Ehab A Abd El-Atty, El-Sayed I El Shayeb, Ahmed Abd El-Rahman Sonbol, Abdalaziz M M SalamaMenoufia Medical Journal 2019 32(3):906-909Objective The aim of this work was to study the role of interleukin-6 (IL-6) in hepatic encephalopathy (HE) in patients with liver cirrhosis. Background IL-6 is an interleukin that acts as both proinflammatory response and anti-immune response. Patients and methods This study included 80 patients divided into three groups: group I represents the control group...
Mohsen M Deeb, Ashraf A Dawoud, Mahmoud A El-Hawy, Yasser F. M. Wasel, El Sayed A ElsayedMenoufia Medical Journal 2019 32(3):1051-1058Objective The objective of this study was to assess visfatin and resistin levels in children with β-thalassemia major and intermedia. Background β-Thalassemia represents a major public health problem in Egypt. Adipocytokines are bioactive mediators released from the adipose tissue including adipocytes and other cells present within fat tissues. Patients and...
Mahmoud A.E.A. Kora, Ahmed R Tawfeek, Mahmoud A SakrMenoufia Medical Journal 2019 32(3):910-915Objective The aim of this research was to study the value of serum zinc in early detection of nephropathy in patients with type 2 diabetes. Background Zinc is involved in multiple aspects of cellular metabolism. It is required for the catalytic activity of nearly 100 enzymes and it plays a major role in immunity, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc is also important...
Maha A Tawfik, Soheir S Abou-El Ella, Sally M El-Hefnawy, Mai A El-BoraiMenoufia Medical Journal 2019 32(3):1064-1070Objective The aim of the study was to measure the levels of vitamin D-binding protein (VDBP) and microalbumin in the urine of diabetic children (type 1) and to analyze the correlation of VDBP with other parameters. Background Elevated urinary vitamin D-binding protein (UVDBP) level in patients with diabetes indicates that renal tubular damage may be involved in early stages of...
Hassan Abd El Hady, Yassin S Yassin, Khaled M El Zorkany, Belal A Montaser, Sara M H. KashkoushMenoufia Medical Journal 2019 32(3):916-921Objective The aim of this study was to evaluate ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) plasma level in patients under maintenance hemodialysis (HD) to determine its relation in the occurrence of vascular access thrombosis (VAT) in such patients. Background An increased thrombotic tendency is an important...
Ahmed T Mahmoud, Maha A Tawfik, Sameh A Abd-El-Naby, Dina Abd El-Aziz HammadMenoufia Medical Journal 2019 32(3):1078-1082Objective The aim of this study was to determine DNA damage in epileptic children due to seizures and/or due to the most widely used antiepileptic drugs (valproic acid or carbamazepine). Background Epilepsy is a common neurological disease that requires early diagnosis and treatment. However, long-term use of antiepileptic drugs has been shown to cause oxidative damage to...
Hassan A Ahmed, Yassein S Yassein, Khaled M. A. Elzorkany, Ahmad T. H. AbouseriwaMenoufia Medical Journal 2019 32(3):922-927 Objective The aim of this work was to assess the influence of secondary hyperparathyroidism (SHPT) on left ventricular function in end-stage kidney disease in Egyptian patients under maintenance hemodialysis. Background SHPT is a common disorder in patients with chronic kidney disease. Parathyroid hormone (PTH) is a major uremic toxin and may be responsible for long-term...
Dileep Garg, Aditya P Singh, Vinay Mathur, Dinesh K BaroliaMenoufia Medical Journal 2019 32(3):1090-1093Background The management of abdominal blunt trauma in children has changed considerably. Nonoperative treatment is successful in more than 85% of the appropriately selected cases. Aim To evaluate the incidence of various modes of abdominal blunt trauma and the effectiveness of conservative treatment. Patients and methods A retrospective study of 101 cases of abdominal blunt trauma in...
Mohamed A Shaaban, Walid A Shehab El-Din, Mohamed Z Nouh, Belal A Montaser, Mukhtar R Al-ShabrawyMenoufia Medical Journal 2019 32(3):928-931 Objective The aim was to judge thyroid dysfunction in patients receiving new direct-acting antiviral agents (DAAs) for treatment of hepatitis C pathogen. Background Persistent hepatitis C is a gradually progressive disease. DAAs provide high sustained viral response rates and much reduced adverse effects and impaired health-related quality of life during...
