- Cancers, Vol. 11, Pages 1480: Epigenetic Mechanisms of Escape from BRAF Oncogene DependencyCancers, Vol. 11, Pages 1480: Epigenetic Mechanisms of Escape from BRAF Oncogene Dependency Cancers doi: 10.3390/cancers11101480 Authors: Khaliq Fallahi-Sichani About eight percent of all human tumors (including 50% of melanomas) carry gain-of-function mutations in the BRAF oncogene. Mutated BRAF and subsequent hyperactivation of the MAPK signaling pathway has motivated the use of MAPK-targeted therapies for these tumors. Despit
- Cancers, Vol. 11, Pages 1479: STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast CancerCancers, Vol. 11, Pages 1479: STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer Cancers doi: 10.3390/cancers11101479 Authors: Zerdes Wallerius Sifakis Wallmann Betts Bartish Tsesmetzis Tobin Coucoravas Bergh Rassidakis Rolny Foukakis Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted tra
- Cancers, Vol. 11, Pages 1478: Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer CellsCancers, Vol. 11, Pages 1478: Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells Cancers doi: 10.3390/cancers11101478 Authors: Leo Therachiyil Siveen Uddin Kulinski Buddenkotte Steinhoff Krishnankutty Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignan
Cells
- Cells, Vol. 8, Pages 1188: Reliable Reference Genes for Gene Expression Assessment in Tendon-Derived Cells under Inflammatory and Pro-Fibrotic/Healing StimuliCells, Vol. 8, Pages 1188: Reliable Reference Genes for Gene Expression Assessment in Tendon-Derived Cells under Inflammatory and Pro-Fibrotic/Healing Stimuli Cells doi: 10.3390/cells8101188 Authors: Enrico Ragni Carlotta Perucca Orfei Annie C. Bowles Laura de Girolamo Diego Correa Tendon cells (TCs) are important for homeostatic maintenance in the healthy tendon and to promote tissue healing after injury. Further, reside
- Cells, Vol. 8, Pages 1185: Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA StabilizationCells, Vol. 8, Pages 1185: Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization Cells doi: 10.3390/cells8101185 Authors: Alina Astakhova Dmitry Chistyakov Dominique Thomas Gerd Geisslinger Bernhard Brüne Marina Sergeeva Dmitry Namgaladze Inflammatory activation of astroglia adds to the pathology of various neurological diseases. Astrocytes
- Cells, Vol. 8, Pages 1186: Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC)Cells, Vol. 8, Pages 1186: Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC) Cells doi: 10.3390/cells8101186 Authors: Marica Garziera Erika Cecchin Giorgio Giorda Roberto Sorio Simona Scalone Elena De Mattia Rossana Roncato Sara Gagno Elena Poletto Loredana Romanato Fabrizio Ecca Vincenzo Canzonieri Gi
- Cells, Vol. 8, Pages 1184: Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic FibrogenesisCells, Vol. 8, Pages 1184: Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic Fibrogenesis Cells doi: 10.3390/cells8101184 Authors: Pei-Wen Wang Tung-Ho Wu Tung-Yi Lin Mu-Hong Chen Chau-Ting Yeh Tai-Long Pan The activation of hepatic stellate cells (HSCs) manifested as proliferation and migration is the pivotal event involved in liver fibrogenesis. The vimenti
- Cells, Vol. 8, Pages 1187: Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in Dictyostelium DiscoideumCells, Vol. 8, Pages 1187: Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins in Dictyostelium Discoideum Cells doi: 10.3390/cells8101187 Authors: González-Velasco De Las Rivas Lacal Cyclic AMP acts as a secondary messenger involving different cellular functions in eukaryotes. Here, proteomic and transcriptomic profiling has been combined to identify novel early developmentally regulat
- Children, Vol. 6, Pages 106: Delivering Elder- and Community-Led Aboriginal Early Childhood Development Research: Lessons from the Ngulluk Koolunga Ngulluk Koort ProjectChildren, Vol. 6, Pages 106: Delivering Elder- and Community-Led Aboriginal Early Childhood Development Research: Lessons from the Ngulluk Koolunga Ngulluk Koort Project Children doi: 10.3390/children6100106 Authors: Brad M. Farrant Carrington C. J. Shepherd Carol Michie Clair Scrine Michael Wright Nicole Ilich Tanya Jones Glenn Pearson Elder- and community-led research processes are increasingly being acknowledg
