Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Saber Yezli, Kingsley Bieh, Anas Khan
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Satish K Dhingra, Jennifer L Small-Saunders, Didier Ménard, David A Fidock
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Jigang Wang, Chengchao Xu, Fu Long Liao, Tingliang Jiang, Sanjeev Krishna, Youyou Tu
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Fabia Hannan Mone, Sahadat Hossain, M Tasdik Hasan, Gule Tajkia, Fahad Ahmed
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Oon Tek Ng, Vernon Lee, Kalisvar Marimuthu, Shawn Vasoo, Guanhao Chan, Raymond Tzer Pin Lin, Yee Sin Leo
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Johannes C van der Wouden, Ivo Smeele
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Paul Turner, Elizabeth A Ashley
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Ed J Kuijper, Jessica Allegretii, Peter Hawkey, Harry Sokol, Simon Goldenberg, Gianluca Ianiro, Antonio Gasbarrini, Patrizia Kump, Samuel P Costello, Josbert Keller, Maria J G T Vehreschild
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): Stephen Obaro
Publication date: November 2019Source: The Lancet Infectious Diseases, Volume 19, Issue 11Author(s): The Lancet Infectious Diseases
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Objectives/Hypothesis The purpose of the study was to compare the prevalence of vocal fold pathologies among first‐year singing students from the classical, musical theatre, and contemporary commercial music (CCM) genres. Study Design Prospective cohort study. Methods Videostroboscopic examinations were rated by blinded expert raters. Vocal pathology was defined as a vocal fold abnormality on the membranous or cartilaginous portions of the vocal folds or hypomobility. Consensus among...
Objective Most type 1 thyroplasty implants and some common injectable materials are mechanically stiff. Placing them close to the supple vocal fold mucosa can potentially dampen vibration and adversely impact phonation, yet this effect has not been systematically investigated. This study aims to examine the effect of implant depth on vocal fold vibration and vocal output. Study Design Computational simulation. Methods Voice production was simulated with a fiber‐gel finite element computational...
Objectives Determine rates and reasons for unplanned revisits after ambulatory otologic surgery. Methods Cross‐sectional analysis of State Ambulatory Surgery Databases of California, Florida, Iowa, and New York was performed for years 2010 and 2011. Ambulatory adult otology surgical procedures were linked to ambulatory, emergency, and inpatient databases for revisit encounters occurring within 30 days. The numbers of revisits and associated diagnoses were analyzed. Results A total of...
Background/Objectives Idiopathic progressive subglottic stenosis (IPSS) predominantly affects females in perimenopause. It has, therefore, been hypothesized that estrogen is involved in its pathogenesis. There are two main types of estrogen receptors: ER‐α and ER‐β. Abnormal variants of ER‐β have previously been shown to be associated with poor wound healing. Estrogen receptors have recently been identified in subglottic tissue samples, with elevated levels of ER‐α and progesterone receptors, and...
Objectives Globus pharyngeus (GP) is described as the subjective sensation of having a “lump” in the throat in the absence of correlating physical findings or dysphagia. Historically, despite the frequency of patient complaints, GP has been difficult to quantify with current outcome measures. This is in large part due to lack of a user‐friendly, modernized, objective patient‐reported outcome measure (PROM) of symptom severity. The aim of this study is to develop a modernized, practical, validated...
Objectives/Hypothesis To outline a possible decision‐making process for sporadic vestibular schwannoma (VS) with contralateral nonserviceable hearing at diagnosis. Study Design Retrospective case series. Methods Diagnosed VS was studied in a tertiary referral center from 1995 to 2013. Results Twenty‐eight patients were included, with a mean follow‐up of 6.9 years (range = 0.5–20 years). Ten were stage 1, 10 were stage 2, five were stage 3, and three were stage 4. Ipsilateral hearing...
Objective To investigate the relations of monoallelic (M1), biallelic (M2), or the absence of mutations (M0) in SLC26A4 to inner ear morphology and hearing levels in individuals with Pendred syndrome (PS) or nonsyndromic enlarged vestibular aqueduct (NSEVA) associated with hearing loss. Methods In a cohort of 139 PS/NSEVA individuals, 115 persons from 95 unrelated families had full genetic sequencing of SLC26A4, and 113 had retrievable images for re‐assessment of inner ear morphology. The...
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Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Guy SlonimskySaccular disorders extending beyond the thyrohyoid membrane are classified as external, or combined, based on to their extension beyond the thyrohyoid membrane and the proportion of the external to the internal component. The workup is the same as for internal saccular disorders and airway safety is of utmost importance. The open/transcervical approach is currently...
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Stefan Mattheis, Timon Hussain, Benedikt Höing, Pia Haßkamp, Laura Holtmann, Stephan LangWhile transoral laser microsurgery has been the gold standard for laryngeal surgery for many years, recently transoral robotic surgery (TORS) has become a new treatment option not being restricted to a straight line of view which can be an obstacle during resection. In combination with...
Publication date: Available online 24 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Guy SlonimskyLaryngeal saccular disorders are rare lesions presenting as abnormal saccular dilation, either mainly filled with air (laryngoceles) or fluid (saccular cysts). These are further categorized as internal when confined in the endolarynx, external, or combined. In adults, saccular disorders are mostly idiopathic with various reported proportion associated with...
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Abstract Purpose According to the updated WHO classification of gliomas with its emphasis on molecular parameters, tumours with an IDH-wildtype status have a dismal prognosis. To ensure timely adjustment of treatment, demand for non-invasive prediction methods is high. 18F-FET PET has been shown to be an important diagnostic tool for glioma management. The aim of this study was to assess the value of dynamic 18F-FET PET for the non-invasive...
Abstract Purpose Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. We analyzed the target affinity and specificity of two FAP ligands (FAPI-02 and FAPI-04) in vitro, and the pharmacokinetics and biodistribution in mice in vivo. Clinically, we used 68Ga-labeled FAPI-02/04 for PET imaging in 18 glioma patients...
Abstract Purpose Diagnostic imaging modalities have moderate sensitivity for the identification of lymph node (LN) metastases in prostate cancer (PCa) patients. Mapping the lymphatic drainage from the prostate can help to identify the LNs directly draining from the tumour (sentinel nodes (SNs)); the LNs stated to have the highest chance of containing metastatic cancer cells. Although the lymphatic drainage may differ between segments...
Abstract Objective To review the literature on the clinical application of radiolabeled somatostatin receptor scintigraphy (SRS) by SPECT and PET in adults with chronic inflammatory diseases. Research design Systematic review of published observational studies between 1993 and 2017. ...
Abstract Purpose To develop a prostate-specific membrane antigen (PSMA)-targeted radiotherapeutic for metastatic castration-resistant prostate cancer (mCRPC) with optimized efficacy and minimized toxicity employing the β-particle radiation of 177Lu. Methods We synthesized 14 new PSMA-targeted, 177Lu-labeled radioligands (177Lu-L1–177Lu-L14)...
Abstract Purpose To improve the test–retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements. Methods We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition...
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