Publication date: Available online 22 October 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Wagener Inga, Jungen Meike, von Hörsten Stephan, Stephan Michael, Schmiedl AndreasAbstractBackgroundRodents are born with morphological immature lungs and an intact surfactant system. CD26/DPP4 is a multifactorialtransmembrane integral type II protein, which is involved in physiological and pathophysiological processes and is already expressed during development. CD26/DPP4, called CD26 in...
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Related ArticlesAltered secretory profile of dysfunctional endothelial cells impairs in vitro satellite cell activity in humans. J Physiol. 2019 Oct 21;: Authors: Hinkley JM PMID: 31634985 [PubMed - as supplied by publisher]
Related ArticlesThe contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells. J Physiol. 2019 Oct 21;: Authors: Goldring AC, Beurg M, Fettiplace R Abstract KEY POINTS: •Hair cell mechanoelectrical transducer channels are opened by deflections of the hair bundle about a resting position set by incompletely understood adaptation mechanisms. •We used three characteristics to define adaptation in hair cell...
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Publication date: Available online 22 October 2019Source: Medical HypothesesAuthor(s): F. Comhaire, J.P. DeslypereAbstractThough affecting many thousands of patients, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) should be considered an orphan disease, since the cause remains elusive and no treatment is available that can provide complete cure. There is reasonable insight into the pathogenesis of signs and symptoms, and treatments specifically directed to immunological, inflammatory...
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Related ArticlesOral Rehabilitation of Patients Sustaining Orofacial Injuries: The UPenn Initiative. Adv Dent Res. 2019 Nov;30(2):50-56 Authors: Zhang QZ, Chen C, Chang MB, Shanti RM, Cannady SB, O'Malley BW, Shi S, Le AD Abstract Tissue injuries in the oral and maxillofacial structures secondary to trauma, warfare, ablative cancer, and benign tumor surgery result in significant losses of speech, masticatory and swallowing functions, aesthetic deformities,...
Related ArticlesImplementation of speech pathology telepractice services for clinical swallowing assessment: An evaluation of service outcomes, costs and consumer satisfaction. J Telemed Telecare. 2019 Oct;25(9):545-551 Authors: Burns CL, Ward EC, Gray A, Baker L, Cowie B, Winter N, Rusch R, Saxon R, Barnes S, Turvey J PMID: 31631757 [PubMed - in process]
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Publication date: Available online 21 October 2019Source: World NeurosurgeryAuthor(s): Yilan Xiang, Tingting Zhang, Yanxuan Li, Jinjin Liu, Haoli Xu, Wenwen He, Qian Chen, Yunjun YangAbstractObjectiveUltra-early hematoma growth(uHG), the black hole sign, and the blend sign are common predictors of hematoma enlargement(HE). This study aimed to develop a new diagnostic criterion for predicting HE using uHG and to compare the accuracy of uHG, the black hole sign, and the blend sign in predicting HE...
Publication date: Available online 21 October 2019Source: World NeurosurgeryAuthor(s): Lubdha M. Shah, Erica F. BissonAbstractBackgroundThe adult spinal cord is typically resistant to hypoxic ischemic injury (HII) because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilatation, such as superimposed hemodynamic stresses, that cannot be accommodated, leaving the spinal cord vulnerable to ischemic injury.Case DescriptionWe present a rare case...
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Related ArticlesActivation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling. Brain Res. 2019 Oct 18;:146516 Authors: Zavala-Tecuapetla C, Orozco-Suarez S, Manjarrez J, Cuellar-Herrera M, Vega-Garcia A, Buzoianu-Anguiano V Abstract Up-regulation of efflux transporters in brain capillaries...
Related ArticlesAn Energy Efficient AdaBoost Cascade Method for Long-term Seizure Detection in Portable Neurostimulators. IEEE Trans Neural Syst Rehabil Eng. 2019 Oct 15;: Authors: Xu K, Zheng Y, Zhang F, Jiang Z, Qi Y, Chen H, Zhu J Abstract Responsive neurostimulation (RNS) is becoming a promising therapy in refractory epilepsy control. In a RNS system, a critical challenge is how to detect seizure onsets accurately with low computational costs. In...
