Related ArticlesRepair of a large primary subtemporal encephalocele in a 3-year-old child: case report. J Neurosurg Pediatr. 2019 Oct 18;:1-6 Authors: Thatikunta M, Bumpous J, Little J, Karia S, Herring NR, Nuru M, Engineer N, Mutchnick I Abstract Primary encephaloceles (PEs) present only rarely in the temporal region; in the rare instance that they project through the floor of the middle fossa they are secondary. In this case report the authors report...
Sun Oct 20, 2019 13:27
Oncocytic adrenocortical neoplasms (OANs) are very rare. Although most cases have benign behavior, the risk of recurrence/metastasis is variable. Based on Lin-Weiss-Bisceglia (LWB) system criteria, OANs can be classified as benign, borderline, or malignant. A concomitant development of OANs with second primary neoplasm is extremely uncommon, and is limited to very few case reports. None of these reported cases was found to be associated with hepatocellular carcinoma (HCC). In this case report, we...
Sun Oct 20, 2019 13:05
Related ArticlesExome sequencing of 22 genes using tissue from patients with biliary tract cancer. APMIS. 2019 Oct 19;: Authors: Høgdall D, Larsen OF, Linnemann D, Poulsen TS, Høgdall EV Abstract BACKGROUND: Biliary tract cancers (BTC) are a rare heterogeneous disease group with a dismal prognosis and limited treatment options. The mutational landscape consists of genetic aberrations both shared by and characteristic for anatomical location. Here we...
Sun Oct 20, 2019 13:26
Related ArticlesCurrent Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2019 Oct 17;11(10): Authors: Barth DA, Slaby O, Klec C, Juracek J, Drula R, Calin GA, Pichler M Abstract Renal cell carcinoma (RCC) is a relatively rare malignancy of the urinary tract system. RCC is a heterogenous disease in terms of underlying histology and its associated underlying pathobiology, prognosis and treatment schedule....
Sun Oct 20, 2019 13:26
Related ArticlesGastrointestinal tract metastasis presenting as intussusception in invasive lobular carcinoma of the breast: A case report. Int J Surg Case Rep. 2019 Oct 07;64:109-112 Authors: Mosiun JA, Idris MSB, Teoh LY, Teh MS, Chandran PA, See MH Abstract INTRODUCTION: Breast cancer metastasis to the gastrointestinal (GI) tract is rare and occurs more frequently in invasive lobular carcinoma. Patients may be asymptomatic or present with variable...
Sun Oct 20, 2019 15:21
Related Articles"Synchronous versus Staged Carotid Endarterectomy (CEA) and Coronary Artery Bypass Graft (CABG) for Patients with Concomitant Severe Coronary and Carotid Artery Stenosis: a Systematic Review and Meta-analysis". Ann Vasc Surg. 2019 Oct 16;: Authors: Tzoumas A, Giannopoulos S, Texakalidis P, Charisis N, Machinis T, Koullias GJ Abstract BACKGROUND: Due to the systemic nature of atherosclerosis, arteries at different sites are commonly simultaneously...
Sun Oct 20, 2019 14:24
Related ArticlesClinical investigation of CAR T cells for solid tumors: lessons learned and future directions. Pharmacol Ther. 2019 Oct 16;:107419 Authors: Bagley SJ, O'Rourke DM Abstract Chimeric antigen receptor (CAR) T cells are a form of autologous immunotherapy that has changed the therapeutic landscape of hematologic malignancies. CAR T cell therapy involves collection of a patient's T cells by apheresis, ex vivo genetic modification of the T cells...
Sun Oct 20, 2019 14:24
Related ArticlesPBPK models for evaluating membrane transporter mediated DDIs: Current capabilities, case studies, future opportunities and recommendations. Clin Pharmacol Ther. 2019 Oct 19;: Authors: Taskar K, Pilla Reddy V, Howard B, Posada MM, Varma M, Zheng M, Ullah M, Emami Riedmaier A, Umehara KI, Snoeys J, Nakakariya M, Chu X, Beneton M, Chen Y, Huth F, Narayanan R, Mukherjee D, Dixit V, Sugiyama Y, Neuhoff S Abstract Physiology-based pharmacokinetic...
Sun Oct 20, 2019 14:24
Related Articles[Salivary gland malignancies-highlights of the 2019 ASCO Annual Meeting]. HNO. 2019 Oct 18;: Authors: Doescher J, Schuler PJ, Greve J, Meyer MF, Weissinger S, Hoffmann TK, Laban S Abstract BACKGROUND: Due to their comparatively low incidence, salivary gland carcinomas have only been the subject of isolated clinical studies in recent years. In addition, surgery with/without adjuvant radiotherapy is considered standard treatment. Systemic...
