Plastic, Reconstructive & Aesthetic Surgery
- Can Plastic Surgeons Really Tell What Type of Implant a Patient Is Wearing?Breast augmentation is the second most commonly performed aesthetic surgery in the United States and the use of different implant materials has changed over the years. Aesthetic goals and results in implant-based breast surgery vary widely based on age, geography, and surgeon preference.1 Most surgeons have emphatically returned to silicone implants once the moratorium on them was lifted, claiming they yield identifiably better results. This is s
- Reel it in – a readily available and high-fidelity model for microvascular trainingTraining in microvascular techniques is essential for plastic surgeons and many of our surgical colleagues, who may be expected to undertake procedures such as revascularisation, replantation and free tissue transfer routinely, in addition to composite tissue allotransplantation and supermicrosurgery within specialised centres.
- Better nerve regeneration with distally based fascicular turnover flap than conventional autologous nerve graft in a rat sciatic nerve defect modelThe authors hypothesize that the fascicular turnover flap will achieve better nerve regeneration in nerve gap repair than the conventional nerve graft in a rat sciatic nerve defect model. Seven-millimeter-long sciatic nerve defects were repaired with an autologous nerve graft, a proximal fascicular turnover flap, or a distal fascicular turnover flap. Following walking footprint analysis at 8 weeks after the surgery, the gastrocnemius-soleus muscl
- Use of computed tomography in an upright position for preoperative planning in orbital wall fracture treatment: a pilot studyEnophthalmos is defined as a backward and downward displacement of the globe into the bony orbit. Clinically, more than 2 mm of enophthalmos is noticeable and a 5% increase in the total volume of the orbital cavity is sufficient to result in significant enophthalmos.1
- Serratus fascia flap in immediate breast reconstruction with tissue expander: Is all that glitters gold?Since single stage breast reconstruction both with silicone gel prosthesis and with Becker expander-implant have an higher complications rate,1 the two-stage expander\implant technique is still the most performed one.
- Anatomic Location of a Sensory Nerve to the Profunda Artery Perforator (PAP) Flap: A Novel Option for Sensate Autologous Tissue ReconstructionThe field of sensate autologous reconstruction is rapidly expanding. The renewed public interest in providing and expediting the return of breast sensation and the availability of cadaveric nerve grafts have both led to a surge in research. Autologous breast reconstruction typically utilizes an abdominal donor site and the majority of research in sensate autologous tissue has been performed in DIEP or TRAM flaps. However, not all patients are can
- Relation between palatal index and the incidence of postoperative fistula in patients with complete unilateral cleft palate (a prospective cohort study)Objective: To examine whether there is a relation between the palatal index and the incidence of postoperative fistula in patients with complete unilateral cleft palate.Materials & Methods: Thirty patients with complete unilateral cleft palate were included in this study. The palatal index was obtained preoperatively with the patient under general anesthesia. Postoperatively each patient was followed up at1st, 3rd week, 3rd, 6th, 9th month for fi
- Current Practices in Peri-operative Free Flap Anticoagulation and Post-operative Monitoring of Microsurgeons in USAThe free flap composite tissue transfer is a corner-stone operation in the field of plastic surgery. This seemingly impossible surgery, first conceptualized by Harry Buncke in 1964,1 has become commonplace, with 15,000 free flap surgeries performed in USA annually.2 These surgeries are paramount to achieving successful reconstruction for defects caused by tissue-deforming wound infections, trauma, and complex oncologic resections. Due to its wide
- The long-term results of polyacrylamide hydrogel for augmentation mammoplastyPolyacrylamide hydrogel (PAAG) is a synthetic macromolecule material that had been widely used for breast augmentation in Asia. However, complications such as filler migration, infection, haematoma, and lumps were increasingly noticed.1,2
- The impact of rhinoplasty on observer attention before and after rhinoplastyRhinoplasty is one of the most common plastic surgeries in the world. Despite the development of several ideal angles and ratios for objective assessment of facial aesthetics, how the face is perceived by a naive observer is an area of active study. Eye tracking technology offers an objective method to track the viewer's attention to facial features.
