American Journal of Medical Genetics Part A ,
- Brain white matter abnormalities associated with copy number variantsAbstract White matter (WM) signal abnormalities are demonstrated in various neurodevelopmental disorders on brain magnetic resonance imaging (MRI). The pattern of WM abnormalities can aid in the diagnostic process. This study aims to characterize the WM changes found in microdeletion/microduplication syndromes. Thirteen patients with neurodevelopmental disorders due to copy number variations were collected from a cohort of children with evidence
G3: .Genes, Genomes, Genetics Mission - Online First Articles
- Classification-Based Inference of Dynamical Models of Gene Regulatory NetworksCell-fate decisions during development are controlled by densely interconnected gene regulatory networks (GRNs) consisting of many genes. Inferring and predictively modeling these GRNs is crucial for understanding development and other physiological processes. Gene circuits, coupled differential equations that represent gene product synthesis with a switch-like function, provide a biologically realistic framework for modeling the time evolution o
- Expression of Heat Shock Protein 70 Is Insufficient To Extend Drosophila melanogaster LongevityIt has been known for over 20 years that Drosophila melanogaster flies with twelve additional copies of the hsp70 gene encoding the 70 kDa heat shock protein lives longer after a non-lethal heat treatment. Since the heat treatment also induces the expression of additional heat shock proteins, the biological effect can be due either to HSP70 acting alone or in combination. This study used the UAS/GAL4 system to determine whether hsp70 is sufficien
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου