Medgadget
- Complex Hydrogel Structures to Host Living Cells Printed Using New TechniqueHydrogels are one of the hottest materials in biomedical research these days, as anyone following this publication will attest to. They’re biocompatible, have the squishy consistency of soft tissues, and they can be tinkered with to host living cells, deliver drugs, and hopefully one day serve as replacements for diseased tissues and organs. Hydrogels’ unique lightness and softness, though, makes it hard to 3D print structures and living c
- Exoskeleton Walks to Brain’s CommandsPowered exoskeletons are used to help people with lower limb paralysis get on their feet and allow post-stroke patients to recover faster. They’re pretty impressive devices, but people who are severely disabled, including those suffering from tetraplegia, can’t get much benefit from them. Now, a team of researchers in France has succeeded in getting a man, who otherwise can’t move his arms or legs because of a spinal cord injury, t
- Free App Scans Everyday Photos of Kids for Signs of DiseaseLeukocoria, also known as white puppilary reflex, is a symptom of a number of diseases, including retinoblastoma, Coats’ disease, and congenital cataracts. When light enters the eye at certain angles in people with leukocoria, a white reflection from the retina can be seen. While easy to spot with ophthalmic equipment, the condition, and the underlying disease, often goes unnoticed for much too long. Retinoblastoma, for example, is detected via i
Angewandte Chemie International Edition
- Construction of Covalent‐Organic Frameworks from Amorphous Covalent Organic Polymers via Linkage ReplacementCovalent‐organic frameworks (COFs) as porous crystalline materials show promising application potentials. However, developing facile strategies for the construction of COFs directly from amorphous covalent organic polymers (COPs) is still a great challenge. To this end, we report a novel approach for easy preparation of COFs from amorphous COPs through the linkage replacement under different types of reactions, where four COFs with high crystalli
- A DNA‐Azobenzene Nanopump Fueled by Upconversion Luminance for Controllable Intracellular Drug ReleaseStimulus‐responsive drug release possesses considerable significance in cancer precise therapy. Inspired by the continuous rotation‐inversion movement of photoisomerizable azobenzene (Azo), this work designs an upconversion luminance fueled DNA‐Azo nanopump for rapid and efficient drug release. The nanopump is constructed by assembling the Azo‐functionalized DNA strands on upconversion nanoparticles (UCNPs). The selective intercalation of doxorub
- Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base.The electrophotocatalytic SNAr reaction of unactivated aryl fluorides at ambient temperature without strong base is demonstrated.
- Loading Photochromic Molecule into Luminescent Metal‐Organic Framework for Potential Information Anti‐counterfeitingStimuli‐responsive photoluminescent materials have attracted particular attention due to their potential applications in security protection field, because the data or information recorded directly in materials with static luminescent outputs are usually visible under either ambient or UV light. Especially the ones with remote control over reversible luminescence ON‐OFF switch behavior are extremely expected, as reversible visible/invisible infor
- A Stark Contrast to Modern Earth: Phosphate Mineral Transformation and Nucleoside Phosphorylation in an Iron‐ and Cyanide‐Rich Early Earth ScenarioIron and cyanide: A new role is proposed for cyanide as a geochemical agent in promoting prebiotic phosphorylation. Cyanide and its metal complexes can transform and mobilize phosphate from its insoluble iron and calcium minerals, suggesting that phosphate could have been more mobile and prebiotic phosphorylation not as challenging as previously believed on the early Earth. Abstract Organophosphates were likely an important class of prebiot
- Response‐retaliation behaviour in synthetic protocell communitiesTwo different artificial predation strategies are spatially and temporally coupled to generate a simple tit‐for‐tat mechanism in a ternary protocell network capable of antagonistic enzyme‐mediated interactions. The consortium initially consists of protease‐sensitive glucose oxidase‐containing proteinosomes (1), non‐interacting pH‐sensitive polypeptide/mononucleotide coacervate droplets containing protease‐K (2), and proteinosome‐adhered pH‐resist
- Long‐term photostability in Terephthalate Metal Organic FrameworksProlonged (weeks) UV‐Vis irradiation under Ar of UiO‐66(Zr), UiO66 Zr‐NO 2 , MIL101 Fe, MIL125 Ti‐NH 2 , MIL101 Cr and MIL101 Cr(Pt) shows that these MOFs undergo photodecarboxylation of benzenedicarboxylate (BDC) linker in a significant percentage depending on the structure and composition of the material. Routine characterization techniques such as XRD, UV‐Vis spectroscopy and TGA fail to detect changes in the material, although porosity an
- Regioselective oxidative arylation of fluorophenolsA metal free and highly regioselective oxidative arylation reaction of fluorophenols is described. The relative position of the fluoride leaving group (ie ortho or para ) controls the 1,2 or 1,4 nature of the arylated quinone product, lending versatility and generality to this oxidative, defluorinative, arylation concept.
- RAFT‐mediated polymerization‐induced self‐assemblyAfter a brief history that positions polymerisation‐induced self‐assembly (PISA) in the field of polymer chemistry, this review will cover the fundamentals of the PISA mechanism and review some features and limitations of RAFT‐mediated PISA in terms of the choice of the components involved, the nature of the nano‐objects that is achievable, the morphologies that are accessible and how they can be controlled, and some potential applications. This
- Self‐Generation of Surface Roughness by Low‐Surface‐Energy Alkyl Chains for Highly Stable Superhydrophobic/Superoleophilic MOFs with Multiple FunctionalitiesSimply super: Alkyl chains were introduced into the organic linkers of UiO‐67 to provide highly chemically stable hydrophobic MOFs. The alkyl groups protected the hydrophilic Zr6O8 clusters and made the MOF interspace superoleophilic, as well as generating a rough crystal surface for superhydrophobicity. The MOFs are suitable for oil/water separation and water purification, and were modified with metal‐binding ligands for environmentally friendly
- Facile Exfoliation of Single‐Crystalline Copper Alkylphosphates to Single‐Layer Nanosheets and Enhanced SupercapacitanceOne in a million! Single‐crystalline layered copper organophosphates, with nearly a million metal phosphate layers in a single crystal, have been delaminated to a single nanosheet by rapid solvent‐assisted exfoliation. This process aids the formation of high‐surface‐area pyrophosphates with enhanced supercapacitance. Abstract Manipulation of low‐dimensional solids through soft chemical routes is an elegant way to realize newer materials. A
- Identifying Multinuclear Organometallic Intermediates in On‐Surface [2+2] Cycloaddition ReactionsSilver surfer: The [2+2] cycloaddition reaction pathway of 2,3,6,7,10,11‐hexabromotriphenylene (HBTP) molecules on a Ag(111) surface results in a porous covalent network via a multinuclear organo‐silver intermediate. In contrast on a Cu(111) surface no cycloaddition occurs. Abstract We investigate the on‐surface [2+2] cycloaddition reaction of 2,3,6,7,10,11‐hexabromotriphenylene (HBTP) on Ag(111), Cu(111), Au(111), and Cu‐dosed Au(111) surf
- Intermolecular Carbonyl–olefin Metathesis with Vinyl Ethers Catalyzed by Homogeneous and Solid Acids in FlowThe intermolecular carbonyl–olefin metathesis between aromatic ketones/aldehydes and vinyl ethers is accomplished with not only simple soluble but also solid acid catalysts to give trans alkenes in high yields, multi‐gram amounts, and in‐flow. Abstract The carbonyl–olefin metathesis reaction has experienced significant advances in the last seven years with new catalysts and reaction protocols. However, most of these procedures involve solub
- Base Metal Catalyzed Isocyanide InsertionsBack to basics: Base metal catalyzed processes involving isocyanide insertion have recently evolved as promising cross‐coupling reactions. While mechanistic studies are still scarce, proposed catalytic cycles are discussed in this Minireview and the literature is categorized accordingly. This should facilitate the development of new processes to efficiently assemble high added‐value compounds. Abstract Isocyanides are diverse C1 building bl
- Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized AllenylsilanesA copper‐catalyzed silylation reaction of propargyl dichlorides has been developed. In this protocol, racemic and enantioenriched chloro‐substituted allenylsilanes can be accessed in high efficiency under mild reaction conditions. The corresponding products were transformed into a variety of useful synthons. Abstract A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild r
- Effect of Intermolecular Interactions on Metal‐to‐Metal Charge Transfer: A Combined Experimental and Theoretical InvestigationTransfer window: A series of solvent‐free {[Fe(PzTp)(CN)3]2[Co(dpq)2]2}⋅2 A− compounds were synthesized. The variation in π⋅⋅⋅π interactions between dpq ligands coordinated to Co centers can alter the distortion of the CoN6 octahedron and ligand field around the Co ions, thereby allowing control of the thermally and photo‐induced metal‐to‐metal charge transfer (MMCT). Abstract Understanding the effects of intermolecular interactions on meta
- Endowing g‐C3N4 Membranes with Superior Permeability and Stability by Using Acid SpacersAcid spacers: Inspired by the architecture of graphene oxide laminates, we modulated g‐C3N4 membranes by intercalating SO3H and benzene moieties containing molecules between layers. The modified g‐C3N4 membranes give rise to two orders magnitude higher water permeances without sacrificing the separation efficiency, compared with the pure g‐C3N4 membrane. Abstract g‐C3N4 membranes were modulated by intercalating molecules with SO3H and benze
- Surface‐Electron Coupling for Efficient Hydrogen EvolutionSmall modifications have N effect: The controllable modification of graphene/V8C7 heterostructures by nitrogen is reported. Due to changes in the electronic structure of the different parts of the modified heterostructure, it displays an exceptional alkaline hydrogen‐evolution capability, the most efficient alkaline hydrogen‐evolution catalysis among transition‐metal carbides reported thus far. Abstract Maximizing the activity of materials
- S‐Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low PotentialsBlood, sweat & Trp: Electrochemical sensors are essential for point‐of‐care testing and wearable sensing devices. Efficient electron transfer from a redox enzyme to an electrode is established by wiring the two together with S‐click chemistry. These biosensors are sensitive and selective for tryptophan and glycine in blood and sweat. Key: l‐tryptophan oxidase (TrpOx), boron‐dipyrromethene (Bodipy), reduced semiquinone in flavoprotein (FAD⋅).
- In situ Spectroscopic Insight into the Origin of the Enhanced Performance of Bimetallic Nanocatalysts towards the Oxygen Reduction Reaction (ORR)SHINERS (shell‐isolated nanoparticle enhanced Raman spectroscopy) was used to reveal in situ the oxygen reduction reaction (ORR) process on Pt3Co nanocatalysts. An associative mechanism was proposed for ORR on nanocatalysts and the weaker *O adsorption lead to the improved activity. Abstract It is vital to understand the oxygen reduction reaction (ORR) mechanism at the molecular level for the rational design and synthesis of high activity f
- Integration of Graphite and Silicon Anodes for the Commercialization of High‐Energy Lithium‐Ion BatteriesWhy graphite and Si? The practical realization of Si anodes is still a big challenge, but the co‐utilization of graphite and Si could solve this. This Review provides insight into the commercialization of Si anodes, emphasizing the necessity for the co‐utilization of graphite and Si and the development of graphite/Si anodes as well as giving a detailed discussion on their electrochemical behavior and critical factors. Abstract Silicon is co
- An Illumination‐Assisted Flexible Self‐Powered Energy System Based on a Li–O2 BatteryA flexible self‐powered energy system was fabricated by combining a flexible Li‐O2 battery with a flexible solar cell. By exploring the evolution of the electrode morphology and discharge products (Li2O2), the charging process of the Li‐O2 battery powered by solar energy and solar cell is demonstrated. Abstract The flexible Li‐O2 battery is suitable to satisfy the requirements of a self‐powered energy system, thanks to environmental friendl
- Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐SelectivityIsoforms of protein kinase Akt (Akt1/2/3) are involved in a myriad of essential processes including cell proliferation, survival, and metabolism. However, their individual roles in health and disease have not been thoroughly evaluated. Thus, there is an urgent need for perturbation studies, preferably mediated by highly selective bioactive small molecules. Here, we present a structure‐guided approach for the design of structurally diverse and pha
- Pyridine/Oxadiazole‐Based Helical Foldamer Ion Channels with Exceptionally High K+/Na+ SelectivityProtein channels are characterized by high transport selectivity essential for maintaining proper cellular functions. Extensive efforts over the past four decades to recapitulate such high selectivity have not been very successfully. In this work, we report a novel series of aromatic foldamer‐based polymeric channels, with the backbone stabilized by differential electrostatic repulsions among heteroatoms helically arrayed along in the helical bac
Cortex
- A network underlying human higher-order motor control: Insights from machine learning-based lesion-behaviour mapping in apraxia of pantomimePublication date: Available online 4 October 2019Source: CortexAuthor(s): Christoph Sperber, Daniel Wiesen, Georg Goldenberg, Hans-Otto KarnathAbstractNeurological patients with apraxia of pantomime provide us with a unique opportunity to study the neural correlates of higher-order motor function. Previous studies using lesion-behaviour mapping methods led to inconsistent anatomical results, reporting various lesion locations to induce this sympt
- Functional dissociation of anterior cingulate cortex and intraparietal sulcus in visual working memoryPublication date: Available online 4 October 2019Source: CortexAuthor(s): Gian Marco Duma, Giovanni Mento, Simone Cutini, Paola Sessa, Sylvain Baillet, Sabrina Brigadoi, Roberto Dell’AcquaAbstractPrevious electrophysiological studies of lateralized visual working memory (VWM) identified an ERP component, defined as contralateral delay activity (CDA), directly modulated by the number of items held in memory. One of the main candidate as the cortic
- Posterior brain lesions selectively alter alpha oscillatory activity and predict visual performance in hemianopic patientsPublication date: Available online 4 October 2019Source: CortexAuthor(s): Mattia Pietrelli, Marco Zanon, Elisabetta Làdavas, Paolo A. Grasso, Vincenzo Romei, Caterina BertiniAbstractAlpha oscillatory frequency and amplitude have been linked to visual processing and to the excitability of the visual cortex at rest. Therefore, posterior brain lesions, which damage the neural circuits of the visual system might induce alterations in the alpha oscill
- Using memories to support the self in Alzheimer’s diseasePublication date: Available online 4 October 2019Source: CortexAuthor(s): Clare J. Rathbone, Judi A. Ellis, Samrah Ahmed, Chris J.A. Moulin, Alexandra Ernst, Chris R. ButlerAbstractThe impact of memory loss on the self in Alzheimer’s disease (AD) is poorly understood. Previous research is mixed on whether episodic or semantic memories are most important for supporting identity. The present study examined autobiographical memories cued by self-ima
Analytical Chemistry
- [ASAP] Synergy of Peptide–Nucleic Acid and Spherical Nucleic Acid Enabled Quantitative and Specific Detection of Tumor Exosomal MicroRNAAnalytical ChemistryDOI: 10.1021/acs.analchem.9b03622
- [ASAP] Lowering the Size Detection Limits of Ag and TiO<sub>2</sub> Nanoparticles by Single Particle ICP-MSAnalytical ChemistryDOI: 10.1021/acs.analchem.9b04007
- Predicting 5-Year Progression and Survival Outcomes for Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Ablative Radiotherapy: Development and Validation of Robust Prognostic NomogramsPublication date: Available online 3 October 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jingjing Kang, Matthew S. Ning, Han Feng, Hongqi Li, Houda Bahig, Eric D. Brooks, James W. Welsh, Rui Ye, Hongyu Miao, Joe Y. ChangABSTRACTPurposeTo develop predictive nomograms for overall survival (OS), progression-free survival (PFS), and time-to-progression (TTP) at 5-years in patients with early-stage non-small-cell
- The Phase I/II ACCEPT Trial: Concurrent Cetuximab and Intensity-Modulated Radiotherapy with Carbon Ion Boost for Adenoid Cystic Carcinoma of the Head and Neck: Cetuximab and IMRT/Carbon Ions for ACCPublication date: Available online 3 October 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sebastian Adeberg, Sati Akbaba, Kristin Lang, Thomas Held, Vivek Verma, Anna Nikoghosyan, Denise Bernhardt, Marc Münter, Kolja Freier, Peter Plinkert, Henrik Hauswald, Klaus Herfarth, Stefan Rieken, Juergen Debus, Alexandra Desire JensenAbstractIntroductionThe adenoid cystic carcinoma (ACC), Erbitux®, and Particle Therapy
- Effect of cleaning protocol on silica deposition and silica-mediated bonding to Y-TZPPublication date: Available online 4 October 2019Source: Dental MaterialsAuthor(s): Renally Bezerra Wanderley Lima, Suelem Chasse Barreto, Beshr Hajhamid, Grace Mendonça de Souza, Mario Fernando de GoesAbstractObjectivesTo evaluate the effect of cleaning methods on the deposition of silica on yttria-stabilized zirconium dioxide (Y-TZP) surface and on the silane-silica mediated bond strength between Y-TZP and resin cement.MethodsY-TZP slabs were a
- <em>The “Dermal Cage“- Inferiorly Based Dermal Flap Technique for Breast Reconstruction after Mastectomy</em>Publication date: Available online 5 October 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Zlatko Vlajcic, Kreso Martic, Srecko Budi, Zeljka Roje, Daemon Dewing, Rado ZicSummary“Direct to implant”, “one stage” or “immediate” breast reconstruction procedures have became extremely popular in last decade. The additional task of covering the lower pole of the prosthetic implant for stability can be achieved by one of tw
- “Perforator Branch Flaps”Publication date: Available online 4 October 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Atsushi Imaizumi, Hideki KadotaSummaryBackgroundModern microsurgical reconstruction aims to achieve functional and satisfactory esthetic outcome and the primary thinning procedure results in one-stage reconstruction. However, current techniques are lacking of preoperative knowledge of the peripheral perforator in the adipose l
- Intraluminal fluid infusion in a rat jejunum ischemia/reperfusion model is associated with improved tissue perfusion and less mucosal damagePublication date: Available online 4 October 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Dogus Yalcin, Bülent Saçak, Müge Yalcin, Alper Yildirim, Betul Karademir, Feriha Ercan, Özhan CelebilerAbstractObjectiveThis study used an experimental model mimicking early postoperative enteral feeding after transfer of free jejunal flap and tested the hypothesis that jejunal infusion with dextrose or saline is associated wi
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
- Sensitive Detection of Polycyclic Aromatic Hydrocarbons with Gold Colloid Coupled Chloride Ion SERS SensorAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01540J, PaperXuegang Gong, Xiaoyong Liao, You Li, Hongying Cao, Yishu Zhao, Haonan Li, Daniel P. CassidyA simple surface-enhanced Raman spectroscopy (SERS) sensor based on an undecorated gold-colloid substrate was developed for the rapid and effective detection of polycyclic aromatic hydrocarbons (PAH). The SERS enhancement of...The content of this RSS Feed (c) The Royal Society of Chemistry
- Positional effects of premature termination codons on the biochemical and biophysical properties of CFTRKey points Biochemical and biophysical characterizations of three nonsense mutations of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) associated with severe form of cystic fibrosis (CF) reveal the importance and heterogenous effects of the position of the premature termination codon (PTC) on the CFTR protein function. Electrophysiological studies of W1282X‐CFTR, whose PTC is closer to the C‐terminus of CFTR, suggest the presence
Anthropology-News
- Stephen O. Murray1950–2019 Stephen O. Murray, a San Francisco-based sociologist, anthropologist, and independent scholar, died on August 27, 2019, from an aggressive diffuse large B-cell lymphoma. Murray was born in St. Paul, Minnesota, on May 4, 1950, and grew up in Blue Earth, Minnesota. He graduated from the James Madison College within Michigan State University, with a double major in social psychology and in justice, morality, and constitutional democracy.
- Counter-Extremism as Surveillance on the Somali DiasporaAlthough not often considered a hub of the Somali diaspora in America, there are some 8,000 people of Somali descent living in the metropolitan area of Boston. This Somali community lives among many other communities of color in the culturally diverse neighborhoods of Roxbury, Charleston, and Dorchester. [pquote]Despite being one community among many in the majority-minority city of Boston, Somalis, as Black Muslims, are targeted in ways differen
Σάββατο 5 Οκτωβρίου 2019
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