Anti-Cancer Drugs - Published Ahead-of-Print
- Matrine enhances the efficacy of adriamycin chemotherapy in osteosarcoma cells by the STAT3 pathwayMatrine and adriamycin have been extensively considered to be effective in anticancer therapies. However, the role of matrine in the antitumor activity of adriamycin against human osteosarcoma (OS) remains elusive. The aim of this study was to investigate the effect of matrine in OS chemotherapy of adriamycin. In the study, we found that matrine promoted the inhibitory effect of adriamycin against OS cell proliferation and growth. Wound healing a
- The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesisMacroautophagy (hereafter referred to as autophagy) plays essential roles in cellular and organismal homeostasis. Transcription factor EB (TFEB) is a master regulator of autophagy and lysosome biogenesis. It is not fully understood how the function of TFEB in autophagy pathway is regulated. Here, we show that Rac1 GTPase is a negative modulator of autophagy by targeting TFEB. Mechanistically, Rac1 reduces autophagy flux by repressing the expressi
- Appearance of cutaneous melanoma and subcutaneous metastases in metastatic gastric carcinoma undergoing chemotherapy with oral 5-fluorouracil prodrugMetastatic skin lesions of gastric cancers usually appear as nonspecific, firm, and hyperpigmented nodules. However, they occasionally present as unusual skin manifestations that mimic other skin disorders. We describe a case of multiple cutaneous metastases from gastric cancer resembling sebaceous cysts with a synchronous melanoma, in a patient after fluoropyrimidine-based systemic chemotherapy. Melanoma occurring as a second cancer has been rec
- Palbociclib safety and efficacy beyond Ribociclib-induced liver toxicity in metastatic hormone-receptors positive breast cancer patientCDK4/6 inhibitors in association with aromatase inhibitors have led to a paradigm shift in the management of metastatic positive hormone-receptors breast cancer. Liver toxicity is common with these agents, but no data are reported on the sequential use of these CDK4/6 inhibitors in case of confirmed efficacy and intolerable toxicity. In this article, we report the successful use of Palbociclib in a metastatic positive hormone-receptors breast can
- LncRNA ANRIL promotes cell growth, migration and invasion of hepatocellular carcinoma cells via sponging miR-144Antisense non-coding RNA in the INK4A locus (ANRIL) has been recognized as a cancer-related lncRNA in hepatocellular carcinoma previously. This study aimed to reveal the functional effects and mechanisms of ANRIL on hepatocellular carcinoma cells in vitro. The expression of ANRIL in hepatocellular carcinoma cell lines (MHCC97 and Li-7) and non-tumourigenic liver cell line THLE-3 was detected by qRT-PCR. The expression of ANRIL, miR-144 and PBX3 i
- The let-7c/HoxB7 axis regulates the cell proliferation, migration and apoptosis in hepatocellular carcinomaEctopic expression of HOX-containing genes is closely related to carcinogenesis, acting as either tumor suppressors or oncogenes. A preliminary bioinformatics analysis showed that HoxB7 is a possible target of let-7c. In this study, we aimed to investigate the relationship between HoxB7 and let-7c in liver carcinogenesis. We found that HoxB7 was upregulated in hepatocellular carcinoma (HCC) tissues and cells and negatively correlated with surviva
- Ruxolitinib as monotherapy in a patient with anaplastic lymphoma kinase positive lung adenocarcinomaWe present unusual treatment outcome in a 59-year-old male diagnosed with metastatic lung adenocarcinoma with a very good response to ruxolitinib as monotherapy. In June 2017, this patient was diagnosed with myeloproliferative neoplasm – Janus-associated kinases 2 positive – and in December 2017 ruxolitinib therapy was started. At the same time, patient was diagnosed with lung adenocarcinoma in the left lower lobe with positive anaplastic lymphom
- Sinomenine sensitizes human gastric cancer cells to cisplatin through negative regulation of PI3K/AKT/Wnt signaling pathwaySinomenine (SIN) has been reported its antitumor effects on various types of human cancers, but there is no available information regarding the antitumor effects of SIN and cisplatin on gastric cancer. Here, we examined the antitumor effects of SIN combined with cisplatin on gastric cancer cells as well as the underlying biological mechanisms. CCK-8 assay and Calcusyn 2.0 software analysis, Hoechst 33258 staining and flow cytometry, transwell ass
- Heterocyclic organobismuth(III) compound induces nonapoptotic cell death via lipid peroxidationHeterocyclic organobismuth compounds, such as N-tert-butyl-bi-chlorodibenzo[c,f][1,5]azabismocine (compound 1) and bi-chlorodibenzo[c,f][1,5]thiabismocine (compound 3), exert potent antiproliferative activities in vitro in human cancer cell lines. We showed that compound 3 induced both apoptotic and nonapoptotic cell death via reactive oxygen species production and mitotic arrest in a dose-dependent manner. The mechanisms underlying the dose-depe
- Inhibition of the proliferation, migration, and invasion of human breast cancer cells by leucine aminopeptidase 3 inhibitors derived from natural marine productsLeucine aminopeptidase 3 is involved in the progression and metastasis of several cancers. This study aimed to screen anti-tumor lead compounds targeting leucine aminopeptidase 3. The compounds’ suppression effect on enzyme activity and anti-tumor activity were evaluated through a series of assays. Leucine aminopeptidase 3 overexpression K562 cells were used as an enzyme source to screen 43 natural marine compounds. Compounds 5 and 6 exhibited hi
- Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literatureOral mucositis is among the most common tissue toxicities associated with both cytotoxic cancer regimens and head and neck radiotherapy. Current management of oral mucositis might comprise growth factors and cytokines, anti-inflammatory agents, anesthetics, analgesics, antimicrobial and coating agents, cryotherapy and mucosal protectants. Despite its long history and its impact on patients, there are currently no effective options for the prevent
Cancer
Cancer
Cancer Biology & Therapy: Table of Contents: Taylor and Francis
Cancer Immunology, Immunotherapy
- Lenalidomide improves the therapeutic effect of an interferon-α-dendritic cell-based lymphoma vaccineAbstract The perspective of combining cancer vaccines with immunomodulatory drugs is currently regarded as a highly promising approach for boosting tumor-specific T cell immunity and eradicating residual malignant cells. The efficacy of dendritic cell (DC) vaccination in combination with lenalidomide, an anticancer drug effective in several hematologic malignancies, was investigated in a follicular lymphoma (FL) model. First, w
- Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancerAbstract Human leukocyte antigen class I (HLA I) molecules composed of alpha (heavy) chain, including HLA-A, -B, or -C encoded by HLA genes, and beta-2-microglobulin (β2M) are membrane proteins on all nucleated cells that display peptide antigens for recognition by CD8-positive cytotoxic T cells. Here, we examined the clinicopathologic signification of HLA I expression in patients with gastric cancer (GC). Immunohistochemistry
Cancers
- Cancers, Vol. 11, Pages 1582: CAF-1 Subunits Levels Suggest Combined Treatments with PARP-Inhibitors and Ionizing Radiation in Advanced HNSCCCancers, Vol. 11, Pages 1582: CAF-1 Subunits Levels Suggest Combined Treatments with PARP-Inhibitors and Ionizing Radiation in Advanced HNSCC Cancers doi: 10.3390/cancers11101582 Authors: Francesco Morra Francesco Merolla Ida Picardi Daniela Russo Gennaro Ilardi Silvia Varricchio Federica Liotti Roberto Pacelli Luca Palazzo Massimo Mascolo Angela Celetti Stefania Staibano Oral (OSCC) and oropharyngeal
- Cancers, Vol. 11, Pages 1581: Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer CellsCancers, Vol. 11, Pages 1581: Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer Cells Cancers doi: 10.3390/cancers11101581 Authors: Damien Reita Cyril Bour Radhia Benbrika Audrey Groh Erwan Pencreach Eric Guérin Dominique Guenot Advanced colorectal cancer has a poor prognosis because of metastasis formation and resistance to combined therapies. Downstream of PI3K/Akt and Ras/MAPK pathw
- Cancers, Vol. 11, Pages 1580: Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell CarcinomaCancers, Vol. 11, Pages 1580: Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma Cancers doi: 10.3390/cancers11101580 Authors: Dominik A. Barth Ondrej Slaby Christiane Klec Jaroslav Juracek Rares Drula George A. Calin Martin Pichler Renal cell carcinoma (RCC) is a relatively rare malignancy of the urinary tract system. RCC is a heterogenous disease in terms of underlying h
- Cancers, Vol. 11, Pages 1579: Prediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification NetworksCancers, Vol. 11, Pages 1579: Prediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification Networks Cancers doi: 10.3390/cancers11101579 Authors: Muyi Sun Wei Zhou Xingqun Qi Guanhong Zhang Leonard Girnita Stefan Seregard Hans E. Grossniklaus Zeyi Yao Xiaoguang Zhou Gustav Stålhammar Uveal melanoma is the most common primary intraocular malignancy in adults, with nearly half o
- Cancers, Vol. 11, Pages 1578: The CD73/Ado System—A New Player in RT Induced Adverse Late EffectsCancers, Vol. 11, Pages 1578: The CD73/Ado System—A New Player in RT Induced Adverse Late Effects Cancers doi: 10.3390/cancers11101578 Authors: Simone de Leve Florian Wirsdörfer Verena Jendrossek Radiotherapy (RT) is a central component of standard treatment for many cancer patients. RT alone or in multimodal treatment strategies has a documented contribution to enhanced local control and overall survival of cancer patients, an
- Cancers, Vol. 11, Pages 1577: The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic FunctionsCancers, Vol. 11, Pages 1577: The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions Cancers doi: 10.3390/cancers11101577 Authors: Fernando Salgado-Polo Anastassis Perrakis Autotaxin (ATX) is a secreted lysophospholipase D, catalysing the conversion of lysophosphatidylcholine (LPC) to bioactive lysophosphatidic acid (LPA). LPA acts through two families of
- Cancers, Vol. 11, Pages 1576: FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal CancerCancers, Vol. 11, Pages 1576: FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal Cancer Cancers doi: 10.3390/cancers11101576 Authors: Hsi-Hsien Hsu Wei-Wen Kuo Hui-Nung Shih Sue-Fei Cheng Ching-Kuo Yang Ming-Cheng Chen Chuan-Chou Tu Vijaya Padma Viswanadha Po-Hsiang Liao Chih-Yang Huang Colorectal cancer (CRC) is the second leading cause of cancer-related illness w
- Cancers, Vol. 11, Pages 1575: The Complexities of MetastasisCancers, Vol. 11, Pages 1575: The Complexities of Metastasis Cancers doi: 10.3390/cancers11101575 Authors: San Juan Garcia-Leon Rangel Goetz Chaffer Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equi
- Cancers, Vol. 11, Pages 1572: Proteomic Biomarkers for the Detection of Endometrial CancerCancers, Vol. 11, Pages 1572: Proteomic Biomarkers for the Detection of Endometrial Cancer Cancers doi: 10.3390/cancers11101572 Authors: Kelechi Njoku Davide Chiasserini Anthony D. Whetton Emma J. Crosbie Endometrial cancer is the leading gynaecological malignancy in the western world and its incidence is rising in tandem with the global epidemic of obesity. Early diagnosis is key to improving survival, which at 5 years is l
- Cancers, Vol. 11, Pages 1573: Clinical Application of Next-Generation Sequencing as A Liquid Biopsy Technique in Advanced Colorectal Cancer: A Trick or A Treat?Cancers, Vol. 11, Pages 1573: Clinical Application of Next-Generation Sequencing as A Liquid Biopsy Technique in Advanced Colorectal Cancer: A Trick or A Treat? Cancers doi: 10.3390/cancers11101573 Authors: Myrto Kastrisiou George Zarkavelis George Pentheroudakis Angeliki Magklara Owing to its advantages over prior relevant technologies, massive parallel or next-generation sequencing (NGS) is rapidly evolving, with growing a
- Cancers, Vol. 11, Pages 1574: The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind?Cancers, Vol. 11, Pages 1574: The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind? Cancers doi: 10.3390/cancers11101574 Authors: Sara Loponte Sara Lovisa Angela K. Deem Alessandro Carugo Andrea Viale Tumor functional heterogeneity has been recognized for decades, and technological advancements are fueling renewed interest in uncovering the cell-intrinsic and extrinsic factors that influence tumor developm
- Cancers, Vol. 11, Pages 1571: Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver CabazitaxelCancers, Vol. 11, Pages 1571: Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel Cancers doi: 10.3390/cancers11101571 Authors: Fanchao Meng Yating Sun Robert J. Lee Guiyuan Wang Xiaolong Zheng Huan Zhang Yige Fu Guojun Yan Yifan Wang Weiye Deng Emily Parks Betty Y.S. Kim Zhaogang Yang Wen Jiang Lesheng Teng Microfluidic technology (MF) has i
- Long noncoding RNA CASC2c inhibited cell proliferation in hepatocellular carcinoma by inactivated ERK1/2 and Wnt/β-catenin signaling pathwayAbstract Purpose Long non-coding RNAs (lncRNAs) have been shown to play important roles in tumorigenesis, but their biological functions and the underlying molecular mechanisms remain unclear. Alternative splicing of five exons results in three transcript variants of cancer susceptibility 2 (CASC2): the lncRNAs CASC2a, CASC2b, and CASC2c. CASC2a/b have been found to have crucial regula
- Development of Novel Male ContraceptivesAbstract Unintended pregnancy is surprisingly common, accounting for 40‐50% of pregnancies worldwide. Contraception is the most effective means of preventing unintended pregnancy. Seventy percent of all contraceptives are used by women; however, some women are unable to use contraceptives due to health conditions or side effects. Many men wish to take a more active role family planning, but currently have only two effective male contraceptive op
Clinical Cancer Research Online First Articles
- Lucitanib for the treatment of HR+/ HER2-metastatic breast cancer: results from the multicohort phase II FINESSE studyPurpose:FGFR1 gene is amplified in 14% of HR+/ HER2- breast cancer patients. Efficacy and safety of lucitanib, an inhibitor of VEGFR1-3, FGFR1-3 and PDGFRα/β, were assessed. Experimental Design: HR+/ HER2- MBC patients received oral lucitanib in 3 centrally confirmed cohorts: 1) FGFR1 amplified, 2) FGFR1 non-amplified, 11q13 amplified, 3) FGFR1 and 11q13 non-amplified. Key inclusion criteria included ECOG PS <2, >1 line of anti-cancer therapy, bu
Future Oncology.
- PD1+ tumor associated macrophages predict poor prognosis of locally advanced esophageal squamous cell carcinoma.Related ArticlesPD1+ tumor associated macrophages predict poor prognosis of locally advanced esophageal squamous cell carcinoma. Future Oncol. 2019 Oct 15;: Authors: Lu Y, Guo L, Ding G Abstract Aim: Tumor associated macrophages are the most abundant cancer immune cells. However, little was known about the identity of CD68+PD1+ macrophages as well as the contributions in the prognosis of esophageal s
- Evaluation of the antibody response to the EBV proteome in EBV‐associated classic Hodgkin lymphomaThe humoral immune response to Epstein‐Barr virus (EBV) in classic Hodgkin lymphoma (cHL) stratified by EBV tumor status is unclear. We examined IgG and IgA antibody responses against 202 protein sequences representing 86 EBV proteins using a microarray and sera from 139 EBV‐positive cHL cases, 70 EBV‐negative cHL cases, and 141 population‐based controls frequency matched to EBV‐positive cHL cases on sex and age by area (UK, Denmark, and Sweden).
- Novel genetic variants in KIF16B and NEDD4L in the endosome‐related genes are associated with non‐small cell lung cancer survivalThe endosome is a membrane‐bound organ inside most eukaryotic cells, playing an important role in adaptive immunity by delivering endocytosed antigens to both MHC class I and II pathways. Here, by analyzing two published genome‐wide association studies (GWASs), we evaluated associations between genetic variants in the endosome‐related gene‐set and survival of patients with non‐small cell lung cancer (NSCLC). The discovery included 44,112 (3,478 g
- Guideline‐concordant endometrial cancer treatment and survival in the Women's Health Initiative Life and Longevity After Cancer studyIn the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) cohort we examined predictors of guideline‐concordant treatment among endometrial cancer (EC) survivors and associations between receipt of guideline‐concordant treatment and survival. Receipt of guideline‐concordant EC treatment was defined according to year‐specific National Comprehensive Cancer Network (NCCN) guidelines. Multivariable logistic regression was used to
- Favorable prognosis in pediatric brainstem low‐grade glioma – report from the German SIOP‐LGG 2004 cohortReports on pediatric low‐grade glioma (LGG) of the caudal brainstem are retrospective with heterogeneous cohorts, variable treatments and inconsistent outcome‐data. We analyzed their natural history and asked whether brainstem location proved unfavorable for survival within the framework of the comprehensive SIOP‐LGG 2004 management strategy. Within the prospectively registered, population‐based German SIOP‐LGG 2004 cohort 116 patients (age 0.2–
- Co-targeting PI3K/Akt and MAPK/ERK pathways leads to an enhanced antitumor effect on human hypopharyngeal squamous cell carcinomaAbstract Purpose The present study aims to determine whether co-targeting PI3K/Akt and MAPK/ERK pathways in human hypopharyngeal squamous cell carcinoma (HSCC) is a potential anticancer strategy. Methods We retrospectively analyzed the clinical data of HSCC patients, and the phosphorylation status of Akt
- Are shape morphologies associated with survival? A potential shape-based biomarker predicting survival in lung cancerAbstract Purpose Imaging biomarkers (IBMs) are increasingly investigated as prognostic indicators. IBMs might be capable of assisting treatment selection by providing useful insights into tumor-specific factors in a non-invasive manner. Methods We investigated six three-dimensional shape-based IBMs: eccen
- Precision oncotherapy based on liquid biopsies in multidisciplinary treatment of unresectable recurrent rectal cancer: a retrospective cohort studyAbstract Background Third line innovative systemic treatments and loco-regional chemotherapy by hypoxic pelvic perfusion (HPP) have both been proposed for the treatment of unresectable not responsive recurrent rectal cancer (URRC). In the present study, we have compared the safety and efficacy of HPP/target therapy, using drug regimens selected by liquid biopsy precision oncotherapy, t
Journal of Experimental & Clinical Cancer Research - Latest Articles
- NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesisAt the beginning of tumorigenesis, newly born cancer cells must successfully avoid attack by the immune system. Although most abnormal cells are efficiently identified and destroyed by the immune system, parti...
