Abstract Hepatic stellate cells (HSCs) are important stromal cells and pivotal mediators involved in the pathogenesis and immunosuppression of hepatocellular carcinoma (HCC). The liver has been demonstrated to be a site for accumulation of tumor-induced myeloid-derived suppressor cells (MDSCs). We previously reported that HSCs induced an increase in the number of MDSCs in HCC. However, how MDSCs are recruited in HCC remains largely unclear. In the present study, we found that HSC-conditioned...
03:00
Abstract Background Due to the strong tumoricidal activities of activated natural killer T (NKT) cells, invariant NKT cell-based immunotherapy has shown promising clinical efficacy. However, suppressive factors, such as regulatory T cells (Tregs), may be obstacles in the use of NKT cell-based cancer immunotherapy for advanced cancer patients. Here, we investigated the suppressive effects of Tregs on NKT cells and the underlying mechanisms...
Tue Oct 22, 2019 03:00
Abstract Tumour-associated macrophages (TAMs) are the key components in the tumour microenvironment. TAMs have two major subtypes, M1 and M2. M1 macrophages are tumour inhibitory, while M2 macrophages are tumour promotive. Repolarising TAMs from M2 to M1 is a promising strategy in cancer treatment. M1 and M2 macrophages were generated from murine bone marrow-derived macrophages (BMDMs). We found that chloroquine (CQ), an autophagy inhibitor, was able to repolarise M2 macrophages...
Tue Oct 22, 2019 03:00
Public unrest about the use of antimicrobial agents in farming practice is the leading cause of increasing and the emergences of Multi-drug Resistant Bacteria that have placed pressure on the agri-food industr...
Mon Oct 21, 2019 03:00
Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for selected diseases of the hematopoietic system. In the context of HSCT, bloodstream infections caused by Gram-negative bacteria ...
Mon Oct 21, 2019 03:00
Mozambique classifies but does not yet enforce antibiotics as prescription-only-medicine (POM) allowing the public access to a variety of antibiotics that otherwise are provided on prescription. This contribut...
Mon Oct 21, 2019 03:00
Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance ...
Mon Oct 21, 2019 03:00
Indocyanine green (ICG) lymphography is the new gold standard for diagnosis of lymphedema. With sensitivity and specificity superior to those the conventional technetium-based lymphoscintigraphy,1 it has become many lymphedema surgeons’ diagnostic modality of choice. Indeed, at University of Iowa Lymphedema Reconstruction Center, the ICG technology has for many years been successfully relied upon for diagnosis, treatment planning, intraoperative guidance,2 and postoperative tracking of lymphedema...
Tue Oct 22, 2019 03:00
Abstract Hair growth, a complex process, has long been the subject of intense research. Recent developments in material technology have revealed boehmite as a new therapeutic modality for use in wound healing and scar reduction, indicating its beneficial effects. Nonetheless, the biological bases of the beneficial effects of boehmite remain unknown. We investigated the hair‐growth properties of boehmite in vitro and in vivo and observed dose‐dependent proliferation of human dermal papilla cells...
Tue Oct 22, 2019 13:34
During the last decade, several studies have evaluated the potential association between vitamin D receptor (VDR) gene polymorphism and susceptibility to asthma. In spite of valuable finding, the results are still contradictory. Therefore, a comprehensive meta-analysis not only solves discrepancies but provides a clue for future projects.
Tue Oct 22, 2019 03:00
Sustanon® is a testosterone replacement therapy used for induction of puberty in males with testosterone deficiency due to primary hypogonadism. It contains four esters of the natural hormone testosterone, testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, and testosterone decanoate, in an oil solution. The oil solution contains arachis oil. The summary of product characteristics (SPC) of Sustanon® states (in sections 4.3 and 4.4) that it is contraindicated in patients...
Tue Oct 22, 2019 03:00
To determine the prevalence of and risk factors for malignant transformation of ovarian endometrioma during dienogest therapy, which is very rare, we examined multiple cases of malignant transformation of ovar...
Tue Oct 22, 2019 03:00
Maternally inherited diabetes and deafness, and mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes are examples of mitochondrial diseases that are relatively common in the adult ...
Mon Oct 21, 2019 03:00
Abstract Mucopolysaccharidosis Type I (MPS I), caused by deficiency of α‐L‐iduronidase results in progressive, multisystemic disease with a broad phenotypic spectrum including patients with severe (Hurler syndrome) to attenuated (Hurler–Scheie and Scheie syndromes) disease. Disordered growth is common with either phenotype. The study objectives were to construct sex‐ and age‐specific estimated length/height and head circumference growth curves for untreated individuals with severe and attenuated...
Tue Oct 22, 2019 19:42
Abstract The hedgehog (Hh) pathway is highly conserved and required for embryonic patterning and determination. Mutations in the Hh pathway are observed in sporadic tumors as well as under syndromic conditions. Common to these syndromes are the findings of polydactyly/syndactyly and brain overgrowth. The latter is also a finding most commonly observed in the cases of mutations in the PI3K/AKT/mTOR pathway. We have identified novel Hh pathway mutations and structural copy number variations in individuals...
Tue Oct 22, 2019 19:26
Abstract Research about Alzheimer's disease (AD) in individuals with Down syndrome (DS) has predominantly focused on the underlying genetics and neuropathology. Few studies have addressed how AD risk impacts caregivers of adults with DS. This study aimed to explore the perceived impact of AD development in adults with DS on caregivers by assessing caregiver knowledge, concerns, effect on personal life, and resource utilization via a 40‐question (maximum) online survey. Survey distribution by four...
Tue Oct 22, 2019 19:23
Abstract Background The S100a7a protein is expressed in keratinocytes, its level is increased in acne condition. As isotretinoin therapy is known to alter some of S100 peptides, these could be important specific targets for acne therapy and may have an important role in clinical remission. Methodology A randomized controlled trial was held in a dermatology clinic in Baghdad, where 30 patients with moderate to severe acne vulgaris condition aged 16‐31 years were enrolled. Five milliliters...
Tue Oct 22, 2019 19:40
Summary Psoriasis is a chronic, multifactorial inflammatory disease; its clinical severity can vary widely. Treatment of severe cases during pregnancy are of special interest. To date there is scarce information available and most data comes from other medical specialties that use similar treatments. Immunosuppressors are strongly discouraged during pregnancy and breastfeeding. Amongst biologic agents, anti‐TNFα having been the longest on the market has allowed for the most experience. It is known...
Tue Oct 22, 2019 19:38
Abstract Patients with atopic dermatitis commonly experience ophthalmic complications, and a higher incidence of conjunctivitis has been observed during treatment with dupilumab. We present the case of a 49‐year‐old woman with persistent severe atopic dermatitis who complained of refractory conjunctivitis associated with dupilumab. Ocular examination showed features of atopic conjunctivitis for which an external topical application to the eyelids of pimecrolimus 10 mg/g cream was prescribed. The...
Tue Oct 22, 2019 19:36
Despite many advances in surgery, radiotherapy, and systemic treatments, only modest improvements in survival, function, and quality of life have been achieved after treatment of squamous cell carcinoma (SCC) of the head and neck. With a better understanding of the biology and genetics of tumours, the emergence of a paradigm shift towards the further development of non-surgical treatments may result in less morbidity and better outcomes than are seen currently. SCC of the head and neck is known to...
Tue Oct 22, 2019 03:00
Abstract Purpose To evaluate the diagnostic performance of texture analysis for discriminating human papillomavirus (HPV) status in patients with oropharyngeal squamous cell carcinoma (OPSCC) in the primary tumours and metastatic lymph nodes. Methods Ninety-five patients with primary tumour and 91 with metastatic lymph nodes with confirmed HPV status, who...
Tue Oct 22, 2019 03:00
Previous studies of subjects with unilateral vocal fold paralysis (UVFP) as observed in a positron emission tomography-computed tomography (PET-CT) examination have demonstrated false positive results in the contralateral cricoarytenoid, in which the metabolism may be higher. This area may also be the site of contralateral compensatory movement in these patients. In this study, we compared the adduction speed of the contralateral vocal folds in patients with UVFP and in healthy subjects as measured...
Tue Oct 22, 2019 03:00
Research on side effects of radiotherapy has been a steadily growing field of interest, as advances in treatment (e.g. multimodality imaging, proton therapy, targeted agents) have led to both increased life expectancy in cancer survivors and a greater degree of control in sparing organs-at-risk (OARs) [1]. Adequate delineation of OARs is crucial when investigating the association between radiation dose and side effects and when optimizing treatment planning. However, manual contouring of OARs is...
Tue Oct 22, 2019 03:00
Radiation Therapy (RT) for patients with thoracic or upper abdominal tumours involves complex motion mitigation strategies to ensure accurate irradiation of the target [1]. These strategies, however, have shortcomings. For instance, patient-specific margin strategies like Internal Target Volume (ITV) or MidPosition, which encompass the tumour trajectory, inevitably, either completely or probabilistically, lead to futile irradiation of healthy tissues, while breathing-synchronized strategies like...
Tue Oct 22, 2019 03:00
Abstract CDGSH iron sulfur domain 2 (CISD2) is reported to be highly expressed in several cancers, but the role of it in neuroblastoma has not been identified yet. Here, for the first time, we show that CISD2 is involved in neuroblastoma tumorigenesis and regulates neuroblastoma cell proliferation and differentiation. We found that high CISD2 expression correlated significantly with poor outcome of neuroblastoma patients, as well as advanced neuroblastoma tumor stages. Knockdown...
Tue Oct 22, 2019 03:00
Abstract Long noncoding RNAs (lncRNAs) play important roles in regulating the apoptosis of gastric cancer (GC) cells. This study aims to investigate the underlying mechanism of lncRNA CASC9 in regulating the apoptosis of GC cells. The expressions of lncRNA and protein in GC tissues and cell lines were detected by qRT-PCR and western blot. GC cell apoptosis was detected by flow cytometry analysis. RNA pull-down and RNA immunoprecipitation (RIP) assays were conducted to verify the...
Tue Oct 22, 2019 03:00
Abstract The classification of ampullary adenocarcinoma into intestinal and pancreatobiliary sub-types has been found to be important in predicting prognosis and determining therapeutic strategy. Due to considerable inter-observer variability in sub-typing based solely on morphology, higher frequency of poorly differentiated cancers and low incidence of the disease, the histomorphologic classification of ampullary adenocarcinoma remains one of the grey zones in surgical pathology....
Tue Oct 22, 2019 03:00
Snoring is a main concern in patients who consult an otolaryngologist (ENT physicians) and patients who have cardiovascular comorbidities or excessive daytime sleepiness who usually consult with other speciali...
Tue Oct 22, 2019 03:00
Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and ...
Tue Oct 22, 2019 03:00
Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The majority are caused by genomic Merkel cell polyom...
Tue Oct 22, 2019 03:00
Galectins are beta-galactose specific binding proteins. In human cancers, including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be overexpressed. In order to combat the dismal diagnosi...
Tue Oct 22, 2019 03:00
Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell population, is resonsible for driving the tumor maintenance and metastasis, and is a source of chemotherapy and radiation-therapy resista...
Tue Oct 22, 2019 03:00
The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4 members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci. The common features of MCPIP proteins are ...
Mon Oct 21, 2019 03:00
The purpose of the present study was to describe the CT imaging findings of normal incisive canals and incisive canal cysts and propose cut-off values to differentiate between them.
Tue Oct 22, 2019 03:00
Correction to: A bibliometric analysis of scientific production in the field of lingual orthodontics
Following publication of the original article [1], the author informed
Mon Oct 21, 2019 03:00
Oncogenesis, Published online: 22 October 2019; doi:10.1038/s41389-019-0171-xThe protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells
Tue Oct 22, 2019 03:00
Tue Oct 22, 2019 03:00
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