Related ArticlesDiiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity. Mol Cell Endocrinol. 2019 Sep 30;:110604 Authors: Gnocchi D, Ellis ECS, Johansson H, Eriksson M, Bruscalupi G, Steffensen KR, Parini P Abstract Until three decades, ago 3,5-diiodothyronine (3,5-T2) and 3,3'-diiodothyronine (3,3'-T2) were considered products of thyroid hormone catabolism without biological activity. Some...
Fri Oct 04, 2019 15:59
Related ArticlesHot-Spots of Mcl-1 Protein. J Med Chem. 2019 Oct 03;: Authors: Denis C, Sopková-de Oliveira Santos J, Bureau R, Voisin-Chiret AS Abstract Protein-protein interactions (PPIs) control many important physiological processes within human cells. Apoptosis or programmed cell death is closely regulated by pro- and anti-apoptotic signals. Dysregulation of this homeostasis is implicated in tumorigenesis and acquired resistance to treatments. The...
Fri Oct 04, 2019 15:59
Related ArticlesThe transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis. Mol Oncol. 2019 Oct 03;: Authors: Hoesl C, Fröhlich T, Hundt JE, Kneitz H, Goebeler M, Wolf R, Schneider MR, Dahlhoff M Abstract Over the last few decades, cases of non-melanoma skin cancer (NMSC) have risen to over three million cases every year worldwide. Members of the ERBB receptor family are important regulators of skin development and homeostasis...
Fri Oct 04, 2019 15:59
Related ArticlesMechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Sci Adv. 2019 Sep;5(9):eaau7802 Authors: Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y Abstract Mechanical loading plays an important role in bone homeostasis. However,...
Fri Oct 04, 2019 15:59
Related ArticlesThe left atrial appendage in humans: structure, physiology, and pathogenesis. Europace. 2019 Oct 03;: Authors: Karim N, Ho SY, Nicol E, Li W, Zemrak F, Markides V, Reddy V, Wong T Abstract For many years, the left atrial appendage (LAA) was considered a dormant embryological remnant; however, it is a structurally complex and functional organ that contributes to cardiac haemodynamic changes and volume homeostasis through both its contractile...
Fri Oct 04, 2019 13:57
Related ArticlesBiological importance of podoplanin expression in chorionic villous stromal cells and its relationship to placental pathologies. Sci Rep. 2019 Oct 02;9(1):14230 Authors: Onak Kandemir N, Barut F, Barut A, Birol İE, Dogan Gun B, Ozdamar SO Abstract Podoplanin, a reliable marker of lymphatic endothelium, is a mucin-type transmembrane protein. Although the human placenta is devoid of a lymphatic system, chorionic villous stromal (CVS) cells...
Fri Oct 04, 2019 13:57
Related ArticlesPublisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019 Oct 02;10(1):4555 Authors: Serwas NK, Hoeger B, Ardy RC, Stulz SV, Sui Z, Memaran N, Meeths M, Krolo A, Petronczki ÖY, Pfajfer L, Hou TZ, Halliday N, Santos-Valente E, Kalinichenko A, Kennedy A, Mace EM, Mukherjee M, Tesi B, Schrempf A, Pickl WF, Loizou JI, Kain R, Bidmon-Fliegenschnee B, Schickel...
Fri Oct 04, 2019 13:57
Related ArticlesActivation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients. J Immunol. 2019 Oct 02;: Authors: Zhang M, Ming S, Gong S, Liang S, Luo Y, Liang Z, Cao C, Lao J, Shang Y, Li X, Wang M, Zhong G, Xu L, Wu M, Wu Y Abstract Mucosal-associated invariant T (MAIT) cells play a key role in local and systemic immune responses. Studies suggest that type 2 diabetes (T2D) is associated with...
Fri Oct 04, 2019 13:57
Related ArticlesMining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Huang J, Willems P, Wei B, Tian C, Ferreira RB, Bodra N, Martínez Gache SA, Wahni K, Liu K, Vertommen D, Gevaert K, Carroll KS, Van Montagu M, Yang J, Van Breusegem F, Messens J Abstract Hydrogen peroxide (H2O2) is an important messenger molecule for diverse cellular processes. H2O2 oxidizes proteinaceous...
