Systematic review and meta-analysis of carbapenem-resistance of Acinetobacter baumannii in Iran.Systematic review and meta-analysis of carbapenem-resistance of Acinetobacter baumannii in Iran. Infect Disord Drug Targets. 2019 Sep 29;: Authors: Shakib P, Choolandaimy ZB, Rezaie F, Bahmani M, Delfani S Abstract INTRODUCTION: The prevalence of carbapenem resistance in Acinetobacter baumannii (A. baumannii) has been increased in worldwide. Thus therapeutic options are extremely limited. We performeExpert Opinion on Drug Discovery
- What are the challenges in commercial non-tuberculous mycobacteria (NTM) drug discovery and how should we move forward?What are the challenges in commercial non-tuberculous mycobacteria (NTM) drug discovery and how should we move forward? Expert Opin Drug Discov. 2019 Sep 30;:1-3 Authors: Timmins GS Abstract Introduction: Despite the great clinical need, the development of drugs for treating non-tuberculous mycobacteria lung disease (NTM-LD), partly from the scientific difficulty, but also because the eventual size a
- The Skin Cancer Index: Quality-of-life outcomes of treatments for nonmelanoma skin cancer.The Skin Cancer Index: Quality-of-life outcomes of treatments for nonmelanoma skin cancer. J Dermatolog Treat. 2019 Sep 30;:1-10 Authors: Sanchez N, Griggs J, Nanda S, Fayne R, Castillo D, De Bedout V, Meirson D, Nichols A Abstract Introduction: Non-melanoma skin cancers (NMSCs) are the most common malignancies in humans1. When treating NMSC, quality-of-life (QOL) is an important consideration. The p
- Correction.Related ArticlesCorrection. J Dermatolog Treat. 2019 Dec;30(8):I Authors: PMID: 31564229 [PubMed - in process]
- Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9.Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3904-3912 Authors: Zhao W, Tang L, Gao S, Xin L, Zhang H, Li Y Abstract This study aimed to investigate the effect of Junduqing extractive on proliferation, apoptosis, migration and i
- An integrated analysis of the circRNA-miRNA-mRNA network reveals novel insights into potential mechanisms of cell proliferation during liver regeneration.An integrated analysis of the circRNA-miRNA-mRNA network reveals novel insights into potential mechanisms of cell proliferation during liver regeneration. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3873-3884 Authors: Wang G, Guo X, Cheng L, Chu P, Chen M, Chen Y, Chang C Abstract Cell proliferation constitutes the fundamental process and driving force behind regrowth during liver regeneration (LR
- Can CDK4/6 inhibitors cause fatal lung injury?Can CDK4/6 inhibitors cause fatal lung injury? Expert Rev Anticancer Ther. 2019 Sep 30;: Authors: Jazieh KA, Budd GT, Dalpiaz N, Abraham J PMID: 31566017 [PubMed - as supplied by publisher]
Massachusetts Medical Society: New England Journal of Medicine: Table of Contents
- Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate CancerNew England Journal of Medicine, Ahead of Print.
