Facial plast Surg 2019; 35: 561-562DOI: 10.1055/s-0039-1696991Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Facial plast Surg 2019; 35: 446-457DOI: 10.1055/s-0039-1696653Reductive nasal profileplasty is often the pillar of aesthetic nasal surgery. The surgeon must be knowledgable in the key tenants of preoperative analysis and examination to better approach the core elements for hump takedown. Photo imaging or morphing is a practical and technically easy means to open the discussion with the patients to determine their specific goals and ensure that these goals align with their needs functionally. Various...
Facial plast Surg 2019; 35: 486-491DOI: 10.1055/s-0039-1695751In rhinoplasty, the nasal dorsum represents an important aspect for form and function. Surgical management should be performed accurately to avoid complications. The goal for dorsal preservation is to preserve the keystone area intact above the nasal bones and its relationship with the upper lateral cartilages. Unlike other rhinoplasty techniques, the lowering of the nasal dorsum requires dorsal modification prior to the surgery of the...
Facial plast Surg 2019; 35: 458-466DOI: 10.1055/s-0039-1695752In rhinoplasty, osteotomies are performed to manipulate the bony nasal vault to improve the function and/or the aesthetics of the nose. This article provides an overview of the instruments used for osteotomies, as well as the indications and techniques for osteotomies in nasal profileplasty.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | Full text
Facial plast Surg 2019; 35: 499-515DOI: 10.1055/s-0039-1695750After studying this article, the reader should be able to understand how various implants, osteotomies, and reductive tissue techniques affect the aesthetic outcomes of chin reshaping surgery. The roles of standard versus custom chin implants, the operative steps and indications for a bony genioplasty and the techniques for chin reduction are described with emphasis on proper patient selection and avoiding their common complications.[...]Thieme...
Facial plast Surg 2019; 35: 467-475DOI: 10.1055/s-0039-1695727Hump reduction is one of the most common reasons patients seek cosmetic rhinoplasty. Spreader grafts or spreader flaps have become a key maneuver in supporting and reconstructing the nasal midvault after reductive profileplasty to prevent long-term functional and cosmetic sequelae. This article reviews the pertinent anatomy, describes indications for spreader graft or spreader flap placement, discusses surgical techniques and approaches...
Facial plast Surg 2019; 35: 421-422DOI: 10.1055/s-0039-1696660Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Facial plast Surg 2019; 35: 559-560DOI: 10.1055/s-0039-3399607Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
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The MS2 system, with an MS2 binding site (MBS) and an MS2 coat protein fused to a fluorescent protein (MCP-FP), has been widely used to fluorescently label mRNA in live cells. However, one of its limitations is the constant background fluorescence signal generated from free MCP-FPs. To overcome this obstacle, we used a superfolder GFP (sfGFP) split into two or three nonfluorescent fragments that reassemble and emit fluorescence only when bound to the target mRNA. Using the high-affinity interactions...
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Abstract Photobiomodulation therapy (PBMT) is a method currently used in the treatment of hard and soft tissue injuries due to its accelerating and enhancing effects on healing. In this study, we aimed to evaluate the possible additional benefits of applying PBMT with nonsurgical periodontal treatment in type 2 diabetes mellitus (DM) patients with chronic periodontitis (CP). Twenty-two type 2 DM patients with CP were enrolled in this clinical split-mouth study. Probing pocket depth...
Abstract There is a pressing need for monitoring cancerous tissue response to laser therapy. In this work, we evaluate the viability of elastic scattering spectroscopy (ESS) to monitor malignant transformations and effects of laser therapy of induced skin cancer in a hamster model. Skin tumors were induced in 35 mice, half of which were irradiated with 980 nm laser diode. Physiological and morphological transformations in the tumor were monitored over a period of 36 weeks using...
Abstract Barrett’s esophagus (BE) is associated with an intestinal metaplasia that replaces normal squamous epithelium by columnar epithelium. The aim of the current study was to evaluate the feasible endoscopic treatment on esophageal tissue with circumferential laser irradiation. A 532-nm laser was used to deliver 10 W in a continuous manner through a balloon catheter-integrated diffuser. Ex vivo leporine esophagus was tested to identify thermal responses at various irradiation...
