Exploiting genetically diverse lines to identify genes for improving crop performance is needed to ensure global food security. A genome-wide association study (GWAS) was conducted using 46,268 SNP markers on a diverse panel of 143 hexaploid bread and synthetic wheat to identify potential genes/genomic regions controlling agronomic performance (yield and 26 yield-related traits), disease resistance, and grain quality traits. From phenotypic evaluation, we found large genetic variation among the 35...
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Oncogenesis, Published online: 23 October 2019; doi:10.1038/s41389-019-0167-6The TWIST1-centered competing endogenous RNA network promotes proliferation, invasion, and migration of lung adenocarcinoma
Wed Oct 23, 2019 03:00
Wed Oct 23, 2019 03:00
Abstract Introduction Facial and mandibular aggression with gunshot wound (GSW) is highly complex and represents a challenge for the assistant surgical team because in addition to the inherent lethal potential, they have the capacity for destruction and mutilation caused by the high kinetic energy conferred to the firearm projectile. Among these lesions, comminutive mandibular fractures are difficult to treat because the anatomical planes...
Wed Oct 23, 2019 03:00
Objective. Tofacitinib is a novel therapy for rheumatoid arthritis (RA). The aim of this study was to measure various serum cytokines levels and to explore potential markers predictive of therapeutic efficacy of tofacitinib for RA patients. Methods. Thirty-two patients with RA were given tofacitinib (5 mg bid). Serum cytokines levels of Th1 (IFN-γ), Th2 (IL-6), Th17 (IL-17), Tregs (IL-35), and TNF-α were detected by enzyme-linked immunosorbent assays. Results. Disease activity was significantly decreased...
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Mast cells play an important role in immunomodulation and in the maintenance of vascular integrity. Interleukin-6 (IL-6) is one of the key biomarkers and therapeutic target in systemic vasculitis. The objective of the current study is to describe the role of mast cells in arterial IL-6 homeostasis. Eight- to ten-week-old male C57BL/6 (wild-type) mice were injected with either (a) saline, (b) compound 48/80 (a systemic mast cell degranulating agent), (c) lipopolysaccharide (LPS), or (d) a combination...
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Wed Oct 23, 2019 18:05
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08173
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05561
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09460
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07658
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08362
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09508
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09102
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09116
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05524
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07381
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06410
Wed Oct 23, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10217
Wed Oct 23, 2019 07:00
Publication date: Available online 22 October 2019Source: Human PathologyAuthor(s): Robert H. Young, FRC, PATHAbstractThe author reviews highlights of advances in knowledge concerning ovarian tumor pathology since the time of an essay in the first issue of this journal written by Dr. Robert E. Scully, who, both before and for several decades after the Journal was instituted, made many original contributions to the field and was the major architect of the 1973 World Health Organization classification...
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Publication date: Available online 22 October 2019Source: Human PathologyAuthor(s): Kyle M. Devins, Michael T. Tetzlaff, Zubair Baloch, Virginia A. LiVolsiSummaryHuman papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now includes a newly described...
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Publication date: Available online 22 October 2019Source: Human PathologyAuthor(s): Zubair Baloch, Virginia A. LiVolsiSummaryThe past half century has seen a number of advances in pathology of thyroid diseases, especially neoplastic lesions. These include the description of new entities, the definition of prognostically important lesions, the incorporation of fine needle aspiration biopsy and its functional risk stratification of diagnoses into the clinical evaluation and therapeutic recommendations...
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Abstract Association between cancer and myositis has been extensively reported and malignancy is a potentially life-threating complication in myositis. In this retrospective study authors give an overview of Hungarian cancer-associated myositis (CAM) patients treated at a single centre managing 450 myositis patients. All patients were diagnosed according to Bohan and Peter. Statistical analysis of disease onset, age, sex, muscle, skin and extramuscular symptoms, muscle enzymes,...
Wed Oct 23, 2019 03:00
Abstract Although radical nephroureterectomy is the standard treatment method for upper urinary tract urothelial carcinoma, it is associated with a high risk of intravesical recurrence. There are no models for predicting IVR after RNU in patients with organ-confined UTUC. Therefore, we developed and validated a model for postoperative prediction of IVR after RNU. The development cohort consisted of 416 patients who underwent RNU with bladder cuff excision at our center between...
Wed Oct 23, 2019 03:00
J Neurol Surg BDOI: 10.1055/s-0039-1700510Odontoidectomy is a standard procedure employed in the treatment of irreducible, compressive ventral pathologies of the craniovertebral junction (CVJ). The traditionally used transoral route is often challenging due to the increased depth of the surgical corridor and risk of injuries to the soft tissues in the oral cavity. The emergence of endoscopic endonasal (EE) surgery has provided an attractive alternative route to the traditional treatment algorithm,...
