Τετάρτη 23 Οκτωβρίου 2019


The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity.
Related ArticlesThe Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity. Trends Neurosci. 2019 Oct 18;: Authors: Guyenet PG, Stornetta RL, Souza GMPR, Abbott SBG, Shi Y, Bayliss DA Abstract The ventral surface of the rostral medulla oblongata has been suspected since the 1960s to harbor central respiratory chemoreceptors [i.e., acid-activated neurons that regulate breathing to maintain a constant arterial PCO2 (PaCO2)]....
pubmed: sleep apnea
Wed Oct 23, 2019 14:20
Five-Year Objective and Subjective Outcomes of Velopharyngeal Surgery for Patients with Obstructive Sleep Apnea.
Related ArticlesFive-Year Objective and Subjective Outcomes of Velopharyngeal Surgery for Patients with Obstructive Sleep Apnea. Otolaryngol Head Neck Surg. 2019 Oct 22;:194599819884889 Authors: Yin G, He M, Cao X, Xu J, Zhang Y, Kang D, Ye J Abstract OBJECTIVE: To assess the long-term effects of velopharyngeal surgery on objective and subjective symptoms in patients with obstructive sleep apnea (OSA). STUDY DESIGN: Prospective cohort study....
pubmed: sleep apnea
Wed Oct 23, 2019 14:20
Legal ramifications of the ADA Protocol on sleep-related breathing disorders (SRBD).
Related ArticlesLegal ramifications of the ADA Protocol on sleep-related breathing disorders (SRBD). Cranio. 2019 Nov;37(6):342-343 Authors: Berley K PMID: 31581938 [PubMed - indexed for MEDLINE]
pubmed: sleep apnea
Wed Oct 23, 2019 14:20
Letters to the Editor.
Related ArticlesLetters to the Editor. JAAPA. 2019 04;32(4):1-2 Authors: Jacobson MD, Malik B PMID: 30913157 [PubMed - indexed for MEDLINE]
pubmed: sleep apnea
Wed Oct 23, 2019 14:20
Right Cu2- x S@MnS Core-Shell Nanoparticles as a Photo/H2O2-Responsive Platform for Effective Cancer Theranostics.
Related ArticlesRight Cu2- x S@MnS Core-Shell Nanoparticles as a Photo/H2O2-Responsive Platform for Effective Cancer Theranostics. Adv Sci (Weinh). 2019 Oct 16;6(20):1901461 Authors: Huang X, Deng G, Han Y, Yang G, Zou R, Zhang Z, Sun S, Hu J Abstract Stimuli-responsive nanomedicines have become a recent research focus as a candidate for cancer treatment because of their effectiveness, sensibility, and minimal invasiveness. In this work, a novel nanosystem...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Clinical applications of three-dimensional printing in otolaryngology-head and neck surgery: A systematic review.
Related ArticlesClinical applications of three-dimensional printing in otolaryngology-head and neck surgery: A systematic review. Laryngoscope. 2019 09;129(9):2045-2052 Authors: Hong CJ, Giannopoulos AA, Hong BY, Witterick IJ, Irish JC, Lee J, Vescan A, Mitsouras D, Dang W, Campisi P, de Almeida JR, Monteiro E Abstract OBJECTIVES: Medical three-dimensional (3D) printing, the fabrication of handheld models from medical images, has the potential to become...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study.
Related ArticlesTumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study. Hum Pathol. 2018 11;81:211-219 Authors: Almangush A, Ruuskanen M, Hagström J, Hirvikoski P, Tommola S, Kosma VM, Nieminen P, Mäkitie A, Leivo I Abstract The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been studied recently in many cancers. For the first time in a nonendemic region, we have evaluated...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Differentiation of neural crest stem cells from nasal mucosa into motor neuron-like cells.
Related ArticlesDifferentiation of neural crest stem cells from nasal mucosa into motor neuron-like cells. J Chem Neuroanat. 2018 10;92:35-40 Authors: Bagher Z, Kamrava SK, Alizadeh R, Farhadi M, Absalan M, Falah M, Faghihi F, Zare-Sadeghi A, Komeili A Abstract Cell transplantation is a potential therapeutic approach for repairing neuropathological and neurodegenerative disorders of central nervous system by replacing the degenerated cells with new...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Effect of Adaptive Compression and Fast-Acting WDRC Strategies on Sentence Recognition in Noise in Mandarin-Speaking Pediatric Hearing Aid Users.
