Increasing the diagnostic yield of stereotactic brain biopsy using intraoperative histological smear
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Bertrand Mathon, Aymeric Amelot, Karima Mokhtari, Franck BielleAbstractObjectiveThe negative biopsy rate approaches 5% in the literature. In our institution, this rate was 2.6% (42/1638) over a ten-year period (2007-2016). We aimed to assess the diagnostic yield of intraoperative smear during stereotactic biopsies to reduce this negative biopsy rate.Patients and MethodsWe retrospectively analyzed...
Fri Oct 04, 2019 15:17
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Mark R. Jones, Ethan Y. Brovman, Matthew B. Novitch, Nikhilesh Rao, Richard D. UrmanAbstractObjectiveUnderstanding the clinical and economic impact of opioid-related adverse drug events (ORADEs) within spine surgery may guide both the clinician’s and hospital administration’s approach to treating perioperative pain, thus improving patient care and reducing hospital costs. The objective of this analysis...
Fri Oct 04, 2019 15:17
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Joe Faddoul, Pascal Jabbour
Fri Oct 04, 2019 15:17
Publication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): William Clifton, Carlos Fernando Nicolas Cruz, Conrad Dove, Aaron Damon, Mark Pichelmann, Eric Nottmeier
Fri Oct 04, 2019 15:17
Publication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Anitha Pasupathy, Taekjun Kim, Dina V PopovkinaRecognizing a myriad visual objects rapidly is a hallmark of the primate visual system. Traditional theories of object recognition have focused on how crucial form features, for example, the orientation of edges, may be extracted in early visual cortex and utilized to recognize objects. An alternative view argues that much of early and mid-level visual processing...
Fri Oct 04, 2019 17:26
Publication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Tilo Schwalger, Anton V ChizhovThe dominant modeling framework for understanding cortical computations are heuristic firing rate models. Despite their success, these models fall short to capture spike synchronization effects, to link to biophysical parameters and to describe finite-size fluctuations. In this opinion article, we propose that the refractory density method (RDM), also known as age-structured population...
Fri Oct 04, 2019 17:26
Abstract Fundamental human studies which address associations between glutamate and iron metabolism are needed. Basic research reports associations between glutamate and iron metabolism. Human studies report sex differences in iron metabolism and glutamate concentrations, which suggests that these relationships may differ by sex. We hypothesised associations would be apparent between in vivo glutamate and peripheral markers of iron metabolism, and these associations would differ by sex. To test...
Fri Oct 04, 2019 12:14
Abstract This study aims to investigate the impact of type 2 diabetes (T2D) and diabetic peripheral neuropathy (DPN) on pinch proprioception and to establish the correlations with sensory impairments. We collected data from a total of 36 participants (healthy, n = 12; T2D without DPN, n = 11; and T2D + DPN, n = 13), all matched for age, 60 ± 6 years. Pinch proprioception was determined through 3 trials of attempts to actively reproduce 15° of pinch position without visual feedback....
Fri Oct 04, 2019 03:00
Publication date: 1 December 2019Source: Journal of Neuroscience Methods, Volume 328Author(s): Chandramouli Chandrasekaran, Guy E. HawkinsAbstractBackgroundDecision-making is the process of choosing and performing actions in response to sensory cues to achieve behavioral goals. Many mathematical models have been developed to describe the choice behavior and response time (RT) distributions of observers performing decision-making tasks. However, relatively few researchers use these models because...
Fri Oct 04, 2019 21:21
Journal of Neurotrauma, Ahead of Print.
Fri Oct 04, 2019 10:00
Abstract The assessment of intracranial pressure (ICP) in children with neurological disease remains a cornerstone in their routine management. The quest for a reliable, reproducible and radiation-free non-invasive technique for assessing ICP in children remains somewhat of a holy grail for neurosurgery. This work assesses some of the recent advances in ultrasound-based techniques, addressing both novel processes and modifications aimed at improving the accuracy of existing techniques.
Fri Oct 04, 2019 03:00
Related ArticlesAntiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: case report. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Maynard K, LoPresti M, Iacobas I, Kan P, Lam S Abstract Intracerebral arteriovenous malformations (AVMs) are high-flow collections of abnormal vessels and a common cause of pediatric intracranial hemorrhage. There are few treatment options available for AVMs not amenable to surgical...
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Related ArticlesPediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Oushy S, Perry A, Graffeo CS, Raghunathan A, Carlstrom LP, Daniels DJ Abstract OBJECTIVE: Ganglioglioma is a low-grade central nervous system neoplasm with a pediatric predominance, accounting for 10% of all brain tumors in children. Gangliogliomas of the cervicomedullary junction (GGCMJs)...
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Related ArticlesSalvage sacrococcygeal resection for yolk sac tumors after chemotherapy: report of 2 cases. J Neurosurg Pediatr. 2019 Oct 04;:1-8 Authors: Ravindra VM, Ruggieri L, Vasudevan SA, Hicks MJ, Muscal JA, Quintanilla NM, Schady DA, Aldave G Abstract Pediatric germ cell tumors (GCTs) are neoplasms that originate from primordial germ cells and, according to their site of presentation, are classified as gonadal or extragonadal. The most common...
