Related Articlesβ-Caryophyllene in the Essential Oil from Chrysanthemum Boreale Induces G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells. Molecules. 2019 Oct 18;24(20): Authors: Chung KS, Hong JY, Lee JH, Lee HJ, Park JY, Choi JH, Park HJ, Hong J, Lee KT Abstract Chrysanthemum boreale is a plant widespread in East Asia, used in folk medicine to treat various disorders, such as pneumonia, colitis, stomatitis, and carbuncle. Whether the essential...
Wed Oct 23, 2019 13:32
[Research progress on anti-tumor effects and mechanisms of triptolide and its combined application].
Related Articles[Research progress on anti-tumor effects and mechanisms of triptolide and its combined application]. Zhongguo Zhong Yao Za Zhi. 2019 Aug;44(16):3391-3398 Authors: Shi JF, Luo YY, Li JX, Luo RF, Chen L, Li J, Zhang JM, Fu CM Abstract Tumors are major chronic diseases and seriously threaten human health all over the world. How to effectively control and cure tumors is one of the most pivotal problems in the medical field. At present,surgery,radiotherapy...
Wed Oct 23, 2019 13:32
Related ArticlesRole of Checkpoint Inhibition in Localized Bladder Cancer. Eur Urol Oncol. 2018 08;1(3):190-198 Authors: Hahn NM, Necchi A, Loriot Y, Powles T, Plimack ER, Sonpavde G, Roupret M, Kamat AM Abstract CONTEXT: Checkpoint inhibitors (CPIs) are established as a standard therapy option for metastatic bladder cancer; however, their role in earlier-stage disease remains undefined. OBJECTIVE: To summarize the preclinical and clinical...
Wed Oct 23, 2019 13:32
Related ArticlesThe Tuberin and Cyclin B1 complex functions as a novel G2/M sensor of serum conditions and Akt signaling. PLoS One. 2019;14(1):e0210612 Authors: Fidalgo da Silva E, Botsford S, Dare-Shih J, Hanna MA, Porter LA Abstract A great deal of ground breaking work has determined that the Tuberin and Hamartin Complex function as a negative regulator of protein synthesis and cell cycle progression through G1/S. This is largely attributed to the...
Wed Oct 23, 2019 13:32
Related ArticlesInhibition of mitochondrial translation as a therapeutic strategy for human ovarian cancer to overcome chemoresistance. Biochem Biophys Res Commun. 2019 02 05;509(2):373-378 Authors: Hu B, Guo Y Abstract Aberrant increase in mitochondrial biogenesis is common in human ovarian cancer and has great therapeutic value. In this work, we demonstrate that tigecycline, a FDA-approved broad spectrum antibiotic, selectively targets ovarian cancer...
Wed Oct 23, 2019 13:32
Related ArticlesChk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation. Sci Rep. 2018 12 03;8(1):17536 Authors: Gong EY, Hernández B, Nielsen JH, Smits VAJ, Freire R, Gillespie DA Abstract The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain poorly understood. We have identified two...
Wed Oct 23, 2019 13:32
Related ArticlesCell-cycle control of cell polarity in yeast. J Cell Biol. 2019 01 07;218(1):171-189 Authors: Moran KD, Kang H, Araujo AV, Zyla TR, Saito K, Tsygankov D, Lew DJ Abstract In many cells, morphogenetic events are coordinated with the cell cycle by cyclin-dependent kinases (CDKs). For example, many mammalian cells display extended morphologies during interphase but round up into more spherical shapes during mitosis (high CDK activity) and...
Wed Oct 23, 2019 13:32
Related ArticlesTemozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB. Cancer Res. 2019 01 01;79(1):99-113 Authors: Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M Abstract The DNA-methylating drug temozolomide, which induces cell death through apoptosis, is used for the treatment of malignant...
Wed Oct 23, 2019 13:32
Related ArticlesTumor necrosis factor α-induced protein 8 expression as a predictor of prognosis and resistance in patients with advanced ovarian cancer treated with neoadjuvant chemotherapy. Hum Pathol. 2018 12;82:239-248 Authors: Wang J, Gao H, Liu G, Gu L, Yang C, Zhang F, Liu T Abstract We explored the correlation of tumor necrosis factor α-induced protein 8 (TNFAIP8) with platinum resistance in ovarian cancers treated with neoadjuvant chemotherapy...
Wed Oct 23, 2019 13:32
Related ArticlesGrowth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice. Sci Rep. 2018 08 02;8(1):11627 Authors: Santi AMM, Lanza JS, Tunes LG, Fiuza JA, Roy G, Orfanó ADS, de Carvalho AT, Frézard F, Barros ALB, Murta SMF, do Monte-Neto RL Abstract There is no safe and efficacious vaccine against human leishmaniasis available and live attenuated vaccines have been used as a...
Wed Oct 23, 2019 13:32
Related ArticlesActivation of MET signaling by HDAC6 offers a rationale for a novel ricolinostat and crizotinib combinatorial therapeutic strategy in diffuse large B-cell lymphoma. J Pathol. 2018 10;246(2):141-153 Authors: Liu Z, Cai Y, Yang Y, Li A, Bi R, Wang L, Shen X, Wang W, Jia Y, Yu B, Cao B, Cui W, Wei P, Zhou X Abstract Some histone deacetylases (HDACs) promote tumor cell growth and pan- or selective HDAC inhibitors are active in some cancers;...
Wed Oct 23, 2019 13:32
Related ArticlesC10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes. Sci Rep. 2018 06 05;8(1):8590 Authors: Chen C, Wu N, Duan Q, Yang H, Wang X, Yang P, Zhang M, Liu J, Liu Z, Shao Y, Zheng Y Abstract Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose...
Wed Oct 23, 2019 13:32
Related ArticlesIntrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis. J Pathol. 2018 08;245(4):502-513 Authors: Li TN, Wu YJ, Tsai HW, Sun CP, Wu YH, Wu HL, Pei YN, Lu KY, Yen TT, Chang CW, Chan HL, Tao MH, Liou JY, Chang MD, Su IJ, Wang LH Abstract Hepatitis B virus (HBV) is an aetiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Despite current antiviral therapies that...
Wed Oct 23, 2019 13:32
Related ArticlesThe O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation. J Cell Biochem. 2018 09;119(9):7377-7387 Authors: Park S, Bazer FW, Lim W, Song G Abstract Formononetin is an isoflavone that is extracted from red clovers or soy. It has anti-oxidant, anti-proliferative, and anti-tumor effects against cells in various diseases. Several cohort...
Wed Oct 23, 2019 13:32
Related ArticlesOverexpression of EZH2 in conjunctival melanoma offers a new therapeutic target. J Pathol. 2018 08;245(4):433-444 Authors: Cao J, Pontes KC, Heijkants RC, Brouwer NJ, Groenewoud A, Jordanova ES, Marinkovic M, van Duinen S, Teunisse AF, Verdijk RM, Snaar-Jagalska E, Jochemsen AG, Jager MJ Abstract Malignant melanoma of the conjunctiva (CM) is an uncommon but potentially deadly disorder. Many malignancies show an increased activity of...
Wed Oct 23, 2019 13:32
Related ArticlesMechanisms and consequences of oxidant-induced renal preconditioning: an Nrf2-dependent, P21-independent, anti-senescence pathway. Nephrol Dial Transplant. 2018 11 01;33(11):1927-1941 Authors: Johnson ACM, Zager RA Abstract Background: P21, a cyclin kinase inhibitor, is upregulated by renal 'ischemic preconditioning' (IPC), and induces a 'cytoresistant' state. However, P21-induced cell cycle inhibition can also contribute to cellular...
Wed Oct 23, 2019 13:32
Related ArticlesMagnetic resonance imaging for vestibular schwannoma: cost-effective protocol for referrals. J Laryngol Otol. 2019 Oct 22;:1-5 Authors: Mettias BAD, Lyons M Abstract OBJECTIVE: Vestibular schwannoma is the most common neoplasm in the cerebellopontine angle, and fast spin-echo T2-weighted magnetic resonance imaging is the most sensitive test for diagnosing it. This study evaluated the financial and time costs of unnecessary magnetic resonance...
Wed Oct 23, 2019 13:32
Related ArticlesComparative study of two different perimodiolar and a straight cochlear implant electrode array: surgical and audiological outcomes. Eur Arch Otorhinolaryngol. 2019 Oct 21;: Authors: Garaycochea O, Manrique-Huarte R, Lazaro C, Huarte A, Prieto C, Alvarez de Linera-Alperi M, Manrique M Abstract PURPOSE: To compare the surgical and audiological outcomes with two perimodiolar electrode arrays (Nucleus 512-Contour Advance® y Nucleus 532-Slim...
Wed Oct 23, 2019 13:31
Related ArticlesRehabilitation of dynamic visual acuity in patients with unilateral vestibular hypofunction: earlier is better. Eur Arch Otorhinolaryngol. 2019 Oct 21;: Authors: Michel L, Laurent T, Alain T Abstract PURPOSE: Patients with acute peripheral unilateral hypofunction (UVH) complain of vertigo and dizziness and show posture imbalance and gaze instability. Vestibular rehabilitation therapy (VR) enhances the functional recovery and it has been...
Wed Oct 23, 2019 13:31
Related ArticlesUsefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Ménière's Disease. Sci Rep. 2018 12 03;8(1):17562 Authors: Cho YS, Ahn JM, Choi JE, Park HW, Kim YK, Kim HJ, Chung WH Abstract This study aimed to investigate the usefulness of the intravenous gadolinium enhanced inner ear magnetic resonance imaging (IV-Gd inner ear MRI) in diagnosing Ménière's disease(MD) and find a correlation between the degree of endolymphatic...
Wed Oct 23, 2019 13:28
Related ArticlesRelationship between oral environment and development of pneumonia and acute viral respiratory infection in dependent older individuals. Geriatr Gerontol Int. 2019 Oct 21;: Authors: Tashiro H, Kikutani T, Tamura F, Takahashi N, Tohara T, Nawachi K, Maekawa K, Kuboki T Abstract AIM: The importance of oral care has been recognized for the prevention of airway infections in older individuals who require long-term care. The present prospective...
Wed Oct 23, 2019 13:28
Related ArticlesHospital costs impact of post ischemic stroke dysphagia: Database analyses of hospital discharges in France and Switzerland. PLoS One. 2019;14(1):e0210313 Authors: Muehlemann N, Jouaneton B, de Léotoing L, Chalé JJ, Fernandes J, Kägi G, Sarikaya H, Arnold M Abstract INTRODUCTION: Oropharyngeal dysphagia is frequent in hospitalized post-stroke patients and is associated with increased mortality and comorbidities. The aim of our analysis...
Wed Oct 23, 2019 13:28
Related ArticlesEstablishing Goals of Care for Patients With Stroke and Feeding Problems: An Interdisciplinary Trigger-Based Continuous Quality Improvement Project. J Pain Symptom Manage. 2018 10;56(4):588-593 Authors: Hwang F, Boardingham C, Walther S, Jacob M, Hidalgo A, Gandhi CD, Mosenthal AC, Lamba S, Berlin A Abstract BACKGROUND: Few patients with dysphagia because of stroke receive early palliative care (PC) to align treatment goals with their...
Wed Oct 23, 2019 13:28
Related ArticlesClinical applications of IDDSI framework for texture recommendation for dysphagia patients. J Texture Stud. 2018 02;49(1):2-10 Authors: Su M, Zheng G, Chen Y, Xie H, Han W, Yang Q, Sun J, Lv Z, Chen J Abstract Dysphagia is a highly prevalent eating and swallowing disorder among elderly people, impacting negatively on the health and well-being of those afflicted. With increasing populations of elderly people, food industries are under...
Wed Oct 23, 2019 13:28
Related ArticlesComparison of accelerometer-derived physical activity levels between individuals with and without cancer: a UK Biobank study. Future Oncol. 2019 Oct 22;: Authors: McDonald L, Oguz M, Carroll R, Thakkar P, Yang F, Dhalwani N, Cox A, Merinopoulou E, Malcolm B, Mehmud F, Ramagopalan S Abstract Aim: To identify the difference in physical activity (PA) levels between individuals with and without cancer, and to estimate all-cause mortality...
Wed Oct 23, 2019 15:30
Related ArticlesInhibitory Effects On Retinal Neovascularization by Ranibizumab and sTie2-Fc in An Oxygen-Induced Retinopathy Mouse Model. Curr Eye Res. 2018 09;43(9):1190-1198 Authors: Jiang C, Ruan L, Zhang J, Huang X Abstract PURPOSE: To study retinal neovascularization (RNV) inhibition by intravitreal injections (IVs) of ranibizumab, sTie2 fusion protein (sTie2-Fc), and a combined therapy in an oxygen-induced retinopathy (OIR) model. MATERIALS...
Wed Oct 23, 2019 13:21
Related ArticlesCervical epidural hematoma after spinal manipulation therapy: a case report. BMC Musculoskelet Disord. 2019 Oct 22;20(1):461 Authors: Chen Q, Feng JF, Tang X, Li YL, Chen L, Chen G Abstract BACKGROUND: Cervical spinal manipulation therapy is a common non-invasive treatment for neck pain and stiffness, and has been widely used in the population. However, most people do not pay attention to the potential risks of neck manipulation, such...
Wed Oct 23, 2019 14:29
Related ArticlesA pathological complete response by chemotherapy with S-1 and oxaliplatin for a locally advanced duodenal adenocarcinoma in Lynch syndrome: a case report. Surg Case Rep. 2019 Oct 21;5(1):146 Authors: Yasuda S, Harada S, Tsujimoto A, Aoki S, Takei T, Migita K, Ueno M, Tatsumi M, Watanabe A Abstract BACKGROUND: Although primary duodenal adenocarcinoma (DA) is a rare malignancy representing ~ 0.5% of all gastrointestinal cancers, the incidence...
Wed Oct 23, 2019 13:19
Related ArticlesA Case of Gastric Amphicrine Signet-Ring Cell Carcinoma. Clin Pathol. 2019 Jan-Dec;12:2632010X19880535 Authors: Hanamatsu Y, Saigo C, Asano N, Kito Y, Nakada K, Takeda Y, Takeuchi T Abstract "Amphicrine" (in Greek, amphi- means "both" or "double") refers to cells that synchronously exhibit the endocrine and exocrine phenotypes. Gastric amphicrine carcinoma is very rare, and only a few case reports are found in the English literature;...
Wed Oct 23, 2019 13:19
Related ArticlesA rare case of spontaneous splenic rupture complicated by hemophilia A. J Surg Case Rep. 2019 Oct;2019(10):rjz259 Authors: Mahan ME, Jordan RM, Me JCP, Toy F Abstract Splenic lymphangiomas are benign neoplasms resulting from congenital malformations of lymphatic channels manifesting as cystic lesions, occurring mostly in childhood. This process usually involves additional sites in a diffuse or multifocal fashion but although rare, can...
Wed Oct 23, 2019 13:19
Related ArticlesEvaluation of Spheroid 3D Culture Methods to Study a Pancreatic Neuroendocrine Neoplasm Cell Line. Front Endocrinol (Lausanne). 2019;10:682 Authors: Bresciani G, Hofland LJ, Dogan F, Giamas G, Gagliano T, Zatelli MC Abstract Pancreatic Neuroendocrine Neoplasms (pNEN) are rare tumors which treatment still represent an important clinical problem, due to the paucity of medical treatments. Due to tumor complexity, techniques as 3D cultures...
Wed Oct 23, 2019 13:19
Polymicrobial bacteremia after treatment of transcatheter arterial chemoembolization: A case report.
Related ArticlesPolymicrobial bacteremia after treatment of transcatheter arterial chemoembolization: A case report. Medicine (Baltimore). 2019 Oct;98(40):e17393 Authors: Fang XY, Hu LH, Hang YP, Chen YH, Xu XH, Hu XY, Liu YH, Zhang N, Zhong QS Abstract RATIONALE: Bacteremia caused by polymicrobial infections are rare but dangerous. We report a case of hepatic abscess combined with polymicrobial bacteremia in a 49-year-old male patient after surgery...
Wed Oct 23, 2019 13:19
Related ArticlesUnusual form of the distal bone defect of ulna with neurofibromatosis type 1: A case report. Medicine (Baltimore). 2019 Oct;98(40):e17226 Authors: Shen Y, Chen F Abstract RATIONALE: Bone malformation occurs in 10% to 25% neurofibromatosis type 1 (NF-1) patients, and the manifestations are scoliosis, congenital arch and pseudo-joint formation, bone cyst, and pathologic fracture. However, a large segmental defect without obvious signs...
Wed Oct 23, 2019 13:19
Related ArticlesPeripheral osteoma of the nasal bone after laser treatment: A case report. Medicine (Baltimore). 2019 Oct;98(40):e17036 Authors: Hwang JH, Lee DG, Kim KS, Lee SY Abstract INTRODUCTION: Peripheral osteoma, which arises from the periosteum, commonly develops in the head and neck region and is found frequently in the mandible, maxilla, and paranasal sinuses. However, osteoma of the face, especially from the nasal bone, is quite rare. ...
Wed Oct 23, 2019 13:19
Related ArticlesHepatocellular carcinoma arising from left accessory liver lobe supplied by the branch of left hepatic artery: A case report. Medicine (Baltimore). 2019 Oct;98(40):e16912 Authors: Wang X, Zhang Q, Xu K Abstract INTRODUCTION: Accessory liver lobe (ALL) is a rare congenital anomaly. ALL combined with hepatocellular carcinoma (HCC) is even rarer. Most ALLs with HCC are often located in the right liver, and are not supplied by the left hepatic...
Wed Oct 23, 2019 13:19
Related ArticlesTransluminal removal of a giant fibrovascular polyp of the esophagus. Acta Gastroenterol Belg. 2019 Jul-Sep;82(3):437-439 Authors: Mana F, Schoneveld M, Simoens C, Urbain D, Michel O Abstract Giant fibrovascular polyps of the esophagus are rare benign tumors that originate at the hypopharynx or the upper third of the esophagus. Because of the indolent and benign nature they are mostly discovered when very large with symptoms like dysphagia...
Wed Oct 23, 2019 13:19
Related ArticlesSurvival : a rare outcome in large cell neuroendocrine carcinoma of the gallbladder. Acta Gastroenterol Belg. 2019 Jul-Sep;82(3):433-436 Authors: Shapera E, Bitting C Abstract Large cell neuroendocrine carcinoma of the gallbladder is extremely rare. We present a case report and review of literature. We report the rare outcome of survival at 19 month follow-up and hope to raise awareness about this lesion, its treatment modalities and...
Wed Oct 23, 2019 13:19
Related ArticlesClinical outcomes and prognostic factors for cavernous hemangiomas of the spinal cord: a retrospective cohort study J Neurosurg Spine. 2019 04 12;31(2):271-278 Authors: Nagoshi N, Tsuji O, Nakashima D, Takeuchi A, Kameyama K, Okada E, Fujita N, Yagi M, Matsumoto M, Nakamura M, Watanabe K Abstract OBJECTIVE: Intramedullary cavernous hemangioma (CH) is a rare vascular lesion that is mainly characterized by the sudden onset of hemorrhage...
Wed Oct 23, 2019 13:19
Related ArticlesIntraosseous Hibernoma: Five Cases and a Review of the Literature. J Comput Assist Tomogr. 2019 Sep/Oct;43(5):793-798 Authors: Myslicki FA, Rosenberg AE, Chaitowitz I, Subhawong TK Abstract We present 5 cases of intraosseous hibernoma, a rare benign tumor of brown fat. Our literature review reveals that the average age at presentation is 58.6 years, and 69.7% of patients are female. Lesions are most often located in the spine and pelvis....
Wed Oct 23, 2019 13:19
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