Sun Oct 20, 2019 13:24
Related ArticlesMonocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation. Cancer Immunol Immunother. 2019 Oct 18;: Authors: Bialek-Waldmann JK, Heuser M, Ganser A, Stripecke R Abstract Acute myeloid leukemia (AML) is the most common acute leukemia in adults and overall survival remains poor. Chemotherapy is the standard of care for...
Sun Oct 20, 2019 13:24
Related ArticlesAquaporin-2 and Na+ /H+ exchanger isoform 1 modulate the efficiency of renal cell migration. J Cell Physiol. 2019 Oct 19;: Authors: Di Giusto G, Pizzoni A, Rivarola V, Beltramone N, White A, Ford P, Capurro C Abstract Aquaporin-2 (AQP2) promotes renal cell migration by the modulation of integrin β1 trafficking and the turnover of focal adhesions. The aim of this study was to investigate whether AQP2 also works in cooperation with Na+...
Sun Oct 20, 2019 13:20
Related ArticlesLong noncoding MIAT acting as a ceRNA to sponge microRNA-204-5p to participate in cerebral microvascular endothelial cell injury after cerebral ischemia through regulating HMGB1. J Cell Physiol. 2019 Oct 19;: Authors: Deng W, Fan C, Shen R, Wu Y, Du R, Teng J Abstract This study is applied to the investigation of the long noncoding RNA myocardial infarction associated transcript's (MIAT's) role in regulating the expression of high-mobility...
Sun Oct 20, 2019 13:20
Trichoderma species are found in soil and in association with plants. They can act directly or indirectly in the biological control of plant diseases and in the promotion of plant growth, being among the most use...
Fri Oct 18, 2019 03:00
Related ArticlesDiscovery of Prolyl Hydroxylase 2 (PHD2) Inhibitors with New Chemical Scaffolds as In Vivo Active Erythropoietin Inducers through a Combined Virtual Screening Strategy. Chem Biol Drug Des. 2019 Oct 19;: Authors: Yu Z, Li Z, Yu Q, Wang Z, Song H, Sun H, Fan R, Bi A, Zhang J, Zhang X Abstract Hypoxia inducible factor (HIF) is identified to be a promising target to mediate the response to hypoxia. Its stability and activation are negatively...
Sun Oct 20, 2019 16:19
Related ArticlesAssociations of urinary phthalate metabolites with risk of papillary thyroid cancer. Chemosphere. 2019 Oct 11;241:125093 Authors: Miao H, Liu X, Li J, Zhang L, Zhao Y, Liu S, Ni S, Wu Y Abstract Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case-control study of 111 PTC cases and 111 age- and sex-matched...
Sun Oct 20, 2019 14:15
Related ArticlesA hypothetical proposal for association between migraine and Meniere's disease. Med Hypotheses. 2019 Oct 12;134:109430 Authors: Sarna B, Abouzari M, Lin HW, Djalilian HR Abstract Meniere's disease (MD) is a chronic condition affecting the inner ear whose precise etiology is currently unknown. We propose the hypothesis that MD is a migraine-related phenomenon which may have implications for future treatment options for both diseases. The...
Sun Oct 20, 2019 14:15
Related ArticlesAssociation of human papillomavirus related squamous cell carcinomas of the oropharynx and cervix. Papillomavirus Res. 2019 Oct 16;:100188 Authors: Gazzaz MJ, Jeffery C, O'Connell D, Harris J, Seikaly H, Biron V Abstract BACKGROUND: Human Papillomavirus (HPV) infection is well established in oropharyngeal squamous cell carcinoma (OPSCC) and cervical cancer (CC). However, the association between both HPV related cancers remains unclear....
Sun Oct 20, 2019 14:15
Related ArticlesUpregulation of microRNA-141 contributes to suppressing epithelial-mesenchymal transition and lymph node metastasis in laryngeal cancer through HOXC6-dependent TGF-β signaling pathway. Cell Signal. 2019 Oct 16;:109444 Authors: Chen L, Sun DZ, Fu YG, Yang PZ, Lv HQ, Gao Y, Zhang XY Abstract Laryngeal cancer is one of the most malignant cancers among the head and neck malignant tumors. Abnormal expression of microRNAs (miRNAs) contributes...
Sun Oct 20, 2019 14:15
Related ArticlesIdentification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice. Life Sci. 2019 Oct 16;:116968 Authors: Hammad A, Zheng ZH, Gao Y, Namani A, Shi HF, Tang X Abstract AIMS: Colorectal cancer (CRC) is the third most common cancer worldwide. Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of many cytoprotective genes, plays a protective role in carcinogenesis....
Sun Oct 20, 2019 14:15
Related ArticlesSpontaneous Massive Extracapsular Hemorrhage in a Parathyroid Carcinoma. Clin Endocrinol (Oxf). 2019 Oct 19;: Authors: Ivkić B, Košec A, Vagić D, Bedeković V Abstract A 68-year-old white male patient was admitted to the otorhinolaryngology clinic after acute onset of dysphagia and dysphonia followed by a fast-growing neck mass measuring up to 8 centimeters in its cranio-caudal diameter in the projection of the left lobe and isthmus of...
Sun Oct 20, 2019 14:15
Related ArticlesImmunologic tolerance of low-risk HPV in recurrent respiratory papillomatosis. Clin Exp Immunol. 2019 Oct 19;: Authors: Ivancic R, Iqbal H, DeSilva B, Pan Q, Matrka L Abstract Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the...
Sun Oct 20, 2019 14:15
Related ArticlesPredictors for failure of supraglottic superimposed high-frequency jet ventilation during upper airway surgery in adult patients; a retrospective cohort study of 224 cases. Clin Otolaryngol. 2019 Oct 19;: Authors: Halmos GB, Plate CMA, Krenz G, Molenbuur B, Dikkers FG, van Dijk BAC, Wachters JE Abstract Supraglottic Superimposed High Frequency Jet Ventilation (SSHFJV) maximizes surgical field during endoscopic upper airway surgery. In...
Sun Oct 20, 2019 13:16
Related ArticlesQuantitative criteria for age-related hearing loss using audiometric configuration analysis. Eur Arch Otorhinolaryngol. 2019 Oct 18;: Authors: Lee JH, Bahng J, Kim C, Kim YY Abstract OBJECTIVES: To suggest the most adaptable criteria of age-related hearing loss (ARHL) using prevalence matching with population-based data. METHODS: We chose 30, 25, 20, and 15 dB as gap ranges of cutoff values of the descending type of hearing loss,...
Sun Oct 20, 2019 13:16
Related Articles[New aspects in thyroid cancer treatment : Highlights of the 2019 ASCO Annual Meeting]. HNO. 2019 Oct 18;: Authors: Möckelmann N, Betz C Abstract The majority of patients with thyroid cancer have a remarkably good chance of cure in the context of surgical treatment, due to their mostly local tumor spread. However, a small proportion of patients with advanced and metastatic thyroid tumors usually require multimodality treatment. Abstracts...
Sun Oct 20, 2019 13:16
Related ArticlesElmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia. Hum Mol Genet. 2019 Oct 19;: Authors: Li W, Feng Y, Chen A, Li T, Huang S, Liu J, Liu X, Liu Y, Gao J, Yan D, Sun J, Mei L, Liu X, Ling J Abstract ELMOD3, an ARL2 GTPase-activating protein, is implicated in causing hearing impairment in humans. However, the specific role of ELMOD3 in auditory function is still far from being elucidated....
Sun Oct 20, 2019 13:16
Related ArticlesMultidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue. Sci Immunol. 2019 Oct 18;4(40): Authors: Si Y, Merz SF, Jansen P, Wang B, Bruderek K, Altenhoff P, Mattheis S, Lang S, Gunzer M, Klode J, Squire A, Brandau S Abstract A high intratumoral frequency of neutrophils is associated with poor clinical outcome in most cancer entities. It is hypothesized that immunosuppressive...
Sun Oct 20, 2019 13:16
Related ArticlesEfficacy, safety, and biomarker analysis of ensartinib in crizotinib-resistant, ALK-positive non-small-cell lung cancer: a multicentre, phase 2 trial. Lancet Respir Med. 2019 Oct 15;: Authors: Yang Y, Zhou J, Zhou J, Feng J, Zhuang W, Chen J, Zhao J, Zhong W, Zhao Y, Zhang Y, Song Y, Hu Y, Yu Z, Gong Y, Chen Y, Ye F, Zhang S, Cao L, Fan Y, Wu G, Guo Y, Zhou C, Ma K, Fang J, Feng W, Liu Y, Zheng Z, Li G, Wu N, Song W, Liu X, Zhao S, Ding L, Mao L, Selvaggi...
Sun Oct 20, 2019 13:16
Related ArticlesExercise Science and the Vocalist. J Voice. 2019 Oct 15;: Authors: Johnson AM, Sandage MJ Abstract The application of exercise science training knowledge has been of growing interest to voice professionals. This tutorial, derived from the authors' invited presentations from the "Exercise and the Voice" Special Session at the 2018 Voice Foundation Symposium, proposes a foundational theoretical structure based in exercise science, clarifies...
