Background Fibrolamellar carcinoma (FLC) is a rare primary liver cancer of young adults. A functional chimeric transcript resulting from the in‐frame fusion of the DNAJ homolog, subfamily B, member 1 (DNAJB1 ), and the catalytic subunit of protein kinase A (PRKACA ) genes on chromosome 19 is believed to be unique in FLC, with a possible role in pathogenesis, yet with no established therapeutic value. The objective of the current study was to understand the molecular landscape of FLC and to identify...
Tue Jul 14, 2020 19:08
Background To the authors' knowledge, carbon ion radiotherapy (CIRT) is one of the few curative treatments for unresectable pelvic bone sarcoma. The current study investigated the complications, functional outcomes, and risk factors of CIRT. Methods Of 112 patients who were treated with CIRT for unresectable pelvic bone sarcoma, the authors enrolled 29 patients who were without local disease recurrence or distant metastasis. The mean follow‐up was 93 months. Complications, functional outcomes,...
Mon Jul 13, 2020 22:00
Background For adolescents and young adults (AYAs), the diagnosis of cancer can impede social development, especially with respect to education, employment, and financial independence. However, there are limited quantitative data on the extent and trajectory of life disruptions during cancer treatment for AYA patients. Methods This was a longitudinal, prospective, questionnaire‐based cohort study of 145 AYA patients with cancer aged 15 to 29 years who were treated at a large academic cancer...
Mon Jul 13, 2020 16:54
Tue Jul 14, 2020 16:20
Abstract Tumor mutational burden analysis using whole exome sequencing highlights features of a tumor with a number of mutations or known driver alterations. However, cancers with few changes in the exon regions have unclear characteristics, even though low‐mutated tumors are often detected in pan‐cancer analysis. In the present study, we analyzed tumors with low tumor mutational burden in the Japanese version of The Cancer Genome Atlas, a data set of 5020 primary solid tumors. Our analysis revealed...
Tue Jul 14, 2020 12:34
Abstract The well‐known gene‐environment interaction between alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in upper aerodigestive tract cancer risk may improve our ability to identify high‐risk subjects. Here, we developed and validated risk prediction models for this cancer in Japanese men and evaluated whether adding the gene‐environment interaction to the model improved predictive performance. We developed two case‐cohort datasets in the Japan Public Health Center‐based...
Tue Jul 14, 2020 12:29
Purpose: Pembrolizumab improved survival in recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC) patients. The aims of this study were to determine if pembrolizumab would be safe, result in pathologic tumor response (pTR), and lower the relapse rate in patients with resectable human papillomavirus (HPV)-unrelated HNSCC. Methods: Neoadjuvant pembrolizumab (200 mg) was administered and followed 2-3 weeks later by surgical tumor ablation. Post-operative (chemo) radiation was planned....
Tue Jul 14, 2020 15:43
RET gene encodes a receptor tyrosine kinase essential for many physiological functions but RET-aberrations are involved in many pathologies. While RET loss-of-function mutations are associated with congenital disorders like Hirschsprung disease and CAKUT, RET gain-of-function mutations and rearrangements are critical drivers of tumor growth and proliferation in many different cancers. RET-altered (RET+) tumors have been hitherto targeted with multikinase inhibitors (MKIs) having anti-RET activities,...
Tue Jul 14, 2020 15:43
Publication date: Available online 14 July 2020Source: European Journal of Surgical OncologyAuthor(s): Angela Santoro, Giuseppe Angelico, Frediano Inzani, Saveria Spadola, Damiano Arciuolo, Michele Valente, Teresa Musarra, Giovanni Capelli, Francesco Fanfani, Valerio Gallotta, Giovanni Scambia, Gian Franco Zannoni
Tue Jul 14, 2020 18:10
Publication date: Available online 14 July 2020Source: European Journal of Surgical OncologyAuthor(s): Xu Guan, Zhao Lu, Song Wang, Enrui Liu, Zhixun Zhao, Haipeng Chen, Mingguang Zhang, Xiyue Hu, Shan Muhammad, Chenxi Ma, Xiaolong Ma, Haiyang Huang, Zheng Jiang, Zheng Liu, Guiyu Wang, Xishan Wang
Tue Jul 14, 2020 18:10
Publication date: Available online 13 July 2020Source: European Journal of Surgical OncologyAuthor(s): Timothy J. Kenyon-Smith, Hidde M. Kroon, John T. Miura, J. Teras, Georgia M. Beasley, Dean Mullen, Norma E. Farrow, Paul J. Mosca, Michael C. Lowe, Clara R. Farley, Aishwarya Potdar, Hala Daou, James Sun, Jeffrey M. Farma, Michael A. Henderson, David Speakman, Jonathan Serpell, Keith A. Delman, B. Mark Smithers, Andrew Barbour
Tue Jul 14, 2020 18:10
Future Oncology, Ahead of Print.
Tue Jul 14, 2020 13:13
Related Articles The psychological challenges for oncological patients in times of COVID-19 pandemic: telemedicine, a solution? Future Oncol. 2020 Jul 13;: Authors: Schade EC, Elkaddoum R, Kourie HR PMID: 32659118 [PubMed - as supplied by publisher]
Tue Jul 14, 2020 17:45
Related Articles The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer. Future Oncol. 2020 Jul 13;: Authors: Mollica V, Rizzo A, Massari F PMID: 32658591 [PubMed - as supplied by publisher]
Tue Jul 14, 2020 17:45
Related Articles Copanlisib in the treatment of non-Hodgkin lymphoma. Future Oncol. 2020 Jul 13;: Authors: Narkhede M, Cheson BD Abstract B-cell receptor signaling is important in the pathogenesis of non-Hodgkin lymphoma. The PI3K pathway is activated by B-cell receptor signaling. Recently, several PI3K inhibitors have been in development for the treatment of indolent non-Hodgkin lymphomas. Copanlisib is a PI3Kα and PI3Kδ inhibitor that has...
Tue Jul 14, 2020 17:45
Abstract Chromosomal losses resulting in a marked hypodiploidy are a specificity of chromophobe renal cell carcinoma (ChRCC), the third most frequent type of kidney cancer. Its detection is useful in challenging cases. However some ChRCC, especially the eosinophilic variant, do not exhibit hypodiploidy and deserve to be better explored. Using comparative genomic hybridization (array‐CGH) we observed chromosomal gains in five cases of non‐metastatic ChRCC. Our objective was to determine whether...
Mon Jul 13, 2020 15:39
Abstract Most breast cancer patients in sub‐Saharan Africa (SSA) are diagnosed at advanced stages after prolonged symptomatic periods. In the multi‐country African Breast Cancer‐Disparities in Outcomes cohort, we dissected the diagnostic journey to inform down‐staging interventions. At hospital presentation for breast, women recalled their diagnostic journey, including dates of first noticing symptoms and healthcare provider (HCP) visits. Negative binomial regression models were used to identify...
Tue Jul 14, 2020 22:21
Abstract The mortality benefit of esophageal squamous cell carcinoma (ESCC) screening has been reported in several studies; however, the results of ESCC screening programs in China are suboptimal. This study aimed to develop an ESCC risk prediction model to identify high‐risk individuals for population‐based esophageal cancer screening. In total, 86 745 participants enrolled in a population‐based esophageal cancer screening program in rural China between 2007 and 2012 were included in the present...
Tue Jul 14, 2020 22:20
Abstract Birth cohorts vaccinated against human papillomavirus (HPV) are now entering cervical cancer screening. Assessment of (pre)cancer (CIN3+) risk is needed to assess the residual screening need in vaccinated women. We estimated the lifetime (screen‐detected) CIN3+ risk under five‐yearly primary HPV screening between age 30‐60, using HPV genotyping and histology data of 21 287 women participating in a screening trial with two HPV‐based screening rounds, five years apart. The maximum follow‐up...
Tue Jul 14, 2020 22:19
Abstract Inherited pathogenic variants account for 5‐10% of all breast cancer (BC) and colorectal cancer (CRC) cases. Here we sought to profile the pathogenic variants in 25 cancer susceptibility genes in Turkish population. Germline pathogenic variants were screened in 732 BC patients, 189 CRC patients, and 490 cancer‐free elderly controls, using NGS‐based multigene panel testing and MLPA testing. Pathogenic variants were detected in 17.2% of high‐risk BC patients and 26.4% of high‐risk CRC patients....
Mon Jul 13, 2020 16:10
Abstract Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two‐sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low‐density lipoprotein (LDL) and high‐density lipoprotein...
Mon Jul 13, 2020 16:04
Abstract Risk stratification in Stage II and III colorectal cancer (CRC) patients is critical, as it allows patient selection for adjuvant chemotherapy. In view of the inadequacy of current clinicopathological features for risk‐stratification, we undertook a systematic and comprehensive biomarker discovery effort to develop a risk‐assessment signature in CRC patients. The biomarker discovery phase examined 853 CRC patients, and identified a gene signature for predicting recurrence‐free survival...
Mon Jul 13, 2020 14:01
Abstract Advances in cancer treatment are impeded by low accrual rates of patients to cancer clinical trials (CCTs). The national rates of recruitment of underserved groups, including racial/ethnic minorities, are limiting the generalizability of research findings and are likely to enhance inequities in cancer outcomes. The goal of this study was to examine willingness to participate (WTP) in CCTs and factors associated with this willingness among patients and caregivers attending...
Tue Jul 14, 2020 03:00
Transfer of noncoding microRNAs (miRNAs) by extracellular vesicles (EVs) promotes the development of chemoresistance in many tumor types. Additionally, restoration or depletion of several miRNAs has been obser...
Mon Jul 13, 2020 03:00
Abstract Objective This qualitative systematic review aims to synthesize qualitative evidence from primary studies on experiencing health‐related quality of life (HRQoL) in extended and permanent cancer survivors. Methods A systematic literature search was performed in PubMed, CINAHL, LILACS, PsycINFO, Scopus, and Web of Science. It followed guidelines from the statement in the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ). A quality appraisal of each...
Mon Jul 13, 2020 17:28
Mon Jul 13, 2020 17:28
Abstract Objective In order to optimize psycho‐oncological care, studies that quantify the extent of distress and identify certain risk groups are needed. Among patients with prostate cancer (PCa), findings on depression and anxiety are limited. Methods We analyzed data of PCa patients selected from a German multi‐center study. Depression and anxiety were assessed with the PHQ‐9 and the GAD‐7 (cut‐off ≥7). We provided physical symptom burden, calculated absolute and relative risk (AR and...
Mon Jul 13, 2020 17:26
Mon Jul 13, 2020 17:26
Abstract Objective Health risk behaviors (HRB) of childhood cancer survivors (CCS) are generally studied separately, despite the evidence suggesting that HRB are not independent. To our knowledge, few studies have examined HRB profiles in the former pediatric cancer patients. In this study, we identified HRB profiles and examined predictors engaging in unhealthy behaviors in CCS. Methods We used data from a French cohort of CCS that includes five‐year survivors diagnosed between 1945 and...
Mon Jul 13, 2020 17:26
Abstract Objective Cancer‐related fatigue (CRF) affects a substantial number of cancer patients and survivors. Recommendations for CRF treatments are largely based on results of randomized controlled trials. The interpretability of such results is limited to patients eligible and willing to participate in these trials. We aimed to address this limitation in a retrospective study of patients seen at a CRF clinic in a comprehensive cancer center. The objectives were to 1) determine the effectiveness...
Mon Jul 13, 2020 17:26
Mon Jul 13, 2020 17:25
Mon Jul 13, 2020 17:25
Abstract Objective Patients hospitalized with multiple myeloma (MM) are particularly vulnerable to depression. The present study aims to determine the frequency of depression among MM hospitalized patients, in order to assess the possible differences between those with and without depression in relation to sociodemographic and clinical variables and to measure the impact of depression on hospitalization outcomes. Methods An observational retrospective study was performed using an administrative...
Mon Jul 13, 2020 17:25
This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework include...
Mon Jul 13, 2020 03:00
Radiotherapy is widely used as a cancer treatment either alone or in combination with systemic or targeted therapies [1-3]. In addition to killing tumor cells via radiation-induced DNA damage, radiation can also enhance tumor immunogenicity through various mechanisms [4,5], among them the release of tumor-associated antigens and danger-associated molecular patterns [6,7]. Additionally, radiation can also cause rapid depletion of circulating lymphocytes (CLs) [8]. Thus, radiation has both immunostimulant...
Tue Jul 14, 2020 03:00
External beam radiotherapy (EBRT) and brachytherapy (BT) are the two types of radiotherapy techniques that are used clinically [1]. In BT, the radiation device is placed within or close to the tumour or target volume and irradiates internally by means of isotopes. The integration of man-made radioisotopes and remote afterloading techniques has diminished or even completely banned radiation exposure hazards. Innovative imaging modalities (computed tomography, magnetic resonance imaging, ultrasound)...
Tue Jul 14, 2020 03:00
Although a high-dose Radiation Therapy (RT) exposure of the chest and mediastinum represents an effective medical treatment for many tumours, adverse effects on hearth and vessels, also defined as Radiation Induced Heart Disease (RIHD), might arise [1–3].
Tue Jul 14, 2020 03:00
Nasopharyngeal carcinoma (NPC) is the most common head and neck cancer in southern China. Radiotherapy is the primary therapeutic approach for NPC, rather than surgery. With the wide application of intensity-modulated radiation therapy (IMRT), better treatment outcomes of NPC patients were achieved in modern era. But distant metastasis and local-regional relapse are still the causes of treatment failure, especially the former [1–4]. Screening NPC patients with a high risk of distant metastases and...
Tue Jul 14, 2020 03:00
Radiation therapy for head neck cancers (HNCs) at the skull base can result in high doses of radiation delivered to the brain, potentially leading to radiation-associated image changes (RAIC) (1). Often the diagnosis of RAIC is based solely on radiographic findings on post-treatment MRIs obtained for routine cancer surveillance purposes. For HNCs, information on RAIC stems largely from studies in patients with nasopharyngeal cancers (NPC) treated with Intensity Modulated Radiation Therapy (IMRT),...
Tue Jul 14, 2020 03:00
Cancer survival rates are generally increasing worldwide [1], making survivorship research a key component of cancer care. The growing number of cancer survivors includes a large fraction of long-term survivors; in the United States, 45% of the 16.9 million people with a history of cancer who were alive in 2019 had been diagnosed more than 10 years ago [2]. Understanding determinants of second primary cancer risks among long-term survivors is essential for patient information, screening and/or prophylactic...
Tue Jul 14, 2020 03:00
Radiation treatment planning is difficult in gastric cancer patients because of the close adjacency to organs at risk, e.g., the liver, kidney, intestine, lung, heart and spinal cord. The radiobiological exploration of the side effects of radiation therapy in organs at risk, as well as risk doses and clinical factors, which have an influence on radiation damage, is crucial in terms of the safety of radiotherapy. Currently, the QUANTEC (Quantitative Analysis of Normal Tissue Effect in the Clinic)...
Tue Jul 14, 2020 03:00
Soft tissue sarcomas (STS) represent a rare and heterogeneous group of malignant diseases [1]. They arise most often in the extremities and trunk (∼55%), followed by the retroperitoneal/intraabdominal space (∼35%) and the head and neck region (∼10%) [1]. The most important prognostic factors include tumour grade, tumour size, location (deep vs. superficial) and resection margin [2,3]. Complete surgical removal is the cornerstone of curative intent treatment, although its extent has been subject to...
Tue Jul 14, 2020 03:00
With great interest, we have read the publication of Vitullo et al, regarding the use of simulation-CT’s as an opportunistic coronavirus disease 2019 screening tool during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (1). Within the Iridium Network, a radiation therapy (RT) department consisting of 10 linear accelerators, a very similar approach (Figure 1) was adopted. In this short communication, we want to describe our methodology and report the outcome in a population...
Tue Jul 14, 2020 03:00
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Dimitrios Doganis, Andreas Katsimpris, Paraskevi Panagopoulou, Panagiota Bouka, Evdoxia Bouka, Maria Moschovi, Sofia Polychronopoulou, Evgenia Papakonstantinou, Athanasios Tragiannidis, Nick Katzilakis, Helen Dana, Kondilia Antoniadi, Kalliopi Stefanaki, Katerina Strantzia, Nick Dessypris, Joachim Schüz, Eleni Th. Petridou
Tue Jul 14, 2020 12:44
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Greta Rait, Laura Horsfall
Tue Jul 14, 2020 12:44
Publication date: Available online 13 July 2020Source: Seminars in OncologyAuthor(s): Ritika Harjani Hinduja, Karishma George, Mansi Barthwal, Vibhay Pareek
Tue Jul 14, 2020 14:49
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