Related ArticlesRole of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A potential novel drug for epilepsy. Curr Drug Targets. 2019 Oct 13;: Authors: Wang X, Li T Abstract Epilepsy, an ancient disease, is defined as an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological and social consequences of this condition. Antiepileptic drugs (AEDs) is currently used as first-line...
Related ArticlesEnergy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy. Front Neurol. 2019;10:1007 Authors: Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC Abstract The Wistar Audiogenic Rat (WAR) strain is a genetic model of epilepsy, specifically brainstem-dependent tonic-clonic seizures, triggered by acute auditory stimulation. Chronic...
Related ArticlesAlterations in GABAA Receptor Subunit Expression in the Amygdala and Entorhinal Cortex in Human Temporal Lobe Epilepsy. J Neuropathol Exp Neurol. 2019 Nov 01;78(11):1022-1048 Authors: Stefanits H, Milenkovic I, Mahr N, Pataraia E, Baumgartner C, Hainfellner JA, Kovacs GG, Kasprian G, Sieghart W, Yilmazer-Hanke D, Czech T Abstract The amygdala has long been implicated in the pathophysiology of human temporal lobe epilepsy (TLE). The different...
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Related ArticlesAssociation Between Pregnancy Outcomes and Radioactive Iodine Treatment After Thyroidectomy Among Women With Thyroid Cancer. JAMA Intern Med. 2019 Oct 21;: Authors: Kim HO, Lee K, Lee SM, Seo GH Abstract Importance: Current guidelines recommend that women delay pregnancy for 6 to 12 months after the receipt of radioactive iodine treatment (RAIT) following thyroidectomy for differentiated thyroid carcinoma. Although concerns exist regarding...
Related ArticlesControllable synthesis of porous Cu-BTC@polymer composite beads for iodine capture. ACS Appl Mater Interfaces. 2019 Oct 21;: Authors: Zhao Q, Zhu L, Lin G, Chen G, Liu B, Zhang L, Duan T, Lei J Abstract The efficient and safe capture of radioactive iodine (129I or 131I) is of great significance in nuclear waste disposal. Here, we report millimeter-scale porous Cu-BTC [Cu3(BTC)2, BTC = 1,3,5-benzenetricarboxylate] loaded polyethersulfone...
Related ArticlesIncreasing Use of Thyroidectomy as Definitive Treatment for Hyperthyroidism. J Surg Res. 2019 Oct 17;: Authors: Asban A, Anue A, Xie R, Chen H Abstract BACKGROUND: Thyroidectomy is a definitive treatment for hyperthyroidism. The purpose of this study is to examine how often patients with hyperthyroidism are referred for thyroidectomy and what are the common reasons for referral. MATERIALS AND METHODS: We identified 864 patients...
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Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12761-xNumerous fluorescent Zn2+ sensors are available but most are unsuitable to detect physiological dynamics of cytosolic Zn2+. In this study, the authors present a genetically encoded sensor with sub-nanomolar sensitivity and show that Zn2 + is released from endolysosomal vesicles via TRPML1 in neurons.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12794-2It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12789-zIt remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and...
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12629-0During meiotic prophase chromosomes organise into a series of chromatin loops, but the mechanisms of assembly remain unclear. Here the authors use Saccharomyces cerevisiae to elucidate how this elaborate three-dimensional chromosome organisation is linked to genomic sequence, and demonstrate an essential role for cohesin during this process.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12544-4Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that consistently, its reduced expression enhances anti-tumor T-cell responses in two syngeneic cancer mouse models.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12695-4Based on single worm whole genome sequencing, the authors here characterise the global evolution of the gastrointestinal parasite Haemonchus contortus and identify genes that play a role in drug resistance as well as climate-driven adaptations involving an epigenetic regulator.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12756-8Late childhood is an important period for the development of inhibitory control underlying self-regulation and impulse control behavior. Here, the authors identify brain mechanisms and functional cortical-basal ganglia circuits that predict inhibitory control in children.
Nature Communications, Published online: 22 October 2019; doi:10.1038/s41467-019-12747-9Professor Marie Edmonds is a volcanologist at the University of Cambridge. She is interested in the role of magmatic volatiles in magma genesis, volcanic eruptions, and volatile geochemical cycling. Dr. Robert Hazen is a geologist at Carnegie Science and executive director of the Deep Carbon Observatory. His latest research has focused on the co-evolution of the geospheres and biospheres, and mineral diversity...
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Related ArticlesSilibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4059-4065 Authors: Shen Y, Zhao H, Wang Z, Guan W, Kang X, Tai X, Sun Y Abstract Purpose: This study aimed to assess the protective effects of silibinin on blue light-emitting diode (LED)-induced retinal ganglion cells (RGCs) damage. Methods: Silibinin was applied in RGCs damage...
Related ArticlesNeferine hinders choriocarcinoma cell proliferation, migration and invasion through repression of long noncoding RNA-CHRF. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4089-4096 Authors: Wang G, Wang P, Yan X, Liu J Abstract The comprehensive pathological peculiarities of Neferine (NEF) have been testified in disparate diseases. But, the functions of NEF in choriocarcinoma progression remain unexplored. The research endeavoured to uncover...
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Abstract Opioid‐related deaths from respiratory depression are increasing but there is only limited information on the effect of morphine on breathing during sleep. This study aimed to detect and quantify opioid‐induced cardiorespiratory pattern changes during sleep in obstructive sleep apnea (OSA) patients using novel automated methods and correlate these with conventional polysomnography (PSG) measures. Under a randomized double‐blind placebo‐controlled crossover design, 60 male OSA patients attended...
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Related ArticlesDiffuse histology-proven mucinous cystic neoplasm of the pancreas: A case report and review of literature. Int J Surg Case Rep. 2019 Oct 15;64:123-127 Authors: Nicolas CT, Al Diffalha S, Reddy S Abstract INTRODUCTION: Mucinous cystic neoplasms (MCN) are rare premalignant neoplasms of the pancreas that are typically found as single lesions in the pancreatic body and tail of women in the fifth and sixth decade of life, do not communicate...
Related ArticlesSevere penile injury due to condom catheter fixed by a rubber band: A case report. Int J Surg Case Rep. 2019 Oct 15;64:120-122 Authors: Zaghbib S, Chakroun M, Saadi A, Boussaffa H, Bouzouita A, Derouiche A, Ben Slama MR, Ayed H, Chebil M Abstract INTRODUCTION: Condom catheters are considered as a safe tool in the management of male urinary incontinence, yet complications may occur, especially in debilitated patients, with psychiatric...
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Publication date: Available online 22 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jocelyn Wang, Mark H. Kaplan, Kai Yang
Publication date: Available online 21 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Licheng Sun, Jinrong Fu, Sheng-Hao Lin, Jin-Lyu Sun, Li Xia, Ching-Hsiung Lin, Lijuan Liu, Caiyan Zhang, Lan Yang, Ping Xue, Xiang Wang, Saihua Huang, Xiao Han, Hua-Ling Chen, Ming-Shyan Huang, Xiaobo Zhang, Shau-Ku Huang, Yufeng ZhouAbstractBackgroundEpidemiologic evidence suggests that exposure to particulate matter ≤2.5 μm (PM2.5) aggravates asthma.ObjectiveInvestigate the underlying...
Publication date: Available online 21 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Simone Vanoni, Chang Zeng, Sahiti Marella, Jazib Uddin, David Wu, Kavisha Arora, Catherine Ptaschinski, Jianwen Que, Taeko Noah, Lisa Waggoner, Artem Barski, Andrey Kartashov, Mark Rochman, Ting Wen, Lisa Martin, Jason Spence, Margaret Collins, Vincent Mukkada, Phillip Putnam, Anjaparavanda NarenAbstractBackgroundThe pathology of eosinophilic esophagitis (EoE) is characterized by eosinophil-rich...
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After a sphincter augmentation procedure (Linx), a significant reduction in the incidence of GERD symptoms was noted. Postoperatively, ineffective esophageal motility reversed to normal in 36% of patients, and a significant correlation between IRP and DCI was found. Baseline dysphagia was the only factor significantly associated with postoperative dysphagia. Abstract Background Magnetic sphincter augmentation with the Linx® system is a novel laparoscopic procedure for the treatment of gastro‐esophageal...