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Related ArticlesAssessment of craniocervical motion in Down syndrome: a pilot study of two measurement techniques. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Martin JE, Rocque BG, Jea A, Anderson RCE, Pahys J, Brockmeyer D Abstract OBJECTIVE: Hypermobility of the craniocervical junction (CCJ) in patients with Down syndrome (DS) is common. Whereas atlantoaxial (C1-2) hypermobility is well characterized, occipitoatlantal (Oc-C1) laxity is recognized...
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Publication date: Available online 4 October 2019Source: Brain Research BulletinAuthor(s): Sina Pejman, Maryam Kamarehei, Gholamhossein Riazi, Shahriar Pooyan, Saeed BalalaieAbstractDespite the attention given to the treatment of multiple sclerosis (MS), still no certain cure is available. The main purpose of MS drugs is acting against neuroinflammation which underlies the pathology of MS. Neuroinflammation is associated with endoplasmic reticulum (ER) stress that mediates neural apoptosis. In the...
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Publication date: Available online 4 October 2019Source: Brain Research BulletinAuthor(s): Zhangrong Li, Huiling Ye, Xueli Cai, Weiwen Sun, Bin He, Zhihua Yang, Pingyi XuAbstractAimBone marrow-mesenchymal stem cells (BM-MSCs) possess immunomodulatory properties in the brain. However, it remains unclear whether intravenously transplanted BM-MSCs have a neuromodulator effect on the activation of microglias after ischemic stroke. This study aimed to investigate the immunomodulatory effect of BM-MSCs...
Fri Oct 04, 2019 14:47
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Fibroblast activation protein (FAP), which promotes tumor growth and progression, is overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Owing to its low expression in normal organs, FAP is an excellent target for theranostics. In this study, we used radionuclides with relatively long half-lives, 64Cu (half-life = 12.7 h) and 225Ac (half-life = 10 days), to label FAP inhibitors (FAPI) in mice with human pancreatic cancer xenografts. Methods: Male nude mice (body weight...
Fri Oct 04, 2019 23:09
Background: Therapies targeting reductive/oxidative (redox) metabolism hold potential in cancers resistant to chemotherapy and radiation. A redox imaging marker would help identify cancers susceptible to redox-directed therapies. Copper(II)-diacetyl-bis(4-methylthiosemicarbazonato) (Cu-ATSM) is a positron emission tomography (PET) tracer developed for hypoxia imaging that could potentially be used for this purpose. We aimed to demonstrate that Cu-ATSM signal is dependent upon cellular redox state,...
Fri Oct 04, 2019 23:09
Rationale: For effective clinical management of patients being treated with Ra-223, there is a need for radiographic response biomarkers to minimize disease progression and to stratify patients for subsequent treatment options. The objective of this study was to evaluate automated Bone Scan Index (aBSI) as a quantitative assessment of bone scan for radiographic response in patients with metastatic castration resistant prostate cancer (mCRPC). Methods: In a multi-center retrospective study, bone...
Fri Oct 04, 2019 23:09
Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients respond to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in anti-tumor immune responses. Non-invasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of 89Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging...
Fri Oct 04, 2019 23:09
Fri Oct 04, 2019 23:09
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): William S. Coggins, Nguyen K. Pham, Anthony V. Nguyen, Daniel W. Branch, June Y. Guillet, Genevieve Korst, Rishi R. LallObjectiveAtypical and anaplastic meningiomas, unlike their benign counterparts, are highly aggressive, locally destructive, and likely to recur after treatment. These diseases are difficult to definitively treat with traditional radiotherapy without injuring adjacent brain parenchyma. The physical properties...
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Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Laura Stone McGuire, Mark Keldahl, Asterios TsimpasBackgroundEndovascular embolization is an important tool in the management of multiple pathologies as a preoperative adjunct in the care of arteriovenous malformations or vascular tumors.Case DescriptionWe report a case of delayed distal Onyx migration after surgical resection of a glomus vagale tumor, which had been preoperatively embolized. In this report, the patient...
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Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Theresa Elder, Alankrita Raghavan, Arvin Smith, Christina Huang Wright, James Wright, Christopher Burant, Martha Sajatovic, Alan HofferBackgroundIntracranial hemorrhage (ICH) is a common complication in patients with left ventricular assist devices (LVADs) and carries a dismal prognosis. Limited data are available on the management and outcomes in this population, which are essential to determine an optimal treatment...
Fri Oct 04, 2019 13:51
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Hui Li, Jian-Feng Liu, Cong-Hui Li, Ji-Wei Wang, Yang-Yang TianBackgroundLittle literature is available on mechanical thrombus aspiration in acute ischemic stroke with coincident ipsilateral unruptured aneurysm, especially with aneurysm proximal to the occlusion site. In this report, we describe a case of ischemic stroke in a patient with acute occlusion of M1 segment of the middle cerebral artery with coincident ipsilateral...
Fri Oct 04, 2019 13:51
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