ABSTRACT A considerable proportion of high grade cervical intraepithelial lesions (CIN2/3) are known to resolve on their own especially among young women. However, since reliable prognostic markers are still lacking, the diagnosis “CIN3” is still an indication for surgery which may result in overtreatment. It is conceivable that a combination of different, ideally independent molecular markers may provide more reliable results. In the present cross‐sectional study two established triage markers,...
Sun Oct 20, 2019 19:49
Abstract An extragonadal yolk sac tumor (YST) is a rare malignant germ cell tumor that usually occurs in childhood. The pathogenesis of extragonadal YST remains largely unknown, especially with regards to its cell of origin. Herein, we report a case of extragonadal YST arising in the uterine round ligament. A 31‐year‐old Japanese woman, para 2, underwent partial resection of a left‐sided, 5‐cm, solid inguinal mass. Intraoperative findings showed enlargement of the uterine round ligament in the inguinal...
Sun Oct 20, 2019 19:45
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01513B, PaperMayank ., Richa Rani, Ashutosh Singh, Neha Garg, Navneet Kaur, Narinder SinghLabelling and imaging of mitochondria and nucleolus have attracted very great attention because of the involvement of these cellular organelles in critical cellular activities. Therefore, a large number of mitochondria...The content of this RSS Feed (c) The Royal Society of Chemistry
02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01647C, CommunicationLijun Zong, Yufeng Han, Lei Gao, Chao Du, Xiaopan Zhang, Lin Li, Xiao Huang, Jinhua Liu, Hai-Dong Yu, Wei HuangThis communication describes a rational design of transparent paper-based biosensing platform for multi-target detection by wavelength-dependent absorbance/transmittance. The platform was successfully applied in examination of protein and cholesterol in serum...The content of this RSS Feed (c) The Royal Society of Chemistry
02:00
Abstract We read with great interest the recently published study by Mofors et al. showing an increased risk of cardiovascular disease (CVD) in patients with primary Sjögren’s syndrome (pSS) [1]. These results confirm the data we observed some years ago in a similarly large cohort of pSS subjects [2]. In Mofors’ study, the highest CV risk appears to be globally associated with the presence of circulating anti‐SSA/SSB autoantibodies, that characterize a subset of younger patients, not only with...
Sun Oct 20, 2019 19:43
Abstract Purpose Patients with acute peripheral unilateral hypofunction (UVH) complain of vertigo and dizziness and show posture imbalance and gaze instability. Vestibular rehabilitation therapy (VR) enhances the functional recovery and it has been shown that gaze stabilization exercises improved the dynamic visual acuity (DVA). Whether the effects of VR depend or not on the moment when it is applied remains however unknown, and investigation...
03:00
Abstract Phenotypic plasticity is the primary mechanism of organismal resilience to abiotic and biotic stress, and genetic differentiation in plasticity can evolve if stresses differ among populations. Inducible defense is a common form of adaptive phenotypic plasticity and long‐standing theory predicts that its evolution is shaped by costs of the defensive traits, costs of plasticity, and a trade‐off in allocation to constitutive versus induced traits. We used a common‐garden to study the evolution...
Sun Oct 20, 2019 19:59
Background and Objectives This study challenges the currently accepted treatment parameters of waiting 1 year following burn injury to treat the resultant scarring. It assesses the impact of treating burn and trauma wounds at less than 3 months of injury on scar formation, providing a new temporal paradigm to patients in the prevention and minimization of scar formation. Study Design/Materials and Methods This randomized clinical trial included 19 patients with moderate‐to‐severe acute burn...
Sun Oct 20, 2019 19:20
Abstract Learning that certain cues or environments predict threat enhances survival by promoting appropriate fear and the resulting defensive responses. Adapting to changing stimulus contingencies by learning that such cues no longer predict threat, or distinguishing between these threat‐related and other innocuous stimuli, also enhances survival by limiting fear responding in an appropriate manner to conserve resources. Importantly, a failure to inhibit fear in response to harmless stimuli is...
Sun Oct 20, 2019 19:29
Abstract The presentations of laryngopharyngeal reflux (LPR) are diverse and include chronic hoarseness, sensation of foreign body in the throat, sore throat etc. 24 h pH monitoring considered the gold standard of investigation for LPR is costly, cumbersome and not readily available at all centers. Empirical trial of Proton pump inhibitor (PPI) as a diagnostic tool after assessment by Reflux Symptom Index (RSI) and Reflux Findings Score (RFS) is a cheaper, simple and readily available...
03:00
This panel session presents an overview of the emerging clinical research on the ADHEAR System, the world’s first adhesive, pressure-free, non-surgical bone conduction system. Clinical experiences are shared by Charlotte Douglas, an audiologist from Saskatoon, Saskatchewan, Canada.
