Radiotherapy and Oncology
- End-to-end empirical validation of dose accumulation in MRI-guided adaptive radiotherapy for prostate cancer using an anthropomorphic deformable pelvis phantomIn-room image-guidance has become a cornerstone in radiotherapy, both for assessing inter-fractional anatomical changes and performing adaptive radiotherapy (ART) [1,2]. The position and shape of target and critical organs may vary during the course of radiotherapy and, in the absence of online plan adaptation, can lead to differences between the planned and the actual delivered dose distribution [3,4]. Recently, the potential of MR-guided radiot
Radiation Molecular Biology.
- Proton Beam Therapy for Histologically or Clinically Diagnosed Stage I Non-small Cell Lung Cancer (NSCLC): The First Nationwide Retrospective Study in JapanPublication date: Available online 1 October 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Kayoko Ohnishi, Naoki Nakamura, Hideyuki Harada, Sunao Tokumaru, Hitoshi Wada, Takeshi Arimura, Hiromitsu Iwata, Yoshitaka Sato, Yuta Sekino, Hiroyasu Tamamura, Jun-etsu Mizoe, Takashi Ogino, Hitoshi Ishikawa, Yasuhito Kikuchi, Tomoaki Okimoto, Shigeyuki Murayama, Tetsuo Akimoto, Hideyuki SakuraiAbstractPurposeTo investig
- Pelvic insufficiency fractures after external beam radiotherapy for gynecologic cancers: a meta-analysis and meta-regression of 3,929 patientsPublication date: Available online 30 September 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Lucas Gomes Sapienza, Mila Pontremoli Salcedo, Matthew Stephen Ning, Anuja Jhingran, Ann H. Klopp, Vinícius Fernando Calsavara, Kathleen M. Schmeler, Maria José Leite Gomes, Emanuel de Freitas Carvalho, Glauco BaiocchiAbstractPurposeTo estimate the overall rate, symptomatic proportion, and most common sites of pelvic i
- Estimating PTV margins in head and neck stereotactic ablative radiation therapy (SABR) through target site analysis of positioning and intrafractional accuracyPublication date: Available online 30 September 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Shane Mesko, He Wang, Samuel Tung, Congjun Wang, Dario Pasalic, Bhavana V. Chapman, Amy C. Moreno, Jay P. Reddy, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Steven J. Frank, Clifton D. Fuller, William Morrison, Jack PhanAbstractPurpose/Objective(s)Recurrent and/or previously irradiated head and neck cancers (H
- Selection of Head and Neck Cancer Patients for Intensive TherapyPublication date: Available online 30 September 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Lucas K. Vitzthum, Helen Park, Kaveh Zakeri, Alex K. Bryant, Christine Feng, Hanjie Shen, Ezra E.W. Cohen, James D. Murphy, Loren K. MellAbstractPurposePrevious studies have found that head and neck cancer (HNC) patients with a higher relative hazard for recurrence vs. competing mortality (ω+ ratio) are more likely to
Experimental Dermatology
- Increased expression of TLR7 and TLR9 in alopecia areataAbstract Alopecia areata (AA) is thought to be an autoimmune process. In other autoimmune diseases, the innate immune system and Toll‐like receptors (TLRs) can play a significant role. Expression of TLR7, TLR9, and associated inducible genes were evaluated by quantitative PCR in peripheral blood mononuclear cells (PBMCs) from 10 healthy individuals and 19 AA patients, categorized according to disease duration, activity, and hair loss extent. Mic
- Ex vivo culture of mouse skin activates an interleukin 1 alpha‐dependent inflammatory responseAbstract Ex vivo culture of mouse and human skin causes an inflammatory response characterized by production of multiple cytokines. We used ex vivo culture of mouse tail skin specimens to investigate mechanisms of this skin culture‐induced inflammatory response. Multiplex assays revealed production of interleukin 1 alpha (IL‐1α), interleukin 1 beta (IL‐1β), interleukin 6 (IL‐6), chemokine C‐X‐C motif ligand 1 (CXCL1), granulocyte colony stimulat
- Morphological and elemental analysis of silver penetration into sound/demineralized dentin after SDF applicationPublication date: Available online 30 September 2019Source: Dental MaterialsAuthor(s): Mahmoud Sayed, Naoko Matsui, Motohiro Uo, Toru Nikaido, Masakazu Oikawa, Michael F. Burrow, Junji TagamiAbstractObjectiveThe aim of this study was to evaluate the penetration depth of silver into sound and demineralized dentin after application of silver diamine fluoride (SDF).MethodsTwo hundred and eighty-eight dentin specimens were used. The specimens were di
- Reply to: Letter comments on: Time course of improvement after re-repair procedure for VPI managementPublication date: Available online 30 September 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Ahmed Elsherbiny, Meghan Amerson, Laura Sconyers, John H. Grant
