Abstract Introduction Scintigraphic evaluation of the thyroid gland enables determination of the iodine-123 iodide or the 99mTc-pertechnetate uptake and distribution and remains the most accurate method for the diagnosis and quantification of thyroid autonomy and the detection of ectopic thyroid tissue. In addition, thyroid scintigraphy and radioiodine uptake test are useful to discriminate hyperthyroidism from destructive thyrotoxicosis...
Abstract Purpose Oncocytic (Hürthle cell) papillary thyroid carcinoma (OPTC) is a rare variant of the papillary thyroid carcinoma (PTC) which comprises approximately 1 to 11 % of PTC cases. Its clinical course and prognosis have not been comprehensively documented and the clinical outcome remains a controversial issue. Therefore, we investigated the long-term prognosis after thyroidectomy and (adjuvant) initial radioactive iodine...
Abstract Purpose To evaluate the diagnostic performance of PET-MR enterography in detecting histological active inflammation in patients with ulcerative colitis and the impact of bowel purgation on diagnostic accuracies of PET-MR parameters. Methods Fifty patients were enrolled in this randomized controlled trial (clinicaltrials.gov [NCT03781284]). Forty...
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Related ArticlesGeographic stomatitis with palate involvement. An Bras Dermatol. 2019;94(4):449-451 Authors: Campana F, Vigarios E, Fricain JC, Sibaud V Abstract Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal...
Related ArticlesRhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection. Elife. 2019 Oct 23;8: Authors: Liberatore RA, Mastrocola EJ, Cassella E, Schmidt F, Willen JR, Voronin D, Zang TM, Hatziioannou T, Bieniasz PD Abstract Numerous challenges have impeded HIV-1 vaccine development. Among these is the lack of a convenient small animal model in which to study antibody elicitation and efficacy. We describe a chimeric Rhabdo-Immunodeficiency...
Related Articles[The Anti-virus Effect of AY358935 Gene on Vesicular Stomatitis Virus and the Mechanism Study]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jul;50(4):540-545 Authors: Li GP, Ke JL, Lü PP, Zhu X, Wang C, Wang JY, Shen XY, Xiong SQ Abstract OBJECTIVE: To explore the anti-virus effect of AY358935 gene cloned by our research team on vesicular stomatitis virus (VSV), and studytheanti-virus mechanism. METHODS: HEK293 cells were stably...
Related ArticlesOral Immune-Related Adverse Events Associated with PD-1 Inhibitor Therapy: A Case Series. Oral Dis. 2019 Oct 23;: Authors: Shazib MA, Woo SB, Sroussi H, Carvo I, Treister N, Farag A, Schoenfeld J, Haddad R, LeBoeuf N, Villa A Abstract OBJECTIVE: The aim of this study was to characterize clinical and histopathological features, and management outcomes of patients with oral immune-related related adverse events (irAEs) secondary to Programmed...
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Abstract Background The present study aimed to investigate levels of nutrient intakes, including dietary antioxidant quality (DAQ) score, among Saudi females with and without knee osteoarthritis (OA). We also aimed to examine the relationship between nutrient intakes and knee OA severity. Methods One hundred female participants with symptomatic primary knee OA were matched for age with 100 apparently healthy females and were sequentially recruited from the Orthopaedics Department, Faculty...
Abstract Background The present study investigated the effects of fat‐protein (CFP) counting in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal‐bolus insulin therapy. Methods In this single centre, cross‐over, randomised, controlled study, control meal (SM: standard meal using a carbohydrate counting method) and three test meals (HPM: high protein meal using a carbohydrate counting...
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It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group led by Prof. Nadia Mercader of the University of Bern now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.
Aging, and the mechanics behind it, remains one of the most closely guarded secrets of life.
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Related ArticlesLesson of the month 2: A case of Behçet's disease: 70% have ophthalmic involvement. Clin Med (Lond). 2019 Oct 22;: Authors: Auluck I, Karimi A, Taylor S Abstract A 34-year-old man presented to the emergency department with acute painless loss of vision of the left eye. Past medical history included painful lumps in the legs and frequent mouth ulcers, which were undiagnosed. The patient's visual acuity was 6/5 and counting fingers in the...
Related ArticlesProlonged remission in SLE is possible by using reduced doses of prednisone: An observational study from the Lupus-Cruces and Lupus-Bordeaux inception cohorts. Autoimmun Rev. 2019 Sep;18(9):102359 Authors: Ruiz-Irastorza G, Ruiz-Estevez B, Lazaro E, Ruiz-Arruza I, Duffau P, Martin-Cascon M, Richez C, Ugarte A, Blanco P Abstract OBJECTIVE: The aim of this study is to compare the frequency of remission, according to DORIS definitions,...
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Abstract Background Lumbar adhesive arachnoiditis is a debilitating neuropathic condition and is difficult to diagnose owing to lack of definitive diagnostic criteria. By focusing on the intrathecal mobility of nerve roots, we assessed whether useful diagnostic criteria could be established using MRI. Methods Seventeen patients with a high risk for lumbar adhesive arachnoiditis and 18 no‐risk patients with chronic low back pain and/or leg pain participated in this study. The patients underwent...
Abstract Generalized neck pain and painful/limited cervical motions can develop following upper respiratory tract infection.1 The clinical scenario is usually considered to be vague and ‐unless causing severe disability ‐ is tackled conservatively. In this aspect, the purpose of this report was two‐fold; first we aimed to discuss the possible development of nerve entrapment in patients with post‐infectious neck stiffness. Second, we also aimed to demonstrate the potential utility of ultrasound (US)...
Abstract Objectives Post‐traumatic Stress Disorder (PTSD) commonly co‐occurs with chronic pain. Although PTSD symptoms are associated with negative health outcomes in patients with chronic pain, PTSD is typically under‐detected and under‐treated in outpatient pain settings. There is a need for rapid, brief screening tools to identify those at greatest risk for severe PTSD symptoms. To achieve that goal, our aim was to use item response theory (IRT) to identify the most informative PTSD symptoms...
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Abstract Objective This study investigated the effects of abutment screw withdrawal after conical abutment settlement on the stability of the implant–abutment connection. Material and methods Twenty implants of a conical connection system were used. Two two‐piece abutment designs were used: cone only (n = 10; NI) and cone plus octagonal index design (n = 10; I); for each design, five samples were used with (S) and without (NS) abutment screw withdrawal before a cyclic test. Finally, four...
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Abstract Background This study evaluated the combination of tumor budding and depth (BD model) and worst pattern of invasion (WPOI) as histopathological prognostic factors in clinical N0 early oral tongue carcinoma. Methods Data from 62 patients were retrospectively analyzed. Associations between histopathological factors (differentiation, stage, lymphatic invasion, blood vessel invasion, WPOI, and BD model) and regional control (RC) or disease‐free survival (DFS) were evaluated. Results...
Abstract Background Eicosapentaenoic acid (EPA) containing nutritional supplement can reverse weight loss and increase lean body mass in a perioperative period of patients with head and neck cancer. To study effects of an EPA‐enriched supplement compared with a conventional supplement in malnourished patients with head and neck cancer following surgery is primary objective. Methods The patients were randomized into EPA‐enriched and standard formula group. The supplements were prescribed...
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Abstract Objective To investigate the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMP) in the development of cervical metastases in papillary thyroid cancer Our hypothesis is that level of expression of MMPs and TIMPs is associated with the development of cervical metastases and the pattern of metastatic process in papillary thyroid cancer. Design This research retrospectively investigates the expression of MMP‐1, ‐2 and ‐9 as well as TIMP‐1 and ‐2 in papillary thyroid...
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Related ArticlesThe probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats. Nutr Metab Cardiovasc Dis. 2019 Aug 14;: Authors: Cavalcante RGS, de Albuquerque TMR, de Luna Freire MO, Ferreira GAH, Carneiro Dos Santos LA, Magnani M, Cruz JC, Braga VA, de Souza EL, de Brito Alves JL Abstract BACKGROUND AND AIM: High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia,...
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Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Oksana Jackson, Nicholas Wingate, Alfred Lee, Alison E. KayeAbstractObjectivesThe bilateral cleft nasal deformity is characterized by a short columella and a broad, flattened nasal tip. Secondary correction is challenging and often complicated by skin envelope scarring and hypoplastic alar cartilages. Adequate and durable tip projection requires a procedure that adequately augments...
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): F. Jahshan, O. Ertracht, N. Eisenbach, A. Daoud, E. Sela, A. Abu Ammar, M. GruberAbstractObjectiveTracheal mucosal damage is a well-known complication of endo-tracheal intubation and animal models are essential for studying the underlying cellular injury cascade. The novel rat model described here is based on retrograde intubation via tracheotomy and suture fixation of the tube....
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Christen L. Caloway, Sarah Bouhabel, Christopher J. HartnickAbstractWhile Ansa to recurrent laryngeal nerve reinnervation is gaining popularity in the treatment of unilateral vocal fold immobility, little has been reported on commonly encountered surgical challenges with this procedure. Here, we present a cohort of 21 pediatric patients who underwent this procedure with a full...
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Kiri Mealings, Samantha Harkus, Jennifer Hwang, Jacinto Fragoso, King Chung, Harvey DillonAbstractObjectiveOtitis media resulting in conductive hearing loss is a major health issue for Aboriginal and Torres Strait Islander children, which can also lead to the child developing spatial processing disorder (SPD). This study examined the prevalence of hearing loss and deficits in...
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According to the University of Connecticut’s Rudd Center for Food Policy and Obesity, U.S. children are continually increasing the amount of sugary drinks they consume and this is leading to obesity and disease later in life. The problem is that many parents see, hear, or read advertising claims and believe the claims at face value. In reality the median juice content is only 5% while the median sugar amount is 16 grams (which is 1.25 tablespoons). That’s a whopping amount of sugar for a drink...
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Abstract Background Solid organ transplant (SOT) recipients are a special group of patients who require comprehensive evaluation for preventable infectious diseases before transplantation. The main aim of our study was to investigate the number of heart, lung, and liver (HLL) transplant recipients who were evaluated for their immune status against measles, mumps, rubella (MMR) and varicella (VZV). As a secondary aim, we investigated if pre‐transplant Infectious Disease Consultation (IDC) improves...
Abstract Adenovirus (HAdV) infections confer a high risk of morbidity and mortality for immunocompromised patients after stem cell transplantation (SCT). Treatment with standard antiviral drugs is of limited efficacy and associated with a high rate of adverse effects. HAdV‐specific T cells are crucial for sustained viral elimination and the efficacy of adoptive T‐cell therapy with donor‐derived HAdV‐specific T cells has been reported by several investigators. Here, we report our experience with...
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Abstract Periodontitis is one of the most prevalent chronic diseases, affecting more than 743 million people worldwide (Jin et al., 2016). It can be defined as an inflammatory disease induced by oral polymicrobial community dysbiosis. The disproportionate host‐response to pathogen penetration results in a continuous release of proinflammatory mediators and chronic inflammation, characterized by progressive and painless destruction of the tooth supporting apparatus.
Abstract Objective The aim of this study was to characterize clinical and histopathological features, and management outcomes of patients with oral immune‐related related adverse events (irAEs) secondary to Programmed cell death‐1 (PD‐1) inhibitors. Methods This was a case series of cancer patients receiving PD‐1 inhibitor therapy who were referred to Oral Medicine for the development of oral irAEs. Demographic, clinical, and histopathological data were collected from electronic medical...
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Abstract BackgroundEPHX1 gene polymorphisms were recently acknowledged as an important source of individual variability in carbamazepine metabolism, but the result of that association still remains controversial. Aim of the review To obtain a more precise estimation of the associations between EPHX1 polymorphisms and carbamazepine metabolism and resistance. Methods The PubMed, EMBASE, Cochrane library, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals...
Abstract Background Adherence to direct-acting antivirals could be a predictor response to these treatments in hepatitis C. Objective To assess the ability of three methods of measuring adherence to direct-acting antivirals [pill counts, pharmacy dispensing record and Simplified Medication Adherence Questionnaire (SMAQ)] as predictors of their effectiveness. Setting Study conducted by the pharmacy department of the hospital. Methods: A retrospective study was performed. Patients...
Evaluation of a pharmacist-led antimicrobial stewardship service in a pediatric emergency department
Abstract Background To improve antimicrobial use, incorporation of a pharmacist in antimicrobial stewardship initiatives in the emergency department has been recommended. Recognizing the potential value, a pharmacist-led antimicrobial stewardship (AMS) service which included review and follow up of microbiology results for patients discharged from the pediatric emergency department (PED) with suspected infections was implemented at our local institution. Objective The objective...
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