Related ArticlesEffect of Adaptive Compression and Fast-Acting WDRC Strategies on Sentence Recognition in Noise in Mandarin-Speaking Pediatric Hearing Aid Users. J Am Acad Audiol. 2018 04;29(4):273-278 Authors: Liu H, Liu Y, Li Y, Jin X, Li J, Zhou Y, Ge W, Ni X Abstract BACKGROUND: Wide dynamic range compression (WDRC) has been widely used in hearing aid technology. However, several reports indicate that WDRC may improve audibility at the expense of...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Pain management using photobiomodulation: Mechanisms, location, and repeatability quantified by pain threshold and neural biomarkers in mice.
Related ArticlesPain management using photobiomodulation: Mechanisms, location, and repeatability quantified by pain threshold and neural biomarkers in mice. J Biophotonics. 2018 07;11(7):e201700370 Authors: de Sousa MVP, Kawakubo M, Ferraresi C, Kaippert B, Yoshimura EM, Hamblin MR Abstract Photobiomodulation (PBM) is a simple, efficient and cost-effective treatment for both acute and chronic pain. We previously showed that PBM applied to the mouse...
Technologies in Treatment of Head & Neck
Wed Oct 23, 2019 14:19
Complicated Urinary Tract Tuberculosis in a 13-Year-Old Adolescent with Chronic Kidney Disease and Antituberculous Drug-Induced Hepatotoxicity
Urinary tract tuberculosis (TB) is a rare extrapulmonary manifestation of TB in children. The disease is potentially underdiagnosed because it clinically resembles other urinary tract infections. A 13-year-old adolescent girl presented with pain, difficulty in micturition, and gross hematuria for almost two years before admission, and she had left flank pain since one year ago and significant loss of body weight during the illness. The close TB contact was her grandmother who was on TB treatment....
Case Reports in Infectious Diseases
Wed Oct 23, 2019 14:05
Boron.
Related ArticlesBoron. Adv Nutr. 2019 Oct 22;: Authors: Nielsen FH, Eckhert CD PMID: 31639188 [PubMed - as supplied by publisher]
pubmed: "adv nutr"[jour]
Wed Oct 23, 2019 14:16
IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma.
Related ArticlesIL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma. Front Oncol. 2019;9:1022 Authors: Fink AF, Ciliberti G, Popp R, Sirait-Fischer E, Frank AC, Fleming I, Sekar D, Weigert A, Brüne B Abstract IL-27 regulates inflammatory diseases by exerting a pleiotropic impact on immune cells. In cancer, IL-27 restricts tumor growth by acting on tumor cells directly, while its role in the tumor microenvironment...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer.
Related ArticlesTH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer. Front Oncol. 2019;9:1002 Authors: Cui G Abstract In recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and TH22 cells, and their respective cytokine products, IL-9, IL-17, and IL-22, have been reported to play critical roles in the development of chronic inflammation in the colorectum. Since chronic...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico.
Related ArticlesmTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico. Front Oncol. 2019;9:1000 Authors: Zahid KR, Yao S, Khan ARR, Raza U, Gou D Abstract Hepatocellular carcinoma (HCC) is ranked the third deadliest cancer worldwide whose molecular pathogenesis is not fully understood. Although deregulated metabolic pathways have been implicated in HCC onset and...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target.
Related ArticlesCadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target. Front Oncol. 2019;9:989 Authors: Yu W, Yang L, Li T, Zhang Y Abstract Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and differentiation throughout life. Through the establishment of the cadherin-catenin complex, cadherins provide normal cell-cell...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis.
Related ArticlesDiagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis. Front Oncol. 2019;9:981 Authors: Zhang N, Wang X, Wang C, Chen S, Wu J, Zhang G, Zhu W, Liu J, Xu B, Du M, Chen M Abstract Purpose: Evaluate the diagnostic accuracy of multi-parametric magnetic resonance imaging (mp-MRI) for local staging of bladder cancer (BCa). Materials and Methods: The databases of PubMed, Web of...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
Development of Triptolide Self-Microemulsifying Drug Delivery System and Its Anti-tumor Effect on Gastric Cancer Xenografts.
Related ArticlesDevelopment of Triptolide Self-Microemulsifying Drug Delivery System and Its Anti-tumor Effect on Gastric Cancer Xenografts. Front Oncol. 2019;9:978 Authors: Xie M, Wu J, Ji L, Jiang X, Zhang J, Ge M, Cai X Abstract Purpose: To develop a triptolide (TP) self-microemulsifying drug delivery system and to investigate its anti-tumor effect on human gastric cancer line MGC80-3 xenografts in nude mice. Methods: The medium chain triglyceride...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers.
Related ArticlesIntegrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers. Front Oncol. 2019;9:956 Authors: Ding Y, Zhong T, Wang M, Xiang X, Ren G, Jia Z, Lin Q, Liu Q, Dong J, Li L, Li X, Jiang H, Zhu L, Li H, Shen D, Teng L, Li C, Shao J Abstract Mining cancer-omics databases deepens our understanding of cancer biology and can lead to potential breakthroughs in cancer treatment....
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study.
Related ArticlesSERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. Front Oncol. 2019;9:954 Authors: Guo Q, Zhu L, Wang C, Wang S, Nie X, Liu J, Liu Q, Hao Y, Li X, Lin B Abstract Serpin family D member 1 (SERPIND1) belongs to the serine protease inhibitor family. Its role in cancers has gradually attracted interest from researchers in recent years. However, the role of SERPIND1...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
Construction of a Competitive Endogenous RNA Network and Identification of Potential Regulatory Axis in Gastric Cancer.
Related ArticlesConstruction of a Competitive Endogenous RNA Network and Identification of Potential Regulatory Axis in Gastric Cancer. Front Oncol. 2019;9:912 Authors: Pan H, Guo C, Pan J, Guo D, Song S, Zhou Y, Xu D Abstract Background: Increasing studies has found that long non-coding RNAs (lncRNAs) play critical roles in carcinogenesis, but the underlying mechanisms remain unclear. The aim of this study is to construct a competitive endogenous RNA...
pubmed: "front oncol"[jour]
Wed Oct 23, 2019 14:15
head and neck; +106 new citations
106 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/10/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Head and Neck
Wed Oct 23, 2019 14:12
head and neck; +106 new citations
106 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/10/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Head and Neck
Wed Oct 23, 2019 13:11
"J Cell Physiol"[jour]; +20 new citations
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Cell Physiol"[jour] These pubmed results were generated on 2019/10/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
pubmed: "j cell physiol"[jou...
Wed Oct 23, 2019 14:12
Evaluation of Hearing Aid Manufacturers' Software-Derived Fittings to DSL v5.0 Pediatric Targets.
Related ArticlesEvaluation of Hearing Aid Manufacturers' Software-Derived Fittings to DSL v5.0 Pediatric Targets. J Am Acad Audiol. 2019 Oct 07;:1-10 Authors: Folkeard P, Bagatto M, Scollie S Abstract BACKGROUND: Hearing aid prescriptive methods are a commonly recommended component of evidence-based preferred practice guidelines and are often implemented in the hearing aid programming software. Previous studies evaluating hearing aid manufacturers' software-derived...
j am acad audiol
Wed Oct 23, 2019 14:11
Effect of Forward Masking on Frequency Following Response as a Function of Age.
Related ArticlesEffect of Forward Masking on Frequency Following Response as a Function of Age. J Am Acad Audiol. 2019 Oct 07;:0 Authors: Griz SMS, Menezes DC, Angelo Venâncio LG, Holanda da Fonsêca N, do Nascimento TO, de Araújo AKL, de Andrade KCL, de Lemos Menezes P Abstract BACKGROUND: Forward masking occurs when noise is presented before the target signal, making the latter difficult to be perceived. It is related to temporal auditory processing...
j am acad audiol
Wed Oct 23, 2019 14:11
Mitogen-activated protein kinase pathway inhibition for re-differentiation of radioiodine-refractory differentiated thyroid cancer: an evolving protocol.
Related ArticlesMitogen-activated protein kinase pathway inhibition for re-differentiation of radioiodine-refractory differentiated thyroid cancer: an evolving protocol. Thyroid. 2019 Oct 22;: Authors: Iravani A, Solomon B, Pattison DA, Jackson P, Ravi Kumar AS, Kong G, Hofman MS, Akhurst T, Hicks RJ Abstract Background Some patients with metastatic differentiated thyroid cancer (DTC) lack iodine avidity and are therefore unsuitable for radioactive iodine...
radioactive iodine
Wed Oct 23, 2019 14:06
Biomimetics – Nature's roadmap to insights and solutions for burden of lifestyle diseases
This is an article from the symposium: Stenvinkel Biomimetics. Abstract There are over 8 million species in this world that live in widely varying environments, from hot thermal fissures to cold arctic settings. These species have evolved over millions of years and vary markedly in how they have adapted to their environments. In the last decades, studies of how species have succeeded in surviving in different environments and with different resources have been recognized to provide not...
Journal of Internal Medicine
Tue Oct 22, 2019 14:28
An Autopsy Case of Pulmonary Capillary Hemangiomatosis with an Electron Microscopy Study.
Related ArticlesAn Autopsy Case of Pulmonary Capillary Hemangiomatosis with an Electron Microscopy Study. Am J Case Rep. 2019 Oct 22;20:1551-1557 Authors: Kobayashi H, Otsuki Y, Yamaguchi M, Ko K, Mizuno S, Ujita M, Ohashi R, Sato T, Sato H, Suzuki T Abstract BACKGROUND Pulmonary capillary hemangiomatosis (PCH) and pulmonary veno-occlusive disease (PVOD) are rare diseases that share clinical, X-ray, and histological features. Most patients have poor...
pubmed: "am j case rep"[jour...
Wed Oct 23, 2019 14:03
Neurophysiological Evaluation of a Customizable μECoG-based Wireless Brain Implant.
Related ArticlesNeurophysiological Evaluation of a Customizable μECoG-based Wireless Brain Implant. Conf Proc IEEE Eng Med Biol Soc. 2018 07;2018:2953-2956 Authors: Gkogkidis CA, Bentler C, Wang X, Gierthmuehlen M, Scheiwe C, Schmitz HC, Haberstroh J, Stieglitz T, Ball T Abstract The number of implantable bidirectional neural interfaces available for neuroscientific research applications is still limited, despite the rapidly increasing number of customized...
cortical auditory
Wed Oct 23, 2019 14:03
Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study.
Related ArticlesAuditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study. J Neurosci. 2018 09 26;38(39):8441-8452 Authors: Nourski KV, Steinschneider M, Rhone AE, Kawasaki H, Howard MA, Banks MI Abstract The systems-level mechanisms underlying loss of consciousness (LOC) under anesthesia remain unclear. General anesthetics suppress sensory responses within higher-order cortex and feedback connections,...
cortical auditory
Wed Oct 23, 2019 14:03
Mapping Frequency-Specific Tone Predictions in the Human Auditory Cortex at High Spatial Resolution.
Related ArticlesMapping Frequency-Specific Tone Predictions in the Human Auditory Cortex at High Spatial Resolution. J Neurosci. 2018 05 23;38(21):4934-4942 Authors: Berlot E, Formisano E, De Martino F Abstract Auditory inputs reaching our ears are often incomplete, but our brains nevertheless transform them into rich and complete perceptual phenomena such as meaningful conversations or pleasurable music. It has been hypothesized that our brains extract...
cortical auditory
Wed Oct 23, 2019 14:03
Efficacy and safety of HER2 inhibitors in combination with or without pertuzumab for HER2-positive breast cancer: a systematic review and meta-analysis.
Related ArticlesEfficacy and safety of HER2 inhibitors in combination with or without pertuzumab for HER2-positive breast cancer: a systematic review and meta-analysis. BMC Cancer. 2019 Oct 21;19(1):973 Authors: Chen S, Liang Y, Feng Z, Wang M Abstract BACKGROUND: Although the dual anti-HER2 therapy, namely, pertuzumab plus trastuzumab and docetaxel, has shown promising results in HER2+ breast cancer patients, whether the dose, efficacy and safety of...
pubmed: her2-positive breast...
Wed Oct 23, 2019 16:05
Targeted therapeutic options and future perspectives for HER2-positive breast cancer.
Related ArticlesTargeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduct Target Ther. 2019;4:34 Authors: Wang J, Xu B Abstract Over the past 2 decades, there has been an extraordinary progress in the regimens developed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Trastuzumab, pertuzumab, lapatinib, and ado-trastuzumab emtansine (T-DM1) are commonly recommended...
pubmed: her2-positive breast...
Wed Oct 23, 2019 14:02
Pertuzumab and Trastuzumab Emtansine for Human Epidermal Growth Factor Receptor-2-Positive Metastatic Breast Cancer: Contemporary Population-Based Outcomes.
Related ArticlesPertuzumab and Trastuzumab Emtansine for Human Epidermal Growth Factor Receptor-2-Positive Metastatic Breast Cancer: Contemporary Population-Based Outcomes. Breast Cancer (Auckl). 2019;13:1178223419879429 Authors: Lupichuk S, Cheung WY, Stewart D Abstract Background: Real-world outcomes for patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer (MBC) treated with pertuzumab in combination with...
pubmed: her2-positive breast...
Wed Oct 23, 2019 14:02
CSF volume provocation maneuvers during lumbar puncture as a possible predictive tool for diagnosing spontaneous intracranial hypotension.
Related ArticlesCSF volume provocation maneuvers during lumbar puncture as a possible predictive tool for diagnosing spontaneous intracranial hypotension. Clin Neurol Neurosurg. 2019 Oct 07;186:105552 Authors: Griffin AS, Lu L, Peacock S, Gray L, Kranz PG, Amrhein TJ Abstract OBJECTIVES: Spontaneous intracranial hypotension (SIH) is a pathologic state of low CSF volume caused by a CSF to venous fistula or CSF leak. It is diagnosed based on symptoms,...
leak of cerebrospinal fluid
Wed Oct 23, 2019 15:56
Adverse Events Associated with Balloon Sinuplasty: A MAUDE Database Analysis.
Related ArticlesAdverse Events Associated with Balloon Sinuplasty: A MAUDE Database Analysis. Otolaryngol Head Neck Surg. 2019 Oct 22;:194599819884902 Authors: Hur K, Ge M, Kim J, Ference EH Abstract OBJECTIVE: Balloon sinuplasty utilization has increased significantly since its introduction over a decade ago. However, the most common associated complications are still unknown. The objective of this study was to analyze adverse events related to balloon...
leak of cerebrospinal fluid
Wed Oct 23, 2019 15:56
Identification of Risk Factors for Postoperative Cerebrospinal Fluid Leakage and Comparison of Two Alternative Dural Augmentation Techniques in Posterior Fossa and Spinal Surgeries.
Related ArticlesIdentification of Risk Factors for Postoperative Cerebrospinal Fluid Leakage and Comparison of Two Alternative Dural Augmentation Techniques in Posterior Fossa and Spinal Surgeries. Turk Neurosurg. 2019;29(3):377-385 Authors: Eser MT, Hanalioglu S, Cetiner MZ, Dinc S, Peker HO, Sorar M, Dolgun H, Turkoglu E Abstract AIM: To investigate comparative efficacy of a novel absorbable adhesive membrane (TissuePatchDuralTM "TPD") and a fibrin...
leak of cerebrospinal fluid
Wed Oct 23, 2019 14:02
A Rare Case of Negative-Pressure Hydrocephalus: A Plausible Explanation and the Role of Transmantle Theory.
Related ArticlesA Rare Case of Negative-Pressure Hydrocephalus: A Plausible Explanation and the Role of Transmantle Theory. World Neurosurg. 2019 05;125:6-9 Authors: Diaz-Romero Paz R, Avendaño Altimira P, Coloma Valverde G, Balhen Martin C Abstract BACKGROUND: Negative-pressure hydrocephalus is a rare condition with the development of symptomatic hydrocephalus despite subnormal intracranial pressure (ICP). The etiology remains unclear. Some authors...
leak of cerebrospinal fluid
Wed Oct 23, 2019 14:02

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