Σάββατο 5 Οκτωβρίου 2019


Increasing the diagnostic yield of stereotactic brain biopsy using intraoperative histological smear
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Bertrand Mathon, Aymeric Amelot, Karima Mokhtari, Franck BielleAbstractObjectiveThe negative biopsy rate approaches 5% in the literature. In our institution, this rate was 2.6% (42/1638) over a ten-year period (2007-2016). We aimed to assess the diagnostic yield of intraoperative smear during stereotactic biopsies to reduce this negative biopsy rate.Patients and MethodsWe retrospectively analyzed...
Clinical Neurology and Neurosurgery
Fri Oct 04, 2019 15:17
Opioid-Related Adverse Events Following Spine Surgery in Elderly Patients
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Mark R. Jones, Ethan Y. Brovman, Matthew B. Novitch, Nikhilesh Rao, Richard D. UrmanAbstractObjectiveUnderstanding the clinical and economic impact of opioid-related adverse drug events (ORADEs) within spine surgery may guide both the clinician’s and hospital administration’s approach to treating perioperative pain, thus improving patient care and reducing hospital costs. The objective of this analysis...
Clinical Neurology and Neurosurgery
Fri Oct 04, 2019 15:17
Cervical Intradural Recurrence of Multiple Myeloma during Hematological Remission: A Case Report and Literature Review
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Joe Faddoul, Pascal Jabbour
Clinical Neurology and Neurosurgery
Fri Oct 04, 2019 15:17
Abdominal wall paresis after posterior spine surgery: An anatomic explanation
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): William Clifton, Carlos Fernando Nicolas Cruz, Conrad Dove, Aaron Damon, Mark Pichelmann, Eric Nottmeier
Clinical Neurology and Neurosurgery
Fri Oct 04, 2019 15:17
Object shape and surface properties are jointly encoded in mid-level ventral visual cortex
Publication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Anitha Pasupathy, Taekjun Kim, Dina V PopovkinaRecognizing a myriad visual objects rapidly is a hallmark of the primate visual system. Traditional theories of object recognition have focused on how crucial form features, for example, the orientation of edges, may be extracted in early visual cortex and utilized to recognize objects. An alternative view argues that much of early and mid-level visual processing...
Current Opinion in Neurobiology
Fri Oct 04, 2019 17:26
Mind the last spike — firing rate models for mesoscopic populations of spiking neurons
Publication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Tilo Schwalger, Anton V ChizhovThe dominant modeling framework for understanding cortical computations are heuristic firing rate models. Despite their success, these models fall short to capture spike synchronization effects, to link to biophysical parameters and to describe finite-size fluctuations. In this opinion article, we propose that the refractory density method (RDM), also known as age-structured population...
Current Opinion in Neurobiology
Fri Oct 04, 2019 17:26
The relationship between a measure of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults
Abstract Fundamental human studies which address associations between glutamate and iron metabolism are needed. Basic research reports associations between glutamate and iron metabolism. Human studies report sex differences in iron metabolism and glutamate concentrations, which suggests that these relationships may differ by sex. We hypothesised associations would be apparent between in vivo glutamate and peripheral markers of iron metabolism, and these associations would differ by sex. To test...
European Journal of Neuroscience
Fri Oct 04, 2019 12:14
The impact of diabetic peripheral neuropathy on pinch proprioception
Abstract This study aims to investigate the impact of type 2 diabetes (T2D) and diabetic peripheral neuropathy (DPN) on pinch proprioception and to establish the correlations with sensory impairments. We collected data from a total of 36 participants (healthy, n = 12; T2D without DPN, n = 11; and T2D + DPN, n = 13), all matched for age, 60 ± 6 years. Pinch proprioception was determined through 3 trials of attempts to actively reproduce 15° of pinch position without visual feedback....
Experimental Brain Research
Fri Oct 04, 2019 03:00
ChaRTr: An R toolbox for modeling choices and response times in decision-making tasks
Publication date: 1 December 2019Source: Journal of Neuroscience Methods, Volume 328Author(s): Chandramouli Chandrasekaran, Guy E. HawkinsAbstractBackgroundDecision-making is the process of choosing and performing actions in response to sensory cues to achieve behavioral goals. Many mathematical models have been developed to describe the choice behavior and response time (RT) distributions of observers performing decision-making tasks. However, relatively few researchers use these models because...
Journal of Neuroscience Methods
Fri Oct 04, 2019 21:21
Subjective Cognitive Complaints in Concussion
Journal of Neurotrauma, Ahead of Print.
Journal of Neurotrauma
Fri Oct 04, 2019 10:00
Non-invasive assessment of ICP in children: advances in ultrasound-based techniques
Abstract The assessment of intracranial pressure (ICP) in children with neurological disease remains a cornerstone in their routine management. The quest for a reliable, reproducible and radiation-free non-invasive technique for assessing ICP in children remains somewhat of a holy grail for neurosurgery. This work assesses some of the recent advances in ultrasound-based techniques, addressing both novel processes and modifications aimed at improving the accuracy of existing techniques.
Latest Results for Child's Nervous System
Fri Oct 04, 2019 03:00
Antiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: case report.
Related ArticlesAntiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: case report. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Maynard K, LoPresti M, Iacobas I, Kan P, Lam S Abstract Intracerebral arteriovenous malformations (AVMs) are high-flow collections of abnormal vessels and a common cause of pediatric intracranial hemorrhage. There are few treatment options available for AVMs not amenable to surgical...
Pediatric Neurosurgeons
15:41
Pediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study.
Related ArticlesPediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Oushy S, Perry A, Graffeo CS, Raghunathan A, Carlstrom LP, Daniels DJ Abstract OBJECTIVE: Ganglioglioma is a low-grade central nervous system neoplasm with a pediatric predominance, accounting for 10% of all brain tumors in children. Gangliogliomas of the cervicomedullary junction (GGCMJs)...
Pediatric Neurosurgeons
15:41
Salvage sacrococcygeal resection for yolk sac tumors after chemotherapy: report of 2 cases.
Related ArticlesSalvage sacrococcygeal resection for yolk sac tumors after chemotherapy: report of 2 cases. J Neurosurg Pediatr. 2019 Oct 04;:1-8 Authors: Ravindra VM, Ruggieri L, Vasudevan SA, Hicks MJ, Muscal JA, Quintanilla NM, Schady DA, Aldave G Abstract Pediatric germ cell tumors (GCTs) are neoplasms that originate from primordial germ cells and, according to their site of presentation, are classified as gonadal or extragonadal. The most common...
Pediatric Neurosurgeons
15:41
Assessment of craniocervical motion in Down syndrome: a pilot study of two measurement techniques.
Related ArticlesAssessment of craniocervical motion in Down syndrome: a pilot study of two measurement techniques. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Martin JE, Rocque BG, Jea A, Anderson RCE, Pahys J, Brockmeyer D Abstract OBJECTIVE: Hypermobility of the craniocervical junction (CCJ) in patients with Down syndrome (DS) is common. Whereas atlantoaxial (C1-2) hypermobility is well characterized, occipitoatlantal (Oc-C1) laxity is recognized...
Pediatric Neurosurgeons
15:41
Ac-SDKP ameliorates the progression of experimental autoimmune encephalomyelitis via inhibition of ER stress and oxidative stress in the hippocampus of C57BL/6 mice
Publication date: Available online 4 October 2019Source: Brain Research BulletinAuthor(s): Sina Pejman, Maryam Kamarehei, Gholamhossein Riazi, Shahriar Pooyan, Saeed BalalaieAbstractDespite the attention given to the treatment of multiple sclerosis (MS), still no certain cure is available. The main purpose of MS drugs is acting against neuroinflammation which underlies the pathology of MS. Neuroinflammation is associated with endoplasmic reticulum (ER) stress that mediates neural apoptosis. In the...
ScienceDirect Publication: Brain Research Bulletin
14:11
Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke
Publication date: Available online 4 October 2019Source: Brain Research BulletinAuthor(s): Zhangrong Li, Huiling Ye, Xueli Cai, Weiwen Sun, Bin He, Zhihua Yang, Pingyi XuAbstractAimBone marrow-mesenchymal stem cells (BM-MSCs) possess immunomodulatory properties in the brain. However, it remains unclear whether intravenously transplanted BM-MSCs have a neuromodulator effect on the activation of microglias after ischemic stroke. This study aimed to investigate the immunomodulatory effect of BM-MSCs...
