Purpose: To evaluate early-stage prostate cancer (PCa) radiotherapy treatment patterns and outcomes among Ghanaian men (GM) compared with US men (USM). Materials and Methods: This retrospective study consists of 987 National Comprehensive Cancer Network low risk, favorable intermediate risk, and unfavorable intermediate risk PCa patient subgroups; GM (173) and USM (814). Differences in baseline covariates and clinical characteristics between GM and USM were analyzed using χ2 and Mann-Whitney...
Thu Oct 03, 2019 03:00
Objectives: Given the relative novelty of stereotactic body radiation therapy as a treatment modality low-risk and intermediate-risk prostate cancer, little data exist evaluating dosimetry and its impact on patient-reported quality of life (PR-QOL) metrics. Herein, we present an interim analysis of a phase II clinical trial of PR-QOL and dosimetric correlates. Methods: Patients with biopsy-proven low-risk or intermediate-risk prostate cancer, prostate volume ≤100 cm3, and life expectancy...
Thu Oct 03, 2019 03:00
Background Patients with metastatic melanoma have variable responses to combination ipilimumab and nivolumab. The objectives of this study were to examine the patterns of response and survival in patients treated with combination ipilimumab and anti–PD‐1 therapy (IPI + PD1) and to explore the nature of pseudoprogression and acquired resistance. Methods Patients with metastatic melanoma who received treatment with first‐line IPI + PD1 had all metastases ≥5 mm measured on computed tomography/magnetic...
Fri Oct 04, 2019 16:00
Background Many parents of children with advanced cancer pursue curative goals when cure is no longer possible. To the authors' knowledge, no pediatric studies to date have prospectively evaluated prognosis communication or influences on decision making in poor‐prognosis childhood cancer. Methods The authors conducted a prospective cohort study at 9 pediatric cancer centers that enrolled 95 parents of children with recurrent or refractory, high‐risk neuroblastoma (63% of those who were approached),...
Fri Oct 04, 2019 15:58
Background An elevated neutrophil‐to‐lymphocyte ratio (NLR) is associated with poor survival in patients with cancer, including those who receive immunotherapies. The authors sought to investigate NLR as a biomarker of treatment outcomes in patients with melanoma who were treated with PD‐1 inhibition. Methods Patients undergoing initial treatment with PD‐1 inhibitor monotherapy for stage IV melanoma at a single center from 2012 to 2015 were included. Clinical characteristics and the NLR at...
Fri Oct 04, 2019 15:55
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Oct 04, 2019 10:00
Background Solid pseudopapillary neoplasm (SPN) is an uncommon tumor that is challenging to diagnose on cytology due to morphologic overlap with other pancreatic neoplasms. Recently, putative diagnostic markers for SPN have been reported in the surgical pathology literature, with nuclear positivity for lymphoid enhancer‐binding factor 1 (LEF1) and androgen receptor (AR) identified in >90% and >80% of cases, respectively. In the current study, the authors sought to evaluate the sensitivity...
Fri Oct 04, 2019 15:55
Abstract The ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of NEDD8 activating enzyme, selectively inactivates cullin‐RING ubiquitin E3 ligases, resulting in accumulation of their substrates. Here, we examined 14 MM cell lines treated with TAS4464. TAS4464 induced growth arrest and cell death in the MM cell lines even in the presence of bone marrow stromal cells. It also induced the accumulation...
Fri Oct 04, 2019 12:15
Publication date: Available online 4 October 2019Source: Cancer/RadiothérapieAuthor(s): Mylène Wespiser, Morgan Goujon, Thierry Nguyen Tan Hon, Tristan Maurina, François Kleinclauss, Gilles Créhange, Antoine Thiery-VuilleminRésuméCet article est une revue de la littérature qui a pour objectif de clarifier la place des traitements systémiques et des traitements locorégionaux, en particulier la radiothérapie et la chirurgie, dans la prise en charge des patients atteints de cancer du rein oligométastatiques....
15:37
Cancers, Vol. 11, Pages 1496: Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts Cancers doi: 10.3390/cancers11101496 Authors: Wei Hackman Wang Mackenzie Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination...
03:00
Cancers, Vol. 11, Pages 1495: Unclassifiable Isolated Monoclonal Lymphocytosis: Comprehensive Description of a Retrospective Cohort Cancers doi: 10.3390/cancers11101495 Authors: Degaud Baseggio Grange Manzoni Huet Callet-Bauchu Traverse-Glehen Davi Ghesquières Salles Sujobert According to the World Health Organization (WHO) classification, the nosology of B-cell neoplasms integrates clinical, morphological, phenotypic, and genetic data. In this...
Fri Oct 04, 2019 03:00
Cancers, Vol. 11, Pages 1494: Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells Cancers doi: 10.3390/cancers11101494 Authors: Park Cha Choi Lee Hwang-Bo Ji Kim Kim Hong Cheong Kim Yun Hwang Kim Choi Isorhamnetin is an O-methylated flavonol that is predominantly found in the fruits and leaves of various...
Fri Oct 04, 2019 03:00
Abstract Numerous inherent and acquired genetic alterations have been demonstrated with resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy in metastatic colorectal cancer (mCRC) patients. Although the common oncogenic driver mutations identified include KRAS, NRAS, BRAF, and PI3K, recent studies report a vital role played by human epithelial growth factor receptor-2 (HER2) amplification in acquired resistance to anti-EGFR therapy. HER2 amplification has been...
03:00
Abstract Objective To validate the Catalan minimum basic data set (MBDS) of hospital discharges as an information source for detecting incident breast (BC) and colorectal cancer (CRC), against the Hospital del Mar Cancer Registry (RTHMar) in Barcelona (Spain) as the gold standard. Methods Using ASEDAT software (Analysis, Selection and Extraction of Tumour...
Fri Oct 04, 2019 03:00
Purpose:Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvironment are still unknown. Here, we aimed to characterize the multiple facets of neoadjuvant therapy-induced alterations in the pancreatic cancer (PCa) microenvironment. Experimental Design: We performed the currently most comprehensive histopathological analysis...
Fri Oct 04, 2019 17:49
Precision oncology relies on the identification of molecular alterations, responsible for tumor initiation and growth, that are suitable targets of specific inhibitors. The development of FGFR inhibitors represents an edifying example of the rapid evolution in the field of targeted oncology, with 10 different FGFR tyrosine kinase inhibitors actually under clinical investigation. In parallel, the discovery of FGFR activating molecular alterations (mainly FGFR3 mutations and FGFR2 fusions) across many...
Fri Oct 04, 2019 17:49
Purpose: Lorlatinib is a third-generation ALK tyrosine kinase inhibitor with proven efficacy in patients with ALK-rearranged lung cancer previously treated with first and second-generation ALK inhibitors. Beside compound mutations in the ALK kinase domain, other resistance mechanisms driving lorlatinib resistance remain unknown. We aimed to characterize mechanisms of resistance to lorlatinib occurring in patients with ALK-rearranged lung cancer and design new therapeutic strategies in this setting....
Fri Oct 04, 2019 17:49
Different classes of BRAF mutations are present in colorectal and other cancers. Non-V600 mutations are rare; however, their detection rate will increase as the use of next-generation sequencing ramps up quickly in clinical practice. Different biochemical signalling pathways are active in non-V600 BRAF mutant cancers and may affect treatment response.
Fri Oct 04, 2019 17:49
Related ArticlesPrognostic values of lymphocyte and eosinophil counts in resectable cervical squamous cell carcinoma. Future Oncol. 2019 Oct 03;: Authors: Zhu J, Wang H, Gao MJ, Li YF, Huang YQ, Shi JP, Wang WJ Abstract Aim: Cervical cancer is one of the leading causes of cancer mortality in women. Peripheral white blood cell parameters such as neutrophil (NE), eosinophil (EO), basophil (BA), as well as lymphocyte (LY) and monocyte (MO), are correlated...
Fri Oct 04, 2019 14:17
Related ArticlesComputational metabolism modeling predicts risk of distant relapse-free survival in breast cancer patients. Future Oncol. 2019 Oct 03;: Authors: Trilla-Fuertes L, Gámez-Pozo A, Díaz-Almirón M, Prado-Vázquez G, Zapater-Moros A, López-Vacas R, Nanni P, Zamora P, Espinosa E, Fresno Vara JÁ Abstract Aim: Differences in metabolism among breast cancer subtypes suggest that metabolism plays an important role in this disease. Flux balance analysis...
Fri Oct 04, 2019 14:17
Related ArticlesRisk factors for developing osteonecrosis of jaw in advanced cancer patients underwent zoledronic acid treatment. Future Oncol. 2019 Oct 03;: Authors: Qi WX, Zhao S, Chen J Abstract Aim: To investigate the risk factors for developing osteonecrosis of jaw (ONJ) in advanced cancer patients with bone metastases underwent zoledronic acid (ZA) treatment. Materials & methods: Univariate and multivariate logistic regression analyses were...
Fri Oct 04, 2019 14:17
Related ArticlesFinal results of a prospective study of scalp cooling in preventing chemotherapy-induced alopecia. Future Oncol. 2019 Oct 03;: Authors: Orlando L, Loparco D, Fedele P, Schiavone P, Quaranta A, Caliolo C, Cinefra M, Rizzo P, Calvani N, Morleo A, Varriano R, Bonuso V, Falcone LL, Caloro M, Cinieri S Abstract Aim: Alopecia is a distressing effect of cancer treatments. Our study examined efficacy and safety of scalp cooling to prevent chemotherapy-induced...
Fri Oct 04, 2019 14:17
Related ArticlesChallenges and innovations in personalized medicine care. Future Oncol. 2019 Oct 03;: Authors: Sedda G, Gasparri R, Spaggiari L PMID: 31578884 [PubMed - as supplied by publisher]
Fri Oct 04, 2019 14:17
Related ArticlesCirculating tumor DNA RASSF1 methylation for predicting cancer risk: a diagnostic meta-analysis. Future Oncol. 2019 Oct 03;: Authors: Sun X, Li H, Sun M, Yuan Y, Sun L Abstract Aim: We conducted a meta-analysis to assess diagnostic accuracy of circulating tumor DNA RASSF1 methylation in cancer. Materials & methods: Studies were searched from PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases for articles...
Fri Oct 04, 2019 14:17
Related ArticlesAre targeted agents the key to unlock the code for immune checkpoint inhibitors in soft-tissue sarcomas? Future Oncol. 2019 Oct 03;: Authors: Assi T PMID: 31578878 [PubMed - as supplied by publisher]
Fri Oct 04, 2019 14:17
Related ArticlesImplication of clinical target delineation for T1b/T2 thoracic esophageal squamous cell carcinoma based on the pattern of lymph node metastases. Future Oncol. 2019 Oct 03;: Authors: Guan H, Yu Y, Ge H, Zhu S, Huang W, Li B Abstract Aim: This study aimed to explore different patterns of lymph node metastases (LNM) in T1b and T2 thoracic esophageal squamous cell carcinoma (ESCC), and to further clarify its significance in radiotherapy target...
Fri Oct 04, 2019 14:17
Our previous researches have identified immunoevasive subtype muscle‐invasive bladder cancer (MIBC) characterized with immune cells infiltration patterns. This study explored the clinical significance, immunoregulatory role and therapeutic value of intratumoral IL22‐producing cells in MIBC. 259 formalin‐fixed paraffin‐embedded MIBC samples and 83 freshly resected MIBC tissues and 391 TCGA MIBC samples were retrospectively evaluated. Immunohistochemistry and flow cytometry were applied to identify...
Fri Oct 04, 2019 15:24
Human papillomavirus (HPV) infection and tobacco smoking are well known risk factors for head and neck cancers (HNC). Although an effect modification between oral HPV infection and tobacco smoking may exist, evidence is lacking on how they interact temporally. We investigated the latency and life course effects of tobacco smoking on risk of HNC among HPV‐positive (HPV+ve) and negative (HPV‐ve) individuals. We used data from 631 ever‐smoker participants of a hospital‐based case‐control study conducted...
Fri Oct 04, 2019 15:23
Breast cancer has been suggested to potentially have prenatal origins. We examined associations between birth weight, body mass index (BMI) at four time points over 25‐years of adulthood, and risk of postmenopausal breast cancer, with emphasis on whether the association between birth weight and risk of breast cancer was mediated by weight and height changes over the adult life course. Postmenopausal women (n=70,397) aged 50‐79 years without breast cancer at enrollment (1993‐1998) were followed up...
Fri Oct 04, 2019 15:23
Bladder cancer is the 6th most common cancer in the U.S., and it exhibits an alarming 70% recurrence rate. Thus, development of more efficient anti‐bladder cancer approaches is a high priority. Accordingly, this work provides the basis for a transformative anti‐cancer strategy that takes advantage of the unique characteristics of the bladder. Unlike mucin‐shielded normal bladder cells, cancer cells are exposed to the bladder lumen and overexpress EGFR. Therefore, we used an EGF‐conjugated anthrax...
Fri Oct 04, 2019 15:23
We have developed an oncolytic Newcastle disease virus (NDV) that has potent in vitro and in vivo anti‐tumor activities and attenuated pathogenicity in chickens. In this ex vivo study using the same recombinant NDV backbone with GFP transgene (rNDV), we found that rNDV induces maturation of monocyte‐derived immature dendritic cells (iDCs) by both direct and indirect mechanisms, which promote development of antigen‐specific T cell responses. Addition of rNDV directly to iDCs culture induced DC maturation,...
Fri Oct 04, 2019 14:57
Fri Oct 04, 2019 14:55
The consumption of processed meat has been associated with non‐cardia gastric cancer, but evidence regarding a possible role of red meat is more limited. This study aims to quantify the association between meat consumption, namely white, red and processed meat, and the risk of gastric cancer, through individual participant data meta‐analysis of studies participating in the ‘Stomach cancer Pooling (StoP) Project’. Data from 22 studies, including 11,443 cases and 28,029 controls, were used. Study‐specific...
Fri Oct 04, 2019 14:55
Although menopausal hormone therapy (MHT) seemingly increases the risk of ovarian cancer, evidence is insufficient whether the risk varies between various MHT formulations, regimens and administration modes. With the aim of filling these knowledge gaps, we investigated the effect of different MHT treatment options on the risk of ovarian cancer. This prospective Swedish population based matched‐cohort study included all women ≥40 years having used systemic MHT between 2005‐2012 (288,950 ever‐users),...
Fri Oct 04, 2019 14:55
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri Oct 04, 2019 10:00
Abstract Purpose Solid organ (SOT) and allogeneic haematopoietic stem cell (HSCT) transplant recipients have elevated risks of de novo or secondary cancer. We explored risk factors hereof. Methods Among SOT and HSCT between January 2004 and December 2014, standardised incidence ratio (SIR) of de novo/secondary cancer compared with the Danish population was...
03:00
Abstract Background Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality rates and poor prognosis. Signs and symptoms of GBC are not specific and often arise at late stage of disease. For this reason, diagnosis is typically made when the cancer is already in advanced stages, and prognosis for survival is less than 5 years in 90% of cases. Biomarkers to monitor disease progression and novel therapeutic alternative...
Fri Oct 04, 2019 03:00
Abstract Background Large tumor suppressor (LATS) proteins are putative tumor suppressors and poorly expressed associated with poor outcome in many cancers. A recent immunohistochemistry study showed that LATS protein expression correlated with poor outcome in serous ovarian cancer. Materials and methods We analyzed LATS expression in various ovarian cancer...
Fri Oct 04, 2019 03:00
Abstract Tumor suppressor genes encode different proteins that inhibit the uncontrolled proliferation of cell growth and tumor development. To acquire clues for predicting gene expression level, it is essential to understand the codon usage bias (CUB) of genes to characterize genome which possesses its own compositional characteristics and unique coding sequences. We used bioinformatic tools to analyze the codon usage patterns of 637 human tumor suppressor genes as no work was reported earlier....
Thu Oct 03, 2019 18:58
Publication date: Available online 3 October 2019Source: Practical Radiation OncologyAuthor(s): Daniel G. Tanenbaum, Zachary S. Buchwald, Jaymin Jhaveri, Eduard Schreibmann, Jeffrey M. Switchenko, Roshan S. Prabhu, Mudit Chowdhary, Mustafa Abugidieri, Neil T. Pfister, Bree Eaton, Shannon E. Kahn, Jeffrey J. Olson, Hui-Kuo G. Shu, Ian R. Crocker, Walter J. Curran, Kirtesh R. PatelAbstractPurposeStereotactic Radiosurgery (SRS) is increasingly utilized in the management of patients with resected brain...
Fri Oct 04, 2019 15:53
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Chun-Pin Chang, Shen-Chih Chang, Shu-Chun Chuang, Julien Berthiller, Gilles Ferro, Keitaro Matsuo, Victor Wünsch-Filho, Tatiana N. Toporcov, Marcos Brasilino de Carvalho, Carlo La Vecchia, Andrew F. Olshan, Jose P. Zevallos, Diego Serraino, Joshua Muscat, Erich M. Sturgis, Guojun Li, Hal Morgenstern, Fabio Levi, Luigino Dal Maso, Elaine SmithAbstractBackgroundTobacco use is a well-established risk factor for head and...
Fri Oct 04, 2019 15:20
Abstract Background and purpose Radiation necrosis is a possible adverse event after cranial radiation therapy and can cause severe symptoms, such as an increased intracranial pressure or neurological deterioration. The vascular endothelial growth factor (VEGF) inhibitor bevacizumab (BEV) has been shown to be a feasible therapeutic option for symptomatic radiation necrosis, either when traditional antiedematous steroid treatment fails,...
Fri Oct 04, 2019 03:00
Abstract Background Adding concurrent chemotherapy (CTx) to definitive radiation therapy (RT) in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) improves overall survival. A comparable effect has been reported for hyperfractionated radiotherapy (HFX-RT) alone. Adding concurrent CTx to HFX-RT has been investigated in multiple trials, yet an evident effect on oncological outcomes and toxicity profile has not...
Fri Oct 04, 2019 03:00
Abstract Purpose Abdominal recurrences of gastrointestinal malignancies are common. Evidence in clinical studies has shown that re-irradiation (Re-I) is tolerable and efficient in different tumor locations. In contrast, little clinical data are available on normal long-term Re‑I tolerance doses. A systematic review of upper abdominal Re‑I was performed with the aim of exploring the cumulative dose, toxicity, and outcomes. ...
Fri Oct 04, 2019 03:00
Abstract Purpose An increase of skin dose during head and neck cancer (HNC) radiotherapy is potentially dangerous. Aim of this study was to quantify skin dose variation and to assess the need of planning adaptation (ART) to counteract it. Methods Planning CTs of 32 patients treated with helical tomotherapy (HT) according to a Simultaneous Integrated Boost...
Fri Oct 04, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου