The use of either immune checkpoint blockade or RAF/MEK inhibitors represents standard of care treatment options for metastatic melanoma. Each class of these drugs has distinct response kinetics, adverse effects, and unique clinical challenges. Combination of immune checkpoint blockade and RAF/MEK inhibitors may result in rapid and durable responses, however, the potential adverse effects of such combinations are poorly characterized. Here, we describe the case of a patient with BRAF-mutant melanoma...
Thu Oct 17, 2019 03:00
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Ha-Yeon Song, Woo Sik Kim, Jin-Man Kim, Dong-Ho Bak, Jeong Moo Han, Seung-Taik Lim, Eui-Baek ByunAbstractInflammatory bowel disease (IBD) is a chronic disease that occurs in the intestinal tract. Phyto-ingredients have been evaluated for their ability to protect against IBD because of their anti-inflammatory activities. In our previous study, we identified a novel derivative of chrysin (HE-chrysin) using...
Sun Oct 20, 2019 19:06
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Qingqing Shen, Jingjing Wang, Ziqiao Yuan, Zhenzhou Jiang, Ting Shu, Dengqiu Xu, Jinyong He, Luyong Zhang, Xin HuangAbstractTripterygium wilfordii Hook. F. (TwHF), a traditional Chinese Medicine, is effective in treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive application. The nephrotoxic mechanism of Triptolide (TP), the main pharmacological and toxic component of TwHF,...
Sun Oct 20, 2019 19:06
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s):
Sun Oct 20, 2019 19:06
Publication date: Available online 19 October 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Aric Vaidya, Yusuke Ohmichi, Munekazu Naito, Takashi Nakano, Hirohiko Kakizaki, Yasuhiro TakahashiAbstractPurposeTo examine the positional relationship between the medial canthal tendon (MCT) and the common canalicular orifice (CCO) in cadavers.MethodsThis experimental anatomical study was conducted using 75 orbits from 48 embalmed Japanese cadavers fixed in 10% buffered formalin (24 orbits...
Sun Oct 20, 2019 18:24
Publication date: Available online 19 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Steven Halepas, Scott M. Peters, Jenna L. Goldsmith, Elie M. FerneiniAbstractThe use of facial fillers for soft tissue augmentation is becoming a mainstream treatment modality for patients. Due to the relative ease of administration, as well as the lucrative nature of such procedures, the number of providers offering facial fillers has been expanding. While many of these are minor and localized...
Sun Oct 20, 2019 18:24
Publication date: Available online 19 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Chad M. Rasmussen, Paul J. Meyer, John E. Volz, James M. Van Ess, Thomas J. SalinasPurposeThe purpose of this investigation was to evaluate the diagnostic agreement in anterior-posterior categorization of the maxilla and mandible between a skeletal landmark analysis versus a facial landmark analysis for treatment planning orthognathic surgery and orthodontics.MethodsA retrospective consecutive...
Sun Oct 20, 2019 18:24
Abstract Objectives Salivary exosomes harbour numerous constituents associated with oral and systemic diseases. However, no reports addressed components of salivary exosomes in patients with periodontitis. Our study aims to explore salivary exosomal proteins in young adults with severe periodontitis (SP) and to analyse the relationships between different proteins. Materials and Methods We collected saliva from 11 young adults with SP and 11 periodontally healthy subjects. After isolation...
Sun Oct 20, 2019 16:39
Publication date: Available online 19 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Maryam Pourhajibagher, Nasim Chiniforush, Abbas BahadorAbstractBackgroundThe limitations of conventional chemo-mechanic therapy in endodontic have given rise to introduce and develop photoactivated disinfection (PAD) as an adjunctive treatment. The objective of this ex vivo study was to evaluate the effects of PAD using C-Phycocyanin, as a natural photosensitizer, on biological activities and...
Sun Oct 20, 2019 17:59
Publication date: Available online 19 October 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): M. Ibrahim Khot, Candice L. Downey, Gemma Armstrong, Hafdis S. Svavarsdottir, Fazain Jarral, Helen Andrew, David G. JayneAbstractThe ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) transmembrane protein transporter is known for conferring resistance to treatment in cancers. Photodynamic therapy (PDT) is a promising anti-cancer method involving the use of light-activated photosensitisers...
Sun Oct 20, 2019 17:59
Publication date: Available online 19 October 2019Source: NeuroImageAuthor(s): Maxi Becker, Tobias Sommer, Simone KühnAbstractIn verbal creative problems like compound remote associates (CRAs), the solution is semantically distant and there is no predefined path to the solution. Therefore, people first search through the space of possible solutions before retrieving the correct semantic content by extending their search space. We assume that search and solution are both part of a semantic control...
Sun Oct 20, 2019 17:34
Publication date: Available online 19 October 2019Source: NeuroImageAuthor(s): Anita Harrewijn, Rany Abend, Julia Linke, Melissa A. Brotman, Nathan A. Fox, Ellen Leibenluft, Anderson M. Winkler, Daniel S. PineAbstractNeuroimaging studies typically focus on either resting state or task-based fMRI data. Prior research has shown that similarity in functional connectivity between rest and cognitive tasks, interpreted as reconfiguration efficiency, is related to task performance and IQ. Here, we extend...
Sun Oct 20, 2019 17:34
Publication date: Available online 19 October 2019Source: NeuroImageAuthor(s): Kenneth F. Valyear, Benjamin A. Philip, Carmen M. Cirstea, Pin-Wei Chen, Nathan Baune, Noah Marchal, Scott H. FreyAbstractAnimal models reveal that deafferenting forelimb injuries precipitate reorganization in both contralateral and ipsilateral somatosensory cortices. The functional significance and duration of these effects are unknown, and it is unclear whether they also occur in injured humans. We delivered cutaneous...
Sun Oct 20, 2019 17:34
Publication date: Available online 19 October 2019Source: NeuroImageAuthor(s): Kati Roesmann, Nele Wiens, Constantin Winker, Maimu Alissa Rehbein, Ida Wessing, Markus JunghoeferAbstractConditioned fear frequently generalizes towards perceptually similar, but harmless stimuli. Knowledge on these similarities between conditioned stimuli (CS) and generalization stimuli (GS) may be explicit or implicit. Employing behavioral measures and whole-head magnetoencephalography, we here investigated the neurocognitive...
Sun Oct 20, 2019 17:34
Publication date: Available online 19 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leighton Reed, Anthony Grady, Caleb Wilson, Rosemary StocksAbstractCoffin-Siris Syndrome (CSS) is a genetic syndrome associated with multiple congenital anomalies due to mutations in the BAF-complex or SOX gene. Although well characterized overall, the subunits of the BAF-complex or SOX gene affected demonstrate phenotypic differences which are continuing to be defined. Among...
Sun Oct 20, 2019 16:55
Publication date: Available online 19 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Diane Lee, Matt Wallden
Sun Oct 20, 2019 16:51
Halotolerant Rhizobacterial Strains Mitigate the Adverse Effects of NaCl Stress in Soybean Seedlings
Background. Salinity is one of the major abiotic constraints that hinder health and quality of crops. Conversely, halotolerant plant growth-promoting rhizospheric (PGPR) bacteria are considered biologically safe for alleviating salinity stress. Results. We isolated halotolerant PGPR strains from the rhizospheric soil of Artemisia princeps, Chenopodium ficifolium, Echinochloa crus-galli, and Oenothera biennis plants; overall, 126 strains were isolated. The plant growth-promoting traits of these isolates...
Sun Oct 20, 2019 16:05
Aim. The aim of our study was to assay circulating interleukin-15 (IL-15) and interleukin-6 (IL-6) levels and insulin resistance measured by two different methods in newly diagnosed autoimmune diabetes (AD) patients, their I° relatives, and healthy controls. Material and Methods. The group studied consisted of 54 patients with AD (28 with Latent Autoimmune Diabetes in Adults (LADA) and 26 with type 1 diabetes (T1D)), 70 first-degree relatives, and 60 controls. IL-6, IL-15, and anti-islet antibodies...
Sun Oct 20, 2019 16:05
We present entry and exit screening outcomes on all persons passing through Freetown International Airport (FNA) in Sierra Leone during the period 1st September 2014 to 4th February 2016. A total of 166,242 persons underwent screening for Ebola Virus Disease (EVD) at FNA. Five persons were denied air travel from Sierra Leone after secondary screening. Laboratory testing revealed none were positive for EVD. No cases were identified through entry screening route. The public health value of airport...
Sun Oct 20, 2019 16:05
ACK1 is a nonreceptor tyrosine kinase with a unique structure, which is tightly related to the biological behavior of tumors. Previous studies have demonstrated that ACK1 was involved with multiple signaling pathways of tumor progression. Its crucial role in tumor cell proliferation, apoptosis, invasion, and metastasis was tightly related to the prognosis and clinicopathology of cancer. ACK1 has a unique way of regulating cellular pathways, different from other nonreceptor tyrosine kinases. As an...
Sun Oct 20, 2019 16:05
Related ArticlesExercise Science and the Vocalist. J Voice. 2019 Oct 15;: Authors: Johnson AM, Sandage MJ Abstract The application of exercise science training knowledge has been of growing interest to voice professionals. This tutorial, derived from the authors' invited presentations from the "Exercise and the Voice" Special Session at the 2018 Voice Foundation Symposium, proposes a foundational theoretical structure based in exercise science, clarifies...
Sun Oct 20, 2019 16:21
Publication date: Available online 19 October 2019Source: Cancer/RadiothérapieAuthor(s): S. Yuce Sari, M. Cengiz, A. Dauletkazin, G. Yazici, M. Gultekin, P. Hurmuz, F. Yildiz, F. Zorlu, M. Gurkaynak, F. Akyol, G. OzyigitAbstractPurposeTo evaluate the efficacy and toxicity of hypofractionated radiotherapy in non-metastatic soft tissue and bone sarcomas.Patients and methodsThirty patients underwent hypofractionated radiotherapy between 2007 and 2015. Overall, 17 patients underwent primary hypofractionated...
Sun Oct 20, 2019 16:05
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