- Relative contributions of implant hydrophilicity and nanotopography to implant anchorage in bone at Early Time PointsAbstract Objective To compare the contributions of implant hydrophilicity and nanotopography on anchorage in bone. The effect of elevated calcium surface chemistry on bone anchorage was also investigated. Materials and Methods A full factorial study design was implemented to evaluate the effects of ultraviolet (UV) light and/or sodium lactate (SL), and discrete crystalline deposition of nanocrystals (DCD) treatments on the osseointegrat
- The Effect of Different Wax Pattern Fabrication Techniques on the Marginal Fit of Customized Lithium Disilicate Implant AbutmentsAbstract Purpose To evaluate the effect of different wax pattern fabrication techniques on the fit of customized pressed lithium disilicate implant abutments on titanium inserts before and after pressing. The marginal fit results of pressed lithium disilicate implant abutments were then compared with those of milled lithium disilicate abutments Materials and Methods After scanning the titanium inserts and designing an implant abutment,
JNM Current Issue
- Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax ProteinsIncreased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (to form PA-L1). Anthrax lethal factor (LF) is then able to translocate through these pores. Here, we used a 111In-radiolabeled form of LF with the PA/LF system for noninvasive in vivo
- A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence ImagingAntibody-based dual-modality (PET/fluorescence) imaging enables both presurgery antigen-specific immuno-PET for noninvasive whole-body evaluation and intraoperative fluorescence for visualization of superficial tissue layers for image-guided surgery. Methods: We developed a universal dual-modality linker (DML) that facilitates site-specific conjugation to a cysteine residue–bearing antibody fragment, introduction of a commercially available fluor
- Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET StudyThe standardization of preclinical imaging is a key factor to ensure the reliability, reproducibility, validity, and translatability of preclinical data. Preclinical standardization has been slowly progressing in recent years and has mainly been performed within a single institution, whereas little has been done in regards to multicenter standardization between facilities. This study aimed to investigate the comparability among preclinical imagin
- Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple SclerosisCerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer disease. The current study investigates the magnitude of 11C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer and mild cognitive impairment subjects. We have also evaluated multiple scleros
- Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life SpanMeasuring early tau accumulation is important in studying aging and Alzheimer disease and is only as accurate as the signal-to-noise ratio of the tracer. Along with aggregated tau in the form of neurofibrillary tangles, 18F-flortaucipir has been reported to bind to neuromelanin, monoamine oxidase, calcifications, iron, leptomeningeal melanocytes, and microhemorrages. Although 18F-flortaucipir successfully differentiates healthy controls (HCs) fro
- Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot StudyThis study aimed at evaluating hybrid multispectral optoacoustic tomography/ultrasound for imaging of thyroid disorders, including Graves’ disease and thyroid nodules. Methods: The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves’ disease (n = 6), thyroid lobes with healthy tissue
- 64Cu-Intraperitoneal Radioimmunotherapy: A Novel Approach for Adjuvant Treatment in a Clinically Relevant Preclinical Model of Pancreatic CancerPancreatic cancer (PC) has a very poor prognosis. Surgery is the primary treatment for patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal dissemination often occur even after extensive surgery. Adjuvant chemotherapy, typically with gemcitabine, has been used clinically but with only a modest survival benefit. To achieve a better outcome, we investigated the efficacy of 64Cu-intraperitoneal radioimmunotherap
- Bone Marrow Absorbed Doses and Correlations with Hematologic Response During 177Lu-DOTATATE Treatments Are Influenced by Image-Based Dosimetry Method and Presence of Skeletal MetastasesThis study aimed to compare different image-based methods for bone marrow dosimetry and study the dose–response relationship during treatment with 177Lu-DOTATATE in patients with and without skeletal metastases. Methods: This study included 46 patients with advanced neuroendocrine tumors treated with at least 2 fractions of 177Lu-DOTATATE at Sahlgrenska University Hospital. High- and low-uptake compartments were automatically outlined in planar i
- Multimodality Imaging of Prostate CancerProstate cancer is a very heterogeneous disease, and contemporary management is focused on identification and treatment of the prognostically adverse high-risk tumors while minimizing overtreatment of indolent, low-risk tumors. In recent years, imaging has gained increasing importance in the detection, staging, posttreatment assessment, and detection of recurrence of prostate cancer. Several imaging modalities including conventional and functiona
- Bridging the Imaging Gap: PSMA PET/CT Has a High Impact on Treatment Planning in Prostate Cancer Patients with Biochemical Recurrence--A Narrative Review of the Literature68Ga- and 18F-labeled prostate-specific membrane antigen (PSMA) molecules have created new opportunities for the unmet diagnostic needs in prostate cancer. The purpose of this article is to give an overview of studies that have examined the role of PSMA PET in treatment planning for prostate cancer patients with biochemical recurrence (BCR). Methods: Medline, Embase, Web of Science, Google Scholar, and Cochrane Central were searched for relevant
- Intention-to-Treat Analysis of 68Ga-PSMA and 11C-Choline PET/CT Versus CT for Prostate Cancer Recurrence After SurgeryBiochemical recurrence (BCR) after prostate cancer surgery is common, even after additional salvage radiotherapy. BCR might be explained by target miss. Improved diagnostic accuracy provided by PET could potentially circumvent this therapeutic gap. Therefore, we evaluated consecutive 68Ga-prostate-specific membrane antigen (PSMA) PET/CT, 11C-choline PET/CT, and standard CT imaging in the same patient with regard to TNM-stage migration and accordi
- Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor RetentionCancer-associated fibroblasts constitute a vital subpopulation of the tumor stroma and are present in more than 90% of epithelial carcinomas. The overexpression of the serine protease fibroblast activation protein (FAP) allows a selective targeting of a variety of tumors by inhibitor-based radiopharmaceuticals (FAPIs). Of these compounds, FAPI-04 has been recently introduced as a theranostic radiotracer and demonstrated high uptake into different
- Combining 18F-FDG PET/CT-Based Metabolically Active Tumor Volume and Circulating Cell-Free DNA Significantly Improves Outcome Prediction in Chemorefractory Metastatic Colorectal CancerBaseline whole-body metabolically active tumor volume (WB-MATV) measured by 18F-FDG PET/CT and circulating cell-free DNA (cfDNA) have been separately validated as predictors of overall and progression-free survival (OS/PFS) in chemorefractory metastatic colorectal cancer (mCRC) patients. This study assessed the correlation between WB-MATV and cfDNA, evaluating the added prognostic value of these in combination, along with clinical parameters. Met
- Treatment-Related Uptake of O-(2-18F-Fluoroethyl)-L-Tyrosine and L-[Methyl-3H]-Methionine After Tumor Resection in Rat Glioma ModelsAssessment of residual tumor after resection of cerebral gliomas can be difficult with MRI and may be improved by amino acid PET. The aim of this experimental study was to investigate uptake of 2-18F-fluoroethyl-l-tyrosine (18F-FET) and l-[methyl-3H]-methionine (3H-MET) in residual tumor after surgery and possible false-positive uptake in treatment-related changes. Methods: F98 or GS-9L rat gliomas were implanted into the brain of 64 rats. Tumors
- Side Effects of CXC-Chemokine Receptor 4-Directed Endoradiotherapy with Pentixather Before Hematopoietic Stem Cell TransplantationThe chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane receptor involved in survival, proliferation, and dissemination of different cancers, including hematopoietic malignancies. Relapsed or refractory hematopoietic cancers are frequently resistant to conventional therapy, and novel highly active strategies are urgently needed. CXCR4-directed endoradiotherapy constitutes a highly promising targeted therapeutic concept. Here, w
- Preclinical Pharmacokinetics and Dosimetry Studies of 124I/131I-CLR1404 for Treatment of Pediatric Solid Tumors in Murine Xenograft ModelsCancer is the second leading cause of death for children between the ages of 5 and 14 y. For children diagnosed with metastatic or recurrent solid tumors, for which the utility of external-beam radiotherapy is limited, the prognosis is particularly poor. The availability of tumor-targeting radiopharmaceuticals for molecular radiotherapy (MRT) has demonstrated improved outcomes in these patient populations, but options are nonexistent or limited f
- A Pilot Study on Hepatobiliary Scintigraphy to Monitor Regional Liver Function in 90Y RadioembolizationRadioembolization is increasingly used as a bridge to resection (i.e., radiation lobectomy). It combines ipsilateral tumor control with the induction of contralateral hypertrophy to facilitate lobar resection. The aim of this pilot study was to investigate the complementary value of hepatobiliary scintigraphy (HBS) before and after radioembolization in the assessment of the future remnant liver. Methods: Consecutive patients with liver tumors who