Osama F Mansour, Mohammed Abd El-Sattar Agha, Ahmed Abd El-Rahman El-Asdody, Naglaa S. B. MehanaMenoufia Medical Journal 2019 32(3):1099-1103Objective The aim of this study was to determine the diagnostic value of lung ultrasound (US) in the detection of interstitial lung diseases (ILDs), and to assess the correlations of these features with diagnostic parameters of the disease. Background Chest US can be used as a complementary method for the diagnosis of ILDs especially in situations where...
Ahmed R Al Arbagy, Yassein S Yassein, Mahmoud M Emara, Mahmoud A ElsayedMenoufia Medical Journal 2019 32(3):932-937Objective The objective of this study was to study the risk factors of hyperparathyroidism based on hemodialysis vintage (duration in months or years that hemodialysis patients spend on dialysis). Background Hyperparathyroidism is associated with high risk of fractures, cardiovascular morbidity, and death; therefore, it is important to identify risk factors predicting or influencing...
Samar J Suleiman, Alaa A Labeeb, Mahmoud A El-SorogyMenoufia Medical Journal 2019 32(3):1108-1112Objectives The aim of this study was to determine the effect of local injection of platelet-rich plasma (PRP) in patients with mild and moderate knee osteoarthritis (OA) and its effect on pain in comparison to corticosteroid injection. Background OA is one of the most prevalent chronic musculoskeletal diseases worldwide. The use of PRP appeared in the last years for the management of symptoms of...
Study of serum level of vascular endothelial growth factor in patients with hepatocellular carcinoma
Ashraf G Dala, Mohamed H Badr, Fathia I Elbassal, Mohamed A. A. Al DiyarMenoufia Medical Journal 2019 32(3):938-942Objective The aim of this study was to investigate the role of serum vascular endothelial growth factor (VEGF) as a marker for diagnosis and early detection of hepatocellular carcinoma (HCC). Background HCC is one of the most common malignancies. VEGF is a master regulator of angiogenesis in normal and malignant tissues. Participants and methods This was a cross-sectional study...
Mohamed A Nouh, Moamena S El-Hammoly, Safaa A Mohamed, Maha M HanaMenoufia Medical Journal 2019 32(3):1119-1125Objective To assess the role of portal congestion index (PCI) in prediction of esophageal varices (EV) in hepatitis C virus (HCV)-infected patients. Background Portal hypertension (PH) often develops in HCV-infected patients. EV rupture leads to variceal bleeding, the most lethal complication of cirrhosis. Duplex Doppler ultrasonography of portal vein is a noninvasive method to assess...
Ehab A Abd El-Atty, El-Sayed I El-Shayb, Mohammed O BelalMenoufia Medical Journal 2019 32(3):943-948Objective The objective of this study is to compare several noninvasive methods of fibrosis assessment (platelet count, the aspartate aminotransferase/platelet ratio index, the Lok score, and the fibrosis-4 score) versus percutaneous liver biopsy (LB) in chronic hepatitis C virus infection. Background Noninvasive methods for assessment of hepatic fibrosis are increasingly needed. LB is an invasive...
Hatem M Soltan, Mohammed S Ammar, Mohammed A El Balshy, Ehab S. A. MahmoudMenoufia Medical Journal 2019 32(3):1132-1136Objective To evaluate the benefits of routine cystic duct exploration during laparoscopic cholecystectomy (LC). Background The era of LC has been established as it decreases postoperative pain, shortens the hospital stay, and returns the patient to full activity within 1 week. Cystic duct stones (CDS) especially in patients with multiple tiny gallbladder are implicated in postcholecystectomy...
Nabil A El-Kafrawy, Mohamed A El-Said, Mohamed A Abd El-Hafeez, Heba Adel Saleh Omar SaeedMenoufia Medical Journal 2019 32(3):949-954Objective To evaluate the mean platelet volume (MPV) and its correlation with cardiovascular risk in type 2 diabetic patients. Background Platelet functions have important roles in the development of vascular complications in diabetic patients. Platelets with increased volume have increased activity compared to smaller ones, therefore, MPV is used as a marker...
