Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Liying Zhu, Jinxing Zhou, Yu Pan, Jing Lv, Yang Liu, Shanhe Yu, Yifan ZhangAbstractGlucagon-like peptide-1 receptor (GLP-1R) is an important pharmacological target for type 2 diabetes mellitus because it maintains glucose homeostasis and promotes β cell proliferation. Androgen is suggested not only to regulate hypothalamic-pituitary-gonadal axis but also to affect metabolism. In this study, Glp1r mRNA was...
Thu Oct 24, 2019 16:33
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Ying Wang, Lingwei Chen, Kangyao Wang, Yuanting Da, Min Zhou, Haihong Yan, Dan Zheng, Sen Zhong, Shasha Cai, Huiping Zhu, Yunsheng LiAbstractChronic kidney disease (CKD) is a major cause of death. Renal fibrosis and inflammation are common pathways contributing to the development of this disease. However, the molecular mechanisms underlying CKD are not fully understood. TRPM2 (Transient receptor potential...
Thu Oct 24, 2019 16:33
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Mengyun Ke, Zhenhai Zhang, Longlong Cong, Shidi Zhao, Yan Li, Xiaofei Wang, Yi Lv, Ying Zhu, Jian DongAbstractBackgroundMicroRNAs (miRNAs) are small non-coding molecules that exhibit important regulatory roles in various biological or cellular functions, including tumor metastasis. However, the detailed mechanisms of the expression and functions of miRNAs in hepatocellular carcinoma (HCC) have not yet been...
Thu Oct 24, 2019 16:33
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Caiyan Liu, Shenshen Yang, Kailong Wang, Xiaomei Bao, Yiman Liu, Shiyue Zhou, Hongwei Liu, Yuling Qiu, Tao Wang, Haiyang YuAbstractHepatocellular carcinoma (HCC) has become one of the major diseases that are threatening human health in the 21st century. Currently there are many approaches to treat liver cancer, but each has its own advantages and disadvantages. Among various methods of treating liver cancer,...
Thu Oct 24, 2019 16:33
Publication date: Available online 24 October 2019Source: Clinical TherapeuticsAuthor(s): John M. Allen, Brian W. GilbertAbstractPurposeAngiotensin II (ATII) is a potent endogenous vasoconstrictor that has recently garnered regulatory approval for the treatment of distributive shock, including septic shock. Traditional vasoactive substances used in the management of distributive shock include norepinephrine, epinephrine, phenylephrine, and vasopressin. However, their use can be associated with deleterious...
Thu Oct 24, 2019 12:59
Summary Background Esophageal cancer is a very common malignant tumor in China, especially esophageal squamous cell carcinoma (ESCC), but there is currently no effective treatment for patients after first-line chemotherapy failure. Apatinib has shown promising outcomes in treatment with various solid tumors. Objectives To evaluate the clinical efficacy and safety of apatinib combined with S-1 in the treatment of advanced ESCC patients after first-line chemotherapy failure. Methods...
Thu Oct 24, 2019 03:00
Summary Epithelial ovarian cancer (EOC) accounts for nearly 90% of all ovarian malignancies. The standard therapeutic strategy includes cytoreductive surgery and neo (adjuvant) platinum-based chemotherapy. Relapse of advanced high grade serous ovarian cancer (HGSOC) is related to the development of drug resistance. A defective DNA damage response is a defining hallmark of HGSOC. Poly (ADP-ribose) polymerase (PARP) inhibitors exploit this deficiency through synthetic lethality and...
Thu Oct 24, 2019 03:00
Publication date: Available online 23 October 2019Source: Radiotherapy and OncologyAuthor(s): Pirus Ghadjar, Claudio Fiorino, Per Munck af Rosenschöld, Michael Pinkawa, Thomas Zilli, Uulke A. van der HeideAbstractUse of image-guided radiation therapy (IGRT) helps to account for daily prostate position changes during radiation therapy for prostate cancer. However, guidelines for the use of IGRT are scarce.An ESTRO panel consisting of leading radiation oncologists and medical physicists was assembled...
