Related Articles DNA Curtains Shed Light on Complex Molecular Systems During Homologous Recombination. J Vis Exp. 2020 Jun 23;(160): Authors: Meir A, Kong M, Xue C, Greene EC Abstract Homologous recombination (HR) is important for the repair of double-stranded DNA breaks (DSBs) and stalled replication forks in all organisms. Defects in HR are closely associated with a loss of genome integrity and oncogenic transformation in human cells....
Tue Jul 14, 2020 17:38
Related Articles Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications. J Vis Exp. 2020 Jun 29;(160): Authors: Mauti S, Léchenne M, Naïssengar S, Traoré A, Kallo V, Kouakou C, Couacy-Hymann E, Gourlaouen M, Mbilo C, Pyana PP, Madaye E, Dicko I, Cozette P, De Benedictis P, Bourhy H, Zinsstag J, Dacheux L Abstract Functional rabies surveillance systems are crucial...
Tue Jul 14, 2020 17:38
Related Articles Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment. J Vis Exp. 2020 Jun 24;(160): Authors: Monaghan KL, Farris BY, Zheng W, Wan ECK Abstract Immune cell expansion, activation, and trafficking to the lungs, which are controlled by the expression of multiple cytokines and chemokines, may be altered by severe brain injury. This is evidenced by the fact that pneumonia is a major cause...
Tue Jul 14, 2020 17:38
Related Articles Monitoring Cancer Cell Invasion and T-Cell Cytotoxicity in 3D Culture. J Vis Exp. 2020 Jun 23;(160): Authors: Lin YN, Nasir A, Camacho S, Berry DL, Schmidt MO, Pearson GW, Riegel AT, Wellstein A Abstract Significant progress has been made in treating cancer with immunotherapy, although a large number of cancers remain resistant to treatment. A limited number of assays allow for direct monitoring and mechanistic insights...
Tue Jul 14, 2020 17:38
Related Articles Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays. J Vis Exp. 2020 Jun 23;(160): Authors: Kamikubo K, Tsukamoto O, Uyama-Saito Y, Oya R, Tsubota T, Fujino N, Asano Y, Kato H, Matsuoka K, Takashima S Abstract Cardiac-specific myosin regulatory light chain kinase (cMLCK) regulates cardiac sarcomere structure and contractility by phosphorylating the ventricular isoform of the myosin regulatory light chain (MLC2v)....
Tue Jul 14, 2020 17:38
Related Articles Graphene-Assisted Quasi-van der Waals Epitaxy of AlN Film on Nano-Patterned Sapphire Substrate for Ultraviolet Light Emitting Diodes. J Vis Exp. 2020 Jun 25;(160): Authors: Zhang X, Chen Z, Chang H, Yan J, Yang S, Wang J, Gao P, Wei T Abstract This protocol demonstrates a method for graphene-assisted quick growth and coalescence of AlN on nano-pattened sapphire substrate (NPSS). Graphene layers are directly grown on NPSS...
Tue Jul 14, 2020 17:38
Related Articles In vivo Mouse Model of Spinal Implant Infection. J Vis Exp. 2020 Jun 23;(160): Authors: Kelley BV, Zoller SD, Greig D, Hori K, Cevallos N, Ishmael C, Hsiue P, Trikha R, Sekimura T, Olson T, Chaudry A, Le MM, Scaduto AA, Francis KP, Bernthal NM Abstract Spine implant infections portend poor outcomes as diagnosis is challenging and surgical eradication is at odds with mechanical spinal stability. The purpose of this method...
Tue Jul 14, 2020 17:38
Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration.
Related Articles Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration. J Vis Exp. 2020 Jun 24;(160): Authors: Tsai S Abstract Classical experiments in salamander regenerative biology over the last century have long established that the wound epidermis is a crucial signaling structure that forms rapidly post-amputation and is required for limb regeneration. However, methods to study its precise...
Tue Jul 14, 2020 17:38
Related Articles Minimum Volume Vitrification of Immature Feline Oocytes. J Vis Exp. 2020 Jun 24;(160): Authors: Colombo M, Luvoni GC Abstract In wild animals' conservation programs, gamete banking is crucial to safeguard genetic resources of valuable individuals and rare species and to promote biodiversity preservation. In felids, most species are threatened with extinction, and domestic breeds are used as a model to increase the efficiency...
Tue Jul 14, 2020 17:38
Related Articles [Screening on hearing loss with the Mini-Audio-Test - A pilot study]. Laryngorhinootologie. 2020 Jul 13;: Authors: Löhler J, Schönweiler R, Schlattmann P Abstract BACKGROUND: In the second half of life, an untreated hearing impairment seems to be associated to increase the risk of dementia, depression, fall, cognitive decline, or general helpless. Most of the affected persons are not treated adequately, e. g. with hearing aids....
