Biomedicine & Pharmacotherapy
- Application of mass spectrometry-based MHC immunopeptidome profiling in neoantigen identification for tumor immunotherapyPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Xiaomei Zhang, Yue Qi, Qi Zhang, Wei LiuAbstractOne of the challenges for cancer vaccine and adoptive T-cell-based immunotherapy is to identify the major histocompatibility complex (MHC)-associated non-self neoantigens recognized by T cells. T cell epitope in silico prediction algorithms have been widely used for neoantigen prediction; nonetheless, this pla
- Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathwayPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Tianhua Liu, Ling Zuo, Dongqing Guo, Xinlou Chai, Jie Xu, Zhaorui Cui, Zhiyi Wang, Chunying HouAbstractLung cancer is the leading cause of cancer-related deaths. Ginsenoside Rg3 is the main ingredient of Ginseng which is used to treat non-small cell lung cancer (NSCLC). It has been found to enhance the efficiency of chemotherapy thereby reducing its side ef
- Danhong injection enhances angiogenesis after myocardial infarction by activating MiR-126/ERK/VEGF pathwayPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Si-Nai Li, Ping Li, Wei-Hong Liu, Ju-Ju Shang, Sheng-Lei Qiu, Ming-Xue Zhou, Hong-Xu LiuAbstractBackground/aimDanhong injection (DHI) is a Chinese drug used for relieving cardiovascular diseases. This study aimed to identify the effect and mechanism of action of DHI on post-infarct angiogenesis, especially the epigenetic regulation of angiogenesis.MethodsA
- Chung Hun Wha Dam Tang attenuates atherosclerosis in apolipoprotein E-deficient mice <em>via</em> the NF-κB pathwayPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Yeonsoo Joe, Md Jamal Uddin, Jeongmin Park, Jinhyun Ryu, Gyeong Jae Cho, Jeong Woo Park, Hye-Seon Choi, Min Ho Cha, Stefan W. Ryter, Hun Taeg ChungAbstractChung Hun Wha Dam Tang (CHWDT), a traditional Korean herbal formula, has been used for hundreds of years for alleviating dizziness, phlegm, and inflammation. The inhibitory effects of CHWDT on obesity hav
- Yougui pills exert osteoprotective effects on rabbit steroid-related osteonecrosis of the femoral head by activating β-cateninPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Peng Zhang, Huihui Xu, Pinger Wang, Rui Dong, Chenjie Xia, Zhenyu Shi, Rui Xu, Liang Fang, Zhen Zou, Qinwen Ge, Peijian Tong, Hongting JinAbstractObjectiveTo investigate the effect and underlying mechanism of Yougui pills (YGPs) on steroid-related osteonecrosis of the femoral head (SONFH).MethodsMale New Zealand white rabbits were divided into three groups:
- Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjectsPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Alberto Mazza, Danyelle M. Townsend, Laura Schiavon, Gioia Torin, Salvatore Lenti, Ciro Rossetti, Gianluca Rigatelli, Domenico RubelloAbstractBackgroundMost antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination
- Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3pPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Yang Zhou, Zhijun Jin, Chengcai WangAbstractBackgroundOvarian cancer is one of the most common gynecologic cancers with high morbidity and mortality in women. Glycogen metabolism plays a critical role in cancer development and glycogen phosphorylase B (PYGB) has reported to be involved in various tumors. Here, we explored the role of PYGB in ovarian cancer.
- The endocannabinoid system: Novel targets for treating cancer induced bone painPublication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jia Sun, Ya-Qun Zhou, Shu-Ping Chen, Xiao-mei Wang, Bing-Yang Xu, Dan-Yang Li, Yu-Ke Tian, Da-Wei YeAbstractTreating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence suggested the endocannabinoid system (ECS) may play essential roles in CIBP. Here
- Angiogenesis modulatory factors in subjects with chronic ocular complications of Sulfur Mustard exposure: A case-control studyPublication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Fatemeh Heidary, Reza Gharebaghi, Hassan Ghasemi, Mohammad Reza Vaez Mahdavi, Sara Ghaffarpour, Mohammad Mehdi Naghizadeh, Tooba GhazanfariAbstractBackgroundChronic ocular complications of Sulfur Mustard (SM) exposure leads to severe ocular morbidity during time. The aim of this study was to compare serum levels of Interleukin 17 (IL-17), IL-12, vascular
- Photodynamic therapy for atherosclerosis. The potential of Indocyanine GreenPublication date: Available online 15 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): S. Houthoofd, M. Vuylsteke, S. Mordon, I. FourneauAbstractAimThe aim of this article is to summarize and review the use of photodynamic therapy for the treatment of atherosclerotic plaque and the prevention of intimal hyperplasia. Different photosensitizers are discussed and more specifically the role of indocyanine green as a potential pho
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