Stefan Gingele, Thomas Skripuletz, Roland JacobsNeural Regeneration Research 2020 15(4):663-664
Yao-Feng Zhu, Wei-Ping Wang, Xue-Feng Zheng, Zhi Chen, Tao Chen, Zi-Yun Huang, Lin-Ju Jia, Wan-Long LeiNeural Regeneration Research 2020 15(4):724-730Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function, and also regulate pathological processes in brain diseases and injury. However, the role of astrocytes in the dopamine-depleted striatum remains unclear. A rat model of Parkinson’s disease was therefore established by injecting 10 μL 6-hydroxydopamine...
Diego La MendolaNeural Regeneration Research 2020 15(4):665-666
Lan Huong Nguyen, William Ong, Kai Wang, Mingfeng Wang, Dean Nizetic, Sing Yian ChewNeural Regeneration Research 2020 15(4):739-747MiR-219 and miR-338 (miR-219/miR-338) are oligodendrocyte-specific microRNAs. The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes, which may enhance axonal remyelination after nerve injuries in the central nervous system (CNS). As such, the delivery of miR-219/miR-338 to the CNS to promote...
Jun-Jie Zhao, Zun-Wei Liu, Bo Wang, Ting-Qin Huang, Dan Guo, Yong-Lin Zhao, Jin-Ning SongNeural Regeneration Research 2020 15(4):667-675Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor neuroserpin (5 μL, 0.25 mg/mL) was injected into...
Valentina Onesto, Angelo Accardo, Christophe Vieu, Francesco GentileNeural Regeneration Research 2020 15(4):759-768 Understanding the mechanisms underlying cell-surface interaction is of fundamental importance for the rational design of scaffolds aiming at tissue engineering, tissue repair and neural regeneration applications. Here, we examined patterns of neuroblastoma cells cultured in three-dimensional polymeric scaffolds obtained by two-photon lithography. Because of the intrinsic resolution...
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Ahmed K Allam, Ahmed E.A Moamen, Gamal I El-HabbaaThe Egyptian Journal of Surgery 2019 38(4):627-637 Background Continuous and rapid advancement in percutaneous endovascular therapy has led to a significant increase in its use as a primary option for revascularization replacing surgical bypass, and it has become a standard treatment for critical limb ischemia (CLI). Clinical success of percutaneous revascularization has been mostly judged by patency rate and limb salvage, but there is paucity of...
Samy Khalefa, Haitham A Eldmarany, Amr El Bahaey, Maher Abdelmoneam, Khalid HindawyThe Egyptian Journal of Surgery 2019 38(4):783-789 Objective Ischemic wounds of the foot are the most common cause for major amputations in vascular surgical patients. It can be presumed that revascularization of the artery directly supplying the ischemic angiosome may be superior to indirect revascularization (IR) of the concerned ischemic angiosome. Patients and methods This prospective study enrolled patients...
Modified technique for Kasai porto-enterostomy in biliary atresia and its impact on clinical outcome
Ahmed Sallam, Sherif Saleh, Mohamed TahaThe Egyptian Journal of Surgery 2019 38(4):638-642 Background Traditionally, the principle of the Kasai procedure is to remove the atretic extrahepatic ducts so as to establish bile flow to the intestine at an early stage and prevent further progression of the disease. Here, we describe modifications to the procedure via a wider and deeper dissection. Aim To assess the new modified technique over the traditional technique used for type III biliary atresia...
Ashraf M Abdelkader, Nasser A Zaher, Ramy A Mitwally, Sharaf E.A Hassanien, Shaimaa K DawaThe Egyptian Journal of Surgery 2019 38(4):760-765 Objective We aimed to analyze the effect of diagnostic laparoscopy in the identification of the cause of ascites that had been failed to be known by all other diagnostic procedures. Patients and methods This study included 20 patients with an ascites of unknown cause. Before diagnostic laparoscopy, all patients underwent clinical, laboratory, and radiological...
Mahmoud Abdelbaky Mahmoud, Mohamed A Amin SalehThe Egyptian Journal of Surgery 2019 38(4):643-655 Background Lesion location and the volume of breast excised in correlation to the total breast volume are cornerstone issues in oncoplastic surgery after surgical breast-conserving surgery affecting the esthetic management plan and protocol implemented. Aim of the study Verifying the value of using latissimus dorsi (LD) myocutaneous flaps in secondary breast reconstruction after surgical breast conservation. ...
Walid M Abd El Maksoud, Khaled Mostafa, Mohamed Abdel-Latif, Habashy A.B Al HammadiThe Egyptian Journal of Surgery 2019 38(4):807-813 Aim To evaluate the outcome of abdomen (OA) procedure with Bogota bag as a temporary measure to close the abdomen in patients with abdominal catastrophes in terms of mortality and morbidity. Patients and methods The study included adult patients who were treated for abdominal catastrophes with OA and Bogota bag for temporary abdominal closure during the period...
Ahmed S Arafa, Fady Fayek, Joseph RizkI AwadThe Egyptian Journal of Surgery 2019 38(4):656-661 Background Seroma formation is considered the most frequent postoperative complication after breast cancer surgery. Serous fluid is collected just under the skin flaps or in the axillary pace immediately following mastectomy preventing adherence of the flaps to the underlying fascia and muscles leading to delay wound healing, infected wound due to repeated aspiration, wound dehiscence, prolonged hospital...
Ahmed M Yehia, Mohamed F Amin, Mostafa M ElaidyThe Egyptian Journal of Surgery 2019 38(4):748-753 Background Malignant hilar stricture (MHS) is a clinical challenge because of the current therapeutic approach and poor prognosis. Although still controversial, bilateral stenting may be the best option for the palliative drainage of malignant hilar biliary obstruction. Recently, the self-expandable metallic stents have clarified more efficacy than plastic stents for the palliation of MHSs, with the...
Mahmoud Abdelbaky Mahmoud, Samy Gamil, Hany RafikThe Egyptian Journal of Surgery 2019 38(4):662-673 Background Breast cancer is the most common site of cancer in women in Egypt as it accounts for ∼38.8% of total malignancies among Egyptian women; it is an important cause of mortality among women. For many women with early-stage breast cancer, a combination of partial mastectomy and radiation therapy − together referred to as breast-conserving therapy − is preferable to total mastectomy. Objective...
Mahmoud S Eldesouky, Hady S Abo Ashour, Mahmoud A ShahinThe Egyptian Journal of Surgery 2019 38(4):772-775 Objectives Formation of a seroma most frequently occurs after mastectomy and axillary surgery. Prolonged drainage is troublesome as it increases the risk for infection and can significantly delay adjuvant therapy. Topical tranexamic acid as an antifibrinolytic agent may control fluid accumulation in the dead space under the skin flaps and in the axillary fossa after mastectomy. The aim of...
Mohamed S Ghali, Mahmoud Abdelbaky Mahmoud, Samy GamilThe Egyptian Journal of Surgery 2019 38(4):674-678 Objective To evaluate the efficacy and safety of our technique in laparoscopic repair of ventral hernias. Summary background data Laparoscopic ventral hernia repair (LVHR) was first reported in 1993. The successful application of laparoscopic techniques for the repair of ventral hernias has been well accepted. The recurrence rate after standard repair of ventral hernias may be as high as 10%,...
Rabie Ramadan, Mahmoud Hemida, Heba G El-SheredyThe Egyptian Journal of Surgery 2019 38(4):797-801 Background Axillary lymph node status is the single most important prognostic factor in breast cancer. Sentinel lymph node biopsy (SLNB) can give an idea about the axillary nodal status, with a high rate of identification. Because the upper outer quadrant is the most common site for breast cancer, most studies of SLNB of the breast have been performed in patients with breast cancer mostly located...
Doaa A Mansour, Hisham A Abou Eisha, Amgad E AsaadThe Egyptian Journal of Surgery 2019 38(4):679-684 Background High-flow trauma centers face a huge variety of injury patterns and severity warranting an objective measure to reflect injury severity and consequently the intensity of care required in a resource-limited environment. The revised trauma score (RTS) is a physiological triage system based upon Glasgow coma scale, systolic blood pressure, and respiratory rate that can be used as a prognostic...
Atef Abdel Hameed, Abdulrahman MohamedThe Egyptian Journal of Surgery 2019 38(4):820-827 Background Inferior vena cava agenesis (IVCA) is a rare anomaly that presents in 5% of cases of unprovoked lower extremity deep venous thrombosis (DVT), mostly bilateral and significantly under the age of 30 years. Conventional treatment with systemic anticoagulation may not be sufficient in limb-threatening stages. Catheter-directed thrombolysis (CDT) could be the modality of choice in this condition. Aim...
Hazem Nour, Hatem Mohammad, Mohamed I FaridThe Egyptian Journal of Surgery 2019 38(4):685-690 Background Divarication of rectus abdominis muscle is common especially after childbirth. Usually it is asymptomatic but may be associated with backache. Its problem is mainly esthetic and managed by plastic surgeons. General surgeons are called for management of divarication if associated with hernia defects. Till now, there is no unique procedure for the optimal management of divarication of recti associated...
Ahmed AbdElsalam, Ahmed Ghobashy, Mohamed Elshal, Ramy Elhawary, Michael Magdy Shenouda, Doaa M HasanThe Egyptian Journal of Surgery 2019 38(4):743-747 Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health. Besides being a worldwide public health problem, obesity is a major risk factor for a number of noncommunicable diseases, including diabetes, cardiovascular diseases, and cancer. Once considered a problem only in high-income countries, overweight and obesity...
Mahmoud Farghaly, Tarek YoussefThe Egyptian Journal of Surgery 2019 38(4):691-699 Background Right Hemicolectomy (RHC) is a common procedure for various right-sided colon pathologies; cancer colon or terminal ileum, perforated appendix with unhealthy cecal base, traumatic injuries and other less commonly indications. Ileo-colic anastomosis is the preferred next step following resection of the diseased segment, however, in certain situations, ileostomy (IL) and mucus fistula (MF) may be done due...
Mohamed H Abdelmawla, Ayman Refaat, Abdulaziz Z Algaby, Ahmed S Abd El BassetThe Egyptian Journal of Surgery 2019 38(4):754-759 Introduction Treatment of refluxing chronic venous insufficiency nowadays has entered a new era. Now, models of venous ablation with minimally invasive surgery have replaced surgery. Performing venous ablation requires the use of tumescent anesthesia instilled locally deep to the saphenous fascia. This application of tumescent anesthetic made the procedure lengthy with...
Islam Atta, Ahmed Sawaby, Amr El AbdThe Egyptian Journal of Surgery 2019 38(4):700-706 Background Vascular access has always been the Achilles repair of hemodialysis. Developments in health care have carried forward patients requiring management who have no veins appropriate for formation of arteriovenous fistula or insert of central venous catheters. This study reports arterioarterial prosthetic loop (AAPL) graft as an effective access for hemodialysis patients with venous occlusion. Objective...
Ayman Ali, Hany Mostafa, Ahmed Ismail, Mohamed Gamal, Ahmed Salah, Mamdouh RoshdyThe Egyptian Journal of Surgery 2019 38(4):766-771 Objective To evaluate the efficacy and safety of mini-percutaneous nephrolithotripsy (mini-PCNL) and retrograde intrarenal surgery (RIRS) in the treatment of renal stones 20 mm or larger in the longest diameter using holmium:YAG laser. Patients and methods This was a prospective randomized study that included 40 patients who were divided into two groups, with 20...
Hassan A Awaad, Amr Abdel Bari, Ahmed M El Teliti, Hassan AshourThe Egyptian Journal of Surgery 2019 38(4):707-712 Introduction Major abdominal operations result in severe unpredictable scar tissue formation that may contribute to adhesions and then recurrent attacks of acute bowel obstruction, chronic abdominal pain, or both problems. Laparoscopic adhesiolysis provides good relief of symptoms in patients with chronic abdominal pain and/or acute bowel obstruction but without major previous abdominal...
Ahmed Nabil, Mona E Saleh, Ahmed H Khalil, Karim Heiba, Mostafa ElshazlyThe Egyptian Journal of Surgery 2019 38(4):776-782 Aim Anastomotic leakage (AL) following gastrointestinal resection is a complication associated with significant morbidity and mortality. C-reactive protein (CRP) is produced by the liver in response to inflammatory cytokines and is used as an indicator for postoperative complications. This study investigated the role of CRP and total leukocyte count (TLC) in blood and drainage...
Amr Elsayed Fetouh, Sherif Abd El-Fatah Saber, Tamer Elmahdy, Ahmed Swelam, Sherif Elgarf, Hamdy Sedky Abdallah, Gamal Ibrahim MoussaThe Egyptian Journal of Surgery 2019 38(4):713-721 Background Laparoscopic one-anastomosis gastric bypass (OAGB) is a promising bariatric procedure with multiple apparent benefits. However, concerns have been expressed about reported complication rates and the extent of follow-up, with recommendations to establish a registry of complications and revisional procedures. ...
Haitham A Eldmarany, Samy Khalefa, Amr El Bahaey, Ahmed SayedThe Egyptian Journal of Surgery 2019 38(4):790-796 Introduction True renal artery aneurysms (RAAs) are uncommon, and their actual prevalence is unknown. The indications for treating RAAs include symptomatic aneurysms, larger than 20 mm or enlarging aneurysms during follow-up, aneurysms in patients in childbearing age or in pregnant women, ruptured aneurysms, false aneurysms, and aneurysms associated with arteriovenous fistulas or dissection. ...
Khaled S Abbas, Khaled M Madbouly, Mohamed Abdel Salam Abbas, Ahmed Mahmoud Mohii El DeinThe Egyptian Journal of Surgery 2019 38(4):722-728 Purpose To evaluate how preoperative markings of the stoma site influence patients’ quality of life (QOL), whether they improve patients’ independence, and what is their effect on the rates of postoperative early and late complications. Patients and methods This is a nonrandomized prospective cohort study that included 60 patients who underwent elective intestinal...
Mohamed Ibrahim, Ahmed Talha, Ehab HasounaThe Egyptian Journal of Surgery 2019 38(4):802-806 Background Obesity is considered one of the major health problems because of its high incidence and associated comorbidities. Various therapeutic options are available for obesity management, and there has been advancement in bariatric surgery with introduction and development of new techniques. Objective To evaluate the short-term outcomes of intragastric balloon (IGB) in terms of weight loss, tolerance,...
Hany Abdelmawla Mohamed, Maher Abdelmoneim, Mohamed SabryThe Egyptian Journal of Surgery 2019 38(4):729-732 Introduction Central venous obstruction and stenosis are common complications that lead to access dysfunction and morbidity in patients on dialysis. Patients and methods This is a prospective study that was conducted at a tertiary referral center, and 30 patients on regular dialysis who presented with venous hypertension in the upper limb were enrolled. Proper history and examination was...
Ebrahim K Al-Ebrahim, Abrar N Fatani, Reem J Alshareef, Raneem A Andijani, Haneen A Moumina, Hatim A AlabbadiThe Egyptian Journal of Surgery 2019 38(4):814-819 We report an exceptional combination of quadruple neoplasms composed of right-sided adenocarcinoma of the colon, renal cell carcinoma, teratoma of the ovary, uterine leiomyoma, and premalignant high-grade cervix dysplasia. These combinations were not reported before.
El-Sayed A Abd El-Mabood, Waleed A Sorour, Mohamed A ElbegawyThe Egyptian Journal of Surgery 2019 38(4):733-742 Purpose To assess superiority of paclitaxel drug-coated balloons (DCB) in prevention of neointimal hyperplasia and restenosis after treatment of symptomatic superficial femoral artery (SFA) occlusive lesions. Background Endovascular treatment (ET) has become the first choice for SFA atherosclerotic lesions. Despite enhanced immediate technical success, neointimal hyperplasia and restenosis...
Recep Erçin Sönmez, Fatih Büyüker, İbrahim Ali Özemir, Özgür Ekinci, Orhan AlimoğluThe Egyptian Journal of Surgery 2019 38(4):828-831 Duodenal tumors are rare neoplasias of the gastrointestinal tract. Despite segmental resections being proposed for tumors located at the distal duodenal segments, there are few studies in recent literature discussing its efficacy with regard to long-term outcomes. The main objective is to put forward the clinical efficacy of segmental resections performed for duodenal...
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