Molecular Cancer Therapeutics Online First Articles
- On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid TumorsThe PI3K inhibitor copanlisib has efficacy and manageable safety in patients with indolent lymphoma and solid tumors. Pharmacodynamic effects relative to copanlisib dose and plasma exposure were evaluated. Patients with lymphoma or solid tumors received copanlisib 0.4 mg/kg or 0.8 mg/kg on days 1, 8, and 15 of a 28-day cycle. Primary variables were maximum changes in phosphorylated AKT (pAKT) levels in platelet-rich plasma (PRP) and plasma glu
- Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibitionLoss of function of BRCA1 associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate whether this aspect could be exploited for targeted therapy. A genetically engineered model was established expressing either functional or non-functional BAP1 and whole-genome siRNA synthetic lethality screens were performed assessing differentially impaired survival between the t
- Long noncoding RNA ADAMTS9‐AS2 suppresses the progression of esophageal cancer by mediating CDH3 promoter methylationAbstract Long noncoding RNAs (lncRNAs) have been implicated in the biology of esophageal cancer via mRNA degradation or translational inhibition. CDH3 is also aberrantly expressed in numerous cancers. This study was conducted with the hypothesis that ADAMTS9‐AS2 or CDH3 methylation plays a role in esophageal cancer cell activity and in vivo development. Firstly, mRNA levels of ADAMTS9‐AS2 and CDH3 in esophageal cancer tissues and cells were dete
- Cerebrospinal fluid VEGF levels and angiogenic capacity as potential prognostic markers in patients with gliomas: a pilot studyAbstract Introduction Gliomas are tumors of the central nervous system. Despite new classifications, they are still divided in low and high-grade gliomas, being the latter of greater malignancy. The degree of malignancy is directly related with the angiogenic activity in tumoral tissues. We measured VEGF concentrations and angiogenic capacity in cerebrospinal fluid (CSF) from patients
- Observation after surgery for low grade glioma: long-term outcome in the light of the 2016 WHO classificationAbstract Purpose To provide detailed long-term data after initial observation for patients after histological confirmation of low grade (WHO II) gliomas according to molecular stratification. Methods A series of 110 patients with watchful waiting strategy after initial surgery for LGG and re-surgery at tu
- Association between extent of resection on survival in adult brainstem high-grade glioma patientsAbstract Background Brainstem high-grade gliomas (HGG) are rare lesions with aggressive behavior that pose significant treatment challenges. The operative use of brainstem safe entry zones has made such lesions surgically accessible, though the benefits of aggressive resection have been unclear. This study aimed to clarify the survival in adult patients.
- Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimensAbstract Purpose Irradiation-avoiding strategies have been used with relative success in the treatment of infants and young children with medulloblastoma. While advances in cancer genomics have significantly improved our understanding of the tumor biology of medulloblastoma allowing for improved prognostication and risk-stratification, the molecular subgroup-specific outcomes of infant
- White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximabAbstract Purpose White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timing and grade of WMC on MRI in adult patients with newly-diag
- Communicating hydrocephalus after radiosurgery for vestibular schwannomas: does technique matter? A systematic review and meta-analysisAbstract Background Communicating hydrocephalus (cHCP) after radiosurgery (RS) for vestibular schwannomas (VS) has been reported. Many hypothetical mechanisms for this pathology have been proposed without consensus. The aim of this study is to determine if the platform used to treat the disease, Gamma Knife (GK) versus linear accelerator (LINAC)-based RS, makes a difference in outcome.
Practical Radiation Oncology
- Using Robust Optimization for Skin Flashing in Intensity-Modulated Radiotherapy for Breast Cancer Treatment: A Feasibility StudyPublication date: Available online 15 October 2019Source: Practical Radiation OncologyAuthor(s): Xiaoying Liang, Julie A. Bradley, Raymond B. Mailhot Vega, Michael Rutenberg, Dandan Zheng, Nataliya Getman, Kelly W. Norton, Nancy Mendenhall, DSc Zuofeng LiAbstractPurposeTo study the feasibility and the effectiveness of a novel implementation of robust optimization on two sets of CT data simultaneously for skin flashing in intensity-modulated radia
- The Experiences of Patients and their Family Members when Receiving Bad News about Cancer: A Qualitative Meta‐synthesisAbstract Objective This qualitative meta‐synthesis explored the subjective experiences of patients and their family members when receiving bad news about cancer, with a focus on what was important to them during this process and making future recommendations. Methods A search of five electronic databases yielded 587 different records that resulted in 88 articles assessed against the inclusion/exclusion criteria. With the supplement of 4
- Barriers and facilitators to physical activity in men with prostate cancer: a qualitative and quantitative systematic reviewAbstract Objective Existing research indicates that moderate‐to‐vigorous physical activity (PA) alleviates treatment side‐effects, and is associated with survival, in men with prostate cancer. We aimed to ascertain the state of research investigating barriers and facilitators to PA in men with prostate cancer, and synthesise existing qualitative research on this topic. Methods A systematic review of qualitative and quantitative studies
- Issue InformationNo abstract is available for this article.
Radiation Oncology - Latest Articles
- Radiotherapy for pelvic nodal recurrences after radical prostatectomy: patient selection in clinical practiceThere is no general consensus on the optimal treatment for prostate cancer (PC) patients with intrapelvic nodal oligorecurrences after radical prostatectomy. Besides androgen deprivation therapy (ADT) as stand...
- Elective nodal irradiation versus involved-field irradiation in patients with esophageal cancer receiving neoadjuvant chemoradiotherapy: a network meta-analysisTo assess the comparative efficacy and safety of elective nodal irradiation (ENI) and involved-field irradiation (IFI) in patients with esophageal cancer (EC) receiving neoadjuvant chemoradiotherapy plus surge...
Radiotherapy and Oncology
- Intraoperative radiotherapy for glioblastoma: an international pooled analysisGlioblastoma (GB) represents the most frequent primary malignancy of the brain in adults, accounting for more than half of all gliomas [1]. Survival times are still narrow and range between 1 and 3 years [2–6]. Even patients with favorable risk factors, such as young age, high Karnofsky performance status (KPS) and hypermethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter suffer from tumor recurrence, usually occurring 14–17
- Changes in lung volume parameters regarding the received dose in the lobes of the lungs after locoregional radiotherapy of breast cancerPublication date: November–December 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 6Author(s): Mahsa Abdemanafi, Mohammad Bagher Tavakoli, Ali Akhavan, Iraj AbediAbstractAimThe purpose of this study was to evaluate ΔLVP1 and correlate them with MLD2 and V203 in the lobes of the lung.BackgroundRadiation-induced lung injury after breast irradiation is controversial. The incidence of such an injury could have negative con
RNA In Advance
- Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast [Article]During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3'-5' degradation by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5'-3' degradation by the rapid tRNA decay (RTD) pathway. RTD is catalyzed by the 5'-3' exonucleases Xrn1 and Rat1, which act on tRNAs with an exposed 5' end due to the lack of certain body modifications or the presence of destabilizing mutations in the acceptor stem, T-stem, or tRNA
- TOCPublication date: June 2019Source: Seminars in Oncology, Volume 46, Issue 3Author(s):
- Editorial BoardPublication date: June 2019Source: Seminars in Oncology, Volume 46, Issue 3Author(s):
- MastheadPublication date: June 2019Source: Seminars in Oncology, Volume 46, Issue 3Author(s):
- outside front coverPublication date: June 2019Source: Seminars in Oncology, Volume 46, Issue 3Author(s):
Πέμπτη 17 Οκτωβρίου 2019
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