The management of patients with lymph node (LN) positive prostate cancer remains controversial, with some authors advocating systemic therapy [1], and others recommending the use of radiation therapy [2]. With the advent of prostate specific membrane antigen (PSMA) positron emission tomography (PET), LN metastases are being detected early, and curative approaches appear more promising. New guidelines have recommended that LN positive prostate cancer be staged with PSMA PET imaging, and if locoregional...
Wed Oct 23, 2019 03:00
In the treatment of prostate cancer using external beam radiotherapy (EBRT), the motion of the prostate gland affects an accurate delivery of the treatment dose. Image-guided radiotherapy (IGRT) is understood as the use of imaging technology to secure localization of the target position during treatment. IGRT is essential for compensating the motion of the prostate gland in the patient during radiotherapy, ensuring that dose distributions are deposited correctly. The use of IGRT is especially important...
Wed Oct 23, 2019 03:00
Ectopic parathyroid adenomas that affect the submandibular region have not been widely reported. We describe a 34-year-old man who presented with a painless swelling of the submandibular region. The identification of hypercalcaemia encouraged us to engage a multidisciplinary team to evaluate further serum changes. Parathyroid hormone analysis, 99mTc-methoxy-isobutyl-isonitrile (99mTc-MIBI) scintigraphy, and single-photon emission computed tomography (SPECT-CT) were done to rule out hyperparathyroidism.
Wed Oct 23, 2019 03:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Oct 23, 2019 10:00
Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized α-Melanocyte-Stimulating Hormone Peptide
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Wed Oct 23, 2019 10:00
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive lung damage. Tyrosine kinase inhibitors are approved to treat people with IPF while bone marrow–derived mesenchymal stem cell therapy was previously suggested to inhibit pulmonary fibrosis through the alveolar epithelial cell repair. The present study aimed to evaluate the anti-inflammatory and anti-fibrotic effect of the bone marrow–derived...
Wed Oct 23, 2019 03:00
Abstract MCC950 has been proposed as a specific small molecule inhibitor that can selectively block NLRP3 inflammasome activation. However, the exact mechanism of its action is still ambiguous. Accumulating investigations imply that chloride efflux–dependent ASC speck oligomerization and potassium efflux–dependent activation of caspase-1 are the two relatively independent, but indispensable events for NLRP3 inflammasome activation. Previous...
Wed Oct 23, 2019 03:00
Abstract Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death....
Wed Oct 23, 2019 03:00
Publication date: Available online 23 October 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Ambica Parmar, Jorge Chaves-Porras, Ronak Saluja, Kaitlyn Perry, Amanda P. Rahmadian, Seanthel Delos Santos, Yoo-Joung Ko, Scott Berry, Mark Doherty, Kelvin K.W. ChanAbstractAdjuvant chemotherapy has significantly improved outcomes following surgical resection for pancreatic adenocarcinoma; however, the optimal adjuvant strategy remains unclear. This systematic review and network meta-analysis...
Wed Oct 23, 2019 22:42
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Wed Oct 23, 2019 10:00
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s): Danielle R. Heller, Raymond A. Jean, Sajid A. Khan
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s): Paul H. Sugarbaker
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s): Danielle R. Heller, Raymond A. Jean, Sajid A. Khan
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s): John Alfred Carr
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s): Fausto Rosa, Antonio Pio Tortorelli, Giuseppe Quero, Sergio Alfieri
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s):
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s):
Wed Oct 23, 2019 22:29
Publication date: November 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 5Author(s):
Wed Oct 23, 2019 22:29
Publication date: Available online 22 October 2019Source: Journal of the American College of SurgeonsAuthor(s): Tanner C. Carlock, James R. Barrett, James P. Kalvelage, Jason B. Young, Jade M. Nunez, Alexander L. Colonna, Toby M. Enniss, Raminder Nirula, Marta L. McCrumAbstractIntroductionIt is unknown if replacing clinic follow-up visits with telephone follow-up for low-risk core emergency general surgery (cEGS) procedures is safe. We measured the efficacy of telephone follow-up to determine if...
Wed Oct 23, 2019 22:29
This protocol enables the optimization and subsequent efficient generation of nuclear and cytoplasmic fractions from primary chronic lymphocytic leukemia cells. These samples are used to determine protein localization as well as changes in protein trafficking that take place between the nuclear and cytoplasmic compartments upon cell stimulation and drug treatment.
Wed Oct 23, 2019 22:24
This method describes the use of the R26R-Confetti (Confetti) mouse model to study mineralized tissues, covering all steps from the breeding strategy to the image acquirements. Included is a general protocol that can be applied to all soft tissues and a modified protocol that can be applied to mineralized tissues.
Wed Oct 23, 2019 22:00
A detailed protocol for the generation of self-assembled human protein microarrays for the screening of kinase inhibitors is presented.
Wed Oct 23, 2019 21:23
This is a protocol for the optimal tissue preparation for genomic, transcriptomic, and proteomic analyses of bats caught in the wild. It includes protocols for bat capture and dissection, tissue preservation, and cell culturing of bat tissue.
Wed Oct 23, 2019 20:21
This protocol describes implantation of a glass window onto the spinal cord of a mouse to facilitate visualization by intravital microscopy.
Wed Oct 23, 2019 20:00
Thyroid, Ahead of Print.
Wed Oct 23, 2019 10:00
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s):
Wed Oct 23, 2019 22:11
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s): Tiago S. Jesus, Helen Hoenig
Wed Oct 23, 2019 22:11
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s):
Wed Oct 23, 2019 22:11
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s):
Wed Oct 23, 2019 22:11
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s):
Wed Oct 23, 2019 22:11
Publication date: November 2019Source: Archives of Physical Medicine and Rehabilitation, Volume 100, Issue 11Author(s):
Wed Oct 23, 2019 22:11
Publication date: Available online 23 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Noah D. Silverberg, Mary Alexis Iaccarino, William J. Panenka, Grant L. Iverson, Karen L. McCulloch, Kristen Dams-O’Connor, Nick Reed, Michael McCreaAbstractAt least 3 million Americans sustain a mild traumatic brain injury (mTBI) each year, and 1 in 5 have symptoms that persist beyond one month. Standards of mTBI care have evolved rapidly, with numerous expert consensus statements...
Wed Oct 23, 2019 22:11
Publication date: Available online 23 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): James F. Malec
Wed Oct 23, 2019 22:11
Parasitoid wasps rely primarily on venom to suppress the immune response and regulate the physiology of their host. Intraspecific variability of venom protein composition has been documented in some species, but its evolutionary potential is poorly understood. We performed an experimental evolution initiated with crosses of two lines of Leptopilina boulardi of different venom composition to generate variability and create new combinations of venom factors. The offspring were maintained for 10 generations...
Wed Oct 23, 2019 03:00
The internal transcribed spacers (ITS) of the rDNA cistron are the most commonly used DNA barcoding region in Fungi [1]. rDNA genes are repeated dozens to hundreds of times in the eukaryotic genome [2] and it is believed that these arrays are homogenized through concerted evolution [3, 4] preventing the accumulation of intragenomic, and intraspecific, variation. However, numerous studies have reported rampant intragenomic and intraspecific ITS variation [5-11], contradicting our current understanding...
Wed Oct 23, 2019 03:00
Pteropods are a group of planktonic gastropods that are widely regarded as biological indicators for assessing the impacts of ocean acidification (OA). Their thin aragonitic shells are highly sensitive to acute changes in ocean chemistry. However, to gain insight into their potential to adapt to current climate change, we need to accurately reconstruct their evolutionary history and assess their responses to past changes in Earths carbon cycle. Here, we resolve the phylogeny and timing of pteropod...
Wed Oct 23, 2019 03:00
The internal transcribed spacers (ITS) of the rDNA cistron are the most commonly used DNA barcoding region in Fungi [1]. rDNA genes are repeated dozens to hundreds of times in the eukaryotic genome [2] and it is believed that these arrays are homogenized through concerted evolution [3, 4] preventing the accumulation of intragenomic, and intraspecific, variation. However, numerous studies have reported rampant intragenomic and intraspecific ITS variation [5-11], contradicting our current understanding...
Wed Oct 23, 2019 03:00
Concerted evolution of the ribosomal DNA array has been studied in numerous eukaryotic taxa, yet is still poorly understood. rDNA genes are repeated dozens to hundreds of times in the eukaryotic genome [1] and it is believed that these arrays are homogenized through concerted evolution [2,3] preventing the accumulation of intragenomic, and intraspecific, variation. However, numerous studies have reported rampant intragenomic and intraspecific variation in the rDNA array [4-10], contradicting our...
Wed Oct 23, 2019 03:00
The evolutionary transition between winglessness and a full-winged morphology requires selective advantage for intermediate forms. Conversely, repeated secondary wing reductions among the pterygotes indicates relaxation of such selection. However, evolutionary trajectories of such transitions are not well characterized. The stick insects (Phasmatodea) exhibit diverse wing sizes at both interspecific and intersexual levels, and thus provide a system for examining how selection on flight capability,...
Wed Oct 23, 2019 03:00
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