Related ArticlesDemystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome. Signal Transduct Target Ther. 2019;4:41 Authors: Zhang Z, Tang H, Chen P, Xie H, Tao Y Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing...
Wed Oct 23, 2019 13:38
Related ArticlesTargeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduct Target Ther. 2019;4:34 Authors: Wang J, Xu B Abstract Over the past 2 decades, there has been an extraordinary progress in the regimens developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Trastuzumab, pertuzumab, lapatinib, and ado-trastuzumab emtansine (T-DM1) are commonly recommended...
Wed Oct 23, 2019 13:38
Related ArticlesNovel therapeutic avenues in triple-negative breast cancer: PI3K/AKT inhibition, androgen receptor blockade, and beyond. Ther Adv Med Oncol. 2019;11:1758835919880429 Authors: Chan JJ, Tan TJY, Dent RA Abstract Multiomic analyses have shed light upon the molecular heterogeneity and complexity of triple-negative breast cancers (TNBCs). With increasing recognition that TNBC is not a single disease entity but encompasses different disease...
Wed Oct 23, 2019 13:38
Related ArticlesTargeted therapies in metastatic gastric cancer: Current knowledge and future perspectives. World J Gastroenterol. 2019 Oct 14;25(38):5773-5788 Authors: Pellino A, Riello E, Nappo F, Brignola S, Murgioni S, Djaballah SA, Lonardi S, Zagonel V, Rugge M, Loupakis F, Fassan M Abstract Gastric cancer (GC) represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases...
Wed Oct 23, 2019 13:38
Related ArticlesThe Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia. J Pediatr. 2019 Oct 18;: Authors: Wahlund M, Nilsson A, Kahlin AZ, Broliden K, Myrberg IH, Appell ML, Berggren A Abstract OBJECTIVE: To evaluate the roles of thiopurine methyltransferase (TPMT), inosine triphosphatase (ITPA), and Nudix hydrolase 15 (NUDT15) in 6-mercaptopurine (6-MP) sensitivity...
Wed Oct 23, 2019 13:38
Related ArticlesStaging the Host: Personalizing Risk Assessment for Radical Cystectomy Patients. Eur Urol Oncol. 2018 09;1(4):292-304 Authors: Psutka SP, Barocas DA, Catto JWF, Gore JL, Lee CT, Morgan TM, Master VA, Necchi A, Rouprêt M, Boorjian SA Abstract CONTEXT: Perioperative and long-term functional and oncologic outcomes following radical cystectomy (RC) for localized bladder cancer remain unchanged despite advances in technique and perioperative...
Wed Oct 23, 2019 13:38
Related ArticlesProspectively Validated Proteochemometric Models for the Prediction of Small-Molecule Binding to Bromodomain Proteins. J Chem Inf Model. 2018 09 24;58(9):1870-1888 Authors: Giblin KA, Hughes SJ, Boyd H, Hansson P, Bender A Abstract The bromodomain-containing proteins are a ligandable family of epigenetic readers, which play important roles in oncological, cardiovascular, and inflammatory diseases. Achieving selective inhibition of specific...
Wed Oct 23, 2019 13:38
Related ArticlesAAPT Diagnostic Criteria for Chronic Abdominal, Pelvic, and Urogenital Pain: Irritable Bowel Syndrome. J Pain. 2018 03;19(3):257-263 Authors: Zhou Q, Wesselmann U, Walker L, Lee L, Zeltzer L, Verne GN Abstract In conjunction with the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership with the U.S. Food and Drug Administration and the American Pain Society,...
Wed Oct 23, 2019 13:38
Related ArticlesPreparing Cancer Patients and Family Caregivers for Lung Surgery: Development of a Multimedia Self-Management Intervention. J Cancer Educ. 2018 06;33(3):557-563 Authors: Sun V, Kim JY, Raz DJ, Chang W, Erhunmwunsee L, Uranga C, Ireland AM, Reckamp K, Tiep B, Hayter J, Lew M, Ferrell B, McCorkle R Abstract The surgical treatment of lung malignancies often results in persistent symptoms, psychosocial distress, and decrements in quality...
Wed Oct 23, 2019 13:38
Abstract Prolonged duration of obstructive apnea (OA) has been observed in highlanders after descending to low altitude. It is proposed that due to adaptation to a hypoxic high‐altitude environment, Tibetan highlanders (TH) and Han highlanders (HH) would manifest different OA durations at low altitude as compared to Han lowlanders (HL). Data collection on consecutive obstructive sleep apnea patients (167 TH, 210 HH and 233 HL) was performed over a period of 8 years in Chengdu (altitude 500 m). The...