Fri Oct 04, 2019 13:57
29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/10/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesBeyond THC and Endocannabinoids. Annu Rev Pharmacol Toxicol. 2019 Oct 03;: Authors: Pacher P, Kogan NM, Mechoulam R Abstract Research in the cannabinoid field, namely on phytocannabinoids, the endogenous cannabinoids anandamide and 2-arachidonoyl glycerol and their metabolizing and synthetic enzymes, the cannabinoid receptors, and anandamide-like cannabinoid compounds, has expanded tremendously over the last few years. Numerous endocannabinoid-like...
Fri Oct 04, 2019 14:07
Related ArticlesLatent Alcohol Use Typologies and Health Status Among a Cohort of Adults Living with HIV. Alcohol Alcohol. 2019 Oct 03;: Authors: Madkour AS, Felker-Kantor E, Wallace M, Ferguson T, Welsh DA, Molina PE, Theall KP Abstract AIMS: To characterize latent typologies of alcohol use among persons living with human immunodeficiency virus (HIV) (PLWH) and test their relationship with physical and mental health status. METHODS: Baseline...
Fri Oct 04, 2019 14:07
Related ArticlesTissue stiffness at the human maternal-fetal interface. Hum Reprod. 2019 Oct 03;: Authors: Abbas Y, Carnicer-Lombarte A, Gardner L, Thomas J, Brosens JJ, Moffett A, Sharkey AM, Franze K, Burton GJ, Oyen ML Abstract STUDY QUESTION: What is the stiffness (elastic modulus) of human nonpregnant secretory phase endometrium, first trimester decidua, and placenta? SUMMARY ANSWER: The stiffness of decidua basalis, the site of placental...
Fri Oct 04, 2019 14:07
Related ArticlesDisruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Sci Adv. 2019 Sep;5(9):eaax2166 Authors: Guo H, Li Y, Shen L, Wang T, Jia X, Liu L, Xu T, Ou M, Hoekzema K, Wu H, Gillentine MA, Liu C, Ni H, Peng P, Zhao R, Zhang Y, Phornphutkul C, Stegmann APA, Prada CE, Hopkin RJ, Shieh JT, McWalter K, Monaghan KG, van Hasselt PM, van Gassen K, Bai T, Long M, Han L, Quan Y, Chen M, Zhang Y, Li K, Zhang...
Fri Oct 04, 2019 14:07
Related ArticlesDinosaur paleohistology: review, trends and new avenues of investigation. PeerJ. 2019;7:e7764 Authors: Bailleul AM, O'Connor J, Schweitzer MH Abstract In the mid-19th century, the discovery that bone microstructure in fossils could be preserved with fidelity provided a new avenue for understanding the evolution, function, and physiology of long extinct organisms. This resulted in the establishment of paleohistology as a subdiscipline...
Fri Oct 04, 2019 14:07
Related ArticlesThe CK2 inhibitor CX4945 reverses cisplatin resistance in the A549/DDP human lung adenocarcinoma cell line. Oncol Lett. 2019 Oct;18(4):3845-3856 Authors: Jin C, Song P, Pang J Abstract Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains...
Fri Oct 04, 2019 14:07
Related ArticlesManaging Genetic Diversity and Extinction Risk for a Rare Plains Bison (Bison bison bison) Population. Environ Manage. 2019 Oct 02;: Authors: Cherry SG, Merkle JA, Sigaud M, Fortin D, Wilson GA Abstract Unfenced plains bison are rare and only occur in a small number of locations throughout Canada and the United States. We examined management guidelines for maintenance of genetic health and population persistence for a small and isolated...
Fri Oct 04, 2019 14:07
Related ArticlesTarget genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019 Oct 02;: Authors: Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal...
Fri Oct 04, 2019 14:07
Related ArticlesWidening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. Genet Med. 2019 Oct 03;: Authors: Zawerton A, Mignot C, Sigafoos A, Blackburn PR, Haseeb A, McWalter K, Ichikawa S, Nava C, Keren B, Charles P, Marey I, Tabet AC, Levy J, Perrin L, Hartmann A, Lesca G, Schluth-Bolard C, Monin P, Dupuis-Girod S, Guillen Sacoto MJ, Schnur RE, Zhu Z, Poisson A, El Chehadeh S, Alembik Y, Bruel...
Fri Oct 04, 2019 14:07
Related ArticlesHuman amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cells. Sci Rep. 2019 Oct 02;9(1):14193 Authors: Riedel R, Pérez-Pérez A, Carmona-Fernández A, Jaime M, Casale R, Dueñas JL, Guadix P, Sánchez-Margalet V, Varone CL, Maymó JL Abstract The placental stem cells have called the focus of attention for their therapeutic potential to treat different diseases, including...
Fri Oct 04, 2019 14:07
Related ArticlesAnti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus. Sci Rep. 2019 Oct 02;9(1):14233 Authors: Frinchi M, Nuzzo D, Scaduto P, Di Carlo M, Massenti MF, Belluardo N, Mudò G Abstract Recently we found that acute treatment with Oxotremorine (Oxo), a non-selective mAChRs agonist, up-regulates heat shock proteins and activates their transcription factor heat shock factor 1...
Fri Oct 04, 2019 14:07
Related ArticlesThe PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486. Sci Rep. 2019 Oct 02;9(1):14242 Authors: Ghamloush F, Ghayad SE, Rammal G, Fahs A, Ayoub AJ, Merabi Z, Harajly M, Zalzali H, Saab R Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic fusion protein...
Fri Oct 04, 2019 14:07
Related ArticlesDilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil. J Biol Chem. 2019 Oct 02;: Authors: Tang W, Unrath WC, Desetty R, Yengo CM Abstract We investigated a dilated cardiomyopathy (DCM) mutation (F764L) in human beta-cardiac myosin by determining its motor properties in the presence and absence of the heart failure drug omecamtive mecarbil (OM). The mutation...
Fri Oct 04, 2019 14:07
Related ArticlesPivotal Role of PDK1 in Megakaryocyte Cytoskeletal Dynamics and Polarization during Platelet Biogenesis. Blood. 2019 Oct 02;: Authors: Geue S, Aurbach K, Manke MC, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märklin M, Borst CE, Quintanilla-Martinez L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O Abstract During thrombopoiesis megakaryocytes (MKs) form proplatelets...
Fri Oct 04, 2019 14:07
1515 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/10/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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1077 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/10/04PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Oct 04, 2019 14:13
Related ArticlesReproducibility and Validity of A Posteriori Dietary Patterns: A Systematic Review. Adv Nutr. 2019 Oct 03;: Authors: Edefonti V, De Vito R, Dalmartello M, Patel L, Salvatori A, Ferraroni M Abstract The effective use of dietary patterns (DPs) remains limited. There is a need to assess their consistency over multiple administrations of the same dietary source, different dietary sources, or across different studies. Similarly, their generalizability...
Fri Oct 04, 2019 14:14
Related ArticlesA machine learning-based service for estimating quality of genomes using PATRIC. BMC Bioinformatics. 2019 Oct 03;20(1):486 Authors: Parrello B, Butler R, Chlenski P, Olson R, Overbeek J, Pusch GD, Vonstein V, Overbeek R Abstract BACKGROUND: Recent advances in high-volume sequencing technology and mining of genomes from metagenomic samples call for rapid and reliable genome quality evaluation. The current release of the PATRIC database...
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Related ArticlesPimping: a tradition of gendered disempowerment. BMC Med Educ. 2019 Oct 03;19(1):345 Authors: Chen DR, Priest KC Abstract The use of pimping as a method of teaching is widespread in the clinical phase of medical education. In this paper we consider pimping's colloquial meanings and discuss how it was introduced into the language of medical education. We posit that such language reflects persistent gendered hierarchies in medicine, and...
Fri Oct 04, 2019 14:24
Related ArticlesColorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis. BMJ Open. 2019 Oct 02;9(10):e032773 Authors: Jodal HC, Helsingen LM, Anderson JC, Lytvyn L, Vandvik PO, Emilsson L Abstract OBJECTIVE: Evaluate effectiveness, harms and burdens of faecal blood testing, sigmoidoscopy and colonoscopy screening for colorectal cancer over 15 years. DESIGN: We performed an...