07:00
Germline mutations and copy number changes in DNA damage repair (DDR) genes such as BRCA2 are associated with aggressive forms of prostate cancer (PCa). Although the prevalence of BRCA2 variants in PCa is increasing in Japan, the genomic and biological implications in Japanese patients are unclear. An 81‐year‐old male presented with prostatic adenocarcinoma with neuroendocrine differentiation accompanied by metastatic lung nodule and brain metastases. Platinum‐based doublet chemotherapy combined...
Sun Oct 20, 2019 18:58
Abstract This study evaluated the inhibition and interaction of Bacillus velezensis BvL03 as a probiotic agent against Aeromonas hydrophila. Strain BvL03 isolated from sediment samples of fish ponds had excellent antimicrobial activity against several fish pathogenic bacteria, especially Aeromonas, including A. hydrophila, A. veronii, A. caviae, and A. sobria. The successful amplification of lipopeptide antimicrobial chemical biosynthetic genes, including iturin family (ituA, ituB,...
03:00
Abstract (-)-α-Bisabolol (BISA) is an unsaturated monocyclic sesquiterpenes compound, mainly found in the essential oil of chamomile (Matricaria chamomilla). It has been reported that this compound has several biological activities, but there are few studies evaluating the activity of this compound in the systemic inflammatory response in infectious processes. The aim of this study was to evaluate the effect of BISA on the inflammatory...
03:00
THORAC CARDIOV SURG Reports 2019; 08: e30-e32DOI: 10.1055/s-0039-1697602Thymomas are rare tumors that commonly lie in the anterior mediastinum. The arteries supplying thymomas branch from the internal thoracic arteries and their collaterals. This report presents a patient with huge mediastinal thymoma, whose sensational vascularization is ensured directly by a single dominant tributary branch of the left internal thoracic artery. After initially performed computed tomography angiography, the tumor...
Sun Oct 20, 2019 02:00
British Journal of Cancer, Published online: 21 October 2019; doi:10.1038/s41416-019-0604-5YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways
03:00
Objective: The objective of this study was to determine the features of carbohydrate antigen (CA) 19-9 decline that correlates best with survival benefit in patients with metastatic pancreatic cancer. Methods: This is a retrospective study of 225 patients with metastatic pancreatic cancer receiving first-line therapy. Analysis was performed by the Kaplan-Meier method and Cox-proportional hazards ratios. CA 19-9 decline was grouped into quartiles within different CA 19-9 baseline groups. Time...
Fri Oct 18, 2019 03:00
Tumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to infections such as tuberculosis. The aim of this systematic review was to find out whether there is an associated risk of medication-related osteonecrosis of the jaw (MRONJ). Three authors independently searched PubMed, MEDLINE,...
Sun Oct 20, 2019 03:00
Thrombosis of the superior vena cava with propagation to the right heart chambers can be seen in the presence of chronic indwelling catheters. Moreover, the idiopathic right atrial thrombi may become entrapped...
Sat Oct 19, 2019 03:00
Hydatidiform moles are abnormal human pregnancies with heterogeneous aetiologies that can be classified according to their morphological features and parental contribution to the molar genomes. Here, protocols of multiplex microsatellite DNA genotyping and flow cytometry of formalin-fixed paraffin-embedded molar tissues are described in detail, together with results’ interpretation and integration.
Sun Oct 20, 2019 22:15
This manuscript presents protocols for surgically inflicting controlled blunt and sharp spinal cord injuries to a regenerative axolotl (Ambystoma mexicanum).
Sun Oct 20, 2019 22:00
This protocol details how to implement and perform multi-fiber photometry recordings, how to correct for calcium-independent artifacts, and important considerations for dual-color photometry imaging.
Sun Oct 20, 2019 22:00
Here, we present human adipose tissue enzyme-free micro-fragmentation using a closed system device. This new method allows the obtainment of sub-millimeter clusters of adipose tissue suitable for in vivo transplantation, in vitro culture, and further cell isolation and characterization.
Sun Oct 20, 2019 21:13
We describe how to quantify leaf dwelling arthropods by sealing the leaves and end of branches in a bag, clipping and freezing the bagged material, and rinsing the previously frozen material in water to separate arthropods from the substrate for quantification.
Sun Oct 20, 2019 21:00
This protocol describes a method for the isolation of the mouse eyeball with eyelid, ocular surface, anterior and posterior segments in relatively intact position.
Sun Oct 20, 2019 20:13
This method provides a way to couple optogenetics and genetically encoded calcium sensors to image baseline cytosolic calcium levels and changes in evoked calcium transients in the body wall muscles of the model organism C. elegans.
Sun Oct 20, 2019 20:00
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