Allergy
- Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophiliaAbstract Background Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is elevated and promotes immune cell activation, leading to the development of asthma. However, which immune cells are responsible for triggering airway hyperreactivity (AHR), inflammation and eosinophilia remained to be clarified. We aimed to elucidate the individual roles of IL‐33‐activated innate immune cells,
Allergy and Clinical Immunology
- Combined Immunodeficiency due to a loss of function mutation in DNA Polymerase Delta 1Publication date: Available online 16 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Ye Cui, Sevgi Keles, Louis-Marie Charbonnier, Amélie M. Julé, Lauren Henderson, Seyma Celikbilek Celik, Ismail Reisli, Chen Shen, Wen Jun Xie, Klaus Schmitz-Abe, Hao Wu, Talal A. ChatilaAbstractBackgroundMutations affecting DNA polymerases have been implicated in genomic instability and cancer development, but the mechanisms by which the
- Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatmentPublication date: Available online 15 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Cameron H. Flayer, Erik D. Larson, Anjali Joseph, Sean Kao, Wenxiu Qu, Austin Van Haren, Christopher M. Royer, Lisa A. Miller, John P. Capitanio, Thais Sielecki, Melpo Christofidou-Solomidou, Angela HaczkuBackgroundOzone (O3) inhalation elicits airway inflammation and impairs treatment responsiveness in asthmatic patients. The underlying
- Allergy to prebiotic galacto-oligosaccharides: House dust mites the putative primary sensitizerPublication date: Available online 15 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Li Yuan Gabriella Nadine Lee, Youjia Zhong, Si Yuan Leow, Shan Chun Lim, Hongmei Wen, Jian Yi Soh, Wen Chin Chiang, Dianne J. Delsing, Bee Wah Lee, Chiung-Hui Huang
- Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidencePublication date: Available online 15 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jean Bousquet, Holger J. Schünemann, Akdis Togias, Claus Bachert, Martina Erhola, Peter W. Hellings, Ludger Klimek, Oliver Pfaar, Dana Wallace, Ignacio Ansotegui, Ioana Agache, Anna Bedbrook, Karl-Christian Bergmann, Mike Bewick, Philippe Bonniaud, Sinthia Bosnic-Anticevich, Isabelle Bossé, Jacques Bouchard, Louis-Philippe Boulet, Jan Br
- Dichotomous Role of TGF-β Controls Inducible Treg Cell Fate in Allergic Airway Disease Through Smad3 and TAK1Publication date: Available online 15 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Anthony Joetham, Michaela Schedel, Fangkun Ning, Meiqin Wang, Katsuyuki Takeda, Erwin W. GelfandAbstractBackgroundInducible CD4+CD25+ T regulatory cells (iTregs) can become pathogenic effector cells, enhancing lung allergic responses.ObjectiveWe aimed to define the underlying cellular and molecular pathways activated by TGF-β which deter
- Evolution of pathologic T-cell subsets in atopic dermatitis from infancy to adulthoodPublication date: Available online 15 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Tali Czarnowicki, Helen He, Talia Canter, Joseph Han, Rachel Lefferdink, Taylor Erickson, Stephanie Rangel, Naoya Kameyama, Hyun Je Kim, Ana B. Pavel, Yeriel Estrada, James G. Krueger, Amy S. Paller, Emma Guttman-YasskyAbstractBackgroundThe circulating immune phenotype was defined in adults and young children with early atopic dermatitis
- Severe asthma during childhood and adolescence: A longitudinal studyPublication date: Available online 14 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Kristie R. Ross, Ritika Gupta, Mark D. DeBoer, Joe Zein, Brenda R. Phillips, David T. Mauger, Chun Li, Ross E. Myers, Wanda Phipatanakul, Anne M. Fitzpatrick, Ngoc P. Ly, Leonard B. Bacharier, Daniel J. Jackson, Juan C. Celedón, Allyson Larkin, Elliot Israel, Bruce Levy, John V. Fahy, Mario Castro, Eugene R. BleeckerAbstractBackgroundMor
- IκBζ is a key player in the anti-psoriatic effects of secukinumabPublication date: Available online 14 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Trine Bertelsen, Christine Ljungberg, Thomas Litman, Christine Huppertz, Robert Hennze, Kirsten Rønholt, Lars Iversen, Claus JohansenAbstractBackgroundIκBζ plays a key role in psoriasis by mediating IL-17A-driven effects, but the molecular mechanism by which IL-17A regulates IκBζ expression is not clarified.ObjectiveTo explore the molecu
- Cys-LTs’ Pro-phlogistic Lung Actions Are Regulated by Cys-MaresinsPublication date: Available online 14 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Bruce D. Levy, Raja-Elie E. Abdulnour, Alexander Tavares, Thayse R. Brüggemann, Paul C. Norris, Yan Bai, Xingbin Ai, Charles N. SerhanAbstractBackgroundCysteinyl leukotrienes (CysLTs) are potent pro-phlogistic mediators in asthma; however, inhibition of CysLT1 receptors is not a consistently effective treatment, suggesting additional reg
- Relationship between birth weight or fetal growth rate and postnatal allergy: A systematic reviewPublication date: Available online 12 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Amy L. Wooldridge, Mark McMillan, Manpreet Kaur, Lynne C. Giles, Helen S. Marshall, Kathryn L. GatfordBackgroundIndividual susceptibility to allergic diseases is developmentally programmed by early-life exposures. Evidence from preclinical studies suggests that intrauterine growth restriction is protective against later inflammatory resp
- Environmental factors associated with allergy in urban and rural children from the South AFrican Food Allergy (SAFFA) cohortPublication date: Available online 10 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Michael E. Levin, Maresa Botha, Wisdom Basera, Heidi E. Facey-Thomas, Ben Gaunt, Claudia L. Gray, Wanjiku Kiragu, Jordache Ramjith, Alexandra Watkins, Jon GenuneitAbstractBackgroundThe prevalence of allergic diseases differs in urban and rural populations.ObjectiveTo assess associations between environmental and dietary factors with alle
- Frontiers in alopecia areata pathobiology researchPublication date: Available online 9 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Amos Gilhar, Rimma Laufer Britva, Aviad Keren, Ralf PausThis current review explores selected and as yet insufficiently investigated frontiers in current alopecia areata (AA) pathobiology research, with an emphasis on potential “new” players in AA pathobiology that deserve more systematic exploration and therapeutic targeting. Indeed, new
- Targeting LAT1-mediated amino acid transport in innate and adaptive T cells efficiently controls skin inflammationPublication date: Available online 9 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Danay Cibrian, Raquel Castillo-González, Nieves Fernández-Gallego, Hortensia de la Fuente, Inmaculada Jorge, María Laura Saiz, Carmen Punzón, Marta Ramírez-Huesca, Miguel Vicente-Manzanares, Manuel Fresno, Esteban Daudén, Javier Fraga-Fernandez, Jesús Vazquez, Julián Aragonés, Francisco Sánchez-MadridAbstractBackgroundPsoriasis is a frequ
- Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytesPublication date: Available online 9 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Kuo-Kuang Wen, Seong-Su Han, Yatin M. VyasAbstractBackgroundWiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disorder resulting from WASp deficiency. WAS lymphocytes manifest increased DNA damage and lymphopenia from cell death, yet how WASp influences DNA damage-linked cell survival is unknown. A recently-described
- Development and Initial Validation of the Asthma Severity Scoring System (ASSESS)Publication date: Available online 8 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Anne M. Fitzpatrick, Stanley J. Szefler, David T. Mauger, Brenda R. Phillips, Loren C. Denlinger, Wendy C. Moore, Ronald L. Sorkness, Sally E. Wenzel, Peter J. Gergen, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, John V. Fahy, Benjamin M. Gaston, Elliot Israel, Bruce D. Levy, Deborah A. Meyers, W.Gerald Teague, Leonard B. Bacharie
- Revisiting Airway Epithelial Remodeling in Type 2 Immunity: Beyond Goblet Cell MetaplasiaPublication date: Available online 7 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Nora A. Barrett, Alex K. Shalek
- Lymphocyte reference intervals in the era of newborn screening (NBS)Publication date: Available online 7 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Thomas A. Fleisher, Sergio D. Rosenzweig
- Human <em>STAT5b</em> mutation causes dysregulated human natural killer cell maturation and impaired lytic functionPublication date: Available online 7 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Alexander Vargas-Hernández, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Klara Klein, Sanjana Mahapatra, Waleed Al-Herz, Emily M. Mace, Alexandre F. Carisey, Jordan S. Orange, Veronika Sexl, Lisa R. ForbesAbstractBackgroundPatients with STAT5b deficiency have autoimmunity, recurrent infections and combined immune deficiency, whic
- Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge SyndromePublication date: Available online 7 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Joshua D. Bernstock, Arthur H. Totten, Abdel G. Elkahloun, Kory R. Johnson, Anna C. Hurst, Frederick Goldman, Andrew K. Groves, Fady M. Mikhail, T.Prescott AtkinsonAbstractBackgroundThymic hypoplasia/aplasia occurs as a part of DiGeorge Syndrome, which has several known genetic causes, and with loss-of-function mutations in FOXN1.Objectiv
- The Journal of Allergy and Clinical Immunology: Ninety years strongPublication date: Available online 4 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Zuhair K. Ballas
- Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapyPublication date: Available online 4 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Donald MacGlashan
- Information for ReadersPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- News Beyond Our PagesPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s): Marc E. Rothenberg, Jean Bousquet
- The Editors' ChoicePublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s): Zuhair K. Ballas, Associate Editors of the JACI
- In lasting tribute: Philip S. Norman, August 4, 1924–August 2, 2019Publication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s): Peter Socrates Creticos, Zuhair K. Ballas, Bruce S. Bochner
- Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell functionPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell functionPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s): Joshua A. BoyceThe idiosyncratic activation of mast cells (MCs) in response to administration of nonselective COX inhibitors is a cardinal feature of aspirin-exacerbated respiratory disease (AERD). Older studies using MC-stabilizing drugs support a critical role for MCs and their products in driving the severe eosinophilic inflammation
- Table of ContentsPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4, SupplementAuthor(s):
- Title PagePublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4, SupplementAuthor(s):
- Cover 1Publication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4, SupplementAuthor(s):
- Continuing Medical Education CalendarPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Editorial BoardPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Table of ContentsPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Brief Overview of This Month's JACIPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Cover 1Publication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- CorrigendaPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- CorrigendaPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- News & NotesPublication date: October 2019Source: Journal of Allergy and Clinical Immunology, Volume 144, Issue 4Author(s):
- Tissue microarray analysis reveals that cofilin expression is a poor prognostic factor in juvenile nasopharyngeal angiofibromaBackground Juvenile nasopharyngeal angiofibroma (JNA) has a high recurrence rate after surgery. Cofilin overexpression is associated with increased tumor cell metastasis, and progression of various human cancers. However, studies on cofilin expression in JNA are rare. The purpose of this study was to investigate the expression and localization of cofilin in a tissue microarray (TMA) of JNA specimens. In addition, we also analyzed its correlation
- Probiotic extracts ameliorate nasal allergy by inducing interleukin‐35‒producing dendritic cells in miceBackground The therapeutic efficacy of allergic rhinitis (AR) needs to be improved. Probiotics have immunoregulatory functions. In this study we evaluated the effects of protein extracts of probiotics in the amelioration of AR. Methods Extracts of Bifidobacterium infantis (EBI) were prepared by lysing the live probiotics. AR mice were developed to be used to evaluate the therapeutic efficacy of EBI. Results The results show that EBI
- Increased risk of psoriasis in children and elderly patients with asthma: a longitudinal follow‐up study using a national sample cohortBackground Several previous studies reported the elevated risk of asthma in children with psoriasis. This study aimed to extend previous research regarding the risk of psoriasis in children with asthma to an entire population subdivided by age. Methods The 2002‐2013 Korean Health Insurance Review and Assessment Service–National Sample Cohort (HIRA‐NSC) was used. The 167,693 participants with asthma were matched with 167,693 control partici
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