- Summary of the First ISMRM-SNMMI Workshop on PET/MRI: Applications and LimitationsSince the introduction of simultaneous PET/MRI in 2011, there have been significant advancements. In this review, we highlight several technical advancements that have been made primarily in attenuation and motion correction and discuss the status of multiple clinical applications using PET/MRI. This review is based on the experience at the first PET/MRI conference cosponsored by the International Society for Magnetic Resonance in Medicine and th
- 68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in MiceShank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of nuclear factor -light-chain enhancer of activated B cells and regulation of inflammation. Furthermore, SHARPIN controls integrin-dependent cell adhesion and migration in several normal and malignant cell types, and loss of SHARPIN correlates with increased integrin activity in mice. Arginyl-glycyl-aspartic acid (RGD), a cell adhe
- Effect of External Cooling on 177Lu-PSMA Uptake by the Parotid GlandsRecent years have seen the start of treatment of metastatic castration-resistant prostate cancer with prostate-specific membrane antigen (PSMA)–targeted radioligand therapy (PRLT), especially 177Lu-PSMA-617. However, PRLT has side effects on the salivary glands that limit the safety of the treatment. The current study aimed to show the effect of external cooling with ice packs on 177Lu-PSMA-617 uptake by the parotid glands (PGs). Methods: The stu
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
- Sensitive analysis of Multiple Low-molecular-weight Thiols in a Single Human Cervical Cancer Cell by Chemical Derivatization-Liquid Chromatography-Mass SpectrometryAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01566C, PaperHua-Ming Xiao, Xian Wang, Quan-Lan Liao, Shuai Zhao, Wei-Hua Huang, Yu-Qi FengLow-molecular-weight (LMW) thiols are important small molecules that regulate or maintain redox homeostasis in physiological and pathological processes. Assessing the concentrations of LMW thiols in biological systems may provide valuable...The content of this RSS Feed (c) The Royal Society of Chemistry
- Detection of phosphorous species in waters: technology and strategyAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01161G, Critical ReviewHongwei Chen, Linlu Zhao, Fabiao Yu, Qiaoling DuPhosphorus species are the sum of naturally evolved phosphorus elements with diverse forms of existence and unique properties. The detection and analysis to the optical properties of unknown phosphorus species...The content of this RSS Feed (c) The Royal Society of Chemistry
- A fast nucleic acid extraction system for point-of-care and integration of digital PCRAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01067J, PaperJuxin Yin, Jiumei Hu, Jingjing Sun, Ben Wang, Ying MuDigital PCR is a powerful amplification method for absolute quantification of nucleic acids. The systems that integrated the nucleic acid extraction and amplification can reduce detection time, improve accuracy, and...The content of this RSS Feed (c) The Royal Society of Chemistry
- Advances in Nanoplasmonic biosensors for clinical applicationsAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00701F, Critical ReviewElba Mauriz, Priyanka Dey, Laura Maria LechugaBiomarkers are unquestionable biological indicators for diagnosis and therapeutic interventions providing appropriate classification of a wide range of health disorders and risk factors. Nonetheless, detection and quantification of biomarkers need...The content of this RSS Feed (c) The Royal Society of Chemistry
- Zero electrical power pump for portable high-performance liquid chromatographyAnalyst, 2019, Advance ArticleDOI: 10.1039/C9AN01302D, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stelios Chatzimichail, Duncan Casey, Ali Salehi-ReyhaniA major trend in analytical chemistry is the miniaturization of laboratory instrumentation. We present a portable high-performance liquid chromatography system for field based chemical analyses.To cite this article before page numbers ar
- A novel electrochemical sensor based on microporous polymeric nanospheres for measuring peroxynitrite anion released by living cells and studying the synergistic effect of antioxidantsAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01693G, PaperFuxin Liu, Lin Li, Binyan Zhang, Weizhou Fan, Rongjin Zhang, Guoan Liu, Xiuhui LiuPeroxynitrite anion (ONOO–) is a crucial reactive nitrogen species (RNS), which has aroused immense research interest in the biological and biomedical fields because aberrant expression levels of ONOO– are related...The content of this RSS Feed (c) The Royal Society of Chemistry
Τρίτη 1 Οκτωβρίου 2019
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