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Related ArticlesGenomic profiles and current therapeutic agents in neuroendocrine neoplasms. Curr Drug Targets. 2019 Oct 13;: Authors: Ohmoto A, Morizane C Abstract Neuroendocrine neoplasms (NENs) are rare tumors that mainly occur in the gastroenteropancreatic (GEP) tract and lungs. According to the current World Health Organization classification for GEP-NENs and lung NENs, treatment strategies differ for well-differentiated and poorly differentiated...
Related ArticlesManagement of growth failure and growth hormone deficiency after pediatric allogeneic HSCT: Endocrinologists are of importance for further guidelines and studies. Pediatr Hematol Oncol. 2019 Oct 21;:1-10 Authors: Lawitschka A, Schwarze P, Rovelli A, Badoglio M, Socie G, Tichelli A, Bauer D, Rovo A, Basak G, Schoemans H, Peters C, Salooja N Abstract Growth failure (GF) is a frequent problem after pediatric allogeneic hematopoietic stem...
Related ArticlesLight and shadow on innovative clinical trial designs: Reflections from the EORTC-PAMM Course on "Preclinical and Early-phase Clinical Pharmacology". Expert Rev Clin Pharmacol. 2019 Oct 21;: Authors: Leonetti A, Boyd L, Giuliani J, Giovannetti E, Garajová I Abstract Introduction: In the era of 'precision' oncology, novel clinical trial designs have emerged, in order to better address the final goal of translating the above-mentioned preclinical...
Related ArticlesAmbulatory emergency oncology: A key tenet of future emergency oncology care. Int J Clin Pract. 2019 Oct 21;:e13436 Authors: Cooksley T, Marshall W, Ahn S, Lasserson DS, Marshall E, Rice TW, Klotz A Abstract The challenges of emergency oncology alongside its increasing financial burden has led to an interest in developing optimal care models for meeting patients' needs. Ambulatory care is recognized as a key tenet in ensuring the safety...
Related ArticlesCurrent Trends for Improving Safety of Stereotactic Brain Biopsies: Advanced Optical Methods for Vessel Avoidance and Tumor Detection. Front Oncol. 2019;9:947 Authors: Akshulakov SK, Kerimbayev TT, Biryuchkov MY, Urunbayev YA, Farhadi DS, Byvaltsev VA Abstract Stereotactic brain needle biopsies are indicated for deep-seated or multiple brain lesions and for patients with poor prognosis in whom the risks of resection outweigh the potential...
Related ArticlesCyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: Current Status, Resistance, and Combination Strategies. J Cancer. 2019;10(22):5504-5517 Authors: Niu Y, Xu J, Sun T Abstract Dysregulated activation of the cyclin-dependent kinases (CDKs) 4/6, leading to uncontrolled cell division, is hallmark of cancers. Further study of the cell cycle will advance the cancer treatment. As powerful and effective drugs, inhibitors of CDK 4/6 have...
Related ArticlesMacrophages on the Peritoneum are involved in Gastric Cancer Peritoneal Metastasis. J Cancer. 2019;10(22):5377-5387 Authors: Song H, Wang T, Tian L, Bai S, Chen L, Zuo Y, Xue Y Abstract Tumor-associated macrophages (TAM) have been shown to support tumor growth and progression by various mechanisms. However, the roles of TAM in gastric cancer (GC) peritoneal metastasis remain elusive. To explore the roles of macrophages in the process...
Related ArticlesHigh-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma. Ther Adv Med Oncol. 2019;11:1758835919875324 Authors: Lin CH, Li HY, Liu YP, Kuo PF, Wang WC, Lin FC, Chang WL, Sheu BS, Wang YC, Hung WC, Cheng HC, Yao YC, Calkins MJ, Hsiao M, Lu PJ Abstract Background: Esophageal squamous cell carcinoma (ESCC) is the major type of esophageal cancer...
