Ruhi Mehra, Minal Rane, Ujwala D'Mello, Rajesh B SawantGlobal Journal of Transfusion Medicine 2019 4(2):214-218 Introduction: The presence of red blood cell (RBC) auto and/or alloantibodies can pose a serious challenge of finding transfusion support for such patients. Aim and Objectives: The aim of this study was to assess the frequency and type of unexpected RBC antibodies in the patient population of a tertiary care super specialty hospital and analyze the transfusion support and its effectiveness...
Shivaram Chandrashekar, Ambuja KantharajGlobal Journal of Transfusion Medicine 2019 4(2):132-139 Hemovigilance is a set of surveillance procedures starting from the donor vein and ending with the patient vein, aimed at reducing the risks associated with transfusion which could be donor related, recipient related, or process related. Donor-related risks include local and systemic complications which need a variety of interventions to ensure safe blood donation and are mainly aimed at preventing...
Qin-Qin Ma, Hui-Jun Zhu, Li Rui-Shu, Fu Min, Lu PingGlobal Journal of Transfusion Medicine 2019 4(2):243-246 Background: Platelet (PLT) transfusion has been a crucial for clinical blood transfusion and bleeding prophylaxis. Identification of antibody against PLT-specific antigen is important for accurately diagnosing posttransfusion purpura, neonatal alloimmune thrombocytopenia, and platelet refractoriness due to PLT-specific antibodies. However, the presence of anti-human leukocyte antigen (HLA)...
B Sunil Rajadhyaksha, D Priti Desai, A Anisha NavkudkarGlobal Journal of Transfusion Medicine 2019 4(2):140-147 Platelet transfusion support is extensively required for hemato-oncology patients who are multiply transfused. Platelet refractoriness can represent a significant clinical condition that complicates the platelet transfusion support in such patients. It remains a challenge associated with an increased bleeding risk, longer hospital stays, and increased morbidity and mortality. Causes for...
Sadhana Mangwana, Vivek GangwarGlobal Journal of Transfusion Medicine 2019 4(2):231-233 Rh D (D or RH 1) is next clinically important blood group after ABO blood group system. Although most people are either D+ or D−, there are a large number of individuals having different forms of D variants; weak D, partial D, or DEL phenotypes. We present a case report of a 32-year-old male with a history of cough and cold for 5 days with development of petechial rashes all over the body from day 1 and afebrile...
Sadhana Mangwana, Atin Kacker, Nikhil SimonGlobal Journal of Transfusion Medicine 2019 4(2):148-153 Background: Platelet refractoriness complicates the provision of platelet transfusions- a critical and essential part in management of thrombocytopenia in Oncology patients. Platelet refractoriness poses challenge due to alloimmunization to HLA (Class I) and human platelet antigens (HPAs) and is associated with adverse clinical outcomes and increases health care costs. Aim: A prospective, observational...
Rajendran Loganathan, Rajendra G Kulkarni, Rakhee Kar, B Abhishekh, Debdatta BasuGlobal Journal of Transfusion Medicine 2019 4(2):204-207 Background: Indian Drugs and Cosmetics Act and Rules 1945 states that 1% or 4 units/month of any components prepared and stored should meet specific quality control parameter. Currently, our blood center relies on nonancillary tests such as prothrombin time (PT)/activated PT test for quality check of fresh frozen plasma (FFP). However, the guidelines advice to...
Senem Maral, Sule Mine Bakanay, Sema Akıncı, Aysun Senturk Yıkılmaz, Pinar Comert, Imdat DilekGlobal Journal of Transfusion Medicine 2019 4(2):154-157 Introduction: Pretransfusion testing is an essential serological test to protect the recipient from hemolysis and provide compatible blood product. The final step is the crossmatching test which is done by the transfusion center. Although all products are crossmatched in same cases, compatible products may not be available. Aims and Objectives: This...
Chhavi Rajvanshi, Aseem Kumar Tiwari, Pranav Dorwal, Simmi MehraGlobal Journal of Transfusion Medicine 2019 4(2):224-226Introduction: Hepatitis C virus infects 3% people globally, that causes significant morbidity and mortality. For diagnosis and monitoring of treatment of HCV infection; biochemical markers and HCV RNA are tested. Aim of the Study: We tried to find out whether there is an association of liver enzymes (AST, ALT) and anti HCV antibody with the HCV viral load in patient's serum. Material...
Sheela M Mundhada, Gautam R Wankhede, Shefali Desai, Dakhave MinalGlobal Journal of Transfusion Medicine 2019 4(2):158-162 Background: In India serological screening is mandatory for all donated blood for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) while Nucleic Acid Amplification Testing (NAT) is not a mandatory screening test. There is a risk of transfusion-transmitted infections (TTI) during window period using serology. Aims and Objectives: The aim...
Debasish Mishra, Prabodh Kumar Dash, Satya Prakash, Somnath MukherjeeGlobal Journal of Transfusion Medicine 2019 4(2):237-239 Transfusion support remains the mainstay of supportive treatment for thalassemia patients in spite of recent advances such as stem cell transplantation and gene therapy. Thalassemia intermedia (TI) patients generally do not require regular transfusion support but can develop severe anemia, requiring frequent transfusion during the period of stress such as infection and pregnancy....
Sukanya Baruah, Sundar PeriyavanGlobal Journal of Transfusion Medicine 2019 4(2):163-167 Introduction: Therapeutic plasma exchange (TPE) aims at removing harmful substances from patient's plasma. It has become a treatment option in a variety of neurological disorders with good outcome. In the last decade, there has been an increase in the number and spectrum of indications for therapeutic apheresis. Aims and Objectives: To analyse the complications of plasmapheresis patients with varied neurological...