Tue Jul 14, 2020 16:38
Related Articles Impact of treatment modality on survival in patients with stage IV laryngeal cancer: A population-based propensity score analysis. Am J Otolaryngol. 2020 Jun 30;41(6):102626 Authors: Köhler HF, de Carvalho GB, Kowalski LP Abstract INTRODUCTION: The treatment of advanced stage laryngeal suffered a major shift away from surgery and towards larynx-preservation alternatives after the publication of major clinical trials. But its...
Tue Jul 14, 2020 16:08
Related Articles Determining pain in patients with voice disorders: a qualitative study. Logoped Phoniatr Vocol. 2020 Jul 13;:1-8 Authors: Tohidast SA, Mansuri B, Bagheri R, Azimi H Abstract AIM: The present study aimed to determine pain in patients with voice disorders (PWVDs). PATIENTS AND METHODS: A total number of 28 patients with a range of voice disorders and without any other diseases participated in the study. To gain maximum...
Tue Jul 14, 2020 16:08
Related Articles Transoral laser microsurgery for polydimethylsiloxane (VOX Implant®) explantation. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Jul 09;: Authors: Sandre C, Gil H, Castellanos PF, Atallah I Abstract INTRODUCTION: Polydimethylsiloxane (VOX Implant®) injection into the larynx is a surgical technique used to restore volume to paralysed or atrophic vocal folds. We present a case series that demonstrates the feasibility of explantation...
Tue Jul 14, 2020 16:08
Related Articles The Feasibility of a Neck-Surface Accelerometer for Estimating the Amount of Acoustic Output During Phonation Regardless of the Difference in the Mouth Configuration. J Voice. 2020 Jul 09;: Authors: Umatani M, Ogawa M, Iwahashi T, Hosokawa K, Kato C, Inohara H Abstract OBJECTIVES: This study aimed to assess the feasibility of a neck-surface accelerometer (ACC) for estimating the amount of acoustic output produced during phonation...
Tue Jul 14, 2020 16:08
Related Articles Endoscopic removal of a fish bone foreign body in the hypopharynx with the modified Killian's method. Auris Nasus Larynx. 2020 Jul 09;: Authors: Kikuchi D, Ikeda M, Murono S Abstract Observing the entire circumference of the hypopharynx is usually difficult because most of the area is anatomically closed in the resting state. The modified Killian's method, consisting of a combination of the modified Killian position, head torsion,...
Tue Jul 14, 2020 16:08
Related Articles Lost in transition: the challenges of getting airway clinicians to move from the upper airway to the neck during an airway crisis. Br J Anaesth. 2020 07;125(1):e38-e46 Authors: Chrimes N, Higgs A, Rehak A Abstract Technical and psychological factors make performance of an emergency front-of-neck airway (eFONA) a challenging procedure for clinical teams involved in airway management. When 'cannot intubate, cannot oxygenate'...
Tue Jul 14, 2020 16:08
Related Articles Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling. Phytomedicine. 2020 Mar;68:153182 Authors: Zhao Y, Luan H, Gao H, Wu X, Zhang Y, Li R Abstract BACKGROUND: Gegen Qinlian decoction (GQ) is a well-known traditional Chinese medicine that has been clinically proven to be effective in treating ulcerative colitis (UC). However,...
Tue Jul 14, 2020 16:08
Related Articles Training anaesthetists in cricothyrotomy techniques using video demonstrations and a hands-on practice session: a shift towards preferred surgical approaches. Br J Anaesth. 2020 07;125(1):e160-e162 Authors: Fradet L, Iorio-Morin C, Tissot-Therrien M, Fortier PH, Colas MJ PMID: 31862161 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 16:08
Related Articles Evaluation of the association between voice formants and difficult facemask ventilation. Eur J Anaesthesiol. 2019 Dec;36(12):972-973 Authors: de Carvalho CC, da Silva DM, de Carvalho AD, Nóbrega FJF, de Orange FA PMID: 31688299 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 16:08
Related Articles Glottic visibility for laryngeal surgery: Tritube vs. microlaryngeal tube: A randomised controlled trial. Eur J Anaesthesiol. 2019 12;36(12):963-971 Authors: Schmidt J, Günther F, Weber J, Kehm V, Pfeiffer J, Becker C, Wenzel C, Borgmann S, Wirth S, Schumann S Abstract BACKGROUND: Good visibility is essential for successful laryngeal surgery. A Tritube with outer diameter 4.4 mm, combined with flow-controlled ventilation (FCV),...