Related ArticlesCytokine Levels in Inner Ear Fluid of Young and Aged Mice as Molecular Biomarkers of Noise-Induced Hearing Loss. Front Neurol. 2019;10:977 Authors: Landegger LD, Vasilijic S, Fujita T, Soares VY, Seist R, Xu L, Stankovic KM Abstract Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, frequently caused by noise trauma and aging, with inflammation being implicated in both pathologies. Here, we provide the first...
Related ArticlesSurvival advantage and clinicopathological significance of microRNA-22 in cancers: a meta-analysis. Cancer Manag Res. 2019;11:8855-8868 Authors: Xiang Q, Xiang Z, Dou R, Xiong B Abstract An increasing number of studies revealed that microRNA-22 as a biomarker may play a significant role in the cancer patients' prognosis, but the accurate prognosis value of microRNA-22 remains somewhat controversial. Thus, we comprehensively searched the...
Related ArticlesCryoablation In The Management Of Breast Cancer: Evidence To Date. Breast Cancer (Dove Med Press). 2019;11:283-292 Authors: Pusceddu C, Paliogiannis P, Nigri G, Fancellu A Abstract Cryoablation has been successfully used to treat various type of solid tumors, including breast carcinomas. This ablation method has the advantage of being a minimally invasive procedure useful in various clinical situations, including early breast cancer and...
Related ArticlesApplication Of Adoptive Immunotherapy In Ovarian Cancer. Onco Targets Ther. 2019;12:7975-7991 Authors: Yang S, Yin X, Yue Y, Wang S Abstract Ovarian cancer (OC) has been the most fatal gynecological disease that threatens women's health. Surgery and platinum-based chemotherapy are the basic ovarian cancer treatments that can improve survival, but the five-year survival rate has not improved because of delayed diagnosis, drug resistance,...
Related Articles[Nivolumab Treatment for the Patients with Gastric Cancer-Present and Future]. Gan To Kagaku Ryoho. 2019 Oct;46(10):1513-1523 Authors: Imazeki H, Kato K, Boku N Abstract Nivolumab, anti-PD-1 monoclonal antibody, has innovated treatment ofpatients with gastric cancer. Nivolmab has been indicated forBthird-line treatment ofgastric cancer patients in September 2017. Although it has been more than 1 year after nivolumab being widely used...
Related ArticlesMolecular Imaging for Radiotherapy Planning and Response Assessment for Cervical Cancer. Semin Nucl Med. 2019 Nov;49(6):493-500 Authors: Lin AJ, Dehdashti F, Grigsby PW Abstract Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) leverages imaging contrast from accelerated and aberrant glucose metabolism, which is a hallmark of cancer. FDG-PET is essential for assessing involved lymph nodes and distant metastases for...
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Related ArticlesMolecular epidemiology of mycobacteria among herds in Marajó Island, Brazil, reveals strains genetically related and potential zoonotic risk of clinical relevance. Infect Genet Evol. 2019 Oct 18;:104044 Authors: Furlaneto IP, da Conceição ML, Conceição EC, Lopes ML, Rodrigues YC, Macelino BR, Gomes HM, Suffys PN, de Paula Souza E Guimarães RJ, da Silva MG, Duarte RS, da Costa Francez L, do Rosário Casseb A, de Magalhães Câmara V, Pereira WLA, da Costa...
Related ArticlesSafety And Tolerability Of Extended-Release Guaifenesin In Patients With Cough, Thickened Mucus And Chest Congestion Associated With Upper Respiratory Tract Infection. Drug Healthc Patient Saf. 2019;11:87-94 Authors: Tripathi S, Nikhare A, Sharma G, Shea T, Albrecht H Abstract Purpose: An extended-release (ER) formulation of the expectorant guaifenesin has recently been launched in India for the treatment of productive cough accompanied...
Related ArticlesValidation of a host response test to distinguish bacterial and viral respiratory infection. EBioMedicine. 2019 Oct 17;: Authors: Lydon EC, Henao R, Burke TW, Aydin M, Nicholson BP, Glickman SW, Fowler VG, Quackenbush EB, Cairns CB, Kingsmore SF, Jaehne AK, Rivers EP, Langley RJ, Petzold E, Ko ER, McClain MT, Ginsburg GS, Woods CW, Tsalik EL Abstract BACKGROUND: Distinguishing bacterial and viral respiratory infections is challenging....
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