• Journal of Anatomy , 
• Human biological variation in sesamoid bone prevalence: the curious case of the fabella

  The fabella, a sesamoid bone in the knee, is ~3.5× more common today than 100 years ago. We performed meta‐analyses on prevalence rate studies from 1875–2019, and found (i) fabellae are more common in men, older individuals, and Asian/Oceania populations than women, younger individuals, and North American/African populations (ii) 72.94% of cases are bilateral, and (iii) among unilateral cases, there is anti‐symmetry. This supports the roles both

  Journal of Anatomy

  Thu Oct 17, 2019 04:14
• Pathology & Oncology Research
• Genetic Polymorphisms in the Vitamin D Pathway and Non-small Cell Lung Cancer Survival

  Abstract Various genetic polymorphisms have been linked to lung cancer susceptibility and survival outcomes. Vitamin D (VD) regulates cell proliferation and differentiation, inhibits tumor growth and induces apoptosis. Observations from several previous studies including our own suggest that genetic polymorphisms in the VD pathway may be associated with lung cancer risk. The aim of this study is to assess if genetic polymorphis

  Pathology & Oncology Research

  Wed Oct 16, 2019 17:00
• The Journal of Pathology
• Whole‐genome sequencing of synchronous thyroid carcinomas identifies aberrant DNA repair in thyroid cancer dedifferentiation

  Abstract The genetics underlying thyroid cancer dedifferentiation is only partly understood and has not yet been characterized using comprehensive pan‐genomic analyses. We investigated a unique case with synchronous follicular thyroid carcinoma (FTC), poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC), as well as regional lymph node metastases from the PDTC and ATC from a single patient using whole‐genome seque

  The Journal of Pathology

  Thu Oct 17, 2019 05:17