Tue Jul 14, 2020 16:08
Related Articles Changes in laryngeal airway patency in response to complete reversal of rocuronium-induced paralysis with sugammadex in small children with a supraglottic airway: protective effect of fentanyl? Br J Anaesth. 2020 07;125(1):e158-e160 Authors: Ishibashi K, Kitamura Y, Kato S, Sugano M, Sakaguchi Y, Sato Y, Isono S PMID: 31623839 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 16:08
Related Articles Endoscopic Third Ventriculostomy for Hydrocephalus in Infants: A Single-center Experience. Asian J Neurosurg. 2020 Apr-Jun;15(2):302-305 Authors: Lodha KG, Jaiswal G, Gupta TK, Parashar V, Singh Y Abstract Introduction: Hydrocephalus remains one of the more common pathologies managed in pediatric neurosurgery. Endoscopic third ventriculostomy (ETV) has become the procedure of choice for the treatment of hydrocephalus due to...
Tue Jul 14, 2020 15:43
Related Articles Management of antibiotic-resistant Helicobacter pylori infection: current perspective in Iran. J Chemother. 2020 Jul 13;:1-13 Authors: Alihosseini S, Ghotaslou R, Heravi FS, Ahmadian Z, Leylabadlo HE Abstract Helicobacter pylori is a common gastric bacterial pathogen implicated in the pathogenesis of many digestive tract disorders. H. pylori infection prevalence has been reported alarmingly in Iran. A plethora of studies have...
Tue Jul 14, 2020 17:45
Related Articles Broadband Entrainment of Striatal Low-Threshold Spike Interneurons. Front Neural Circuits. 2020;14:36 Authors: Morales JC, Higgs MH, Song SC, Wilson CJ Abstract Striatal interneurons and spiny projection (SP) neurons are differentially tuned to spectral components of their input. Previous studies showed that spike responses of somatostatin/NPY-expressing low threshold spike (LTS) interneurons have broad frequency tuning, setting...
Tue Jul 14, 2020 14:44
Related Articles A Commentary on Gender Does Not Matter: Add-on Repetitive Transcranial Magnetic Stimulation Treatment for Female Methamphetamine Dependents. Front Neural Circuits. 2020;14:27 Authors: Zeng Y, Zheng H, He W PMID: 32655377 [PubMed - in process]
Tue Jul 14, 2020 14:44
Related Articles Design considerations for phase I/II dose finding clinical trials in Immuno-oncology and cell therapy. Contemp Clin Trials. 2020 Jul 10;:106083 Authors: Liu R, Lin J, Li P Abstract Immuno-oncology (IO) and cell therapy, the frontier of cancer treatment, is a rapidly developing area that brings new opportunities to patients. In IO and cell therapy clinical trial development, it is critical to identify the right dose level in...
Tue Jul 14, 2020 14:22
Related Articles High-dose 8% capsaicin patch in treatment of Chemotherapy-induced peripheral neuropathy (CIPN). A Systematic review. J Pain Symptom Manage. 2020 Jul 10;: Authors: Cabezón-Gutiérrez L, Custodio-Cabello S, Palka-Kotlowska M, Khosravi-Shahi P Abstract INTRODUCTION: This is a review of the evidence from studies of the efficacy and tolerability of topically applied, high-concentration (8%) capsaicin in Chemotherapy-induced peripheral...
Tue Jul 14, 2020 14:22
Related Articles The psychological challenges for oncological patients in times of COVID-19 pandemic: telemedicine, a solution? Future Oncol. 2020 Jul 13;: Authors: Schade EC, Elkaddoum R, Kourie HR PMID: 32659118 [PubMed - as supplied by publisher]
Tue Jul 14, 2020 14:22
Related Articles Risk factors and appropriate therapeutic strategies for thrombotic microangiopathy after allogeneic HSCT. Blood Adv. 2020 Jul 14;4(13):3169-3179 Authors: Matsui H, Arai Y, Imoto H, Mitsuyoshi T, Tamura N, Kondo T, Kanda J, Ishikawa T, Imada K, Ueda Y, Toda Y, Anzai N, Yago K, Nohgawa M, Yonezawa A, Tsunemine H, Itoh M, Yamamoto K, Tsuji M, Moriguchi T, Takaori-Kondo A, Kyoto Stem Cell Transplantation Group (KSCTG) Abstract Transplant-associated...