Fri Oct 04, 2019 14:47
Related ArticlesRare but heard: using asynchronous virtual focus groups, interviews and roundtable discussions to create a personalised psychological intervention for primary sclerosing cholangitis: a protocol. BMJ Open. 2019 Oct 02;9(10):e031417 Authors: Ranieri V, Kennedy E, Walmsley M, Thorburn D, McKay K Abstract INTRODUCTION: Primary sclerosing cholangitis (PSC) is a rare and chronic disease characterised by inflammation and fibrosis of the liver's...
Fri Oct 04, 2019 14:47
Related ArticlesAssessing the impact of rising child poverty on the unprecedented rise in infant mortality in England, 2000-2017: time trend analysis. BMJ Open. 2019 Oct 02;9(10):e029424 Authors: Taylor-Robinson D, Lai ETC, Wickham S, Rose T, Norman P, Bambra C, Whitehead M, Barr B Abstract OBJECTIVE: To determine whether there were inequalities in the sustained rise in infant mortality in England in recent years and the contribution of rising child...
Fri Oct 04, 2019 14:47
Related ArticlesThe sounds go boom but then what? Conserv Physiol. 2019;7(1):coz057 Authors: Birnie-Gauvin K PMID: 31579513 [PubMed]
Fri Oct 04, 2019 14:13
Related ArticlesHypoxia modulates stem cell properties and induces EMT through N-glycosylation of EpCAM in breast cancer cells. J Cell Physiol. 2019 Oct 04;: Authors: Zhang D, Yang L, Liu X, Gao J, Liu T, Yan Q, Yang X Abstract Epithelial cell adhesion molecule (EpCAM), which is a transmembrane glycoprotein, is related to tumor progression. We demonstrated that EpCAM plays important roles in proliferation, apoptosis, and metastasis during breast cancer...
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Related ArticlesThe combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy. J Cell Physiol. 2019 Oct 04;: Authors: Chen CH, Lin JW, Huang CY, Yeh YL, Shen CY, Badrealam KF, Ho TJ, Padma VV, Kuo WW, Huang CY Abstract Cardiac hypertrophy is a common phenomenon observed in progressive heart disease associated with heart failure. Insulin-like growth factor receptor II (IGF-IIR) has been much implicated...
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Related ArticlesTransforming growth factor-β signaling confers hepatic stellate cells progenitor features after partial hepatectomy. J Cell Physiol. 2019 Oct 04;: Authors: Chen Z, Wan L, Jin X, Wang W, Li D Abstract Liver regeneration involves not only hepatocyte replication but progenitor aggregation and scarring. Partial hepatectomy (PH), an established model for liver regeneration, reactivates transforming growth factor-β (TGF-β) signaling. Hepatic...
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Related ArticlesDeregulation of UCA1 expression may be involved in the development of chemoresistance to cisplatin in the treatment of non-small-cell lung cancer via regulating the signaling pathway of microRNA-495/NRF2. J Cell Physiol. 2019 Oct 03;: Authors: Li C, Fan K, Qu Y, Zhai W, Huang A, Sun X, Xing S Abstract Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide. As a platinum-based chemotherapeutic drug, cisplatin...
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Related ArticlesLong noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21. J Cell Physiol. 2019 Oct 03;: Authors: Wang Z, Song Y, Han X, Qu P, Wang W Abstract Exosomes derived from differentiated P12 cells and MSCs were proved to suppress apoptosis of neuron cells, and phosphatase and tensin homolog pseudogene 1 (PTENP1) was reported to inhibit cell proliferation. In this study, we aimed to...
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Related ArticlesAnalysis of lncRNA-mRNA networks after MEK1/2 inhibition based on WGCNA in pancreatic ductal adenocarcinoma. J Cell Physiol. 2019 Oct 03;: Authors: Qian J, Yang J, Liu X, Chen Z, Yan X, Gu H, Xue Q, Zhou X, Gai L, Lu P, Shi Y, Yao N Abstract Pancreatic ductal adenocarcinoma (PDA) responds poorly to treatment. Efforts have been exerted to prolong the survival time of PDA, but the 5-year survival rates remain disappointing. Understanding...
