Abstract Purpose According to the updated WHO classification of gliomas with its emphasis on molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure timely adjustment of treatment, demand for non-invasive prediction methods is high. 18F-FET PET has been shown to be an important diagnostic tool for glioma management. The aim of this study was to assess the value of dynamic 18F-FET PET for the non-invasive...
Thu Oct 24, 2019 14:29
Thu Oct 24, 2019 14:29
Thu Oct 24, 2019 14:29
Abstract Purpose Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. We analyzed the target affinity and specificity of two FAP ligands (FAPI-02 and FAPI-04) in vitro, and the pharmacokinetics and biodistribution in mice in vivo. Clinically, we used 68Ga-labeled FAPI-02/04 for PET imaging in 18 glioma patients...
Thu Oct 24, 2019 14:29
Abstract Purpose Diagnostic imaging modalities have moderate sensitivity for the identification of lymph node (LN) metastases in prostate cancer (PCa) patients. Mapping the lymphatic drainage from the prostate can help to identify the LNs directly draining from the tumour (sentinel nodes (SNs)); the LNs stated to have the highest chance of containing metastatic cancer cells. Although the lymphatic drainage may differ between segments...
Thu Oct 24, 2019 14:29
Abstract Objective To review the literature on the clinical application of radiolabeled somatostatin receptor scintigraphy (SRS) by SPECT and PET in adults with chronic inflammatory diseases. Research design Systematic review of published observational studies between 1993 and 2017. ...
Thu Oct 24, 2019 14:29
Thu Oct 24, 2019 14:29
Thu Oct 24, 2019 14:29
Abstract Purpose To develop a prostate-specific membrane antigen (PSMA)-targeted radiotherapeutic for metastatic castration-resistant prostate cancer (mCRPC) with optimized efficacy and minimized toxicity employing the β-particle radiation of 177Lu. Methods We synthesized 14 new PSMA-targeted, 177Lu-labeled radioligands (177Lu-L1–177Lu-L14)...
Thu Oct 24, 2019 14:29
Abstract Purpose To improve the test–retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements. Methods We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition...
Thu Oct 24, 2019 14:29
Thu Oct 24, 2019 14:29
Abstract Introduction Scintigraphic evaluation of the thyroid gland enables determination of the iodine-123 iodide or the 99mTc-pertechnetate uptake and distribution and remains the most accurate method for the diagnosis and quantification of thyroid autonomy and the detection of ectopic thyroid tissue. In addition, thyroid scintigraphy and radioiodine uptake test are useful to discriminate hyperthyroidism from destructive thyrotoxicosis...
Thu Oct 24, 2019 14:29
Abstract Purpose Oncocytic (Hürthle cell) papillary thyroid carcinoma (OPTC) is a rare variant of the papillary thyroid carcinoma (PTC) which comprises approximately 1 to 11 % of PTC cases. Its clinical course and prognosis have not been comprehensively documented and the clinical outcome remains a controversial issue. Therefore, we investigated the long-term prognosis after thyroidectomy and (adjuvant) initial radioactive iodine...
Thu Oct 24, 2019 14:29
Abstract Purpose To evaluate the diagnostic performance of PET-MR enterography in detecting histological active inflammation in patients with ulcerative colitis and the impact of bowel purgation on diagnostic accuracies of PET-MR parameters. Methods Fifty patients were enrolled in this randomized controlled trial (clinicaltrials.gov [NCT03781284]). Forty...
Thu Oct 24, 2019 03:00
Infection with the protozoan Trypanosoma cruzi causes Chagas disease and consequently leads to severe inflammatory heart condition; however, the mechanisms driving this inflammatory response have not been completely elucidated. Nitric oxide (NO) is a key mediator of parasite killing in T. cruzi-infected mice, and previous studies have suggested that leukotrienes (LTs) essentially regulate the NO activity in the heart. We used infected 5-lipoxygenase-deficient mice (5-LO−/−) to explore the participation...
Thu Oct 24, 2019 15:05
Rheumatoid arthritis (RA) is a type of systemic autoimmune arthritis that causes joint inflammation and destruction. One of the pathological mechanisms of RA is known to involve histone acetylation. Although the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) can attenuate arthritis in animal models of RA, the mechanism underlying this effect is poorly understood. This study was performed to examine whether SAHA has therapeutic potential in an animal model of RA and to...
Thu Oct 24, 2019 14:05
Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in rheumatoid arthritis (RA). The aim of the present study is to elucidate the function and potential mechanism of METTL3 in RA pathogenesis. We used quantitative real-time polymerase...
Thu Oct 24, 2019 14:05
Publication date: December 2019Source: Medical Image Analysis, Volume 58Author(s):
Thu Oct 24, 2019 15:16
Publication date: December 2019Source: Medical Image Analysis, Volume 58Author(s):
Thu Oct 24, 2019 15:16
Abstract Background Infant videofluoroscopic swallow studies (VFSSs) require clinicians to make determinations about swallowing deficits based on a limited number of fluoroscopically observed swallows. Although airway protection is known to decline throughout a bottle-feed, the paucity of data regarding the timing of this degradation has limited the development of procedural protocols that maximize diagnostic validity. ...
Fri Oct 18, 2019 03:00
Publication date: Available online 24 October 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): G. Kanyilmaz, B. Benli Yavuz, M. Aktan, O. SahinResumenObjetivosExiste heterogeneidad en la supervivencia entre los pacientes con cáncer de pulmón de células no pequeñas (NSCLC), aun dentro del mismo estadio. Nuestro objetivo fue evaluar el papel pronóstico del máximo valor de captación estandarizado pretratamiento (SUVmáx) en pacientes tratados con quimiorradioterapia concurrente...
Thu Oct 24, 2019 15:44
Quantitative Ultrasound Detects Smooth Muscle Activity at the Cervical Internal Os <em>in Vitro</em>
Publication date: Available online 24 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Andrew P. Santoso, Joy Y. Vink, George Gallos, Helen Feltovich, Timothy J. HallAbstractThe cervix has two biomechanical functions: to remain closed while the fetus develops throughout pregnancy, and to open for delivery of the fetus at full term. This dual function is principally attributed to collagen within the extracellular matrix (ECM). However, recent evidence suggests that other ECM, and...
Thu Oct 24, 2019 21:51
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