Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 13:47
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:37
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:23
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:20
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:16
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:09
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 12:01
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 11:56
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 11:49
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 11:47
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 10:59
Journal of International Medical Research, Ahead of Print.
Wed Oct 23, 2019 10:57
Journal of International Medical Research, Volume 47, Issue 10, Page 4604-4618, October 2019.
Tue Oct 22, 2019 04:27
Summary Oligonucleotide-based gene silencing, using molecules such as antisense oligonucleotides (ASOs), small interfering RNA, and aptamers, is widely studied. Another approach uses DNA/RNA heteroduplex oligonucleotides (HDOs). Here, we developed an antisense double-stranded DNA oligonucleotide (ADO) by modification of the complementary RNA in an HDO to generate DNA for increasing resistance to nucleases. Naked BCR-ABL-targeting ADO was significantly more potent than siRNA at...
03:00
Summary Thymic neuro endocrine tumor (tNET) are extremely rare malignancies with poor prognosis, requiring investigation of novel therapeutic approaches. 177Lu-DOTATATE is a successful systemic treatment modality in patients with metastatic gastroenteropancreatic but it role in tNET is not yet well established. Here we report a case of a 39-year-old man with refractory bone marrow infiltration of a tNET, treated by 4 cycles of peptide receptor radionuclide therapy (PRRT) with 177Lu...
03:00
The Food and Drug Administration (FDA) regulates approximately 6500 types of medical devices using a risk-classification system with three tiers (low, moderate, and high) based on the level of regulatory control considered necessary to reasonably assure safety and effectiveness. Devices classified…
Wed Oct 23, 2019 03:00
Abstract Uveal melanoma (UM) is a rare, aggressive, but the most frequent primary intraocular malignancy in adults, and up to 50% of patients develop a tendency of liver metastases. Great efforts have been made to develop biomarkers that facilitate diagnosis, prediction of the risk, and response to treatment of UM. However, a biologically informative and highly accurate gold standard system for prognostic evaluation of UM remains to be established. To facilitate assessment of the prognosis of UM...
Wed Oct 23, 2019 19:38
Summary Magnetic resonance‐guided radiation therapy (MRgRT) is a promising approach to improving clinical outcomes for patients treated with radiation therapy. The roles of image guidance, adaptive planning and magnetic resonance imaging in radiation therapy have been increasing over the last two decades. Technical advances have led to the feasible combination of magnetic resonance imaging and radiation therapy technologies, leading to improved soft‐tissue visualisation, assessment of inter‐ and...
Wed Oct 23, 2019 19:34
Abstract A right aortic arch with an aberrant left subclavian artery and a Kommerell’s diverticulum represents a rare anatomic variant carrying the risk of dissection or rupture. Resection of the diverticulum and re-implantation of the left subclavian artery during childhood have been recommended. Because of the risk of cerebral blood flow reduction during the aberrant subclavian artery re-implantation to the common carotid artery, monitoring and prompt measures to curb blood flow...
03:00
Abstract Background The issue whether anaesthesia has an impact on the prognosis of carcinoma has been widely discussed and remains debated. Ropivacaine has been widely used in perioperative period as a long acting local anesthetic. An early event during recurrence or metastasis of carcinoma is the adhesion of circulating tumour cells (CTCs) to endothelial cells (ECs) through binding adhesion molecules that are up-regulated on inflamed...
Wed Oct 23, 2019 03:00
Abstract Purpose To evaluate the per-patient diagnostic performance of a minimized non-contrast MRI protocol for hepatocellular carcinoma (HCC) surveillance in cirrhotic liver, as well as factors affecting diagnostic sensitivity. Methods A total of 226 patients who underwent MRI for HCC surveillance over an 8 year period were included in this retrospective...
03:00
Abstract Purpose Gastrointestinal stromal tumor (GIST) is a rare tumor with high risk of recurrence and poor prognosis in case of advanced GIST. The aim of this study was to evaluate the possible role of 18F-FDG PET/CT in restaging GIST. Methods Fifty-four patients (30 male) with histological proven GIST underwent 100 18F-FDG PET/CT for restaging in suspected...
Wed Oct 23, 2019 03:00
Abstract Purpose To evaluate whether PET/CT could be used to assess the extent of colorectal peritoneal metastases. Methods All patients who underwent a PET/CT scan before a CRS-HIPEC procedure between January 1, 2010 and December 31, 2013 were retrospectively included (n = 35). Two nuclear medicine physicians (observer 1 and observer 2) separately reviewed...
Wed Oct 23, 2019 03:00
Abstract Purpose To investigate the usefulness of b value threshold (bThreshold) map in the evaluation of rectal adenocarcinoma by comparing it with diffusion-weighted images and ADC maps regarding lesion detection and the prediction of pathological features. Materials and Methods Thirty-five patients with rectal tumors were enrolled and underwent axial DWI...