Tue Jul 14, 2020 14:22
Related Articles Genome-wide analyses of the prognosis-related mRNA alternative splicing landscape and novel splicing factors based on large-scale low grade glioma cohort. Aging (Albany NY). 2020 Jul 13;12: Authors: Liu WR, Li CY, Xu WH, Liu XJ, Tang HD, Huang HN Abstract Alternative splicing (AS) changes are considered to be critical in predicting treatment response. Our study aimed to investigate differential splicing patterns and to elucidate...
Tue Jul 14, 2020 14:22
Related Articles The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer. Future Oncol. 2020 Jul 13;: Authors: Mollica V, Rizzo A, Massari F PMID: 32658591 [PubMed - as supplied by publisher]
Tue Jul 14, 2020 14:22
Related Articles Copanlisib in the treatment of non-Hodgkin lymphoma. Future Oncol. 2020 Jul 13;: Authors: Narkhede M, Cheson BD Abstract B-cell receptor signaling is important in the pathogenesis of non-Hodgkin lymphoma. The PI3K pathway is activated by B-cell receptor signaling. Recently, several PI3K inhibitors have been in development for the treatment of indolent non-Hodgkin lymphomas. Copanlisib is a PI3Kα and PI3Kδ inhibitor that has...
Tue Jul 14, 2020 14:22
Related Articles An Integrative Review on Factors Contributing to Fear of Cancer Recurrence Among Young Adult Breast Cancer Survivors. Cancer Nurs. 2020 Jul 10;: Authors: Gormley M, Ghazal L, Fu MR, Van Cleave JH, Knobf T, Hammer M Abstract BACKGROUND: Fear of cancer recurrence (FCR) is the most prevalent need among breast cancer survivors. Age is the most consistent predictor of higher FCR, with prevalence rates as high as 70% among young adults....
Tue Jul 14, 2020 14:22
Related Articles Antibody-drug conjugates in breast cancer: the chemotherapy of the future? Curr Opin Oncol. 2020 Jul 09;: Authors: Nicolò E, Zagami P, Curigliano G Abstract PURPOSE OF REVIEW: Antibody-drug conjugates (ADCs) represent an interesting new class of anticancer agents, capable of exploiting the specificity of monoclonal antibodies toward cellular-antigens for a targeted release of potent cytotoxic drugs, with a potential increased...
Tue Jul 14, 2020 14:22
Related Articles A novel mesenchymal-associated transcriptomic signature for risk-stratification and therapeutic response prediction in colorectal cancer. Int J Cancer. 2020 Jul 13;: Authors: Matsuyama T, Kandimalla R, Ishikawa T, Takahashi N, Yamada Y, Yasuno M, Kinugasa Y, Hansen TF, Fakih M, Uetake H, Győrffy B, Goel A Abstract Risk stratification in Stage II and III colorectal cancer (CRC) patients is critical, as it allows patient selection...
Tue Jul 14, 2020 14:22
Related Articles Supporting and preparing patients for radiotherapy: Patients' and radiation therapists' perspectives on their one-to-one consultations. Eur J Cancer Care (Engl). 2020 Jul 13;:e13284 Authors: Halkett GKB, Merchant S, Smith SK, O'Connor M, Jefford M, Aranda S, Schofield P Abstract OBJECTIVE: Patients are often anxious and lack knowledge of radiotherapy prior to commencing treatment. Evidence-based interventions are required to...
Tue Jul 14, 2020 14:22
Related Articles Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient. Int J Hematol. 2020 Jul 11;: Authors: Kanayama T, Imamura T, Mayumi A, Soma E, Sakamoto K, Hayakawa F, Tanizawa A, Kiyokawa N, Hosoi H Abstract PAX5-KIDINS220 (PAX5-K220) is a novel chimeric fusion gene identified in a pediatric Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) patient, but the function...
Tue Jul 14, 2020 14:22
Related Articles Defining the Ideal Patient with Hepatocellular Carcinoma for Second-Line Treatment. J Oncol. 2020;2020:8024124 Authors: Roviello G, Casadei-Gardini A, Nobili S, Mini E, Fancelli S Abstract Background: Second line of treatment of hepatocellular carcinoma (HCC) has notably changed in recent years as three novel drugs with a different mechanism of action have demonstrated to improve survival compared to placebo; thus, there is...
Tue Jul 14, 2020 14:22
Related Articles Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy. World J Gastroenterol. 2020 Jun 28;26(24):3458-3471 Authors: Polk SL, Choi JW, McGettigan MJ, Rose T, Ahmed A, Kim J, Jiang K, Balagurunathan Y, Qi J, Farah PT, Rathi A, Permuth JB, Jeong D Abstract BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive pancreatic precursor lesions that...
Tue Jul 14, 2020 14:22
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