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PURPOSE: To test the validity of OncoMasTR Molecular Score (OMm), OMclin1 and OncoMasTR Risk Score (OMclin2) prognostic scores for prediction of distant recurrence (DR) in ER-positive/HER2-negative breast cancer treated with 5 years' endocrine therapy only and compare their performance with the Oncotype DX Recurrence Score (RS). EXPERIMENTAL DESIGN: OMm incorporates three Master Transcription Regulator genes. OMclin1 combines OMm, tumor size, grade, nodal status; OMclin2 incorporates OMm, tumor...
In December 2018 the FDA approved calaspargase pegol-mknl (Asperlas, Servier Pharmaceuticals, Boston MA, USA) for acute lymphoblastic leukemia in children and young adults up to age 21. Asparaginase is a critical component in the treatment of ALL, but the niche for calaspargase within current treatment protocols is unclear.
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50 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Gan To Kagaku Ryoho"[jour] These pubmed results were generated on 2019/10/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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J Neurol Surg BDOI: 10.1055/s-0039-1698821We present a case in which a retrocondylar far-lateral approach was utilized to resect a hemangioblastoma at the craniocervical junction. The patient was a 33-year-old man presenting with 2 months of symptoms referable to compression at the craniocervical junction (i.e., dizziness and gait instability). Though neurologically intact on exam, his imaging demonstrated a highly vascular cystic lesion dorsolateral to the medulla on the left consistent with a hemangioblastoma....
J Neurol Surg BDOI: 10.1055/s-0039-1700511Patients with von Hippel Lindau (VHL) disease develop multiple central nervous system hemangioblastomas (HB). The surgical resection of VHL-HBs is the standard of clinical care when these HBs become symptomatic due to tumor growth, edema, or cyst formation. VHL-HBs frequently present at the obex of the brainstem, making this a challenging surgical problem. Here, we present a case of a large symptomatic brainstem VHL-HB that was resected using a dorsal midline...
J Neurol Surg BDOI: 10.1055/s-0039-1697979 Objective This study was aimed to achieve gross-total removal of a chordoma of the craniocervical junction via an endonasal approach (Fig. 1). Design The present study is a case report. Setting The study was conducted at neurosurgical clinic of university hospital. Participant A 40-year-old male, with normal neurologic exam and no prior medical history, presented with a 2-year history of cervicalgia....
J Neurol Surg BDOI: 10.1055/s-0039-1698828 Objective Foramen magnum meningiomas present a formidable challenge to resection due to frequent involvement of the lower cranial nerves and vertebrobasilar circulation. The video shows the use of a far lateral craniotomy to resect a foramen magnum meningioma. Design, Setting, and Participant A 49-year-old woman presented with neck pain and was found to have a large foramen magnum meningioma (Fig. 1A, B). Drilling of the posterior occipital...
J Neurol Surg BDOI: 10.1055/s-0039-1698825 Objectives The complex anatomical relationships of neurovascular structures at the craniovertebral junction make the clipping of a posterior inferior cerebellar artery (PICA) aneurysm surgically challenging. We demonstrate the clipping of a PICA aneurysm in the video. Design, Setting, and Participant A 65-year-old woman presented with a nonsymptomatic unruptured left PICA aneurysm; follow-up angiography showed an increase in its size....
J Neurol Surg BDOI: 10.1055/s-0039-1698822 Objective Surgical treatment of foramen magnum (FM) meningiomas is challenging due to proximity of the tumor to critical neurovascular structures, namely, the lower brainstem/upper cervical cord, vertebral artery, PICA, and lower cranial nerves. Controversies in microsurgical resection of meningiomas in this location include the necessity for condyle drilling and the need for vertebral artery mobilization. However, a laminectomy or hemilaminectomy...
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Abstract In female mammals, reproductive senescence is a complex process involving progressive ovarian dysfunction associated with an altered central control of the hypothalamic-pituitary axis. The objective of this study was to compare the longitudinal change in preovulatory luteinizing hormone (LH) secretion as well as estrous cycle in individual C57BL/6 J female mice at 3, 6, 9 and 12 months. Amplitude and timing of LH secretion at the surge were similar from 3 to 9 months but...
Abstract Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1KO mice) have a significant reduction in lifespan, exhibit many phenotypes of accelerated aging, and have high levels of oxidative stress in various tissues. Age-associated cognitive decline is a hallmark of aging and the increase in oxidative stress/damage with age is one of the mechanisms proposed for cognitive decline with age. Therefore, the goal of this study was to determine if Sod1KO mice exhibit...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b04119
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03389
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03415
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02683
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03123
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03746
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03581
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07807
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09002
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11333
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09036
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09538
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08342
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09540
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09902
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08758
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07816
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08085
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08240
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08677
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