- Dapagliflozin in Patients with Heart Failure and Reduced Ejection FractionLarge clinical trials involving patients with type 2 diabetes have shown that inhibitors of sodium–glucose cotransporter 2 (SGLT2) reduce the risk of hospitalization for heart failure. Most patients in these trials did not have heart failure at baseline, so the benefit of treatment with an SGLT2…
- Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate CancerProstate cancer is the second leading cause of cancer-related death among men in the United States and the third leading cause of cancer-related death in Europe. Four different classes of medical treatments have prolonged survival among patients with metastatic castration-resistant prostate cancer,…
- Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal CancerThe BRAF V600E mutation occurs in approximately 10% of patients with metastatic colorectal cancer, with recent estimates ranging from as low as 5% to as high as 21%. This mutation identifies a distinct subtype of colorectal cancer that has a poor prognosis. Initial standard chemotherapy for BRAF…
- Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung CancerSubstantial progress has been made in the first-line treatment of patients with advanced non–small-cell lung cancer (NSCLC) without driver alterations that can be targeted. These treatments include monotherapy blockade of programmed death 1 (PD-1) in patients with tumors that express programmed…
- Craniosynostosis and ENT.Craniosynostosis and ENT. Neurochirurgie. 2019 Sep 27;: Authors: Couloigner V, Khalfallah SA Abstract OBJECTIVE: The aim of the present study was to review the literature on ENT disorders associated with craniosynostosis (CS), focusing on symptoms, diagnostic work-up, treatment and outcome. METHODS: Publications were retrieved by consulting the PubMed® free search engine of the US National L
- Weight gain velocity as a predictor of severe obstructive sleep apnea among obese adolescents.Weight gain velocity as a predictor of severe obstructive sleep apnea among obese adolescents. Laryngoscope. 2019 Sep 30;: Authors: Johnson RF, Hansen A, Narayanan A, Yogesh A, Shah GB, Mitchell RB Abstract OBJECTIVES/HYPOTHESIS: To evaluate a cohort of obese adolescents with obstructive sleep apnea (OSA) to determine if increased yearly weight gain was a predictor of severe OSA. STUDY DESIG
- Diastolic dysfunction in men with severe obstructive sleep apnea syndrome but without cardiovascular or oxidative stress-related comorbidities.Diastolic dysfunction in men with severe obstructive sleep apnea syndrome but without cardiovascular or oxidative stress-related comorbidities. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619880076 Authors: Papanikolaou J, Ntalapascha M, Makris D, Koukoubani T, Tsolaki V, Zakynthinos G, Gourgoulianis K, Zakynthinos E Abstract BACKGROUND: We aimed to evaluate whether the severity of obstructive sleep
- Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure.Olfactory Function in Patients With Obstructive Sleep Apnea Using Positive Airway Pressure. Ear Nose Throat J. 2019 Sep 29;:145561319878949 Authors: Kaya KS, Akpınar M, Turk B, Seyhun N, Cankaya M, Coskun BU Abstract Previous studies reported that positive airway pressure (PAP) treatment may improve olfaction function in patients with obstructive sleep apnea (OSA) through various mechanisms. Olfactor
- Aortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea.Related ArticlesAortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea. J Atheroscler Thromb. 2019 Sep 28;: Authors: Tomita Y, Kasai T, Ishiwata S, Daida H, Narui K Abstract AIM: Patients with obstructive sleep apnea (OSA) are likely to show increased arterial stiffness and progressive systemic atherosclerosis. Chest radiography reveals atherosclerotic changes in the ao
- Comorbid monosymptomatic nocturnal enuresis and snoring exhibit an additive effect on impairments in health-related quality of life.Related ArticlesComorbid monosymptomatic nocturnal enuresis and snoring exhibit an additive effect on impairments in health-related quality of life. J Pediatr Urol. 2019 Aug 24;: Authors: Wolfe-Christensen C, Kovacevic LG, Abdulhamid I, Lakshmanan Y Abstract INTRODUCTION/BACKGROUND: Health-related quality of life (HRQOL) is a relatively new concept in pediatrics, but it has shown to be extremely impo
- Long-Term Objective Adherence to Mandibular Advancement Device Therapy Versus Continuous Positive Airway Pressure in Patients With Moderate Obstructive Sleep Apnea.Related ArticlesLong-Term Objective Adherence to Mandibular Advancement Device Therapy Versus Continuous Positive Airway Pressure in Patients With Moderate Obstructive Sleep Apnea. J Clin Sleep Med. 2019 Sep 30;: Authors: de Vries GE, Hoekema A, Claessen JQPJ, Stellingsma C, Stegenga B, Kerstjens HAM, Wijkstra PJ Abstract STUDY OBJECTIVES: Comparable health effects of mandibular advancement device (M
- Two Years Remission of Type 2 Diabetes Mellitus after Bariatric Surgery.Related ArticlesTwo Years Remission of Type 2 Diabetes Mellitus after Bariatric Surgery. J Coll Physicians Surg Pak. 2019 Oct;29(10):967-971 Authors: Wazir N, Arshad MF, Finney J, Kirk K, Dewan S Abstract OBJECTIVE: To determine the influence of bariatric surgery on remission of type 2 diabetes mellitus (T2DM) in obese patients along with improvements in other obesity-associated comorbidities.
