Κυριακή 20 Οκτωβρίου 2019

Benign Paroxysmal Positional Vertigo in the Elderly: A Single-center Experience
Objectives: Dizziness and balance problems are common in the elderly, and benign paroxysmal positional vertigo (BPPV) is one of the most common causes of dizziness. The aim of this study is to investigate the subtype distribution of geriatric BPPV in a single tertiary referral center, and compare the treatment efficacy according to the subtype of BPPV. Study Design: Retrospective study. Setting: Tertiary referral academic center. Patients: The consecutive 316 elderly patients diagnosed...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Long-term Outcomes in Down Syndrome Children After Cochlear Implantation: Particular Issues and Considerations
Objective: The aim of the study was to analyze the long-term outcomes after cochlear implantation in deaf children with Down syndrome (DS) regarding age at the first implantation and refer the results to preoperative radiological findings as well as postoperative auditory and speech performance. Additionally, the influence of the age at implantation and duration of CI use on postoperative hearing and language skills were closely analyzed in children with DS. Study Design: Retrospective analysis. ...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
NF2-Related Intravestibular Schwannomas: Long-Term Outcomes of Cochlear Implantation
Objective: Intravestibular schwannomas (IVS) are uncommon tumors in Neurofibromatosis type 2 (NF2) and are mainly associated with multiple internal auditory meatus (IAM) and cerebellopontine angle (CPA) tumors. They usually induce profound hearing loss which can be rehabilitated by cochlear implantation (CI). The aim of this study was to analyze the long-term outcomes of CI during the unpredictable evolution of NF2 disease. Study Design: Retrospective case review. Setting: Tertiary referral...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Auditory Characteristics in Patients With Mucopolysaccharidosis
Objective: The purpose of the study was to evaluate audiologic findings according to mucopolysaccharidosis (MPS) subtypes and to estimate hearing changes as the disease progressed, as well as the therapeutic effect of enzyme replacement therapy on the hearing apparatus. Methods: A total of 124 patients who were diagnosed with MPS between September 1994 and December 2016 were retrospectively analyzed. Play audiometry or pure-tone audiometry was performed for hearing assessment, and auditory...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Recidivism After Endoscopic Treatment of Cholesteatoma
Objective: To investigate the recidivism rate of cholesteatoma treated via endoscopic ear surgery (EES), either via transcanal endoscopic ear surgery or endoscopic assisted tympanomastoidectomy compared with a microscopic postauricular approach. Study Design: Retrospective chart review. Setting: Academic otology practice. Patients: Adult patients (18 years and older) with at least 11 months of surgical follow-up who were treated for cholesteatoma via endoscopic techniques or microscopic...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Mortality and Cause of Death in Hearing Loss Participants: A Longitudinal Follow-up Study Using a National Sample Cohort
Objective: The purpose of the present study was to estimate the risk of mortality in hearing loss subjects in accordance with the cause of death. Study Design: A longitudinal follow up study. Setting: Data from the Korean National Health Insurance Service-National Sample Cohort were collected from a period between 2002 and 2013. Patients and Intervention: The 4,606 severe and 1,007 profound hearing loss participants with 40 or more years old were 1:4 matched with control participants,...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Rate of Initial Hearing Loss During Early Observation Predicts Time to Non-Serviceable Hearing in Patients With Conservatively Managed Sporadic Vestibular Schwannoma
Objective: To date, prediction models for estimating risk of acquiring non-serviceable hearing in subjects with observed vestibular schwannoma (VS) have evaluated outcomes primarily based on features at initial diagnosis. Herein, we evaluate the association of rate of hearing decline during the initial period of observation with time to non-serviceable hearing. If significant, rate of hearing decline may inform decision making after an introductory period of observation. Setting: Two tertiary...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Obesity Is Not Associated With Postoperative Complications After Vestibular Schwannoma Surgery in a Large Single Institution Series
Objective: Determine whether elevated body mass index (BMI) is associated with postoperative complications after vestibular schwannoma (VS) surgery. Study Design: Retrospective case series. Setting: Tertiary referral center. Patients: Two hundred six patients undergoing surgery for VS between 2010 and 2017, grouped into obese and nonobese patients. Intervention: Surgery for VS resection. Main Outcome Measures: Postoperative facial nerve outcomes, length of hospital stay,...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Evaluation of Cochlear Duct Length Measurements From a 3D Analytical Cochlear Model Using Synchrotron Radiation Phase-Contrast Imaging
Hypothesis: Evaluating the accuracy of cochlear duct length (CDL) measurements from a published three-dimensional (3D) analytical cochlear model using Synchrotron Radiation Phase–Contrast Imaging (SR-PCI) data will help determine its clinical applicability and allow for model adjustments to increase accuracy. Background: Accurate CDL determination can aid in cochlear implant sizing for full coverage and frequency map programming, which has the potential to improve hearing outcomes in patients....
