As a first-generation epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib was approved by the US Food and Drug Administration for treatment of advanced non-small cell carcinoma with sensitizing EGFR mutations. Gefitinib is known to have adverse effects, which may necessitate dose reduction or even change to alternative preparation of epidermal growth factor receptor-tyrosine kinase inhibitor. There has been concern on dose reduction resulting in reduced dose gefitinib, especially...
Wed Oct 02, 2019 03:00
Although arsenic trioxide (ATO) treatment has transformed acute promyelocytic leukemia (APL) from the most fatal to the most curable hematological cancer, many high-risk APL patients who fail to achieve a complete molecular remission or relapse become resistant to ATO. Herein, we report that 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) exhibits specific anticancer effects on APL and ATO-resistant APL in vitro and in vivo, while showing negligible cytotoxic...
Wed Oct 02, 2019 03:00
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Haiying Sun, Jipeng Jiang, Lei Gong, Xiao Li, Yang Yang, Yuechen Luo, Zhaozeng Guo, Ruiyi Lu, Hongxia Li, Jinlong Li, Jihong Zhao, Ning Yang, Yuming LiAbstractInflammatory monocyte and macrophage subset accumulation during the inflammatory response that drives atherosclerosis can exacerbate the extent of atherosclerosis. It has been demonstrated that voltage-gated sodium channels (VGSCs) can regulate cell...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Wei Xing, Yongli Song, Hongli Li, Zhenglin Wang, Yan Wu, Chun Li, Yong Wang, Yonggang Liu, Wei Wang, Jing HanAbstractFufang Xueshuantong (FXST), a Chinese patent medicine, is composed of Panax notoginseng, Salviae miltiorrhizae, Astragali Radix and Radix Scrophulariae and has been found to prevent diabetic retinopathy. Yes-associated protein (YAP) participates in the pathophysiology of retinal disease and...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Yanan Zhang, Dawei Liu, Haijuan Hu, Puqiang Zhang, Ruiqin Xie, Wei CuiAbstractObjectiveThe study was established to inquire into the protective effect of the HIF-1α (Hypoxia-inducible factor-1α)/ BNIP3(Bcl-2/adenovirus E1B 19-kDa interacting protein) signal path-induced-autophagy during myocardial ischemia/ reperfusion (I/R) and oxygen–glucose deprivation/recovery (OGD/R) injury in heart-derived H9C2 cells...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Jinli Wang, Gaoxing Su, Xiaoqin Yin, Jia Luo, Rongrong Gu, Shuang Wang, Jian Feng, Bohua ChenAbstractAfatinib (Afa), a second-generation irreversible epidermal growth factor inhibitor for the development of non-small cell lung cancer, has low bioavailability and adverse reactions. Nanoscaled drug delivery systems offer promising alternatives to address these defects and improve therapeutic outcomes. In...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Qianhao Yang, Wenjing Yin, Yixuan Chen, Daoyu Zhu, Junhui Yin, Changqing Zhang, Youshui GaoAbstractOsteonecrosis of the femoral head (ONFH) is usually caused by chronic and excessive alcohol dependency, and this condition largely suppresses the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). As a trimethyl derivative of glycine, betaine is an important human nutrient that regulates a...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Xiaohui Tian, Yang Liu, Xiaoli Liu, Shanjun Gao, Xiaofang SunAbstractGlycyrrhizic acid ammonium salt (GAAS) is derived from glycyrrhizic acid, which is an active compound extracted from the Chinese traditional medicine licorice. GAAS is clinically applied to treat immune-mediated liver injury, but its mechanism remains elusive. Therefore, this study aimed to investigate the mechanism in which GAAS alleviates...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Chiao-Yun Chen, Yu-Jung Lin, Charles C.N. Wang, Yu-Hsuan Lan, Shou-Jen Lan, Ming-Jyh SheuAbstractStrategies targeting endoglin are currently being investigated in clinical trials as an anti-angiogenic therapy. The redundancy between endoglin and vascular endothelial growth factor (VEGF) signaling in angiogenesis was verified. Increased endoglin signaling after an anti-VEGF treatment was observed in patients....
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Huan Zhou, Bin Wang, Yingxi Yang, Qiujin Jia, Zhongwen Qi, Ao Zhang, Shichao Lv, Junping ZhangAbstractThe occurrence of ischemic heart disease(IHD) is a multi-step chain process from potential risk factors to overt clinical diseases. Vascular cells, blood cells, cardiomyocytes and stem cells are all involved in the pathophysiological links via continual and polynary crosstalk. Exosomes,as powerful vectors...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Babalwa U. Jack, Christiaan J. Malherbe, Mokadi Mamushi, Christo J.F. Muller, Elizabeth Joubert, Johan Louw, Carmen PheifferAbstractObesity is a significant contributor to increased morbidity and premature mortality due to increasing the risk of many chronic metabolic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle modifications such as energy restriction...
Fri Oct 04, 2019 19:49
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Min Jiang, Mingliang Zhu, Lu Wang, Shuwen YuAbstractMyricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone) is a natural flavonol compound found in a large variety of plants, including berries, oranges, grapes, herbs, teas, and wine. In the last decade, a convergence of evidence has demonstrated that myricetin has good biological activity as an anti-tumor, anti-inflammatory, and anti-oxidation agent. In studies...
Fri Oct 04, 2019 19:49
Publication date: Available online 3 October 2019Source: BrachytherapyAuthor(s): Yaowen Zhang, Angeles Rovirosa, Carlos Ascaso, Antonio Herreros, Aureli Torne, Yan Li, Albert Biete, Joan SánchezAbstractPurposeThe purpose of this study was to analyze the direct economic impact of two vaginal cuff brachytherapy (VBT) schedules in postoperative endometrial carcinoma (PEC) with similar vaginal control and toxicity results.Materials and MethodsFrom 2006 to 2015, 397 PEC patients (p) were treated with...
Fri Oct 04, 2019 18:44
Abstract Excessive activation of the mineralocorticoid receptor underlies the pathophysiology of heart failure and chronic kidney disease. Hyperkalemia risk limits the therapeutic use of conventional mineralocorticoid receptor antagonists. AZD9977 is a nonsteroidal, selective mineralocorticoid receptor modulator that may protect non‐epithelial tissues without disturbing electrolyte balance. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple...
Fri Oct 04, 2019 18:03
Publication date: Available online 4 October 2019Source: Clinical TherapeuticsAuthor(s): Ji-Hee Sung, Da Young Lee, Kyoung Pil Min, Cheol-Young ParkAbstractPurposeThe prevalence of gestational diabetes mellitus (GDM) is increasing, and multifaceted interventions are effective in the management of GDM. This study aimed to develop and evaluate a model for the management of GDM with the use of mobile health care.MethodsThis was a prospective, randomized controlled pilot study. A total of 21 patients...
Fri Oct 04, 2019 13:31
Publication date: Available online 3 October 2019Source: Clinical TherapeuticsAuthor(s): Claire Ervin, Vijay N. Joish, Emily Evans, Dana DiBenedetti, Matthew Reaney, Ronald Preblick, Rita Castro, Thomas Danne, John B. Buse, Pablo LapuertaAbstractPurposeThe purpose of this study was to conduct qualitative participant interviews to provide context to the meaningfulness of improvements in end points seen in 2 large-scale Phase III sotagliflozin trials in participants with type 1 diabetes.MethodsParticipants...
Fri Oct 04, 2019 13:31
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