Wed Oct 23, 2019 13:36
Abstract Cognitive models of insomnia highlight the role of biased cognition in sleep‐related information, which is proposed to underlie pre‐sleep worry, which in turn results in both subjective and objective sleep deficits. To test this hypothesis, the current study investigated interpretational bias, which is a tendency to interpret ambiguous stimuli in a threat‐related (here: insomnia‐related) manner. We specifically hypothesized that interpretational bias would be associated with (a) pre‐sleep...
Tue Oct 22, 2019 13:06
Related ArticlesLaparoscopic repair of perforated peptic ulcer is not prognostic factor for 30-day mortality (a nationwide prospective cohort study). Int J Surg. 2019 Oct 19;: Authors: Zogovic S, Bojesen AB, Andos S, Mortensen FV Abstract BACKGROUND: Laparoscopic surgery has become increasingly popular in treating perforated peptic ulcer (PPU). However, currently it is not recognized as a prognostic factor for mortality within this group of patients....
Wed Oct 23, 2019 14:36
Related ArticlesCommentary on: "Closure of mesenteric defects is associated with a higher incidence of small bowel obstruction due to adhesions after laparoscopic ante colic Roux-en-Y gastric bypass: a retrospective cohort study". Int J Surg. 2019 Oct 19;: Authors: Al Motlaq AA, Al Saleh K PMID: 31639453 [PubMed - as supplied by publisher]
Wed Oct 23, 2019 14:36
Related ArticlesReply letter to: "Commentary on: Ketamine reduces pain and opioid consumption after total knee arthroplasty: a meta-analysis of randomized controlled studies". Int J Surg. 2019 Oct 19;: Authors: Wang C, Zhang J PMID: 31639452 [PubMed - as supplied by publisher]
Wed Oct 23, 2019 14:36
Related ArticlesDural Arteriovenous Fistula Complicated with Cerebral Venous Sinus Thrombosis: A Case Report. World Neurosurg. 2019 Oct 19;: Authors: Yang S, You R, Wu W, Wei Z, Hong M, Peng Z Abstract Cerebral Venous Sinus Thrombosis (CVST) is always complicated with Dural Arteriovenous Fistula (DAVF) in clinical practice, although both of them are very rare cerebral vascular diseases. In this report, we provide one case of DAVF combined with CVST....
Wed Oct 23, 2019 15:31
Related ArticlesTHE ERA OF CORTICAL BONE TRAJECTORY SCREWS IN SPINE SURGERY: A QUALITATIVE REVIEW WITH RATING OF EVIDENCE. World Neurosurg. 2019 Oct 19;: Authors: Cofano F, Marengo N, Ajello M, Penner F, Mammi M, Petrone S, Lavorato A, Zenga F, Garbossa D PMID: 31639506 [PubMed - as supplied by publisher]
Wed Oct 23, 2019 15:31
Related ArticlesIdentifying the Sources of Error when Using 3D Printed Head Models with Surgical Navigation. World Neurosurg. 2019 Oct 19;: Authors: Mehbodniya AH, Moghavvemi M, Narayanan V, Muthusamy KA, Hamdi M, Waran V Abstract OBJECTIVES: The evaluation of sources of error when preparing, printing and using 3D printed head models for training purposes. METHODOLOGY: Two 3D printed models were designed and fabricated using actual patient imaging...
Wed Oct 23, 2019 15:31
Related ArticlesCerebral venous sinus thrombosis after transsphenoidal resection: a rare complication of Cushing disease-associated hypercoagulability. World Neurosurg. 2019 Oct 19;: Authors: Soni P, Koech H, Silva D, Das P, Sindwani R, Dobri G, Recinos PF Abstract BACKGROUND: Venous thromboembolism is a well-known complication of Cushing syndrome. Deep vein thrombosis and pulmonary embolic events have been widely reported in patients with Cushing syndrome,...
Wed Oct 23, 2019 15:31
Related ArticlesAn intraoperative multi-branch abnormal muscle response monitoring method during microvascular decompression for hemifacial spasm. World Neurosurg. 2019 Oct 19;: Authors: Miao S, Chen Y, Hu X, Zhou R, Ma Y Abstract BACKGROUND: Intraoperative abnormal muscle response (AMR) is widely used as an indicator during microvascular decompression (MVD) surgery for hemifacial spasm (HFS). Usually only one muscle was recorded and not all patients...