- Cricopharyngeal Muscle Dysfunction Following Hypoglossal Nerve Stimulator Placement.Related ArticlesCricopharyngeal Muscle Dysfunction Following Hypoglossal Nerve Stimulator Placement. JAMA Otolaryngol Head Neck Surg. 2018 10 01;144(10):948-949 Authors: Stevens BJ, Geer AM, Dion GR, Laury AM, Scalzitti NJ PMID: 30073244 [PubMed - indexed for MEDLINE]
- Desogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells.Related ArticlesDesogestrel down-regulates PHOX2B and its target genes in progesterone responsive neuroblastoma cells. Exp Cell Res. 2018 09 15;370(2):671-679 Authors: Cardani S, Di Lascio S, Belperio D, Di Biase E, Ceccherini I, Benfante R, Fornasari D Abstract The paired-like homeobox 2B gene (PHOX2B) encodes a key transcription factor that plays a role in the development of the autonomic nervous s
- Ondine's curse: With Jean Giraudoux's finishing touches.Related ArticlesOndine's curse: With Jean Giraudoux's finishing touches. J Hist Neurosci. 2018 Oct-Dec;27(4):390-395 Authors: Olry R, Haines DE PMID: 28532281 [PubMed - indexed for MEDLINE]
- A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research.A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol. 2019 Sep 27;:112255 Authors: Yadav V, Krishnan A, Vohora D Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Piper longum, commonly referred as 'Pippali', has found its traditional use in India, Malaysia, Singapore and other South Asian countries as an analge
- TMS as a pharmacodynamic indicator of cortical activity of a novel anti-epileptic drug, XEN1101.TMS as a pharmacodynamic indicator of cortical activity of a novel anti-epileptic drug, XEN1101. Ann Clin Transl Neurol. 2019 Sep 30;: Authors: Premoli I, Rossini PG, Goldberg PY, Posadas K, Green L, Yogo N, Pimstone S, Abela E, Beatch GN, Richardson MP Abstract OBJECTIVE: Transcranial magnetic stimulation (TMS) produces characteristic deflections in the EEG signal named TMS-evoked EEG potentials (TE
- Psychogenic nonepileptic seizures in pediatric population: A review.Psychogenic nonepileptic seizures in pediatric population: A review. Brain Behav. 2019 Sep 30;:e01406 Authors: Operto FF, Coppola G, Mazza R, Pastorino GMG, Campanozzi S, Margari L, Roccella M, Marotta R, Carotenuto M Abstract INTRODUCTION: Psychogenic nonepileptic seizures (PNES) are observable abrupt paroxysmal changes in behavior or consciousness that resemble epileptic seizures, but without concu
- Phenotypic variability of GABRA1-related epilepsy in monozygotic twins.Phenotypic variability of GABRA1-related epilepsy in monozygotic twins. Ann Clin Transl Neurol. 2019 Sep 30;: Authors: Krenn M, Ernst M, Tomschik M, Treven M, Wagner M, Westphal DS, Meitinger T, Pataraia E, Zimprich F, Aull-Watschinger S Abstract Variants in GABRA1 have been associated with different epilepsies ranging from mild generalized forms to epileptic encephalopathies. Despite the broad clini
- New-Onset Refractory Status Epilepticus in Children: Etiologies, Treatments, and Outcomes.New-Onset Refractory Status Epilepticus in Children: Etiologies, Treatments, and Outcomes. Pediatr Crit Care Med. 2019 Sep 20;: Authors: Husari KS, Labiner K, Huang R, Said RR Abstract OBJECTIVES: To elucidate etiologies, treatment, functional and neurocognitive outcomes of children with new-onset refractory status epilepticus. DESIGN: A single-center retrospective study. SETTING: A
- Epilepsy and hypertension: The possible link for SUDEP?Related ArticlesEpilepsy and hypertension: The possible link for SUDEP? Cardiol J. 2019 Sep 30;: Authors: Szczurkowska PJ, Polonis K, Becari C, Hoffmann M, Narkiewicz K, Chrostowska M Abstract Epilepsy affects about 50 million people worldwide. Sudden unexpected death in epilepsy (SUDEP) is the main cause of death in epilepsy accounting for up to 17% of all deaths in epileptic patients, and therefore
- Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature.Related ArticlesSuper-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature. Case Rep Crit Care. 2019;2019:3218231 Authors: Newey CR, Mullaguri N, Hantus S, Punia V, George P Abstract Introduction: Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective
- Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study.Related ArticlesGenetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study. Pharmgenomics Pers Med. 2019;12:225-233 Authors: Al-Eitan LN, Al-Dalalah IM, Mustafa MM, Alghamdi MA, Elshammari AK, Khreisat WH, Al-Quasmi MN, Aljamal HA Abstract Background: A total of 50 million persons were diagnosed worldwide with epilep
- [Clinical presentations of Ross syndrome have changed in their lateralities following the anteriotemporal lobectomy for refractory focal epilepsy].Related Articles[Clinical presentations of Ross syndrome have changed in their lateralities following the anteriotemporal lobectomy for refractory focal epilepsy]. Rinsho Shinkeigaku. 2019 Sep 28;: Authors: Henmi N, Neshige S, Shimotake A, Oishi A, Taki W, Ikeda A, Takahashi R Abstract We describe a 60-year-old woman with medically refractory left mesial temporal lobe epilepsy accompanied by Ross syn
- Prevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats.Related ArticlesPrevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats. Biochem Biophys Res Commun. 2019 Sep 26;: Authors: Yang X, Hei C, Liu P, Li PA Abstract Pre-ischemic hyperglycemia increases the occurrence of post-ischemic seizures both in experimental and clinical settings. The underlying mechanisms are not fully delin
- Potential therapeutic implications of ergogenic compounds on pathophysiology induced by traumatic brain injury: A narrative review.Related ArticlesPotential therapeutic implications of ergogenic compounds on pathophysiology induced by traumatic brain injury: A narrative review. Life Sci. 2019 Sep 15;233:116684 Authors: Cassol G, Godinho DB, de Zorzi VN, Farinha JB, Della-Pace ID, de Carvalho Gonçalves M, Oliveira MS, Furian AF, Fighera MR, Royes LFF Abstract Traumatic brain injury (TBI) is a devastating condition that often trig
- Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age.Related ArticlesTranslational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Front Immunol. 2018;9:2009 Authors: Crippa JA, Guimarães FS, Campos AC, Zuardi AW Abstract Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present re
- Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.Related ArticlesPannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy. Sci Transl Med. 2018 05 30;10(443): Authors: Dossi E, Blauwblomme T, Moulard J, Chever O, Vasile F, Guinard E, Le Bert M, Couillin I, Pallud J, Capelle L, Huberfeld G, Rouach N Abstract Epilepsies are characterized by recurrent seizures, which disrupt normal brain fun
- Child Life Services in an Epilepsy Monitoring Unit.Related ArticlesChild Life Services in an Epilepsy Monitoring Unit. Clin Pediatr (Phila). 2018 10;57(11):1269-1274 Authors: Lowenstein DB, Cervenka MC, Mitchell L, Stewart N, Kossoff EH, Kelley SA Abstract The goal of this study was to determine the value of a certified child life specialist (CCLS) on the patient and staff experiences in an epilepsy monitoring unit (EMU). We integrated a CCLS into th
- Clinical presentations and outcomes of the children with tuberculous meningitis: An experience at a tertiary care hospital.Related ArticlesClinical presentations and outcomes of the children with tuberculous meningitis: An experience at a tertiary care hospital. J Pak Med Assoc. 2018 Jan;68(1):10-15 Authors: Anjum N, Noureen N, Iqbal I Abstract OBJECTIVE: To determine the clinical presentations and outcomes of the children suffering from tuberculous meningitis. METHODS: This prospective, descriptive study was co
- Electroencephalographic Patterns in Neurocritical Care: Pathologic Contributors or Epiphenomena?Related ArticlesElectroencephalographic Patterns in Neurocritical Care: Pathologic Contributors or Epiphenomena? Neurocrit Care. 2018 08;29(1):9-19 Authors: Appavu B, Riviello JJ PMID: 28660340 [PubMed - indexed for MEDLINE]
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