Wed Oct 23, 2019 03:00
Abstract To compare the safety and efficacy of fractional neodymium-doped yttrium aluminum garnet (Nd:YAG) 1064-nm picosecond laser and fractional 1550-nm erbium fiber laser in acne scar treatment and to assess the adverse effects and complications of the two devices. Thirty patients with cosmetically similar acne scars on both sides of the faces were enrolled and treated four times at 4-week intervals. Each side of the face was treated with either fractional 1064-nm Nd:YAG picosecond...
03:00
Abstract To investigate the effect and mechanism of 630-nm laser on human lung adenocarcinoma cell xenograft model in nude mice mediated by hematoporphyrin derivatives (HPD) and provide theoretical basis for clinical photodynamic therapy (PDT). Human lung adenocarcinoma cell xenograft model in nude mice was established and randomly divided into four groups: control group, pure photosensitizer group, pure irradiation group, and photodynamic treatment group. The tumor volume growth...
Wed Oct 23, 2019 03:00
Abstract Rationale A role of group I metabotropic glutamate receptor 5 (mGlu5) in regulating spontaneous locomotion and psychostimulant-induced hyperactivity has been proposed. Objectives This study aims to determine if mGlu5 in GABAergic neurons regulates spontaneous or psychostimulant-induced locomotion. ...
03:00
Abstract Purpose The gender differences in patients with obstructive sleep apnea (OSA) are not fully understood so far, as previous studies had conflicting results. No reports have addressed the differences in OSA between Chinese men and women. Therefore, the purpose of this study was to investigate the clinical and polysomnographic differences between Chinese men and women with OSA. ...
Wed Oct 23, 2019 03:00
In a surgical procedure performed at Memorial Hermann-Texas Medical Center, otorhinolaryngologist Ron Karni, MD, and gastroenterologist Nirav Thosani, MD, opened...
05:19
The rare autoimmune disorder called granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, may develop suddenly or emerge over...
05:15
Amber Luong, MD, PhD, celebrated her 10th anniversary as a faculty member of the Department of Otorhinolaryngology at McGovern Medical...
05:09
Martin J. Citardi, MD, professor and chair of the Department of Otorhinolaryngology-Head and Neck Surgery at McGovern Medical School at...
05:03
Purpose: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant disease relapse remains high. Perioperative immunotherapy may improve outcomes, but mechanistic data supporting the use of neoadjuvant or adjuvant treatment clinically is sparse. Experimental Design: Two...
Wed Oct 23, 2019 16:56
Purpose: Immunotherapy has demonstrated clinical efficacy in subsets of patients with solid carcinomas. Multimodal therapies employing agents that can affect different arms of the immune system and/or tumor microenvironment might increase clinical responses. Experimental Design: We demonstrate that entinostat, a class I histone deacetylase inhibitor, enhances the anti-tumor efficacy of the IL-15 superagonist, N-803 plus vaccine in 4T1 triple-negative breast and MC38-CEA colon murine carcinoma models....
Wed Oct 23, 2019 16:56
Purpose: Early response to ABVD, assessed with interim FDG-PET (iPET), is prognostic for classical Hodgkin's Lymphoma (cHL) and supports the use of response adapted therapy. The aim of this study was to identify a gene-expression profile on diagnostic biopsy to predict iPET positivity (iPET+). Experimental Design: Consecutive untreated patients with stage I-IV cHL who underwent iPET after two cycles of ABVD were identified. Expression of 770 immune related genes was analyzed by digital expression...
Wed Oct 23, 2019 16:56
Bulliform cells comprise specialized cell types that develop on the adaxial (upper) surface of grass leaves, and are patterned to form linear rows along the proximodistal axis of the adult leaf blade. Bulliform cell patterning affects leaf angle and is presumed to function during leaf rolling, thereby reducing water loss during temperature extremes and drought. In this study, epidermal leaf impressions were collected from a genetically and anatomically diverse population of maize inbred lines. Subsequently,...
00:59
The Eastern woodchuck (Marmota monax) has been extensively used in research of chronic hepatitis B and liver cancer because its infection with the woodchuck hepatitis virus closely resembles a human hepatitis B virus infection. Development of novel immunotherapeutic approaches requires genetic information on immune pathway genes in this animal model. The woodchuck genome was assembled with a combination of high-coverage whole-genome shotgun sequencing of Illumina paired-end, mate-pair libraries and...
00:59
Genetic mapping is a primary tool of genetics in model organisms; however, many quantitative trait loci (QTL) contain tens or hundreds of positional candidate genes. Prioritizing these genes for validation is often ad hoc and biased by previous findings. Here we present a technique for prioritizing positional candidates based on computationally inferred gene function. Our method uses machine learning with functional genomic networks, whose links encode functional associations among genes, to identify...
00:59
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