Wed Oct 23, 2019 02:00
J Neurol Surg BDOI: 10.1055/s-0039-1700509Tumors located in the craniocervical junction region are significantly challenging for surgical resection. We shared our experience of a meningioma at craniocervical junction resected through far lateral approach in a 68-year-old female. The patient presented with intermittent headache with discomfort in the neck and shoulders for 3 years without any positive signs. Magnetic resonance imaging (MRI) revealed a tumor of 3.6 cm × 3.0 cm × 2.5 cm lying at the...
Wed Oct 23, 2019 02:00
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Non-invasive ventilation (NIV) is preferred as the initial ventilatory support to treat acute hypercapnic respiratory failure in patients with chronic obstructive pulmonary disease (COPD). High-flow nasal cann...
Tue Oct 22, 2019 03:00
Health care services must engage all relevant healthcare workers, including nurses, in optimal antimicrobial use to address the global threat of drug-resistant infections. Reflecting upon the variety of antimi...
Tue Oct 22, 2019 03:00
Antibiotics require more prudent prescribing, dispensing and administration than other medicines because these medicines are at a greater risk of antimicrobial resistance (AMR). Studying the current medicine u...
Tue Oct 22, 2019 03:00
Publication date: Available online 22 October 2019Source: Gait & PostureAuthor(s): Özden Özkal, Melek Merve Erdem, Kemal Kismet, Semra TopuzAbstractBackgroundLittle is known about whether a simulated upper limb condition reflects a real (burn-injury) upper limb pathology in terms of gait/footprint parameters.Research questionThe main aim of this study was to investigate the differences in these parameters between two conditions (real-simulation).MethodsThe study included burn patients (n = 30)...
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Five biologic therapies have FDA-approved indications for difficult-to-control asthma. The clinical trials that proved the efficacy and safety of these biologics were often similar in their inclusion criteria, study designs, and endpoints. Many of these trials have been re-analyzed post-hoc to identify subsets of subjects considered to be enhanced responders. As a result, it has become increasingly difficult to keep up with the literature and decide on the most appropriate biologic for our patients.
Wed Oct 23, 2019 03:00
A dose escalation, randomized, double-blind, placebo-controlled phase 1 clinical trial was performed in healthy Iranian volunteer women to assess the safety, tolerability, and immunogenicity of NZ8123-HPV16-optiE7 vaccine involving recombinant Lactococcus lactis expressing the codon optimized HPV-16 E7 oncogene. Fifty-five eligible subjects were divided into six cohorts based on the dosages (1x109 CFU/mL, 5x109 CFU/mL, and 1x1010 CFU/mL) of either vaccine or placebo, which were administrated orally...
Wed Oct 23, 2019 17:08
Triple-negative breast cancer (TNBC) accounts for ~15% of breast cancer cases in the United States. TNBC has poorer overall prognosis relative to other molecular subtypes due to rapid onset of drug resistance to conventional chemotherapies and increased risk of visceral metastases. Taxanes like paclitaxel are standard chemotherapies that stabilize microtubules, but their clinical efficacy is often limited by drug resistance and neurotoxicities. We evaluated the preclinical efficacy of a novel, potent...
Wed Oct 23, 2019 17:08
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to the pronounced hydrophobicity of Cer. Missense mutations of the protein p53, which have been detected in approximately 42% of cancer cases, not only lose the tumor suppression activity of wild-type p53, but also gain oncogenic functions promoting tumor...
Wed Oct 23, 2019 17:08
Mutations in extracellular signal regulated kinase signaling drive a significant percentage of malignancies. LY3009120, a pan-RAF and dimer inhibitor, has preclinical activity in RAS- and BRAF-mutated cell lines including BRAF-mutant melanoma resistant to BRAF inhibitors. This multicenter, open-label, Phase 1 clinical trial (NCT02014116) consisted of Part A (dose escalation) and Part B (dose confirmation) in patients with advanced/metastatic cancer. In Part A, oral LY3009120 was dose escalated from...
Wed Oct 23, 2019 17:08
Publication date: Available online 23 October 2019Source: Annals of Diagnostic PathologyAuthor(s): Rhonda K. Yantiss, Joel K. Greenson, Stuart Spechler
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Publication date: Available online 23 October 2019Source: Annals of Diagnostic PathologyAuthor(s): Cynthia Magro, Ziv Schwartz, Jad Saab, Amin HedayatAbstractThe small guanosine triphosphatase Rho and its target Rho kinase are involved in a heterogeneous spectrum of cellular activities, many of which are integral to cytoskeletal organization. Furthermore, the Rho kinases result in NF kappa beta activation and hence the induction of various pro-inflammatory cytokines including TNF-alpha, IL-1B and...
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