ScienceDirect Publication: Brain Research Bulletin
Fri Oct 04, 2019 14:47
Radioactive Iodine Treatment and Cancer Mortality in Hyperthyroid Patients: Concerns with Study Design and Bias
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Pharmacokinetic imaging with radiolabeled molecularly targeted anticancer drugs
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
ABCG2- and ABCB1 inhibition using supratherapeutic doses of erlotinib: clinical implications in the treatment of CNS metastases
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Myocardial Blood Flow and Myocardial Flow Reserve After Cardiac Transplant; Mistakes in Diagnostic Value and Prognosis
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
There is No Association of Radioactive Iodine Treatment with Cancer Mortality in Patients with Hyperthyroidism
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Theranostics targeting fibroblast activation protein in the tumor stroma: 64Cu and 225Ac labelled FAPI-04 in pancreatic cancer xenograft mouse models
Fibroblast activation protein (FAP), which promotes tumor growth and progression, is overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Owing to its low expression in normal organs, FAP is an excellent target for theranostics. In this study, we used radionuclides with relatively long half-lives, 64Cu (half-life = 12.7 h) and 225Ac (half-life = 10 days), to label FAP inhibitors (FAPI) in mice with human pancreatic cancer xenografts. Methods: Male nude mice (body weight...
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Altering cellular reducing potential changes 64Cu-ATSM signal with or without hypoxia
Background: Therapies targeting reductive/oxidative (redox) metabolism hold potential in cancers resistant to chemotherapy and radiation. A redox imaging marker would help identify cancers susceptible to redox-directed therapies. Copper(II)-diacetyl-bis(4-methylthiosemicarbazonato) (Cu-ATSM) is a positron emission tomography (PET) tracer developed for hypoxia imaging that could potentially be used for this purpose. We aimed to demonstrate that Cu-ATSM signal is dependent upon cellular redox state,...
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Assessing Radiographic Response to Ra-223 with Automated Bone Scan Index (aBSI) in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients.
Rationale: For effective clinical management of patients being treated with Ra-223, there is a need for radiographic response biomarkers to minimize disease progression and to stratify patients for subsequent treatment options. The objective of this study was to evaluate automated Bone Scan Index (aBSI) as a quantitative assessment of bone scan for radiographic response in patients with metastatic castration resistant prostate cancer (mCRPC). Methods: In a multi-center retrospective study, bone...
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
First-in-human imaging with 89Zr-Df-IAB22M2C anti-CD8 minibody in patients with solid malignancies: preliminary pharmacokinetics, biodistribution, and lesion targeting
Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients respond to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in anti-tumor immune responses. Non-invasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of 89Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging...
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Radiopharmaceutical Chemistry
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
Comments Re: Draft Regulatory Guide for Release of Patients Administered Radioactive MaterialDocket ID NRC-2019-0154
The Journal of Nuclear Medicine (JNM)
Fri Oct 04, 2019 23:09
A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): William S. Coggins, Nguyen K. Pham, Anthony V. Nguyen, Daniel W. Branch, June Y. Guillet, Genevieve Korst, Rishi R. LallObjectiveAtypical and anaplastic meningiomas, unlike their benign counterparts, are highly aggressive, locally destructive, and likely to recur after treatment. These diseases are difficult to definitively treat with traditional radiotherapy without injuring adjacent brain parenchyma. The physical properties...
World Neurosurgery
15:47
Mechanical Embolectomy of Distally Migrated Onyx After Surgical Resection of Glomus Vagale Tumor: Technical Report and Review of Literature
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Laura Stone McGuire, Mark Keldahl, Asterios TsimpasBackgroundEndovascular embolization is an important tool in the management of multiple pathologies as a preoperative adjunct in the care of arteriovenous malformations or vascular tumors.Case DescriptionWe report a case of delayed distal Onyx migration after surgical resection of a glomus vagale tumor, which had been preoperatively embolized. In this report, the patient...
World Neurosurgery
15:47
Outcomes After Intracranial Hemorrhage in Patients with Left Ventricular Assist Devices: A Systematic Review of Literature
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Theresa Elder, Alankrita Raghavan, Arvin Smith, Christina Huang Wright, James Wright, Christopher Burant, Martha Sajatovic, Alan HofferBackgroundIntracranial hemorrhage (ICH) is a common complication in patients with left ventricular assist devices (LVADs) and carries a dismal prognosis. Limited data are available on the management and outcomes in this population, which are essential to determine an optimal treatment...
World Neurosurgery
Fri Oct 04, 2019 13:51
Successful Thrombectomy Using Sofia (6F) PLUS Catheter in Acute Stroke Patient with Coincident Proximal Unruptured Aneurysm
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Hui Li, Jian-Feng Liu, Cong-Hui Li, Ji-Wei Wang, Yang-Yang TianBackgroundLittle literature is available on mechanical thrombus aspiration in acute ischemic stroke with coincident ipsilateral unruptured aneurysm, especially with aneurysm proximal to the occlusion site. In this report, we describe a case of ischemic stroke in a patient with acute occlusion of M1 segment of the middle cerebral artery with coincident ipsilateral...
World Neurosurgery
Fri Oct 04, 2019 13:51

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