Ahmed S El-Gammal, Mohammed A E-Balshy, Kareem M ZahranMenoufia Medical Journal 2019 32(3):1142-1148Objective The aim of this study was to study the size of thyroid nodule as a risk factor of thyroid malignancy. Background The nodular thyroid lesions are of interest to surgeons and patients since the major differential diagnosis is cancer. These thyroid lesions are present as solitary or multiple nodules. Patients and methods This study was carried out on 330 patients aged from 13 to 65...
Fatma A Elserafy, Hala M E Shaheen, Nora A Khalil, Heba Allah M. AbdelrahmanMenoufia Medical Journal 2019 32(3):955-960Background Urinary incontinence (UI) is considered as a distressing and debilitating condition in elderly women. It has a significant negative impact on quality of life. Objective The aim of this study was to assess the prevalence of UI among elderly women attending a family health center and identify the risk factors associated with the development of UI among the studied...
Aditya P Singh, Arun K Gupta, Ramesh Tanger, Dinesh K BaroliaMenoufia Medical Journal 2019 32(3):1154-1156Congenital diaphragmatic hernia (CDH) is herniation of bowels and abdominal solid organs in the thoracic cavity, causing pulmonary hypoplasia with decreased pulmonary vasculature and dysfunction of the surfactant system. In severe cases, left ventricular hypoplasia is also observed. Usually CDH present in the neonatal period. Late-onset CDH is a rare anomaly with misleading symptoms and signs....
Laila M Montaser, Ahmed A Sonbol, Mohammed A Agha, Mona A IbrahimMenoufia Medical Journal 2019 32(3):961-966Objective This study aimed to investigate the enhanced frequencies of CD14++ CD16 + peripheral blood monocytes in asthmatic patients. Background CD16 + monocytes are increased in inflammatory conditions. It was reported that CD16 + monocytes can be divided into two subsets with different potential of modulating inflammatory responses: CD14++ CD16 + and CD14 + CD16 + monocytes. CD14++...
Mahmood D Al-MendalawiMenoufia Medical Journal 2019 32(3):1161-1161
Mark above section as read
Xin Sun, Xing-Zhen Liu, Jia Wang, Hai-Rong Tao, Tong Zhu, Wen-Jie Jin, Kang-Ping ShenNeural Regeneration Research 2020 15(4):697-704Most animal spinal cord injury models involve a laminectomy, such as the weight drop model or the transection model. However, in clinical practice, many patients undergo spinal cord injury while maintaining a relatively complete spinal canal. Thus, open spinal cord injury models often do not simulate real injuries, and few previous studies have investigated whether having...
Alisa A Shaimardanova, Valeriya V Solovyeva, Daria S Chulpanova, Victoria James, Kristina V Kitaeva, Albert A RizvanovNeural Regeneration Research 2020 15(4):586-596 Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substances into vesicles...
Deepak Jain, Sabrina Mattiassi, Eyleen L Goh, Evelyn K.F. YimNeural Regeneration Research 2020 15(4):573-585 Extracellular matrix (ECM) influences cell differentiation through its structural and biochemical properties. In nervous system, neuronal behavior is influenced by these ECMs structures which are present in a meshwork, fibrous, or tubular forms encompassing specific molecular compositions. In addition to contact guidance, ECM composition and structures also exert its effect on neuronal differentiation....
Haley N Harris, Yuan B PengNeural Regeneration Research 2020 15(4):597-605 The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also plays a large role in the mediation of pain and is effective as a source of analgesia. Evidence for this involvement lies in the NAc’s cortical connections, functions, pharmacology, and therapeutic targeting. The NAc projects to and receives...
Leyang Li, Hiroyuki Yokoyama, Hidetoshi Kaburagi, Takashi Hirai, Kunikazu Tsuji, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Atsushi OkawaNeural Regeneration Research 2020 15(4):731-738 Schwann cell proliferation in peripheral nerve injury (PNI) enhances axonal regeneration compared to central nerve injury. However, even in PNI, long-term nerve damage without repair induces degeneration of neuromuscular junctions (NMJs), and muscle atrophy results in irreversible dysfunction. The peripheral regeneration...
Bridget Martinez, Philip V PeplowNeural Regeneration Research 2020 15(4):606-619 Multiple sclerosis is a chronic autoimmune disease of the central nervous system. It is the main cause of non-traumatic neurological disability in young adults. Multiple sclerosis mostly affects people aged 20–50 years; however, it can occur in young children and much older adults. Factors identified in the distribution of MS include age, gender, genetics, environment, and ethnic background. Multiple sclerosis is usually...