Sun Oct 20, 2019 13:16
Related ArticlesOperative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review. J Voice. 2019 Oct 15;: Authors: Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK Abstract OBJECTIVE: Laryngeal contact granuloma is a disease of benign hypertrophic granulation tissue at the medial side of vocal process. Numerous studies of conservative and surgical management have reported effectiveness, yet optimal treatment has...
Sun Oct 20, 2019 13:16
Related ArticlesDNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon γ signature. EBioMedicine. 2019 Oct 15;: Authors: Sailer V, Sailer U, Bawden EG, Zarbl R, Wiek C, Vogt TJ, Dietrich J, Loick S, Grünwald I, Toma M, Golletz C, Gerstner A, Kristiansen G, Bootz F, Scheckenbach K, Landsberg J, Dietrich D ...
Sun Oct 20, 2019 13:16
Related ArticlesIbuprofen as risk-factor for complications of acute anterior sinusitis in children. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Oct 15;: Authors: Nicollas R, Moreddu E, Le Treut-Gay C, Mancini J, Akkari M, Mondain M, Scavarda D, Hosanna G, Fayoux P, Pondaven-Letourmy S, Lescanne E, Triglia JM Abstract IMPORTANCE: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to inhibit chemotaxis, oxidative burst and phagocytosis, bacterial...
Sun Oct 20, 2019 13:16
Related ArticlesNext-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2019 Oct 15;: Authors: Bousquet J, Schünemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, Klimek L, Pfaar O, Wallace D, Ansotegui I, Agache I, Bedbrook A, Bergmann KC, Bewick M, Bonniaud P, Bosnic-Anticevich S, Bossé I, Bouchard...
Sun Oct 20, 2019 13:16
Related Articles[Myocarditis: Uncommon but severe toxicity of immune checkpoint inhibitors]. Bull Cancer. 2019 Oct 15;: Authors: Courand PY, Bouali A, Harbaoui B, Cautela J, Thuny F, Lantelme P Abstract Traditional cancer therapies, such as treatment with anthracyclines and chest radiation, are known to induce cardiovascular complications. Currently, the increase of cancer therapies will involve new mechanisms such as cancer immunotherapies, also called...
Sun Oct 20, 2019 13:16
Related ArticlesDenial of Illness in a Patient with Infiltrative Basal Cell Carcinoma. Skinmed. 2019;17(4):284-285 Authors: Schwartz Z, Geizhals S, Lipner SR, Fox JL Abstract A 73-year-old Caucasian man presented with a pink, pearly papule anterior to his right ear. He was a well-educated, retired stockbroker. Biopsy revealed an infiltrating basal cell carcinoma (BCC). The dermatologist repeatedly attempted to contact the patient encouraging treatment....
Sun Oct 20, 2019 13:16
Related ArticlesA Qualitative Study Examining the Illness Narrative Master Plots of People with Head and Neck Cancer. Behav Sci (Basel). 2019 Oct 17;9(10): Authors: Reid K, Soundy A Abstract Background: There is a need to understand the common plots (master plots) of illness narratives for people who are treated for cancer. Improved insight would enhance therapeutic relationships and help reduce stress for health care professionals (HCPs). Aim: Identify...
Sun Oct 20, 2019 13:16
Related ArticlesCD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. Cancers (Basel). 2019 Oct 17;11(10): Authors: Shin SP, Goh AR, Kang HG, Kim SJ, Kim JK, Kim KT, Lee JH, Bae YS, Jung YS, Lee SJ Abstract The membrane glycoprotein CD200 binds to its receptor CD200R1 and induces tolerance, mainly in cells of the myeloid lineage; however, information regarding its role...
Sun Oct 20, 2019 13:16
Related ArticlesCAF-1 Subunits Levels Suggest Combined Treatments with PARP-Inhibitors and Ionizing Radiation in Advanced HNSCC. Cancers (Basel). 2019 Oct 17;11(10): Authors: Morra F, Merolla F, Picardi I, Russo D, Ilardi G, Varricchio S, Liotti F, Pacelli R, Palazzo L, Mascolo M, Celetti A, Staibano S Abstract Oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas show high morbidity and mortality rates. We aimed to investigate the role of the...
Sun Oct 20, 2019 13:16
Related ArticlesPost-Lumbar Puncture Headache-Does Hydration before Puncture Prevent Headache and Affect Cerebral Blood Flow? J Clin Med. 2019 Oct 17;8(10): Authors: Nowaczewska M, Kukulska-Pawluczuk B, Kaźmierczak H, Pawlak-Osińska K Abstract Headache is a common complication after diagnostic lumbar puncture (DLP). We aimed to check whether hydration before puncture influences the incidence of post-lumbar puncture headache (PLPH) and affects cerebral...
Sun Oct 20, 2019 13:16
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