Wed Oct 23, 2019 15:31
Related ArticlesUtility and impact of intra-operative imaging for glioma resection on patient outcome and extent of resection: A systematic review and meta-analysis. World Neurosurg. 2019 Oct 19;: Authors: Caras A, Mugge L, Miller WK, Mansour TR, Schroeder J, Medkour A Abstract BACKGROUND: Diffusion tensor imaging (DTI), functional MRI (fMRI), and intraoperative magnetic resonance imaging (iMRI) permit greater visualization and more accurate pre-surgical...
Wed Oct 23, 2019 15:31
Related ArticlesIatrogenic epidermoid cyst of the cauda equina: A late complication of lumbar disc herniation surgery. First case report. World Neurosurg. 2019 Oct 19;: Authors: Rkhami M, Gader G, Loukil B, Badri M, Zammel I Abstract BACKGROUND: Epidermoid cysts (ECs) account for 0.5 -1% of all spinal tumors. They can be congenital or acquired. Acquired spinal ECs are extremely rare and are mostly caused by trauma, or secondary to iatrogenic procedure...
Wed Oct 23, 2019 15:31
Related ArticlesProgress and Prospects of Recurrent Glioma: Bibliometric analyses. World Neurosurg. 2019 Oct 19;: Authors: Chen W, Lei C, Liu P, Liu Y, Guo X, Kong Z, Wang Y, Dai C, Wang Y, Ma W, Wang Y Abstract BACKGROUND: Most glioma patients experience recurrence and have a poor prognosis. Scientometric analysis is effective and widely used to summarize the most influential studies within a certain field. We present the first scientometric analysis...
Wed Oct 23, 2019 15:31
Related ArticlesOutcomes Following Posterior Lumbar Fusion in Polycythemia Vera Patients. World Neurosurg. 2019 Oct 19;: Authors: Labaran LA, Vatani J, Bell J, Puvanesarajah V, Sequeira S, Raad M, Jain A, Hassanzadeh H Abstract BACKGROUND: Polycythemia Vera (PV) is a chronic myeloproliferative neoplasm that is associated with an increased risk for venous and arterial thromboembolism. The aim of this study is to evaluate outcomes following elective posterior...
Wed Oct 23, 2019 15:31
Related ArticlesThe Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment. J Exp Clin Cancer Res. 2019 Oct 21;38(1):420 Authors: Patties I, Kallendrusch S, Böhme L, Kendzia E, Oppermann H, Gaunitz F, Kortmann RD, Glasow A Abstract BACKGROUND: Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy...
Wed Oct 23, 2019 14:33
Related ArticlesTex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway. Oncol Rep. 2019 Oct 16;: Authors: Xiang X, Xiong R, Yu C, Deng L, Bie J, Xiao D, Chen Z, Zhou Y, Li X, Liu K, Feng G Abstract A previous study by our group suggested that testis expressed 10 (Tex10) contributes to tumor progression by promoting stem cell‑like features in hepatocellular carcinoma. However, the relevance of pluripotency...
Wed Oct 23, 2019 14:33
Related ArticlesMicroarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma. Oncol Rep. 2019 Oct 14;: Authors: Deng W, Peng W, Wang T, Chen J, Qiu X, Fu L, Zhu S Abstract Circular RNAs (circRNAs) have emerged as important regulators of carcinogenesis. However, the role of circRNAs in oral squamous cell carcinoma (OSCC) remains limited. Here, total RNAs were extracted...
Wed Oct 23, 2019 14:33
Related ArticlesAntitumor effects and mechanisms of 1,25(OH)2D3 in the Pfeiffer diffuse large B lymphoma cell line. Mol Med Rep. 2019 Oct 17;: Authors: Han J, Tang Y, Zhong M, Wu W Abstract Diffuse large B cell lymphoma (DLBCL) represents the most common subtype of non‑Hodgkin lymphoma in China. 1,25‑Dihydroxyvitamin D3 [1,25(OH)2D3] has been shown to possess significant antitumor potential and is degraded by 25‑hydroxyvitamin D‑24‑hydroxylase (CYP24A1)....
Wed Oct 23, 2019 14:33
Related ArticlesDownregulation of miR‑138‑5p promotes non‑small cell lung cancer progression by regulating CDK8. Mol Med Rep. 2019 Oct 15;: Authors: Xing S, Xu Q, Fan X, Wu S, Tian F Abstract Dysregulation of microRNAs (miRNAs) is frequently observed during cancer development. Aberrant expression of miRNA‑138‑5p (miR‑138‑5p) has been found in many types of cancer. However, the role and the mechanisms underlying miR‑138‑5p function in non‑small cell lung...
Wed Oct 23, 2019 14:33
Related ArticlesApoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling. Int J Mol Med. 2019 Oct 03;: Authors: Xie JH, Lai ZQ, Zheng XH, Xian YF, Li Q, Ip SP, Xie YL, Chen JN, Su ZR, Lin ZX, Yang XB Abstract Bruceine D is one of the active components of Brucea javanica (L.) Merr., which is widely used to treat cancer in China. The aim of the present study was to evaluate the potential...
Wed Oct 23, 2019 14:33
Related ArticlesUbiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT. Med Oncol. 2019 Oct 21;36(11):95 Authors: Yan C, Yuan J, Xu J, Zhang G, Li X, Zhang B, Hu T, Huang X, Mao Y, Song G Abstract Ovarian cancer is one of the most lethal gynecological cancers; owning to its late detection and chemoresistance, understanding the pathogenesis of this malignant tumor is much...
Wed Oct 23, 2019 13:32
Related ArticlesRadiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation. Nanoscale Res Lett. 2019 Oct 21;14(1):328 Authors: Li F, Li Z, Jin X, Liu Y, Li P, Shen Z, Wu A, Zheng X, Chen W, Li Q Abstract Gadolinium-based nanomaterials can not only serve as contrast agents but also contribute to sensitization in the radiotherapy of cancers. Among radiotherapies, carbon ion irradiation is considered one of the...
Wed Oct 23, 2019 13:32
Related ArticlesPBF, a Proto-oncogene in Esophageal Carcinoma. Open Med (Wars). 2019;14:748-756 Authors: Lian SH, Song JD, Huang Y Abstract Emerging evidence shows that the pituitary tumour-transforming gene (PTTG)-binding factor (PBF) functions as a proto-oncogene in some tumors. However, the precise functions of PBF in tumorigenesis and its action mechanisms remain largely unknown. Here for the first time we demonstrated that PBF was associated with...
Wed Oct 23, 2019 13:32
Related ArticlesInhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia. Int J Ophthalmol. 2019;12(10):1539-1547 Authors: Wang LF, Yan ZY, Li YL, Wang YH, Zhang SJ, Jia X, Lu L, Shang YX, Wang X, Li YH, Li SY Abstract AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia. METHODS: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride (CoCl2)....
Wed Oct 23, 2019 13:32
Related ArticlesGatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways. Int J Ophthalmol. 2019;12(10):1524-1530 Authors: Xu B, Sui YL, Fan TJ Abstract AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin (GFX) to stromal fibroblasts (SFs) in vitro. METHODS: SFs were treated with GFX at different concentrations (0.009375%-0.3%), and their viability...
Wed Oct 23, 2019 13:32
Related ArticlesCelastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells. Int J Ophthalmol. 2019;12(10):1517-1523 Authors: Wang LP, Chen BX, Sun Y, Chen JP, Huang S, Liu YZ Abstract AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells (LECs) fibrosis, which is the pathological basis of cataract. METHODS: Human LEC line SRA01/04...
Wed Oct 23, 2019 13:32
Related ArticlesN-Acetyl Cysteine as a Novel Polymethyl Methacrylate Resin Component: Protection against Cell Apoptosis and Genotoxicity. Oxid Med Cell Longev. 2019;2019:1301736 Authors: Zhang Y, Xiao JF, Yang HF, Jiao Y, Cao WW, Shi HM, Cun JF, Tay FR, Ping J, Xiao YH Abstract The present study investigated the antiapoptotic and antigenotoxic capabilities of N-acetyl cysteine- (NAC-) containing polymethyl methacrylate (PMMA) resin. An in vitro Transwell...
Wed Oct 23, 2019 13:32
Related ArticlesMutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors. Proc Natl Acad Sci U S A. 2019 Oct 21;: Authors: Pang Y, Xie F, Cao H, Wang C, Zhu M, Liu X, Lu X, Huang T, Shen Y, Li K, Jia X, Li Z, Zheng X, Wang S, He Y, Wang L, Fletcher JA, Wang Y Abstract Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT or PDGFRA receptor...
Wed Oct 23, 2019 13:32
Related ArticlesCapsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA). Cells. 2019 Oct 18;8(10): Authors: Islam A, Su AJ, Zeng ZM, Chueh PJ, Lin MH Abstract Capsaicin (8-methyl-N-vanillyl-6-noneamide), which is an active component in red chili peppers, is used as a chemopreventive agent that shows favorable cytotoxicity against cancer cells. Accumulating evidence indicates that capsaicin...
Wed Oct 23, 2019 13:32
Related ArticlesATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. 2019 Oct 18;8(10): Authors: Ali R, Alabdullah M, Miligy I, Normatova M, Babaei-Jadidi R, S Nateri A, Rakha EA, Madhusudan S Abstract Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence...
Wed Oct 23, 2019 13:32
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