Li-Hong Duan, Meng Li, Chun-Bao Wang, Qing-Mei Wang, Quan-Quan Liu, Wan-Feng Shang, Ya-Jin Shen, Zhuo-Hua Lin, Tong-Yang Sun, Zheng-Zhi Wu, Ying-Hong Li, Yu-Long Wang, Xun LuoNeural Regeneration Research 2020 15(4):682-689Alpinia oxyphylla, a traditional herb, is widely used for its neuroprotective, antioxidant and memory-improving effects. However, the neuroprotective mechanisms of action of its active ingredients are unclear. In this study, we investigated the neuroprotective effects of various...
Manuel YepesNeural Regeneration Research 2020 15(4):620-624 The last two decades have witnessed a rapid decrease in mortality due to acute cerebral ischemia that paradoxically has led to a rapid increase in the number of patients that survive an acute ischemic stroke with various degrees of disability. Unfortunately, the lack of an effective therapeutic strategy to promote neurological recovery among stroke survivors has led to a rapidly growing population of disabled patients. Thus, understanding...
Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun, Francisco S CayabyabNeural Regeneration Research 2020 15(4):712-723Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases. However, the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear. In this study, rats were intraperitoneally injected...
Henrique Rocha Mendonca, Raul Carpi-Santos, Karin da Costa Calaza, Ana Maria Blanco MartinezNeural Regeneration Research 2020 15(4):625-635 Diabetes is a lifelong disease characterized by glucose metabolic imbalance, in which low insulin levels or impaired insulin signaling lead to hyperglycemic state. Within 20 years of diabetes progression, 95% of patients will have diabetic retinopathy, the leading cause of visual defects in working-age people worldwide. Although diabetes is considered a microvascular...
Kai Qian, Tuo-Ye Xu, Xi Wang, Tao Ma, Kai-Xin Zhang, Kun Yang, Teng-Da Qian, Jing Shi, Li-Xin Li, Zheng WangNeural Regeneration Research 2020 15(4):748-758 Objective: To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources: Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase and Cochrane databases,...
Wensheng Lin, Sarrabeth StoneNeural Regeneration Research 2020 15(4):636-645 Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, including...
Yan Cheng, Mandy Pereira, Neha P Raukar, John L Reagan, Mathew Quesenberry, Laura Goldberg, Theodor Borgovan, W Curt LaFrance, Mark Dooner, Maria Deregibus, Giovanni Camussi, Bharat Ramratnam, Peter QuesenberryNeural Regeneration Research 2020 15(4):676-681At present, there is no reliable biomarker for the diagnosis of traumatic brain injury (TBI). Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI...
Maria Marcella Lagana, Laura Pelizzari, Francesca BaglioNeural Regeneration Research 2020 15(4):646-652 Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim...
Xiao-Qin Ha, Bo Yang, Huai-Jing Hou, Xiao-Ling Cai, Wan-Yuan Xiong, Xu-Pan WeiNeural Regeneration Research 2020 15(4):690-696Rhodioloside has been shown to protect cells from hypoxia injury, and bone marrow mesenchymal stem cells have a good effect on tissue repair. To study the effects of rhodioloside and bone marrow mesenchymal stem cells on spinal cord injury, a rat model of spinal cord injury was established using the Infinite Horizons method. After establishing the model, the rats were randomly...
Rubaiya Tabassum, Na Young Jeong, Junyang JungNeural Regeneration Research 2020 15(4):653-662 Hydrogen sulfide (H2S) is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases. One of the major causes of age-related diseases is oxidative stress. In recent years, the importance of H2S has become clear, although its antioxidant function has not yet been fully explored. The enzymes cystathionine β-synthase,...
Dong An, Xiao-Wei Wei, He-Nan Zhang, Dan Liu, Wei Ma, Zheng-Wei YuanNeural Regeneration Research 2020 15(4):705-711Leukemia inhibitory factor receptor (LIFR), as a neuroregulatory cytokine receptor, generally shows a neuroprotective effect in central nervous system injuries. In this study, to understand the effect of LIFR on pathogenesis of neural tube defects, we explored spatiotemporal expression of LIFR at different stages of fetal development in normal and neural tube defect embryos. Spina bifida...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου