Cancer
- Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancerBritish Journal of Cancer, Published online: 17 October 2019; doi:10.1038/s41416-019-0605-4Correction: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
- LncRNA WT1-AS Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Downregulating Transforming Growth Factor β1Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
- Direct Interstitial Treatment of Solid Tumors Using an Injectable Yttrium-90-Polymer CompositeCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
- Overexpression of Long Noncoding RNA E2F-Mediated Cell Proliferation Enhancing Long Noncoding RNA Is Involved in the Development of Chemoresistance of Cancer Cells to Carboplatin in Ovarian Endometrioid AdenocarcinomaCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
- AHNAK Nucleoprotein 2 Performs a Promoting Role in the Proliferation and Migration of Uveal Melanoma CellsCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancers
- Cancers, Vol. 11, Pages 1586: The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma CellsCancers, Vol. 11, Pages 1586: The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells Cancers doi: 10.3390/cancers11101586 Authors: Anna S. Kirstein Adrien Augustin Melanie Penke Michele Cea Antje Körner Wieland Kiess Antje Garten Germline mutations in the tumor suppressor gene PTEN cause PTEN Hamartoma Tumor Syndrome (PHTS). Pediatric pat
- Cancers, Vol. 11, Pages 1585: The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell ProgramCancers, Vol. 11, Pages 1585: The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program Cancers doi: 10.3390/cancers11101585 Authors: John Verigos Panagiotis Karakaidos Dimitris Kordias Alexandra Papoudou-Bai Zoi Evangelou Haralampos V. Harissis Apostolos Klinakis Angeliki Magklara Breast cancer is the leading cause of cancer death in the female population,
- Cancers, Vol. 11, Pages 1584: Therapeutic Challenges for Cisplatin-Resistant Ovarian Germ Cell TumorsCancers, Vol. 11, Pages 1584: Therapeutic Challenges for Cisplatin-Resistant Ovarian Germ Cell Tumors Cancers doi: 10.3390/cancers11101584 Authors: Ugo De Giorgi Chiara Casadei Alice Bergamini Laura Attademo Gennaro Cormio Domenica Lorusso Sandro Pignata Giorgia Mangili The majority of patients with advanced ovarian germ cell cancer are treated by cisplatin-based chemotherapy. Despite adequate first-line treatmen
- Cancers, Vol. 11, Pages 1583: CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear TranslocationCancers, Vol. 11, Pages 1583: CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation Cancers doi: 10.3390/cancers11101583 Authors: Seung-Phil Shin A-RA Goh Hyeon-Gu Kang Seok-Jun Kim Jong-Kwang Kim Kyung-Tae Kim John H Lee Yong-Soo Bae Yuh-Seog Jung Sang-Jin Lee The membrane glycoprotein CD200 binds to its receptor CD200R1 and
Clinical Cancer Research Online First Articles
- Pilot Trial AMC-063: Safety and Efficacy of Bortezomib in AIDS-associated Kaposi SarcomaPurpose: AIDS-related Kaposi sarcoma (KS) is often incompletely controlled, requiring serial therapies. KS herpesvirus (KSHV) induces transformation of endothelial cells, where it resides in a predominately latent state. We hypothesized proteasome inhibition would have direct anti-tumor activity, induce lytic activation of KSHV, and inhibit HIV infectivity, improving control of both KS and HIV. The primary objective was determining the maximum to
- CD200 Checkpoint Reversal:A Novel Approach to ImmunotherapyPurpose: Advances in immunotherapy have revolutionized care for some cancer patients. However, current checkpoint inhibitors are associated with significant toxicity and yield poor responses for patients with central nervous system tumors, calling into question whether cancer immunotherapy can be applied to glioblastoma multiforme. We determined that targeting the CD200 activation receptors (CD200AR) of the CD200 checkpoint with a peptide inhibit
- A somatostatin receptor subtype-3 (SST3) peptide agonist shows antitumor effects in experimental models of Nonfunctioning Pituitary TumorsPurpose: Somatostatin-analogs (SSAs) are efficacious and safe treatments for a variety of neuroendocrine tumors, especially pituitary neuroendocrine tumors (PitNETs). Their therapeutic effects are mainly mediated by somatostatin receptors SST2 and SST5. Most SSAs, such as Octreotide/Lanreotide/Pasireotide, are either nonselective or activate mainly SST2. However, non-functioning pituitary tumors (NFPTs), the most common PitNET type, mainly expres
Future Oncology
International Journal of Cancer
- GD2‐directed CAR‐T cells in combination with HGF‐targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing SarcomaEwing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform, delta133p53. We further determined that aberrant expression of delta133p53 induced HGF secretion resulting in tumor growth and metastasis. Thereafter,
- Using Pre-Treatment Neutrophil-to-Lymphocyte Ratio to Predict the Prognosis of Young Patients with Hepatocellular Carcinoma Implemented Minimally Invasive TreatmentJournal of Adolescent and Young Adult Oncology, Ahead of Print.
- Mindfulness-Based Cognitive Therapy Intervention for Young Adults with Cancer: A Pilot Mixed-Method StudyJournal of Adolescent and Young Adult Oncology, Ahead of Print.
- Fertility-Related Wishes and Concerns of Adolescent Cancer Patients and Their ParentsJournal of Adolescent and Young Adult Oncology, Ahead of Print.
Journal of Cancer Education
- Orthopedic Oncology Experience During ResidencyAbstract The objective of this study was to determine the characteristics and logistics of orthopedic oncology rotations at various residency programs across the USA and determine the effect of orthopedic oncology rotations on Orthopedic In-Training Examination (OITE) scores. An eight-question survey was sent to 162 orthopedic surgery residency programs obtained from the Accreditation Council for Graduate Medical Education publ
Radiotherapy and Oncology
- Radiotherapy can increase the risk of ischemic cerebrovascular disease in head and neck cancer patients: A Korean population-based cohort studyFor HNC patients, RT is an essential curative and organ-preserving treatment modality, which can be delivered by itself or combined with chemotherapy or surgery. However, several reports have demonstrated that RT is related to an increased risk of CVD in HNC patients [1–3]. It might have resulted from the chronic side effects of RT on the large to medium vasculatures of the head and neck [1,4,5]. The exact mechanism of radiation-induced carotid o
- Cross-modality applicability of rectal normal tissue complication probability models from photon- to proton-based radiotherapyThe dose response relations of the rectum – a key organ at risk (OAR) in radiotherapy (RT) of all pelvic tumour sites – have been investigated in a number of studies, mostly following treatment with photons. The QUANTEC review of the rectum showed that while the high-dose regions (≥60 Gy) in the rectum are connected to the risk of morbidity, also the extent of the low and intermediate doses (40–60 Gy) are associated with morbidity [1–5].
- Long-term survival and complications following bladder-preserving brachytherapy in patients with cT1-T2 bladder cancerRadical cystectomy (RC) is still considered standard of treatment for patients with non-metastatic muscle-invasive bladder cancer (MIBC) and high-risk non-muscle-invasive bladder cancer (NMIBC) refractory to intravesical therapy in most countries [1]. However, RC has significant morbidity and mortality [2].
- Critical review and quality-assessment of cost analyses in radiotherapy: How reliable are the data?Health economic evaluations (HEEs) support healthcare policy decision-making by providing information regarding the costs and the consequences of healthcare interventions [1]. In times of limited public resources in conjunction with ever-increasing healthcare expenses, HEEs have become essential to inform policymakers of the acceptability and affordability of new treatments.
- NTCP model for postoperative complications and one-year mortality after trimodality treatment in oesophageal cancerRadical resection has long been the mainstay of treatment in patients with locoregionally advanced oesophageal cancer. However, outcome with this single modality treatment was poor with five-year survival rates ranging between 14% and 35% [1]. In a quest to improve outcome, several neoadjuvant and adjuvant strategies using chemotherapy or chemoradiotherapy have been investigated [2,3]. Currently, preoperative chemoradiotherapy (preCRT) followed b
- Synthetic MRI-aided multi-organ segmentation on male pelvic CT using cycle consistent deep attention networkTarget and organ art risk (OAR) segmentation are prerequisites of radiotherapy treatment planning. Radiotherapy planning evaluation is based on radiation dose coverage of target volume and dose sparing of highly radiosensitive surrounding OARs. Segmentation accuracy of OARs directly impacts the quality of radiotherapy plans and subsequent clinical outcomes. Current routine clinical practice involves the manual contouring of target and OARs by cli
RNA In Advance
- Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base specific resolution [Bioinformatics]Direct RNA sequencing holds great promise for the de novo identification of RNA modifications at single coordinate resolution, however interpretation of raw sequencing output to discover modified bases remains a challenge. Using Oxford Nanopore’s direct RNA sequencing technology, we developed a Random Forest classifier trained using experimentally detected N6-methyladenosine (m6A) sites within DRACH motifs. Our software MINES (m6A Identification
Surgical Oncology Clinics of North America
- Precision Medicine in Lung Cancer TreatmentPublication date: Available online 16 October 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Dhaval R. Shah, Gregory A. Masters
Πέμπτη 17 Οκτωβρίου 2019
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