- Cosmetics, Vol. 6, Pages 59: Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic AcidCosmetics, Vol. 6, Pages 59: Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid Cosmetics doi: 10.3390/cosmetics6040059 Authors: Rashid Albayati Dodou Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegr
- Cosmetics, Vol. 6, Pages 58: Ascorbic Acid in Skin HealthCosmetics, Vol. 6, Pages 58: Ascorbic Acid in Skin Health Cosmetics doi: 10.3390/cosmetics6040058 Authors: Ravetti Clemente Brignone Hergert Allemandi Palma Ascorbic acid (vitamin C) is a water-soluble vitamin and a recognized antioxidant drug that is used topically in dermatology to treat and prevent the changes associated with photoaging, as well as for the treatment of hyperpigmentation. Ascorbic acid has neut
- Cosmetics, Vol. 6, Pages 57: Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent AdvancesCosmetics, Vol. 6, Pages 57: Natural and Bioinspired Phenolic Compounds as Tyrosinase Inhibitors for the Treatment of Skin Hyperpigmentation: Recent Advances Cosmetics doi: 10.3390/cosmetics6040057 Authors: Lucia Panzella Alessandra Napolitano One of the most common approaches for control of skin pigmentation involves the inhibition of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis. This revi
- Dentistry Journal, Vol. 7, Pages 100: Integrated Digital and Conventional Treatment Workflow in Guided Complete Mouth Implant Rehabilitation: A Clinical Case ReportDentistry Journal, Vol. 7, Pages 100: Integrated Digital and Conventional Treatment Workflow in Guided Complete Mouth Implant Rehabilitation: A Clinical Case Report Dentistry Journal doi: 10.3390/dj7040100 Authors: Lee Jung Wang Lee The introduction of digital dentistry and CAD/CAM technology has redefined treatment concepts in implant dentistry—computer guided implant placement has become routine practice, and CAD
- Dentistry Journal, Vol. 7, Pages 99: Q-Switch Nd:YAG Laser-Assisted Decontamination of Implant SurfaceDentistry Journal, Vol. 7, Pages 99: Q-Switch Nd:YAG Laser-Assisted Decontamination of Implant Surface Dentistry Journal doi: 10.3390/dj7040099 Authors: Namour El Mobadder Magnin Peremans Verspecht Teughels Lamard Nammour Rompen Peri-implantitis (PI) is an inflammatory disease of peri-implant tissues, it represents the most frequent complication of dental implants. Evidence revealed that microorganism
- Dentistry Journal, Vol. 7, Pages 98: The Psychological Impact of Dental Aesthetics in Patients with Juvenile Idiopathic Arthritis Compared with Healthy Peers: A Cross-Sectional StudyDentistry Journal, Vol. 7, Pages 98: The Psychological Impact of Dental Aesthetics in Patients with Juvenile Idiopathic Arthritis Compared with Healthy Peers: A Cross-Sectional Study Dentistry Journal doi: 10.3390/dj7040098 Authors: Bucci Rongo Amato Martina D’Antò Valletta This study aimed to assess whether dental aesthetics had a different impact on the psychosocial domains of adolescents with juvenile idiopath
- Dentistry Journal, Vol. 7, Pages 97: Educational Attainment and Self-Rated Oral Health among American Older Adults: Hispanics’ Diminished ReturnsDentistry Journal, Vol. 7, Pages 97: Educational Attainment and Self-Rated Oral Health among American Older Adults: Hispanics’ Diminished Returns Dentistry Journal doi: 10.3390/dj7040097 Authors: Shervin Assari Mohsen Bazargan Background: Minorities’ diminished returns (MDRs) refer to systemically weaker effects of socioeconomic status (SES), particularly educational attainment, on the health of non-Whites compared to Whites
- Diagnostics, Vol. 9, Pages 136: Serum Anti-Müllerian Hormone in the Diagnosis of Polycystic Ovary Syndrome in Association with Clinical SymptomsDiagnostics, Vol. 9, Pages 136: Serum Anti-Müllerian Hormone in the Diagnosis of Polycystic Ovary Syndrome in Association with Clinical Symptoms Diagnostics doi: 10.3390/diagnostics9040136 Authors: Ahmed Batarfi Bajouh Bakhashab Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine diseases affecting women of reproductive age. The pathogeny of PCOS is still not completely understood, but one
- Diagnostics, Vol. 9, Pages 135: A Pervasive Healthcare System for COPD PatientsDiagnostics, Vol. 9, Pages 135: A Pervasive Healthcare System for COPD Patients Diagnostics doi: 10.3390/diagnostics9040135 Authors: Ajami Mcheick Mustapha Chronic obstructive pulmonary disease (COPD) is one of the most severe public health problems worldwide. Pervasive computing technology creates a new opportunity to redesign the traditional pattern of medical system. While many pervasive healthcare systems are currently f
- Diversity, Vol. 11, Pages 187: Age-Independent Adult Mortality in a Long-Lived HerbDiversity, Vol. 11, Pages 187: Age-Independent Adult Mortality in a Long-Lived Herb Diversity doi: 10.3390/d11100187 Authors: Edelfeldt Lindell Dahlgren Relative to mammals and birds, little is known about the mortality trajectories of perennial plants, as there are few long-term demographic studies following multiple yearly cohorts from birth to death. This is particularly important because if reproductively mature individu
- Diversity, Vol. 11, Pages 186: Nitrogen Metabolism at Tillering Stage Differently Affects the Grain Yield and Grain Protein Content in Two Durum Wheat CultivarsDiversity, Vol. 11, Pages 186: Nitrogen Metabolism at Tillering Stage Differently Affects the Grain Yield and Grain Protein Content in Two Durum Wheat Cultivars Diversity doi: 10.3390/d11100186 Authors: Fortunato Nigro Paradiso Cucci Lacolla Trani Agrimi Blanco de Pinto Gadaleta Soil nitrogen abundance, as well as nitrogen use efficiency (NUE), significantly affect the crop yield and grain protein
- Diversity, Vol. 11, Pages 185: Swimming Abilities of Temperate Pelagic Fish Larvae Prove that they May Control their Dispersion in Coastal AreasDiversity, Vol. 11, Pages 185: Swimming Abilities of Temperate Pelagic Fish Larvae Prove that they May Control their Dispersion in Coastal Areas Diversity doi: 10.3390/d11100185 Authors: Baptista Morais Cruz Castanho Ribeiro Pousão-Ferreira Leitão Wolanski Teodósio The Sense Acuity and Behavioral (SAAB) Hypothesis proposes that the swimming capabilities and sensorial acuity of temperate fish larvae al
- Diversity, Vol. 11, Pages 183: Contrasting Patterns of Pomacea maculata Establishment and Dispersal in an Everglades Wetland Unit and a Central Florida LakeDiversity, Vol. 11, Pages 183: Contrasting Patterns of Pomacea maculata Establishment and Dispersal in an Everglades Wetland Unit and a Central Florida Lake Diversity doi: 10.3390/d11100183 Authors: Gutierre Darby Valentine-Darby Mellow Therrien Watford The spread of non-native species raises concerns about native species displacement, while other negative effects on native species (e.g., habitat degradation) sh
- Diversity, Vol. 11, Pages 184: First Report of the Coral-Killing Sponge Terpios hoshinota Rützler and Muzik, 1993 in Western Australia: A New Threat to Kimberley Coral Reefs?Diversity, Vol. 11, Pages 184: First Report of the Coral-Killing Sponge Terpios hoshinota Rützler and Muzik, 1993 in Western Australia: A New Threat to Kimberley Coral Reefs? Diversity doi: 10.3390/d11100184 Authors: Fromont Wilson The cyanobacteriosponge Terpios hoshinota has been reported throughout the Indo-Pacific including the Great Barrier Reef, Australia. The species encrusts live coral, giant clams, and other benthos and
- Diversity, Vol. 11, Pages 181: Alterations of Arbuscular Mycorrhizal Fungal Diversity in Soil with Elevation in Tropical Forests of ChinaDiversity, Vol. 11, Pages 181: Alterations of Arbuscular Mycorrhizal Fungal Diversity in Soil with Elevation in Tropical Forests of China Diversity doi: 10.3390/d11100181 Authors: Zhaoyong Shi Kejing Yin Fayuan Wang Bede S. Mickan Xugang Wang Wenli Zhou Yajuan Li Mycorrhizas play a vital role in ecosystem function, diversity and productivity. However, mycorrhizas in tropical forests are considered to be a neglected
- Diversity, Vol. 11, Pages 182: Analysis of Lifetime Mortality Trajectories in Wildlife Disease Research: BaSTA and BeyondDiversity, Vol. 11, Pages 182: Analysis of Lifetime Mortality Trajectories in Wildlife Disease Research: BaSTA and Beyond Diversity doi: 10.3390/d11100182 Authors: Dave W. Hudson Richard Delahay Robbie A. McDonald Trevelyan J. McKinley Dave J. Hodgson Wildlife hosts are important reservoirs of a wide range of human and livestock infections worldwide, and in some instances, wildlife populations are threatened by disease. Y
- Diversity, Vol. 11, Pages 180: Host Specialization in Plant-galling Interactions: Contrasting Mites and InsectsDiversity, Vol. 11, Pages 180: Host Specialization in Plant-galling Interactions: Contrasting Mites and Insects Diversity doi: 10.3390/d11100180 Authors: Walter Santos de Araújo Érica Vanessa Durães de Freitas Ján Kollár Rodrigo Oliveira Pessoa Paulo Henrique Costa Corgosinho Henrique Maia Valério Luiz Alberto Dolabela Falcão Marcílio Fagundes Marcio Antonio Silva Pimenta Maurício Lopes de Faria Waldney Pereir
- Environments, Vol. 6, Pages 111: Impact of Zirconium on Freshwater Periphytic MicroorganismsEnvironments, Vol. 6, Pages 111: Impact of Zirconium on Freshwater Periphytic Microorganisms Environments doi: 10.3390/environments6100111 Authors: Caroline Soizic Jacky Claude The majority of studies on biofilms have focused on autotrophic and bacterial taxa, without considering the potential effects on biofilm grazers. In this work, we investigated the effects of realistic environmental concentrations of zirconium (Zr)
- EJIHPE, Vol. 10, Pages 94-109: Ghana’s Journey towards Universal Health Coverage: The Role of the National Health Insurance SchemeEJIHPE, Vol. 10, Pages 94-109: Ghana’s Journey towards Universal Health Coverage: The Role of the National Health Insurance Scheme European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10010009 Authors: Kipo-Sunyehzi Amogre Ayanore Dzidzonu Ayalsuma Yakubu : Background: the main aim of the study is to find if the National Health Insurance Scheme (NHIS) in Ghana is achieving universal he
- Foods, Vol. 8, Pages 450: Tracing the Geographical Origin of Durum Wheat by FT-NIR SpectroscopyFoods, Vol. 8, Pages 450: Tracing the Geographical Origin of Durum Wheat by FT-NIR Spectroscopy Foods doi: 10.3390/foods8100450 Authors: Annalisa De Girolamo Marina Cortese Salvatore Cervellieri Vincenzo Lippolis Michelangelo Pascale Antonio Francesco Logrieco Michele Suman Fourier transform near infrared (FT-NIR) spectroscopy, in combination with principal component-linear discriminant analysis (PC-LDA), was used f
- Foods, Vol. 8, Pages 451: Using Pulses in Baked Products: Lights, Shadows, and Potential SolutionsFoods, Vol. 8, Pages 451: Using Pulses in Baked Products: Lights, Shadows, and Potential Solutions Foods doi: 10.3390/foods8100451 Authors: Andrea Bresciani Alessandra Marti Nowadays, consumers are more conscious of the environmental and nutritional benefits of foods. Pulses—thanks to both nutritional and health-promoting features, together with their low environmental impact—satisfy the demand for high-protein/high-fi
- Foods, Vol. 8, Pages 449: Thermal Transitions of Cocoa Butter: A Novel Characterization Method by Temperature ModulationFoods, Vol. 8, Pages 449: Thermal Transitions of Cocoa Butter: A Novel Characterization Method by Temperature Modulation Foods doi: 10.3390/foods8100449 Authors: Julia Rocha Gouveia Kelly Cristina de Lira Lixandrão Lara Basílio Tavares Paulo Henrique Lixandrão Fernando Guilherme Elias Saltarelli Garcia Demetrio Jackson dos Santos For the first time, the novel experimental technique Temperature Modulated Optical Refract
- Foods, Vol. 8, Pages 448: Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and ErythritolFoods, Vol. 8, Pages 448: Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol Foods doi: 10.3390/foods8100448 Authors: Maeng Yoon Chun Kim Jang Park Kim Kim Kim D-allulose, a C-3 epimer of D-fructose, is a rare monosaccharide used as a food ingredient or a sweetener. In the present study, the in vitro metabolic stability of D-allulose was exa
- Foods, Vol. 8, Pages 447: Prediction of Pasting Properties of Dough from Mixolab Measurements Using Artificial Neuronal NetworksFoods, Vol. 8, Pages 447: Prediction of Pasting Properties of Dough from Mixolab Measurements Using Artificial Neuronal Networks Foods doi: 10.3390/foods8100447 Authors: Codină Dabija Oroian An artificial neuronal network (ANN) system was conducted to predict the Mixolab parameters which described the wheat flour starch-amylase part (torques C3, C4, C5, and the difference between C3-C4and C5-C4, respectively) from physicoche
- Foods, Vol. 8, Pages 446: Oligosaccharides Isolated from MGO™ Manuka Honey Inhibit the Adhesion of Pseudomonas aeruginosa, Escherichia Coli O157:H7 and Staphylococcus Aureus to Human HT-29 cellsFoods, Vol. 8, Pages 446: Oligosaccharides Isolated from MGO™ Manuka Honey Inhibit the Adhesion of Pseudomonas aeruginosa, Escherichia Coli O157:H7 and Staphylococcus Aureus to Human HT-29 cells Foods doi: 10.3390/foods8100446 Authors: Lane Calonne Slattery Hickey Historically, honey is known for its anti-bacterial and anti-fungal activities and its use for treatment of wound infections. Although this practice has been i
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