Shivaram ChandrashekarGlobal Journal of Transfusion Medicine 2019 4(2):129-131
Sangita Darshan Shah, Tarak R Patel, Nidhi M Bhatnagar, Maitrey D Gajjar, Mamta Chintan Shah, Sujata TripathiGlobal Journal of Transfusion Medicine 2019 4(2):168-174 Introduction: Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) in hemophilia A (HA) or factor IX (FIX) in hemophilia B (HB). Accurate diagnosis of hemophilia by factor assay to demonstrate deficiency of FVIII or FIX is essential for appropriate management. Inhibitor development...
Bentolhoda Mozafari, Ali Akbar Pourfathollah, Leila KohanGlobal Journal of Transfusion Medicine 2019 4(2):208-213Introduction: Agglutination in red blood cells can be associated with a number of complications. These complications are related to the amount of antibody titer produced. Some genetic factors, such as HLA-DRB1*15:03 and HLA-DRB1*09:01 alleles, are involved in the production of antibody titers. Aims and Objectives: The aim of this study was to investigate the causative allele of the high...
Vandana Puri, Ipsita Dhal, Kalpana Singh, Geetika Sharma, Preeti Rai, Sunita SharmaGlobal Journal of Transfusion Medicine 2019 4(2):175-179 Introduction: Fresh frozen plasma (FFP) prepared from whole blood contains plasma proteins and all the coagulation factors including factor V and factor VIII. Many FFP transfusion guidelines have been published till now. However, the administration is inappropriate without any scientific basis or clinical indication in many hospital settings. Aims and Objectives:...
Deepti Sachan, G Deepthi Krishna, Suryatapa Saha, Raghuram PrasathGlobal Journal of Transfusion Medicine 2019 4(2):219-223 Background: Although antibody screening is mandatory according to the National Blood Policy of India, the prevalence of irregular red cell antibody and its specificities are not much reported in South Indian population. Aims and Objectives: The objective of this study is to find the prevalence of irregular red cell antibodies and positive direct antiglobulin test (DAT) in healthy...
Basudev Pokhrel, Abhishekh Basavarajegowda, Sai Chandran, Debdatta Basu, Tanveer RehmanGlobal Journal of Transfusion Medicine 2019 4(2):180-185 Introduction: The clinical use of blood with regard to cardiac surgeries should be justifiable as it is associated with significant transfusion requirements, and tends to put a great burden on the blood inventory. Storage of red blood cell (RBC) induces various biochemical, biomechanical, and immunological changes that affect red cell viability, deformability,...
Prathibha Bharathan, Ashish Jain, Neelam MarwahaGlobal Journal of Transfusion Medicine 2019 4(2):227-230 Introduction: Irregular red blood cell (RBC) antibodies may occur in blood donors and potentially can lead to transfusion reactions or decreased survival of transfused RBCs. Therefore, it is necessary to know the prevalence of alloantibodies in donors and their clinical significance. Aims and Objectives: The study was aimed to determine the prevalence of RBC alloantibodies in blood donors. Materials...
Suryatapa Saha, Deepti Sachan, Deepti Krishna, Raghuram Global Journal of Transfusion Medicine 2019 4(2):186-190 Introduction: Thrombocytopenia is one of the most common complications in chronic liver disease and perioperative transplant patients requiring multiple units of platelets transfusion. Aim: This study was undertaken to find out the effectiveness of platelet additive solution (PAS) suspended apheresis platelets in such patients and to compare the in vitro quality of PAS suspended, and...
HA Venkatesh, Abhishek Paul, Ambuja Kantharaj, Shivaram ChandrashekarGlobal Journal of Transfusion Medicine 2019 4(2):234-236 Alloimmune thrombocytopenia is the most common cause of severe thrombocytopenia and intracranial bleed in the perinatal period, resulting from placental transfer of maternal platelet antibodies directed against the paternal-derived fetal platelet antigens. It is estimated to occur in 1 in 2500 births but continues to be an underdiagnosed and underreported condition in our...
Devi Prasad Acharya, Aseem K Tiwari, Geet Aggarwal, Dinesh Arora, Ravi C Dara, Gunjan Bhardwaj, Gautam Kumar GuptaGlobal Journal of Transfusion Medicine 2019 4(2):191-197 Introduction: Serological tests for syphilis contributed greatly to the detection of Treponema pallidum infection in blood donors and especially in those who were missed during the medical selection. Although several different treponemal assays have been evaluated in India, the debate that which treponemal test-formats would be...
Rani Premkumar, Siva DeepthiGlobal Journal of Transfusion Medicine 2019 4(2):240-242 Plasma cell myeloma accounts for 1% of malignant tumors and 10%–15% of hematopoietic neoplasms. Daratumumab (DARA), a novel targeted immunotherapy drug, was approved by the Food and Drug Administration to treat relapsed/refractory multiple myeloma. DARA, which is a CD38-targeted immunomodulatory drug, also cross-reacts with red cells and sensitizes them, causing difficulties and delay in the blood bank. To avoid...
Usman Waheed, Min-woong Hwang, Noor e Saba, Sooncheol Hong, Muhammad Saeed, Akhlaaq Wazeer, Muhammad Arshad, Javaid Usman, Hasan Abbas ZaheerGlobal Journal of Transfusion Medicine 2019 4(2):198-203 Introduction: Hepatitis C has emerged as a fatal epidemic in the country in the past two decades. One of the major risk factors remains unsafe blood transfusions. Aims and Objectives: The present study evaluated the performance of a newly developed automated fluorescent immunoassay system (AFIAS anti-hepatitis...
Li Juan, Zhangfei Wang, Man Fang, Yiqin LuoGlobal Journal of Transfusion Medicine 2019 4(2):247-248
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