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Horizontal Vestibulo-Ocular Reflex Gain Measures During Convergence Using a Monocular Video Technique
Hypothesis: Vestibulo-ocular reflex (VOR) response measures during convergence, which are clinically important to measure peripheral vestibular organ function during rotational and translational rapid head movements, can be implemented using existing clinically available monocular video-oculography (VOG) systems. Background: We have developed and validated a monocular VOG technique that allows for accurate measurement of the convergence angle immediately before a rapid translational or rotational...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00

Transcanal Endoscopic Ear Surgery for Congenital Middle Ear Anomalies
Objective: To demonstrate the efficacy of transcanal endoscopic ear surgery (TEES) for congenital middle ear anomalies. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-one patients ranging in age from 4 to 62 years old (median: 15 yr) who underwent TEES between 2011 and 2017 were compared with 19 patients ranging in age from 3 to 49 years old (median: 11 yr) who underwent microscopic ear surgery (MES) between 2000 and 2011. Intervention:...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Combined Endoscopic and Microscopic Surgery for Perilabyrinthine Lesions: Feasibility and Technique
Objectives: To determine the feasibility of endoscopic-assisted surgery for lesions involving the perilabyrinthine recesses, and develop and validate a technique for this kind of lesions that increases the possibility of preserving the labyrinth and cochlea. Study Design: Observational study. Setting: Referral center. Cases: Five patients who underwent endoscopy-assisted surgery for lateral skull base pathology involving the perilabyrinthine recesses between July 2010 and March...
Otology & Neurotology Published Ahead-of-Print
Fri Oct 18, 2019 03:00
SERPINB2 and miR‐146a/b are coordinately regulated and act in the suppression of psoriasis‐associated inflammatory responses in keratinocytes
Abstract Psoriasis is a chronic inflammatory skin disease with numerous involved factors. miR‐146a and miR‐146b (miR‐146a/b) are anti‐inflammatory miRNAs that are increased in psoriatic skin. SERPINB2 has been shown to be upregulated in the inflammation and infections. Here we aimed to study the relationship between miR‐146a/b and SERPINB2 and to delineate the role of SERPINB2 in association of plaque psoriasis. We report increased SERPINB2 expression in the skin of psoriasis patients, which was...
