D•GDP) permits mTORC1 association. We used cryo–electron microscopy to determine...
Science: Current Issue
Thu Oct 24, 2019 20:40
Trophy hunting: Values inform policy
Science: Current Issue
Thu Oct 24, 2019 20:40
Higher-fitness yeast genotypes are less robust to deleterious mutations
Natural selection drives populations toward higher fitness, but second-order selection for adaptability and mutational robustness can also influence evolution. In many microbial systems, diminishing-returns epistasis contributes to a tendency for more-fit genotypes to be less adaptable, but no analogous patterns for robustness are known. To understand how robustness varies across genotypes, we measure the fitness effects of hundreds of individual insertion mutations in a panel of yeast strains. We...
Science: Current Issue
Thu Oct 24, 2019 20:40
Trophy hunting: Broaden the debate
Science: Current Issue
Thu Oct 24, 2019 20:40
A multifaceted future for wind power
Science: Current Issue
Thu Oct 24, 2019 20:40
Trophy hunting: Bans create opening for change
Science: Current Issue
Thu Oct 24, 2019 20:40
Commensals rule the MAITrix
Science: Current Issue
Thu Oct 24, 2019 20:40
Trophy hunting: Insufficient evidence
Science: Current Issue
Thu Oct 24, 2019 20:40
NODs require S-palmitoylation to signal
Science: Current Issue
Thu Oct 24, 2019 20:40
Trophy hunting: A moral imperative for bans
Science: Current Issue
Thu Oct 24, 2019 20:40
Genetic background affects variation
Science: Current Issue
Thu Oct 24, 2019 20:40
AAAS's "How We Respond" report captures U.S. ingenuity
Science: Current Issue
Thu Oct 24, 2019 20:40
Interior tumor views
Science: Current Issue
Thu Oct 24, 2019 20:40
Women innovators become STEM ambassadors for girls
Science: Current Issue
Thu Oct 24, 2019 20:40
Coherent surface spin manipulation
Science: Current Issue
Thu Oct 24, 2019 20:40
Close-up of human cerebellar development
Science: Current Issue
Thu Oct 24, 2019 20:40
Network rewiring in cancer
Science: Current Issue
Thu Oct 24, 2019 20:40
Alternative influenza target
Science: Current Issue
Thu Oct 24, 2019 20:40
The thermal adaptation of the proteome
Science: Current Issue
Thu Oct 24, 2019 20:40
Measuring street protest events
Science: Current Issue
Thu Oct 24, 2019 20:40
Worldwide river sediment flux
Science: Current Issue
Thu Oct 24, 2019 20:40
Tea for type 1 and type 2 diabetes
Science: Current Issue
Thu Oct 24, 2019 20:40
Dissecting racial bias in an algorithm used to manage the health of populations
Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this industry-wide approach and affecting millions of patients, exhibits significant racial bias: At a given risk score, Black patients are considerably sicker than White patients, as evidenced by signs of uncontrolled illnesses. Remedying this disparity would increase the percentage of Black patients receiving additional help from 17.7...
Science: Current Issue
Thu Oct 24, 2019 20:40
Racial bias in health algorithms
Science: Current Issue
Thu Oct 24, 2019 20:40
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing
The nucleotide oligomerization domain (NOD)–like receptors 1 and 2 (NOD1/2) are intracellular pattern-recognition proteins that activate immune signaling pathways in response to peptidoglycans associated with microorganisms. Recruitment to bacteria-containing endosomes and other intracellular membranes is required for NOD1/2 signaling, and NOD1/2 mutations that disrupt membrane localization are associated with inflammatory bowel disease and other inflammatory conditions. However, little is known...
Science: Current Issue
Thu Oct 24, 2019 20:40
Milling corundum nanoparticles
Science: Current Issue
Thu Oct 24, 2019 20:40
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation
Ferroelectrics are usually inflexible oxides that undergo brittle deformation. We synthesized freestanding single-crystalline ferroelectric barium titanate (BaTiO3) membranes with a damage-free lifting-off process. Our BaTiO3 membranes can undergo a ~180° folding during an in situ bending test, demonstrating a super-elasticity and ultraflexibility. We found that the origin of the super-elasticity was from the dynamic evolution of ferroelectric nanodomains. High stresses modulate the energy landscape...
Science: Current Issue
Thu Oct 24, 2019 20:40
Growing pains
Science: Current Issue
Thu Oct 24, 2019 20:40
High-surface-area corundum by mechanochemically induced phase transformation of boehmite
In its nanoparticulate form, corundum (α-Al2O3) could lead to several applications. However, its production into nanoparticles (NPs) is greatly hampered by the high activation energy barrier for its formation from cubic close-packed oxides and the sporadic nature of its nucleation. We report a simple synthesis of nanometer-sized α-Al2O3 (particle diameter ~13 nm, surface areas ~140 m2 g–1) by the mechanochemical dehydration of boehmite (-AlOOH) at room temperature. This transformation is accompanied...
Science: Current Issue
Thu Oct 24, 2019 20:40
Europe dreams big for future space missions
Science: Current Issue
Thu Oct 24, 2019 20:40
Microbial metabolites control the thymic development of mucosal-associated invariant T cells
How the microbiota modulate immune functions remains poorly understood. Mucosal-associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in germ-free mice. Here, we show that commensal bacteria govern murine MAIT intrathymic development, as MAIT cells did not recirculate to the thymus. MAIT development required RibD expression in bacteria, indicating that production of the MAIT antigen 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) was necessary. 5-OP-RU rapidly...
Science: Current Issue
Thu Oct 24, 2019 20:40
How life blossomed after the dinosaurs died
Science: Current Issue
Thu Oct 24, 2019 20:40
Codes of conduct aim to curb harassment at field sites
Science: Current Issue
Thu Oct 24, 2019 20:40
New drugs target growing threat of fatal fungi
Science: Current Issue
Thu Oct 24, 2019 20:40
Prime editing promises to be a cut above CRISPR
Science: Current Issue
Thu Oct 24, 2019 20:40
Screening embryos for complex genetic traits called premature
Science: Current Issue
Thu Oct 24, 2019 20:40

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