- THE DIAGNOSTIC EFFECTIVENESS OF DERMOSCOPY PERFORMED BY PLASTIC SURGERY REGISTRARS TRAINED IN MELANOMA DIAGNOSISDermoscopy improves sensitivity, specificity and early detection of melanoma and non-melanoma skin cancers. Due to multidisciplinary approach to melanoma, Plastic Surgeons may be asked to perform dermoscopy evaluation. For this reason, in some University Hospitals Plastic Surgeons in training might perform these evaluations. To assess the validity of digital dermoscopy conducted by Plastic Surgery Registrars, authors collected the diagnoses of ex
- Time from Submission to Publication in Plastic Surgery Journals: The Story of Accepted ManuscriptsPublication of research in highly regarded journals is a laborious journey that requires a considerable amount of effort and time. The objective of this article is to obtain insight on the time required for articles to be accepted and published in the top six plastic surgery journals and study the effects of article characteristics on their publication time.
- A prospective comparison of breast sensibility after reduction mammaplasty: superior versus supero-medial pedicleBreast sensitivity is a significant issue in preoperative consultation prior to reduction mammoplasty. Although a range of techniques are used, recovery of sensation is usually evaluated using the inferior pedicle. Our objective was to evaluate and compare the change in breast sensitivity using the superomedial versus the superior pedicle.
- Reconstruction of Complex Hemipelvectomy Defects: A 17-Year Single Institutional Experience with Lower Extremity Free and Pedicled Fillet FlapsHemipelvectomy procedures result in massive soft tissue defects. The standard approach is to reconstruct the defect with anterior or posterior hemipelvectomy flaps. Certain situations preclude the use of local tissue flaps and an alternative is the use of leg fillet flaps, circumferential pedicled or free flaps harvested from the amputated part. The purpose of this study is to present our institution's experience with using pedicled and free fill
- Use of CT in a standing position for preoperative evaluation in abdominal incisional hernia: a pilot studyAbdominal incisional hernia is a complication after open abdominal surgery. Although many studies have investigated the treatment or risk factors of abdominal incisional hernia, there are few reports in the literature describing the diagnostic modalities to identify abdominal incisional hernia. The ‘European Hernia Society guidelines on the closure of abdominal walls' recommends the use of ultrasound or computed tomography (CT) scan for diagnosis
- 3 dimensional computer modeling of standard orbital mean shape in AsiansAlthough the some data for western norms in orbit shape were reported, the standard norms for Asian orbits was not established yet. The data would be very valuable for the various surgical procedures as well as the production of the appropriate instruments and implants. Therefore, we suggest a Korean orbit mean shape model based on the 3D computer modelling which includes the analysis of the various parameters with the calculated average value, t
- Rainbow graft for tip reconstruction in revision rhinoplastyPatients undergoing revision rhinoplasty can show complex tip deformities, such as asymmetry, domes angulation and interruption, alar pinch and retraction and underprojection. When these defects are present at the same time,often multiple cartilage grafts are needed to restore a pleasing tip and functional external nasal valve.This study reports our experience with the rainbow graft, a previously described technique that can repair with a single
- “Naïve” cost-utility analysis of reduction mammoplasty in Brazilian public service using BREAST-Q®: response to the authorsI read with interest the article by Corrêa and colleagues on cost-utility of reduction mammoplasty in Brazilian public service using BREAST-Q® published in the July issue of the JPRAS.1 The authors attempted to combine cost of surgery and health benefits, expressed in quality adjusted life years (QALYs), in one metric with a noble intention of assisting public health care spending. This is the subject of a discipline of health economics that for
- Masseteric or Facial Nerve? Intricacies in Dynamic Facial ReanimationWe read Roy and colleagues’1 commendable systematic synthesis of the literature on the use of free Gracilis muscle transfer (FGMT) for dynamic reanimation with considerable interest. This letter addresses noteworthy findings from Greene et al's2 work that captured long-term outcomes following FGMT in paediatric facial palsy.
rhinol allergy
- Emerging Contribution of Histopathology to Our Understanding of Chronic Rhinosinusitis Endotypes: Tissue Eosinophil Count and Aggregates.Related ArticlesEmerging Contribution of Histopathology to Our Understanding of Chronic Rhinosinusitis Endotypes: Tissue Eosinophil Count and Aggregates. Am J Rhinol Allergy. 2019 Sep 29;:1945892419878322 Authors: Brescia G, Alessandrini L, Parrino D, Franz L, Barion U, Marioni G PMID: 31564111 [PubMed - as supplied by publisher]
- Unintended Consequences of White Noise Therapy for Tinnitus-Otolaryngology's Cobra Effect: A Review.Related ArticlesUnintended Consequences of White Noise Therapy for Tinnitus-Otolaryngology's Cobra Effect: A Review. JAMA Otolaryngol Head Neck Surg. 2018 10 01;144(10):938-943 Authors: Attarha M, Bigelow J, Merzenich MM Abstract Importance: Critical to the success of many medical therapeutics is a consideration of the brain's miraculous ability to dynamically rewire itself anatomically and neurochem
- Vestibular Evoked Myogenic Potentials in Patients With Low Vitamin B12 Levels.Vestibular Evoked Myogenic Potentials in Patients With Low Vitamin B12 Levels. Ear Nose Throat J. 2019 Sep 29;:145561319878952 Authors: Özdemir D, Mehel DM, Küçüköner Ö, Ağrı İ, Yemiş T, Akgül G, Özgür A Abstract OBJECTIVE: Vitamin B12 deficiency-induced hyperhomocysteinemia has been associated with impaired microarterial flow, demyelization, and neuronal damage, resulting in cochlear damage and audi
Acta Otorrinolaringológica Española
- Un caso de sialometaplasia necrosantePublication date: Available online 30 September 2019Source: Acta Otorrinolaringológica EspañolaAuthor(s): Xavier León, Justina Szafranska, Jorge Eliecer Méndez
- Transfer learning of deep neural network representations for fMRI decodingPublication date: 1 December 2019Source: Journal of Neuroscience Methods, Volume 328Author(s): Michele Svanera, Mattia Savardi, Sergio Benini, Alberto Signoroni, Gal Raz, Talma Hendler, Lars Muckli, Rainer Goebel, Giancarlo ValenteAbstractBackgroundDeep neural networks have revolutionised machine learning, with unparalleled performance in object classification. However, in brain imaging (e.g., fMRI), the direct application of Convolutional Neural
- Wide-area measurement-based supervision of the cerebral venous hemodynamic in a novel rat modelPublication date: Available online 30 September 2019Source: Journal of Neuroscience MethodsAuthor(s): Wei Wang, Shuwen Mu, Liang Xue, Shengxiang Liang, Zuanfang Li, Shousen WangAbstractBackgroundTraumatic brain injury (TBI) includes primary and secondary injuries, while monitoring intracranial pressure (ICP) and cerebral blood flow (CBF) is conducive to improve the prognosis of patients. However, the function of cerebral venous in this process is
Allergy
- Highlights and recent developments in airway diseases in EAACI journals (2018)Abstract The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. One of EAACI’s major goals is to support the promotion of health in which prevention of allergy and asthma play a critical role and to disseminate the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic me
- Recent developments and highlights in allergic rhinitisAbstract Allergic rhinitis (AR) is a disease with high prevalence all over the world and therefore needs to be thoroughly investigated and treated accordingly. The mechanisms underlying the pathology and treatment of AR have been widely studied, but many aspects remain unclear and warrant further investigations. This review presents an overview of recently published papers highlighting the risk factors, mechanisms, and treatment of AR. Additiona
- Do young rhesus macaques know what others see?: A comparative developmental perspectiveA juvenile rhesus macaque watches as the experimenter reaches towards one of two locations. In the study, we tested whether infant and juvenile monkeys expected the experimenter to act consistently with her visual perspective. Although juveniles show a looking pattern similar to adults, infant monkeys show the reversed pattern, suggesting some experience watching other agents is required to make predictions based on visual perspective alone. Abs
- Baseline cortisol levels and social behavior differ as a function of handedness in marmosets (Callithrix jacchus)Figure 4. Basal cortisol correlates with right‐handedness in female marmosets. Abstract Population hand preferences are rare in nonhuman primates, but individual hand preferences are consistent over a lifetime and considered to reflect an individual's preference to use a particular hemisphere when engaged in a specific task. Previous findings in marmosets have indicated that left‐handed individuals tend to be more fearful than their right‐hande
Cancers
- Cancers, Vol. 11, Pages 1479: STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast CancerCancers, Vol. 11, Pages 1479: STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer Cancers doi: 10.3390/cancers11101479 Authors: Zerdes Wallerius Sifakis Wallmann Betts Bartish Tsesmetzis Tobin Coucoravas Bergh Rassidakis Rolny Foukakis Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted tra
- Cancers, Vol. 11, Pages 1480: Epigenetic Mechanisms of Escape from BRAF Oncogene DependencyCancers, Vol. 11, Pages 1480: Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency Cancers doi: 10.3390/cancers11101480 Authors: Khaliq Fallahi-Sichani About eight percent of all human tumors (including 50% of melanomas) carry gain-of-function mutations in the BRAF oncogene. Mutated BRAF and subsequent hyperactivation of the MAPK signaling pathway has motivated the use of MAPK-targeted therapies for these tumors. Despit
- Cancers, Vol. 11, Pages 1478: Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer CellsCancers, Vol. 11, Pages 1478: Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells Cancers doi: 10.3390/cancers11101478 Authors: Leo Therachiyil Siveen Uddin Kulinski Buddenkotte Steinhoff Krishnankutty Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignan
Clinical and translational oncology
- Safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodiesAbstract Purpose Immune checkpoint inhibitors (ICIs) show promising clinical activity in advanced cancers. However, the safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies (ANA) are unclear. Methods 191 patients treated with nivolumab, pembrolizumab, atezolizumab
G3: .Genes, Genomes, Genetics Mission - Online First Articles
- Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin AccessibilityTime-course high-throughput assays of gene expression and enhancer usage in zebrafish provide a valuable characterization of the dynamic mechanisms governing gene regulatory programs during CNS axon regeneration. To facilitate the exploration and functional interpretation of a set of fully-processed data on regeneration-associated temporal transcription networks, we have created an interactive web application called Regeneration Rosetta. Using ei
- Genomics Analysis of L-DOPA Exposure in Drosophila sechelliaDrosophila sechellia is a dietary specialist fruit fly that evolved from a generalist ancestor to specialize on the toxic fruit of Morinda citrifolia. This species pair has been the subject of numerous studies where the goal has largely been to determine the genetic basis of adaptations associated with host specialization. Because one of the most striking features of M. citrifolia fruit is the production of toxic volatile compounds that kill inse
- Genome Assemblies of Two Rare Opportunistic Yeast Pathogens: Diutina rugosa (syn. Candida rugosa) and Trichomonascus ciferrii (syn. Candida ciferrii)Infections caused by opportunistic yeast pathogens have increased over the last years. These infections can be originated by a large number of diverse yeast species of varying incidence, and with distinct clinically relevant phenotypic traits, such as different susceptibility profiles to antifungal drugs, which challenge diagnosis and treatment. Diutina rugosa (syn. Candida rugosa) and Trichomonascus ciferrii (syn. Candida ciferrii) are two oppor
- Sex differences in adolescents’ cardiac reactivity and recovery under acute stress: The importance of nonlinear measuresAbstract How well adolescents can self‐regulate in the face of stressors has considerable implications for long‐term well‐being and risk of psychopathology. This study investigated sex differences in adolescents’ cardiac reactivity and recovery during a stressful task. Measures of cardiac variability (linear) and complexity (nonlinear) were obtained from N = 92 adolescents, 41 males (M age = 13.28, SD = 0.69; BMI = 21.9) and 51 females (M age =
- The practice of meditation is not associated with improved interoceptive awareness of the heartbeatAbstract Meditation is commonly assumed to be associated with enhanced interoceptive accuracy. We previously found that experienced meditators did not exhibit a greater ability than nonmeditators to detect heartbeat sensations at rest, despite the meditators' reported subjective ratings of higher accuracy and lower difficulty. Here, attempting to overcome previous methodological limitations, we assessed interoceptive awareness of heartbeat and b
- Emotional and feature‐based modulation of the early posterior negativityAbstract The early posterior negativity (EPN) has been shown to be enhanced by emotional relative to neutral scene perception. A subset of studies has also reported a bias in the EPN toward pleasant relative to unpleasant scenes. Functional MRI research has also identified a region in lateral occipital cortex that shows a sensitivity to the visual perception of body parts, which may contribute to the EPN. Here, we assess the roles of rated scene
- Individual alpha frequency increases during a task but is unchanged by alpha‐band flickerAbstract Visual perception fluctuates in sync with ongoing neural oscillations in the delta, theta, and alpha frequency bands of the human EEG. Supporting the relationship between alpha and perceptual sampling, recent work has demonstrated that variations in individual alpha frequency (IAF) correlate with the ability to discriminate one from two stimuli presented briefly in the same location. Other studies have found that, after being presented
- The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast CancerAbstract Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (LC‐MS/MS), adherence behavior (Morisky medication adherence scale), and CYP2D6 and other pharmacogene polymorphis
- Translating Minimally Invasive Glaucoma Surgery DevicesGlaucoma is the leading cause of irreversible blindness with over 70 million people affected worldwide. The surgical management of glaucoma aims to lower intraocular pressure by increasing aqueous outflow facility. The latest manufacturing techniques have allowed for the development of a number of novel implantable devices to improve safety and outcomes of glaucoma surgery. These are collectively referred to as minimally invasive glaucoma surgery
Clinical Ophthalmology
- Akt Inhibition Synergizes with PRC2 Inhibition in the Treatment of Multiple MyelomaAbstract Polycomb repressive complex 2 (PRC2) components, EZH2 and its homolog EZH1, and PI3K/Akt signaling pathway are focal points as therapeutic targets for multiple myeloma. However, the exact crosstalk between their downstream targets remains unclear. We herein elucidated some epigenetic interactions following Akt inhibition and demonstrated the efficacy of the combined inhibition of Akt and PRC2. We found that TAS‐117, a potent and selecti
- Efficacy of the NCCV Cocktail‐1 vaccine for refractory pediatric solid tumors: a phase I clinical trialAbstract Pediatric refractory solid tumors are aggressive type of malignant diseases, resulting in an extremely poor prognosis. KOC1, FOXM1, and KIF20A are cancer antigens that could be ideal targets for anticancer immunotherapy against pediatric refractory solid tumors with positive expression for these antigens. This nonrandomized, open‐label, phase I clinical trial evaluated the safety and efficacy of the NCCV Cocktail‐1 vaccine, which is a c
- Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complexAbstract ARPC2 is a subunit of the Arp2/3 complex, which is essential for lamellipodia, invadopodia and filopodia, and ARPC2 has been identified as a migrastatic target molecule. To identify ARPC2 inhibitors, we generated an ARPC2 knockout DLD‐1 human colon cancer cell line using the CRISPR/Cas9 system and explored gene signature‐based strategies, such as a connectivity map (CMap) using the gene expression profiling data of ARPC2 knockout and kn
Τρίτη 1 Οκτωβρίου 2019
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