Experimental Dermatology
Sun Oct 20, 2019 16:33
Metastasis of Prostate Adenocarcinoma in the Mandible: Rare Occurrence in Maxillary Bones
Objective: This article describes the case report of a prostate adenocarcinoma in the mandible. Background: Prostate adenocarcinoma is a malignant tumor common in men from the fourth decade of life. The occurrence of oral metastatic lesions is rare. Case Report: A 78-year-old male patient was referred to the oral and maxillofacial surgery service of the Pontifical Catholic University of Rio Grande do Sul for complaints of painless volume increase in the mandible. The diagnosis through...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Filler Migration and Florid Granulomatous Reaction to Hyaluronic Acid Mimicking a Buccal Tumor
Hyaluronic acid is among the most commonly used cosmetic fillers. Although considered biocompatible and safe, it may rarely cause a wide range of complications. The authors report a case of migration of hyaluronic acid concomitant with granulomatous inflammatory response that mimicked a buccal tumor. A 52-year-old female presented with a solid painless mass of the right buccal area. The patient denied any history of trauma and cosmetic procedures of the affected area. Skin and mucosal membrane were...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Surgical Approach in a Patient With Agnathia-Otocephaly Complex: Three-Stage Mandibular Distraction Protocol
Agnathia-otocephaly complex (AOC) is a rare malformation complex of the first pharyngeal arch that is characterized by agnathia/dysgnathia, microstomia, aglossia/hypoglossia and variable displacement of the ears. Only 11 post-infancy patients with severe AOC have been described in the literature, and the incidence of this malformation complex is estimated to be 1 per 70,000 births. In this brief clinical study, the authors describe the case of an 18-year-old female diagnosed with AOC who underwent...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Langerhans Cell Histiocytosis in an Adult: A Discussion of Epidemiology and Treatment Options
Langerhans cell histiocytosis (LCH) is a rare disorder defined by the abnormal proliferation of Langerhans cells. While LCH can present at any age, it is classically described as a pediatric condition, and is therefore overlooked in the adult patient. Additionally, depending on tumor burden and location, LCH can manifest with a host of oral and systemic symptoms which further confuses the clinical presentation and ultimate diagnosis. The authors present a unique report of an elderly Hispanic male...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Orbital Blowout Fracture and Orbital Emphysema caused by Nose Blowing
A 76-year-old man presented with 1 day history of eyelid swelling and decreased vision on the left side. History reveals nose blowing the night prior to the occurrence of the symptoms. Initial examination of the left eye showed decreased visual acuity, increased intraocular pressure, and limited ocular motility with presence of air bubbles under the bulbar conjunctiva. Imaging studies showed medial orbital wall fracture with severe emphysema. The patient was observed for a week and no active surgical...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Platysmaplasty: Is it Possible to Pull the Platysma Effectively in the Medial or Lateral Direction?
The aim of this study was to investigate whether it is possible to pull the platysma effectively in the medial or lateral direction (medial platysmaplasty and lateral platysmaplasty) and to explore the anatomical basis of those findings. Six hemifaces from 3 fresh cadavers were dissected. After skin removal, the platysma was pulled upward and in the medial or lateral direction with the ulnar side of the palm. Its mobility was checked. In 2 volunteers, using wooden bar, the skin overlying platysma...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Nasal Bone Osteoma Approach
Osteoma is a benign osteogenic lesion that arises most frequently in the craniomaxillofacial region. Rarely, it can appear on the outer side of nasal bone and cause aesthetic problems. The authors present an unusual case of outer side nasal bone osteoma with a brief review of its main clinical presentations, diagnostic studies, and treatment options. Address correspondence and reprint requests to André D’Avanço de Morais, MD, Federal University of Paraná, 111 Ferdinando Demarchi Street, São Bernardo...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
The Role of Transoral Robotic Surgery for Parapharyngeal Space: Experience of a Tertiary Center
The parapharyngeal space (PPS) is an anatomically and functionally complex region of the craniofacial district. Tumors that originate from this region are rare, and surgery is currently the best practice in the vast majority of cases with different surgical approaches being reported in the literature. Recently, mini-invasive robotic/endoscopic techniques have begun to emerge as effective alternatives in selected cases. In this work, we retrospectively analyzed 17 patients affected by PPS tumors,...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00
Comparison of Orbital Preadipocyte Adipogenesis Between Pediatric and Adult Graves Ophthalmopathy
To investigate the difference of adipogenesis in orbital preadipocytes between pediatric and adult Graves ophthalmopathy (GO) under lipopolysaccharide (LPS)-induced inflammation in vitro. Orbital preadipocytes from pediatric and adult GO patients during eyelid or orbital surgery were cultured. The orbital preadipocytes in pediatric and adult GO were divided into group A and group B. In group A, pediatric and adult orbital preadipocytes were differentiated in adipogenesis media without LPS intervention,...
Journal of Craniofacial Surgery - Published Ahead-of-Print
Fri Oct 18, 2019 03:00

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