Thu Oct 24, 2019 16:35
Publication date: Available online 23 October 2019Source: Radiotherapy and OncologyAuthor(s): Thomas Philip Shakespeare, Elizabeth Eggert, Maree Wood, Justin Westhuyzen, Kirsty Turnbull, Natalie Rutherford, Noel AherneAbstractPurpose/objectivesThere are no published reports of prostate specific membrane antigen (PSMA) positron emission tomography (PET) guided dose-escalated intensity-modulated radiation therapy (DE-IMRT) in newly diagnosed lymph node (LN) positive prostate cancer. We report early...
Thu Oct 24, 2019 16:35
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Min Feng, Hui Guo, Chen Zhang, Yanlin Wang, Zhaojun Liang, Xiangcong Zhao, Yan Qin, Yanyao Wu, Guangying Liu, Chong Gao, Jing LuoAbstractAimThe study aimed to investigate the changes in peripheral lymphocyte and CD4+T subsets and to observe the regulatory effect of low-dose interleukin-2 (ld-IL2) on these cells in polymyositis or dermatomyositis (PM/DM).MethodsLymphocyte subsets (CD3+T, CD4+T, CD8+T, B and...
Thu Oct 24, 2019 13:34
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Haitao Yu, Hengtong Han, Jiajia Li, Danyang Li, Lili JiangAbstractPurposeTo explore potential biomarkers for identifying systemic lupus erythematosus (SLE) with liver injury.MethodsThis retrospective study examined the records of 158 SLE cases. The Apriori algorithm of association rules was employed to identify laboratory indexes related to liver injury in SLE patients.ResultsThe ratio of albumin to globulin;...
Thu Oct 24, 2019 13:34
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Qian Zhang, Jie Liu, Lei Ma, Na Bai, Huirong XuAbstractPurposeTo explore whether receptor activator of nuclear factor kappa-B ligand (RANKL) is involved in the nosogenesis of peri-implantitis and to reveal the regulatory mechanism in Porphyromonas gingivalis induced RANKL production.MethodsTherefore, we collected peri-implant crevicular fluid (PICF) and gingival tissues from healthy implants and peri-implantitis...
Thu Oct 24, 2019 13:34
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Xue-ke Du, Wang-yun Ge, Ren Jing, Ling-hui PanAbstractZ-DNA combined protein-1 (ZBP-1), an important necroptosis regulator, activates necrosis-associated inflammation and immune response. Increased ZBP-1 expression in necroptosis-associated inflammation correlates with activation of receptor interacting protein kinase (RIPK1)/RIPK3 and nuclear factor (NF)-κB. Here we explored the role of ZBP-1-mediated necroptosis...
Thu Oct 24, 2019 13:34
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Yaxian Wu, Yunjuan Nie, Jianfeng Huang, Yubao Qiu, Binbin Wan, Gang Liu, Junliang Chen, Dan Chen, Qingfeng PangAbstractAcute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) caused by gram-positive bacteria threatens human life because effective treatments and medicines is unavailable. Protostemonine (PSN), an active alkaloid mainly isolated from the roots of Stemona sesslifolia,...
Thu Oct 24, 2019 13:34
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Hui-Ning Fan, Wei Chen, Li-Na Fan, Jing-Tong Wu, Jin-Shui Zhu, Jing ZhangAbstractBackgroundSevere acute pancreatitis (SAP) is a common threat to human health. In the present study, we aimed to investigate the underlying mechanisms by which p38α in macrophages contributes to SAP. We used conditional knockout of p38α in macrophages and p38 MAPK inhibitors to understand the effects of p38α in macrophages on...
Thu Oct 24, 2019 13:34
External Volume Expansion Adjusted Adipose Stem Cell by Shifting the Ratio of Fibronectin to Laminin
Tissue Engineering Part A, Ahead of Print.
Thu Oct 24, 2019 10:00
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