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Related ArticlesModulatory effects of statins on the autophagy: A therapeutic perspective. J Cell Physiol. 2019 Oct 02;: Authors: Ashrafizadeh M, Ahmadi Z, Farkhondeh T, Samarghandian S Abstract Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such...
Fri Oct 04, 2019 13:27
Related ArticlesmiR125a attenuates BMSCs apoptosis via the MAPK-ERK pathways in the setting of craniofacial defect reconstruction. J Cell Physiol. 2019 Oct 02;: Authors: Fan L, Wang J, Ma C Abstract Bone mesenchymal stem cell (BMSC)-based regenerative therapy is critical for the craniofacial defect reconstruction. However, oxidative stress microenvironment after transplantation limits the therapeutic efficiency of BMSC. The miR-181c has been found to...
Fri Oct 04, 2019 13:27
Related ArticlesPrimary colonospheres maintain stem cell-like key features after cryopreservation. J Cell Physiol. 2019 Oct 02;: Authors: Eini L, Naseri M, Karimi-Busheri F, Bozorgmehr M, Ghods R, Madjd Z Abstract The development of efficient and repeatable protocols for biobanking and prolonged storage of cancer stem cells (CSCs), with minimum alterations in biological function, is valuable and desired, particularly for retrospective analysis and clinical...
Fri Oct 04, 2019 13:27
Related ArticlesCytotoxic and apoptotic properties of a novel nano-toxin formulation based on biologically synthesized silver nanoparticle loaded with recombinant truncated pseudomonas exotoxin A. J Cell Physiol. 2019 Oct 02;: Authors: Gholami N, Cohan RA, Razavi A, Bigdeli R, Dashbolaghi A, Asgary V Abstract Bacterial toxins have received a great deal of attention in the development of antitumor agents. Currently, these protein toxins were used in the...
Fri Oct 04, 2019 13:27
Related ArticlesThe Key to Successful Weight Loss on a High-Fiber Diet May Be in Gut Microbiome Prevotella Abundance. J Nutr. 2019 Oct 04;: Authors: Ortega-Santos CP, Whisner CM PMID: 31584088 [PubMed - as supplied by publisher]
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Related ArticlesSmall HDL Particles Are Associated with Gestational Diabetes, Providing a Potential Early Identification Tool. J Nutr. 2019 Oct 04;: Authors: Fernandez ML PMID: 31584080 [PubMed - as supplied by publisher]
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Related ArticlesDietary Garcinol Attenuates Hepatic Pyruvate and Triglyceride Accumulation by Inhibiting P300/CBP-Associated Factor in Mid-to-Late Pregnant Rats. J Nutr. 2019 Oct 03;: Authors: Yao W, Wang T, Xia J, Li J, Yu X, Huang F Abstract BACKGROUND: Increased hepatic glycolysis and lipogenesis are characteristic of pregnancy. OBJECTIVES: The present study aimed to investigate the mechanism of garcinol on the amelioration of hepatic pyruvate...
Fri Oct 04, 2019 14:57
Related ArticlesPositional effects of premature termination codons on the biochemical and biophysical properties of CFTR. J Physiol. 2019 Oct 04;: Authors: Yeh JT, Hwang TC Abstract KEY POINTS: Biochemical and biophysical characterizations of three nonsense mutations of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) associated with severe form of cystic fibrosis (CF) reveal the importance and heterogenous effects of the position of the premature...
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Related ArticlesCorticospinal excitability modulation by pairing peripheral nerve stimulation with cortical states of movement initiation. J Physiol. 2019 Oct 03;: Authors: Fu L, Rocchi L, Hannah R, Xu G, Rothwell JC, Ibáñez J Abstract KEY POINTS: We compare the effects on corticospinal excitability of repeatedly delivering peripheral nerve stimulation at three time points (-30 ms, 0 ms, +50 ms) relative to muscle onset in a cue-guided task. Plastic...
Fri Oct 04, 2019 14:21
Related ArticlesTrust the heart to save the brain. Changes in heart rate patterns have the potential to be a biomarker for hypoxic ischaemic brain injury. J Physiol. 2019 Oct 03;: Authors: Allison BJ PMID: 31578719 [PubMed - as supplied by publisher]
Fri Oct 04, 2019 14:21
Related ArticlesShape-shifting structured lattices via multimaterial 4D printing. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Boley JW, van Rees WM, Lissandrello C, Horenstein MN, Truby RL, Kotikian A, Lewis JA, Mahadevan L Abstract Shape-morphing structured materials have the ability to transform a range of applications. However, their design and fabrication remain challenging due to the difficulty of controlling the underlying metric tensor in...
Fri Oct 04, 2019 14:19
Related ArticlesCapsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Huet A, Duda RL, Boulanger P, Conway JF Abstract The large (90-nm) icosahedral capsid of bacteriophage T5 is composed of 775 copies of the major capsid protein (mcp) together with portal, protease, and decoration proteins. Its assembly is a regulated process that involves several intermediates, including...
Fri Oct 04, 2019 14:19
Related ArticlesOrientationally ordered glasses via controlled deposition. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Harrowell P PMID: 31578254 [PubMed - as supplied by publisher]
Fri Oct 04, 2019 14:19
Related ArticlesMapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Parker BW, Goncz EJ, Krist DT, Statsyuk AV, Nesvizhskii AI, Weiss EL Abstract Short linear peptide motifs that are intracellular ligands of folded proteins are a modular, incompletely understood molecular interaction language in signaling systems. Such motifs, which frequently...
Fri Oct 04, 2019 14:19
Related ArticlesAllele-specific nonstationarity in evolution of influenza A virus surface proteins. Proc Natl Acad Sci U S A. 2019 Oct 02;: Authors: Popova AV, Safina KR, Ptushenko VV, Stolyarova AV, Favorov AV, Neverov AD, Bazykin GA Abstract Influenza A virus (IAV) is a major public health problem and a pandemic threat. Its evolution is largely driven by diversifying positive selection so that relative fitness of different amino acid variants changes...
Fri Oct 04, 2019 14:19
Ένας 28χρονος άνδρας, παράλυτος από τους ώμους και κάτω, ο οποίος είχε σπάσει το λαιμό του μετά την πτώση του από ύψος 14 μέτρων σε ένα νυχτερινό κλαμπ πριν τέσσερα χρόνια, μπόρεσε να περπατήσει ξανά φορώντας έναν ολόσωμο ρομποτικό εξωσκελετό, τον οποίο ελέγχει με τον νου του. Προς το παρόν, ο ασθενής δεν κινείται τελείως ανεξάρτητα, καθώς ο εξωσκελετός με την ονομασία Ours είναι συνδεδεμένος από ψηλά με έναν ιμάντα προσαρτημένο στο ταβάνι. Πάντως το επίτευγμα αποτελεί σημαντικό βήμα προόδου, καθώς...
Fri Oct 04, 2019 13:03
Μια χορτοφαγική διατροφή μπορεί να ανακουφίσει από τα συμπτώματα της Ρευματοειδούς Αρθρίτιδας υποστηρίζει νέα έρευνα που δημοσιεύθηκε στο Frontiers in Nutrition. Η Ρευματοειδής αρθρίτιδα είναι χρόνια νόσος που προκαλεί φλεγμονή στις αρθρώσεις οι οποίες εμφανίζονται θερμές, διογκωμένες, πονούν, μπορεί να είναι ερυθρές και έχουν μειωμένο εύρος κίνησης. Προσβάλλει σχεδόν όλες τις αρθρώσεις του σώματος και το αποτέλεσμα της είναι η καταστροφή του χόνδρου των οστών, των τενόντων και των συνδέσμων τους....
Fri Oct 04, 2019 12:45
Μόλις λίγες σταγόνες αίματος είναι αρκετές για να εντοπιστούν έγκαιρα οι πάσχοντες από σακχαρώδη διαβήτη με απειλητικές για τη ζωή τους αγγειακές παθήσεις όπως η καρδιοπάθεια, η αθηροσκλήρωση και η νεφρική ανεπάρκεια. Την αιματολογική εξέταση δημιούργησαν ερευνητές από την Ιατρική Σχολή του Πανεπιστημίου Northwestern ενώ τα ευρήματα δημοσιεύθηκαν στο Clinical Chemistry. Η εξέταση βασίζεται σε μια νέα τεχνολογία ανάλυσης αίματος που ανέπτυξαν οι ερευνητές και την οποία πρόσφατα χρησιμοποίησαν για...
Fri Oct 04, 2019 08:47
Οι γυναίκες με Σύνδρομο Πολυκυστικών Ωοθηκών (PCOS) έχουν περισσότερες πιθανότητες να εκδηλώσουν αναπνευστικά προβλήματα, σύμφωνα με μία έρευνα που παρουσιάστηκε στο πρόσφατο Διεθνές Συνέδριο της Ευρωπαϊκής Αναπνευστικής Κοινότητας. Το Σύνδρομο Πολυκυστικών Ωοθηκών επηρεάζει τη λειτουργία των ωοθηκών μιας γυναίκας λόγω ορμονικής ανισορροπίας. Μπορεί να προκαλέσει διαταραχές στην έμμηνο ρύση, υπογονιμότητα και διάφορα άλλα συμπτώματα, ενώ θεωρείται ότι επηρεάζει σχεδόν μία στις έξι γυναίκες και σε...
Fri Oct 04, 2019 08:47
Αμερικανοί ερευνητές αποκαλύπτουν ότι η συχνή κατανάλωση αλκοόλ στη μέση ηλικία συνδέεται με κίνδυνο άνοιας, σύμφωνα με τα ευρήματα που δημοσιεύθηκαν στο JAMA. «Υπάρχει μια αποδεδειγμένη σύνδεση μεταξύ της αυξημένης κατανάλωσης αλκοόλ και του κινδύνου εκδήλωσης άνοιας, ωστόσο είναι δύσκολο να καθορίσουμε αν η μέτρια κατανάλωση αλκοόλ έχει κάποια συνέπεια στην εγκεφαλική υγεία, όταν συγκρίνεται με την ολοκληρωτική αποχή από το αλκοόλ», αναφέρει η Δρ. Sara Imarisio, διευθύντρια έρευνας στο Ίδρυμα...
Fri Oct 04, 2019 08:47
Την ώρα που η κυβέρνηση των Παρισίων προωθεί νομοσχέδιο που προβλέπει την επέκταση της «πλήρους» κάλυψης του κόστους που αφορά την αντισύλληψη κοριτσιών κάτω των 15 ετών σε μια προσπάθεια να περιοριστούν οι αμβλώσεις στις έφηβες 12-14 ετών, μια νέα έρευνα που δημοσιεύθηκε στο JAMA Psychiatry αποκαλύπτει ότι οι έφηβες που παίρνουν αντισυλληπτικά χάπια διατρέχουν αυξημένο κίνδυνο καταθλιπτικών συμπτωμάτων Ο τρόπος που τα αντισυλληπτικά επηρεάζουν τη διάθεση διερευνάται από την πρώτη στιγμή που αυτά...
Fri Oct 04, 2019 08:40
Οι ενήλικες με απώλειες δοντιών μη τραυματικής αιτιολογίας ίσως έχουν υψηλότερο κίνδυνο εμφάνισης καρδιαγγειακών νόσων σύμφωνα με παρουσίαση έρευνας στο πλαίσιο του φετινού Συνεδρίου Καρδιολογίας στη Μέση Ανατολή του Αμερικανικού Κολεγίου Καρδιολογίας που λαμβάνει χώρα μαζί με το 10ο Συνέδριο της Καρδιολογικής Εταιρίας των Εμιράτων στο Ντουμπάι των Ηνωμένων Αραβικών Εμιράτων. Η καρδιαγγειακή νόσος είναι η κυριότερη αιτία θανάτου των ανθρώπων μέσης ηλικίας διεθνώς και προηγούμενες έρευνες έχουν συνδέσει...
Fri Oct 04, 2019 08:18
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